Publications

Buerger AN, Thompson CM, Heintz MM, Maberti S, Palermo CM, Haws LC. 2026. Application of quantitative and qualitative uncertainty assessment risk management decision-making: A case study with diisononyl phthalate. Food Chem Toxicol 214(Aug):116110; doi: 10.1016/j.fct.2026116110. PMID: 42035978.

Haws L (Moderator), Maxwell G (Speaker), Kleinstreuer N, Lowit A, Harrill J (Panelists). Next generation risk assessment (NGRA): Emerging best practice & opportunities for regulatory use. Society of Toxicology Risk Assessment Specialty Section (RASS) Risk Assessment Syllabus Webinar, June 17, 2026.

Thompson CM, Heintz MM, Rogers SI, Vincent MJ, Haws LC. 2026. Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA. Toxicol Sci 209(5):kfag045; doi: 10.1093/toxsci/kfag045. PMID: 41968070.

Buerger AN, Heintz MM, Haws LC, Thompson CM. 2026. Mode-of-action and human relevance assessment for diisononyl phthalate-induced liver tumors in rodents. J Appl Toxicol; doi: 10.1002/jat.70223. Online ahead of print May 5th. PMID: 42086044. 

Lea IA, Buerger AN, Vincent MJ,…, Choksi NY, Schaefer H, Britt J, Fitch S, Haws L, Borghoff SJ. 2026. Evaluating the potential carcinogenic hazard of diisononyl phthalate in humans via systematic integration of human, animal cancer studies, and mechanistic data. Curr Res Toxicol 10(Apr 30):100295; doi: 10.1016/j.crtox.2026.100295.

Buerger AN, Heintz MM, Haws LC, Nyambego H, Palermo CM, Thompson CM. Mode of action and human relevance assessment for diisononyl phthalate (DINP)-induced liver tumors in rodents. Abstract 3324, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Buerger AN, Lea IA, Vincent MJ,…, Choksi NY, Britt J, Fitch S, Rogers S, Schaefer H, Haws L,…, Wikoff D, Borghoff SJ. Systematic evaluation of the carcinogenic potential of di-isononyl phthalate in humans. Abstract 3314, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Thompson CM, Heintz MM, Cullen JM, Haws LC. 2026. Evaluation of chronic toxicity and carcinogenicity of HFPO-DA in mice. Regul Toxicol Pharmacol 165(Feb):106014; doi: 10.1016/j.yrtph.2025.106014. PMID: 41391658.

Borghoff SJ, Heintz MM, Rivera BN, Haws L, Thompson C. 2025. Evaluation of an anti-thyroid mode of action for thyroid follicular cell adenomas in female mice exposed to tertiary butyl alcohol. Regul Toxicol Pharmacol 163(Dec):105936; doi: 10.1016/j.yrtph.2025.105936. PMID: 40914479.

Rogers JM, Heintz MM, Haws LC. 2025. Reproductive and developmental toxicity screen (OECD TG 421) and extended one generation reproductive toxicity study (OECD TG 443) of decahydronaphthalene in Sprague Dawley rats. Regul Toxicol Pharmacol 160(Aug):105829; doi: 10.1016/j.yrtph.2025.105829. PMID: 40222475.

Heintz MM, Buerger AN, Haws LC, Cullen JM, East AW, Thompson CM. 2025. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Pparα-null mouse livers. Toxicol Sci 206(1):183-201; doi: 10.1093/toxsci/kfaf049. PMID: 40216583.

Thompson CM, Heintz MM, Cullen JM, Haws LC. Evaluation of the chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (HFPO-DA) in mice. Abstract 4700, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Rogers JM, Heintz MM, Haws LC. Reproduction/developmental toxicity screen and extended one generation reproductive toxicity study of decahydronaphthalene in Sprague Dawley rats. Abstract 3864, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Heintz MM, Buerger AN, Haws LC, East AW, Cullen JM, Thompson CM. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mice. Abstract 3972, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025

Fitch S, Wikoff D, Foreman J, Buerger A, Haws L, Palmero C. Assessment of relative potency factors for six phthalates. Abstract 4235, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Wikoff DS, Vincent MJ, Heintz MM, Pastula ST, Reichert H, Klaren WD, Haws LC. 2025. Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response. Toxicol Sci 204(1):96-115; doi: 10.1093/toxsci/kfae152. PMID: 39792025.

Lea IA, Feifarek D, Mihalchik A, Heintz M, Haws L, Nyambego H, Goyak K, Palermo C, Borghoff SJ. 2025. Evaluation of the endocrine disrupting potential of Di-isodecyl phthalate. Curr Res Toxicol 8:100221; doi: 10.1016/j.crtox.2025.100221. PMID: 40041033.

Rogers JM, Buerger AN, Heintz MM, Palermo CM, Haws LC, Lea IA. 2025. Evaluation of a hypothesized Sertoli cell-based adverse outcome pathway for effects of diisononyl phthalate on the developing testis. Curr Res Toxicol 8:100219; doi: 10.1016/j.crtox.2025.100219. PMID: 40123861.

Lea IA, Buerger AN, Feifarek D, Mihalchik A, Heintz MM, Haws LC, Nyambego H, Goyak K, Palermo C, Borghoff SJ. 2025. Evaluation of the endocrine disrupting potential of Di-isononyl phthalate. Curr Res Toxicol 8:100220; doi: 10.1016/j.crtox.2025.100220. PMID: 40092461. Corrigendum 8:100233; doi: 10.1016/j.crtox.2025.100233; PMID 40529321.