Publications

Fitch S, Rogers J, Marty S, Ellis-Hutchings R, Becker R, Wikoff D. Development of a study quality tool for use in a systematic review of literature reporting microplastic exposure and reproductive and developmental toxicity. Poster presented at Society of Toxicology 62^nd Annual Meeting, Nashville, TN, March 2023.

Fitch S, Wikoff D, Britt J, Lea I, Brown L, Borghoff S, et al. 2022. Systematic literature review and critical appraisal of mammalian reproductive studies evaluation potential effects associated with microplastics. OSF | Systematic Literature Review and Critical Appraisal of Mammalian Reproductive Studies Evaluation Potential Effects Associated with Microplastics

Fitch S, Klaren WD, LaPlaca S, Payne L, Wikoff D. Comparison of public and private literature databases for toxicological investigations. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.

Wikoff D, Fitch S, Borghoff S. Case-study applications using evidence-based approaches to assess endocrine activity for risk assessment. Invited speaker (Wikoff):  61^st Annual Meeting (virtual) of the Society for Birth Defects Research & Prevention, June 2021.

Fitch SE, Payne LE, van de Ligt JLG, Doepker C, Handu D, Cohen SM, Anyangwe N, Wikoff D. 2021. Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): A systematic map. BMC Pub Health 21(1):956; doi: 10.1186/s12889-021-10934-2. PMID: 34016063.

Borghoff SJ, Fitch SE, Black MVB, McMullen PD, Andersen ME, Chappell GA. 2021. A systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole. Regul Toxicol Pharmacol 124(Aug):104977; doi: 10.1016/j.yrtph.2021.104977. PMID: 34174380.

Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE, Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. 2021. Performance of preclinical models in predicting drug-induced liver injury in humans: A systematic review. Sci Reports 11(1)6403; doi: https://doi.org/10.1038/s41598-021-85708-2. PMID: 33737635.

Wikoff DS, Urban JD, Ring C, Britt J, Fitch S, Haws LC. 2021. Development of a range of plausible non-cancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on effects on sperm count: Application of systematic review methods and quantitative integration of dose response using meta-regression. Toxicol Sci 179(2):162-182; doi: 10.1093/toxsci/kfaa171.

Thompson CM, Gentry R, Fitch S, Lu K, Clewell HJ. 2020. An updated mode of action and human relevance framework evaluation for formaldehyde-related nasal tumors. Crit Rev Toxicol 50(10):919–952; doi: 10.1080/10408444.2020.1854679. PMID: 33599198.

Ring C, Fitch S, Haws L, Harris M, Wikoff D. Quantitative integration of dose-response data for relative potency estimates of dioxin-like chemicals. Poster for Society of Toxicology, Virtual Annual Meeting, 2020.

Wikoff DS, Chappell GA, Fitch S, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135(Jan):110866; doi: 10.1016/j.fct.2019.110866.

Thompson CM, Fitch SE, Ring C, Rish W, Cullen JM, Haws LC. 2019. Development of an oral reference dose for the perfluorinated compound GenX. J Appl Toxicol 39(9):1267–1282; doi: 10.1002/jat.3812.

Fitch S, van de Ligt J, Payne L, Doepker C, Kleinman R, Handu D, Cohen SM, Anyangwe N, Wikoff D. 2019. Systematic map protocol: A systematic map of the use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS). Open Science Framework.

Borghoff S, Fitch S, Britt J, Franke K, Wikoff D. Application of the EFSA/ECHA endocrine disruption guidance as a framework for evidence integration in a weight-of-evidence (WoE) analysis for oxybenzone (BP-3). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.

Urban J, Wikoff D, Suh M, Britt J, Harvey S, Chappell G, Haws L. Comparison of NTP OHAT and US EPA TSCA study quality criteria: Trichloroethylene (TCE) and congenital heart defects (CHDs) as a case study. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

Urban J, Wikoff D, Haws L, Fitch S, Ring C, Thompson C, Suh M. 2018. Systematic review protocol: Systematic review and meta-regression to characterize the dose-response relationship between exposure to dioxin-like compounds during sensitive windows of development and reduced sperm count. Zenodo. http://doi.org/10.5281/zenodo.1636357.

Borghoff SJ, Fitch S, Rager JE, Huggett D. 2018. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid. Regul Toxicol Pharmacol 99(Nov):168–181; doi: 10.1016/j.yrtph.2018.09.001.

Wikoff DS, Thompson C, Rager J, Chappell G, Fitch S, Doepker C. 2018. Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates. Food Chem Toxicol 120:709-723; doi: 10.1016/j.fct.2018.08.031.

Thompson CM, Kirman CR, Hays SM, Suh M, Harvey SE, Proctor DM, Rager JE, Haws LC, Harris MA. 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545.