2025 (4 POSTS)
Brorby G, Franzen A, Thompson C, Wikoff D, Doepker C . 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 115490; doi: 10.1016/j.fct.2025.115490 . Online ahead of print May 2, 2025. PMID: 40320068.
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Topics: flavorings , food safety , Food science , genotoxicity , risk assessment , safety , Toxicology
Rivera BN, Lea IA, Fitch S, Choksi N, Franzen A , Bus J, Rushton EK, Borghoff SJ . Systematic evaluation of the evidence base on ethyl tert-butyl ether and tert-butyl alcohol for carcinogenic potential in humans: Low concern based on animal cancer studies and mechanistic data. Abstract 4697, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
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Topics: carcinogens , Cumulative Impact Assessment , ETBE , Exposure Assessment , MTBE , TBA
Borghoff SJ, Rivera BN, Fitch S, Buerger A, Choksi N, Franzen A , Bus J, Rushton EK, Lea I . Systematic evaluation of the evidence base on methyl tert-butyl ether for carcinogenic potential in humans; Low concern based on animal cancer studies and mechanistic data. Abstract 4702, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
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Topics: carcinogens , MTBE
Borghoff SJ, Rivera B, Fitch S, Buerger AN, Choksi N, Franzen A, Vincent MJ, Covington T, Bus J, Rushton E, Lea IA . 2025. Systematic evaluation of the evidence base on methyl tert -butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data. Curr Res Toxicol 8:100224; doi: 10.1016/j.crtox.2025.100224 . PMID: 40084233.
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Topics: Cancer , carcinogens , MTBE , risk assessment
2023 (2 POSTS)
Thompson CM , Brorby G , Keig-Shevlin Z, Smith R, Franzen A , Ulrich K , Blanchette AD, Doepker C . 2023. Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures. Environ Mol Mutagen 64(8–9):420–431; doi: 10.1002/em.22576 . PMID: 37916278.
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Topics: Food science , Toxicology
Henderson RG , Franke KS , Payne LE, Franzen A . 2023. Cannabidiol safety data: A systematic mapping study. Cannabis Cannabinoid Res 8(1):34–40; doi: 10.1089/can.2022.0100 . PMID: 36251454.
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Topics: Cannabinoid/Industrial Hemp , cannabis , Systematic Review
2022 (1 POST)
Goyak KO, Sarang SS, Franzen A , Borghoff SJ , Ryman-Rasumssen JP. 2022. Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats. Crit Rev Toxicol 52(5):345-357; doi: 10.1080/10408444.2022.2082269 . PMID: 35862579.
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Topics: Toxicology
2020 (5 POSTS)
Wikoff D , Lewis JR, Erraguntla N, Franzen A , Foreman J. 2020. Facilitation of risk assessment with evidence-based methods — A framework for use of systematic mapping and systematic reviews in determining hazard, developing toxicity values, and characterizing uncertainty. Regul Toxicol Pharmacol 118:104790; doi: 10.1016/j.yrtph.2020.104790 . PMID: 33038430.
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Topics: risk assessment , Systematic Review
Thompson CM , Donahue DA, Hobbs C, Costecalde Y, Franzen A , Suh M , Proctor DM , Harris MA. 2020. Exposure to environmentally-relevant concentrations of hexavalent chromium does not induce ovarian toxicity in mice. Regul Toxicol Pharmacol 116:104729; doi: 10.1016/j.yrtph.2020.104729 .
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Topics: chromium , Environmental Science , Metals , Toxicology
Franzen A , Borghoff SJ . An adverse outcome pathway for renal tumors in male rats through chemical induction of aa2u-globuline (a2u) nephropathy (a2u-N). Poster for Society of Toxicology 59th Annual Meeting, Virtual, 2020.
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Topics: Cancer , Toxicology
Henderson RG , Franzen A , Franke K , Payne L, Schmitt D , Wikoff D . Creating a literature database for cannabidiol (CBD): Systematic evidence mapping. Poster for Society of Toxicology 59th Annual Meeting, Virtual, 2020.
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Topics: Cannabinoid/Industrial Hemp , Epidemiology , Systematic Review
Gentry R, Thompson CM , Franzen A , Salley J, Albertini R, Lu K, Greene T. 2020. Using mechanistic information to support evidence integration and synthesis: A case study with inhaled formaldehyde and leukemia. Crit Rev Toxicol 50(10):885–918, DOI: 10.1080/10408444.2020.1854678.
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Topics: Toxicology
2017 (3 POSTS)
Greene T, Rogers S, Franzen A , Gentry R. 2017. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol 47(2):98–120. DOI:10.1080/10408444.2016.1236071.
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Topics: Toxicology
Franzen A , Greene T, Van Landingham C, Gentry R. 2017. Toxicology of octamethylcyclotetrasiloxane (D4). Toxicol Lett 279 Suppl 1:2–22. DOI:10.1016/j.toxlet.2017.06.007.
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Topics: Toxicology
Gentry R, Franzen A , Van Landingham C, Greene T, Plotzke K. 2017. A global human health risk assessment for octamethylcyclotetrasiloxane (D4). Regul Toxicol Pharmacol 279(Sup 1):23-41; doi: 10.1016/j.toxlet.2017.05.019 .
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Topics: risk assessment , Toxicology
2016 (2 POSTS)
Franzen A , Van Landingham C, Greene T, Plotzke K, Gentry R. 2016. A global human health risk assessment for decamethylcyclopentasiloxane (D5 ). Regul Toxicol Pharmacol 74(Sup):S25–S43; doi: 10.1016/j.yrtph.2015.10.023 .
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Topics: risk assessment , Toxicology
Campbell J, Franzen A , Van Landingham C, Lumpkin M, Crowell S, Meredith C, Loccisano A, Gentry R, Clewell H. 2016. Predicting lung dosimetry of inhaled particle-borne benzo(a)pyrene using physiologically based pharmacokinetic modeling. Inhal Toxicol 28(11):520–535.
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