Publication Topic

Patlewicz G, Mihalchik A, Thompson CM, East A, Borghoff S. Investigating the feasibility of deriving a new environmentally relevant Thresholds of Toxicological Concern (TTCs) from estimated human equivalent benchmark dose (eBMD_HED) values. Abstract 4013, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Killius A, Wheeler M, Covell L, Price S, Finley B. 2026. Derivation of provisional chronic oral toxicity values (PCOTV) for novel short-chain PFAS congeners. J Appl Toxicol; doi: 10.1002/jat.70156. Online ahead of print March 12. PMID: 41814952.

Zilber D, Messier KP, House J, Parham F, Auerbach SS, Wheeler MW. 2025. Bayesian gene set benchmark dose estimation for “omic” responses. Bioinformatics 41(1):btaf008; doi: 10.1093/bioinformatics/btaf008. PMID: 39786864.

Wheeler MW, Lim S, House JS, Shockley KR, Bailer AJ, Fostel J, Yang L, Talley D, Raghuraman A, Gift JS. 2023. ToxicR: A computational platform in R for computational toxicology and dose–response analyses. Comp Toxicol 25(Feb):100259; doi: 10.1016/j.comtox.2022.100259. PMID: 36909352.

Wheeler MW, Cortiñas Abrahantes J, Aerts M, Gift JS, Allen Davis J. 2022. Continuous model averaging for benchmark dose analysis: Averaging over distributional forms. Environmetrics 33(5):e2728; doi: 10.1002/env.2728. PMID: 36589902.

Aerts M, Wheeler MW, Abrahantes JC. 2020. An extended and unified modeling framework for benchmark dose estimation for both continuous and binary data. Environmetrics 31(7):e2630; doi: 10.1002/env.2630. PMID: 36052215.

Guo X, Seo JE, Petibone D, Tryndyak V, Lee UJ, Zhou T, Robison TW, Mei N. 2020. Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment. J Toxicol Environ Health A 83(21-22):702-717; doi: 10.1080/15287394.2020.1822972.

Wheeler MW, Blessinger T, Shao K, Allen BC, Olszyk L, Davis JA, Gift JS. 2020. Quantitative risk assessment: Developing a Bayesian approach to dichotomous dose–response uncertainty. Risk Anal 40(9):1706-22; doi: 10.1111/risa.13537. PMID: 32602232.

Seo JE, Wu Q, Bryant M, Ren L, Shi Q, Robison TW, Mei N, Manjanatha MG, Guo X. 2020. Performance of high‑throughput CometChip assay using primary human hepatocytes: A comparison of DNA damage responses with in vitro human hepatoma cell lines. Arch Toxicol 94(6):2207-2244; doi: 10.1007/s00204-020-02736-z.

Gadagbui B, Moore J, Parker A, McCready D, Monnot AD, Garnick L, Vincent M, et al. 2020. Derivation of cancer no significant risk levels and screening safety assessment for 2-nitropropane in spray products. J Appl Tox 40(5):691–705; doi: 10.1002/jat.3937. PMID: 32030785.

Thompson CM, Fitch SE, Ring C, Rish W, Cullen JM, Haws LC. 2019. Development of an oral reference dose for the perfluorinated compound GenX. J Appl Toxicol 39(9):1267–1282; doi: 10.1002/jat.3812. PMID: 31215065.

Seo JE, Tryndyak V, Wu Q, Dreval K, Pogribny I, Bryant M, Zhou T, Robison TW, et al. 2019. Quantitative comparison in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-content Comet Chip assay. Arch Toxicol 93(5):1433-1448; doi: 10.1007/s00204-019-02406-9. PMID: 30788552.

Wheeler MW, Piegorsch WW, Bailer AJ. 2019. Quantal risk assessment database: A database for exploring patterns in quantal dose‐response data in risk assessment and its application to develop priors for Bayesian dose‐response analysis. Risk Anal 39(3):616-29; doi: 10.1111/risa.13218. PMID: 30368842.

Haber LT, Dourson ML, Allen BC, Hertzberg RC, Parker A, Vincent MJ, et al. 2018. Benchmark dose (BMD) modeling: Current practice, issues, and challenges. Crit Rev Toxicol 48(5):387–415; doi: 10.1080/10408444.2018.1430121. PMID: 29516780.

Wheeler MW, Bailer AJ, Cole T, Park RM, Shao K. 2017. Bayesian quantile impairment threshold benchmark dose estimation for continuous endpoints. Risk Anal 37(11):2107-18; doi: 10.1111/risa.12762. PMID: 28555874.

Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C, Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; doi: 10.1021/acs.chemrestox.7b00221. PMID: 28927277.

Greene T, Rogers S, Franzen A, Gentry R. 2017. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol 47(2):98–120; doi: 10.1080/10408444.2016.1236071. PMID: 27834107.

Lea I, Yang L, Rashid A, Fostel JM. Benchmark dose analysis of Chemical Effects in Biological Systems (CEBS) datasets. Abstract 2918-P412. Presented at Society of Toxicology 56th Annual Meeting, Baltimore, MD, March 2017.

Wheeler MW, Park R, Bailer A, Whittaker C. 2015. Historical context and recent advances in exposure-response estimation for deriving occupational exposure limits. J Occup Environ Hyg 12(sup1):S7-S17; doi: 10.1080/15459624.2015.1076934. PMCID: PMC4685605.

Wheeler MW, Shao K, Bailer AJ. 2015. Quantile benchmark dose estimation for continuous endpoints. Environmetrics 26(5):363-72; doi: 10.1002/env.2432.