2020 (92 POSTS)
Thompson CM , Gentry R, Fitch S , Lu K, Clewell HJ. 2020. An updated mode of action and human relevance framework evaluation for formaldehyde-related nasal tumors. Crit Rev Toxicol 50(10):919–952; doi: 10.1080/10408444.2020.1854679 . PMID: 33599198.
View Abstract
Topics: formaldehyde
Gentry R, Thompson CM , Franzen A , Salley J, Albertini R, Lu K, Greene T. 2020. Using mechanistic information to support evidence integration and synthesis: A case study with inhaled formaldehyde and leukemia. Crit Rev Toxicol 50(10):885–918; doi: 10.1080/10408444.2020.1854678 . PMID: 33538218.
View Abstract
Topics: Cancer , formaldehyde
Nelms MD, Karmaus AL, Patlewicz G . 2020. An evaluation of the performance of selected (Q)SARs/expert systems for predicting acute oral toxicity. Comput Toxicol 16(Nov):100135; doi: 10.1016/j.comtox.2020.100135 . PMID: 33163737.
View Abstract
Topics: modeling
Aerts M, Wheeler MW , Abrahantes JC. 2020. An extended and unified modeling framework for benchmark dose estimation for both continuous and binary data. Environmetrics 31(7):e2630; doi: 10.1002/env.2630 . PMID: 36052215.
View Abstract
Topics: benchmark dose estimation (BMD) , dose-response
Brusa V, Costa M, Padola NL, Etcheverria A, Sampedro F , Fernandez PS, Leotta GA, Signorini ML. 2020. Quantitative risk assessment of haemolytic uremic syndrome associated with beef consumption in Argentina. PLoS One 15(11): e0242317; doi: 10.1371/journal.pone.0242317 . PMID: 33186398.
View Abstract
Topics: Food science , risk assessment
Pradeep P, Patlewicz G , Pearce R, Wambaugh J, Wetmore B, Judson R. 2020. Using chemical structure information to develop predictive models for in vitro toxicokinetic parameters to inform high-throughput risk-assessment. Comput Toxicol 16(Nov):100136; doi: 10.1016/j.comtox.2020.100136 . PMID: 34124416.
View Abstract
Topics: risk assessment , toxicokinetics
Revollo JR, Dad A, Pearce MG, Mittelstaedt RA, Casildo A, Lapidus RG, Robison TW , Dobrovolsky VN. 2020. CD59-deficient bone marrow erythroid cells from rats treated with procarbazine and propyl-nitrosourea have mutations in the Pig-a gene. Environ Mol Mutagen 61(8):797-806; doi: 10.1002/em.22402 . PMID: 32729949.
View Abstract
Topics: flow cytometry
Thompson CM , Donahue DA, Hobbs C, Costecalde Y, Franzen A , Suh M , Proctor DM , Harris MA. 2020. Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice. Regul Toxicol Pharmacol 116(Oct):104729; doi: 10.1016/j.yrtph.2020.104729 . PMID: 32652207.
View Abstract
Topics: chromium , Environmental Science , Metals
Saldanha G, Ording AG, Bylsma LC , Darvalics B, Solis D, Tang JY, Sorensen HT, Fryzek J. 2020. High frequency basal cell carcinoma (BCC) in Danish patients: Prevalence and consistency. J Eur Acad Dermatol Venereol 34(10):e646-e648; doi: 10.1111/jdv.16512 . PMID: 32314479.
View Abstract
Topics: Cancer
Buerger AN , Dillon DT, Schmidt J, Yang T, Zubcevic J, Martyniuk CJ, et al. 2020. Gastrointestinal dysbiosis following diethylhexyl phthalate exposure in zebrafish (Danio rerio ): Altered microbial diversity, functionality and network connectivity. Environ Pollut 265(Pt B-Oct):114496; doi: 10.1016/j.envpol.2020.11449 . PMID: 32806437.
View Abstract
Topics: phthalates
Gao R, Guan N, Huang M, Foreman J, Kung M , Rong Z, Su Y, Sweet L, et al. 2020. Read-across: Principle, case study and its potential regulatory application in China. Regul Toxicol Pharmacol 116(Oct):104728; doi: 10.1016/j.yrtph.2020.104728 . PMID: 32649957.
View Abstract
Topics: NAMs , read-across , regulatory toxicology
Nelms MD, Patlewicz G . 2020. Derivation of new threshold of toxicological concern values for exposure via inhalation for environmentally-relevant chemicals. Front Toxicol 2:580347; doi: 10.3389/ftox.2020.580347 . PMID: 35296122.
View Abstract
Topics: inhalation toxicology
Levin-Sparenberg E, Bylsma LC , Lowe K, Sangare L, Fryzek JP, Alexander DD. 2020. A systematic literature review and meta-analysis describing the prevalence of KRAS, NRAS, and BRAF gene mutations in metastatic colorectal cancer. Gastroenterol Res 13(5):184–198; doi: 10.14740/gr1167 . PMID: 33224365.
View Abstract
Topics: Cancer , meta-analysis , Systematic Review
Whaley P, Aiassa E, Beausoleil C, Beronius A, Bilotta, G, Boobis A, de Vries R,… , Wikoff D , et al. 2020. Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER). Environ Int 143(Oct):105926; doi: 10.1016/j.envint.2020.105926 . PMID: 32653802.
View Abstract
Topics: Systematic Review
House JS, Grimm FA, Klaren WD , Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, et al. 2020. Grouping of UVCB substances with new approach methodologies (NAMs) data. ALTEX 38(1):123–137; doi: 10.14573/altex.2006262 . PMID: 33086383.
View Abstract
Topics: NAMs
Guo X, Seo JE, Petibone D, Tryndyak V, Lee UJ, Zhou T, Robison TW , Mei N. 2020. Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment. J Toxicol Environ Health A 83(21-22):702-717; doi: 10.1080/15287394.2020.1822972 .
View Abstract
Topics: benchmark dose estimation (BMD) , mode of action
Jackson AC, Liu J, Vallanat B, Jones C, Nelms MD, Patlewicz G , Corton JC. 2020. Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics 12(9):1400-1415; doi: 10.1039/d0mt00071j . PMID: 32661532.
View Abstract
Topics: Metals
Wheeler MW , Blessinger T, Shao K, Allen BC, Olszyk L, Davis JA, Gift JS. 2020. Quantitative risk assessment: Developing a Bayesian approach to dichotomous dose–response uncertainty. Risk Anal 40(9):1706-22; doi: 10.1111/risa.13537 . PMID: 32602232.
View Abstract