Perry CS, Verwiel AH, Covington TR, Proctor DM. 2024. PBPK modeling demonstrates that exposure time adjustment is unnecessary for setting an acute manganese inhalation exposure guideline. Regul Toxicol Pharmacol 153(Nov):105698; doi: 10.1016/j.yrtph.2024.105698.
Abstract
Highlights
- An acute health-based guideline was developed for Mn exposure that was protective of neurological and respiratory effects.
- Physiologically-based pharmacokinetic modeling was used to confirm that an exposure adjustment factor was not required.
- Default risk assessment approaches may not be appropriate for evaluations of Mn and other essential nutrients.