Publications

Brorby G, Franzen A, Thompson C, Wikoff D, Doepker C. 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 115490; doi: 10.1016/j.fct.2025.115490. Online ahead of print May 2, 2025. PMID: 40320068.

Rivera BN, Lea IA, Fitch S, Choksi N, Franzen A, Bus J, Rushton EK, Borghoff SJ. Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Low concern based on animal cancer studies and mechanistic data. Abstract 4697, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Borghoff SJ, Rivera BN, Fitch S, Buerger A, Choksi N, Franzen A, Bus J, Rushton EK, Lea I. Systematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data. Abstract 4702, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Borghoff SJ, Rivera B, Fitch S, Buerger AN, Choksi N, Franzen A, Vincent MJ, Covington T, Bus J, Rushton E, Lea IA. 2025. Systematic evaluation of the evidence base on methyl tert-butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data. Curr Res Toxicol 8:100224; doi: 10.1016/j.crtox.2025.100224. PMID: 40084233.

Thompson CM, Brorby G, Keig-Shevlin Z, Smith R, Franzen A, Ulrich K, Blanchette AD, Doepker C. 2023. Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures. Environ Mol Mutagen 64(8–9):420–431; doi: 10.1002/em.22576. PMID: 37916278.

Henderson RG, Franke KS, Payne LE, Franzen A. 2023. Cannabidiol safety data: A systematic mapping study. Cannabis Cannabinoid Res 8(1):34–40; doi: 10.1089/can.2022.0100. PMID: 36251454.

Franzen AC, Thompson CM, Brorby GP, Wikoff DS, Ilkbahar Z, Doepker C. Risk assessment of three smoke flavoring primary products currently under re-evaluation by EFSA. Poster presented at Society of Toxicology 62^nd Annual Meeting, Nashville, TN, March 2023.

Goyak KO, Sarang SS, Franzen A, Borghoff SJ, Ryman-Rasumssen JP. 2022. Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats. Crit Rev Toxicol 52(5):345-357; doi: 10.1080/10408444.2022.2082269. PMID: 35862579.

Franke K, Payne L, Franzen A, Wikoff D, Henderson R. 2021. Cannabidiol literature scoping review protocol. Center for Open Science, OSFHOME (May 20).

Wikoff D, Lewis JR, Erraguntla N, Franzen A, Foreman J. 2020. Facilitation of risk assessment with evidence-based methods — A framework for use of systematic mapping and systematic reviews in determining hazard, developing toxicity values, and characterizing uncertainty. Regul Toxicol Pharmacol 118:104790; doi: 10.1016/j.yrtph.2020.104790. PMID: 33038430.

Thompson CM, Donahue DA, Hobbs C, Costecalde Y, Franzen A, Suh M, Proctor DM, Harris MA. 2020. Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice. Regul Toxicol Pharmacol 116:104729; doi: 10.1016/j.yrtph.2020.104729.

Franzen A, Borghoff SJ. An adverse outcome pathway for renal tumors in male rats through chemical induction of aa2u-globuline (a2u) nephropathy (a2u-N). Poster for Society of Toxicology 59th Annual Meeting, Virtual, 2020.

Henderson RG, Franzen A, Franke K, Payne L, Schmitt D, Wikoff D. Creating a literature database for cannabidiol (CBD): Systematic evidence mapping. Poster for Society of Toxicology 59th Annual Meeting, Virtual, 2020.

Gentry R, Thompson CM, Franzen A, Salley J, Albertini R, Lu K, Greene T. 2020. Using mechanistic information to support evidence integration and synthesis: A case study with inhaled formaldehyde and leukemia. Crit Rev Toxicol 50(10):885–918, DOI: 10.1080/10408444.2020.1854678.

Greene T, Rogers S, Franzen A, Gentry R. 2017. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol 47(2):98–120. DOI:10.1080/10408444.2016.1236071.

Franzen A, Greene T, Van Landingham C, Gentry R. 2017. Toxicology of octamethylcyclotetrasiloxane (D4). Toxicol Lett 279 Suppl 1:2–22. DOI:10.1016/j.toxlet.2017.06.007.

Gentry R, Franzen A, Van Landingham C, Greene T, Plotzke K. 2017. A global human health risk assessment for octamethylcyclotetrasiloxane (D4). Regul Toxicol Pharmacol 279(Sup 1):23-41; doi: 10.1016/j.toxlet.2017.05.019.

Franzen A, Van Landingham C, Greene T, Plotzke K, Gentry R. 2016. A global human health risk assessment for decamethylcyclopentasiloxane (D₅). Regul Toxicol Pharmacol 74(Sup):S25–S43; doi: 10.1016/j.yrtph.2015.10.023.

Campbell J, Franzen A, Van Landingham C, Lumpkin M, Crowell S, Meredith C, Loccisano A, Gentry R, Clewell H. 2016. Predicting lung dosimetry of inhaled particle-borne benzo(a)pyrene using physiologically based pharmacokinetic modeling. Inhal Toxicol 28(11):520–535.

Gentry R, Clewell H, Greene T, Franzen A, Yager J. 2014. The impact of recent advances in research on arsenic cancer risk assessment. Regul Toxicol Pharmacol 69(1):91–104.