Publications

Covington TR, Ott DK, Gearhart JM, Pangburn HA. Development of a physiologically-based pharmacokinetic model for the virtual high-performance aircraft pilot. Poster presented at the Society of Toxicology Annual Meeting, San Antonio, TX, March 2018.

Covington TR, Pangburn HA, Mayes RS, Ott DK, Gearhart JM. Estimated inter-individual variations in high-performance aircraft pilot exposures using physiologically-based pharmacokinetic (PBPK) modeling and Monte Carlo analysis. Poster presented at the Society of Toxicology Annual Meeting, Baltimore, MD, March 2017.

Covington TR, Lumley LA, Ruark CD, Clarkson ED, Whalley CE, Gearhart JM. 2016. Modeling organophosphorus chemical warfare nerve agents: A physiologically based pharmacokinetic-pharmacodynamic (PBPK-PD) model of VX. In: Worek F, Jenner J, Thiermann H (eds), Chemical Warfare Toxicology: Volume 1: Fundamental Aspects, pp. 213–263. Royal Society of Chemistry.

Hack CE, Gearhart JM, Covington TR, Starr CR, Chapleau RR. Development of a mathematical model of anthrax in humans and application to estimate risk to fielded biological threat identification equipment operators. Poster presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 2016.

Hack CE, Covington TR, Robinson PJ, Shiyanov PA, Mahle DA, Gearhart JM. A PBPK model of hypobaric and hyperbaric toluene exposure. Poster presented at the Society of Toxicology Annual Meeting, Phoenix, AZ, March 2014.

Covington TR, Ruark CD, Yu KO, Gearhart JM. Human lethality predictions from exposure to VX using a physiologically-based pharmacokinetic-pharmacodynamic model. Poster presented at the Society of Toxicology Annual Meeting, San Antonio, TX, March 2013.

Sterner TR, Ruark CD, Covington TR, Yu KO, Gearhart JM. 2013. A physiologically based pharmacokinetic model for theoxime TMB-4: Simulation of rodent and human data. Arch Toxicol 87:661–680.

Sterner T, Ruark C, Covington T, Gearhart J. Monte Carlo and sensitivity analyses of a PBPK model for the oxime TMB-4. Poster presented at the Chemical and Biological Defense Science and Technology Conference, Las Vegas, NV, November 2011.

Covington T, Robinson P, Gearhart J. Exploring issues in simulating dermal exposure using a physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) model for VX. Poster presented at the Society of Toxicology Annual Meeting, Washington, DC, March 2011.

Sterner TR, Ruark CD, Covington TR, Hack CE, Gearhart JM. Characterizing uncertainty and population variability in a PBPK-PD mathematical model for the oxime HI-6. Poster presented at the Chemical and Biological Defense Science and Technology Conference, Orlando, FL, November 2010.

Makley M, Ruark C, Covington T, Robinson P, Gearhart J. Route of entry model for predicting chemical warfare agent miosis. Poster presented at the Chemical and Biological Defense Science and Technology Conference, Orlando, FL, November 2010.

Covington T, Jakubowski E, McGuire J, Byers C, Evans R, Hulet S, Whalley C, Lumley L, Clarkson E, Gearhart J. A multi-species and -route, ion- and isomer-specific physiologically-based pharmacokinetic-pharmacodynamic model for VX. Poster presented at the Bioscience Review Conference, Baltimore, MD, May 2010.

Yu KO, Ruark CD, Hack CE, Sterner TR, Covington TR, Gearhart JM. A physiologically based pharmacokinetic model for pralidoxime in the guinea pig and human. Poster presented at the Society of Toxicology Annual Meeting, Salt Lake City, UT, March 2010.

Yu K, Covington T, Ruark C, Sterner T, Hack E, Gearhart J. A physiologically based pharmacokinetic model for pralidoxime in the guinea pig and in human. Presentation at the Chemical and Biological Defense Science and Technology Conference, Dallas, TX, November 2009.

Covington TR, Jakubowski EM, McGuire JM, Byers CE, Evans RA, Hulet SW, et al. A multi-species and -route ion- and isomer-specific physiologically-based pharmacokinetic-pharmacodynamic model for VX. Presentation at the Chemical and Biological Defense Science and Technology Conference, Dallas, TX, November 2009.

Covington TR, Jakubowski EM, McGuire JM, Evans RA, Hulet SW, Gearhart JM. Accounting for stereo-isomers and ionization in a PBPK/PD model of VX exposure. Poster presented at the Society of Toxicology Annual Meeting, Baltimore, MD, March 2009.

Covington TR, Gearhart JM, Jakubowski EM, McGuire JM, Evans RA, Hulet SW. Physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling of VX exposure through various routes to multiple species. Poster presented at the Chemical and Biological Defense Physical Science and Technology Conference, New Orleans, LA, November 2008.

Teeguarden JG, Bogdanffy MS, Covington TR, Tan C, Jarabek AM. 2008. A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry. Inhal Toxicol 20(4):375–390; doi: 10.1080/08958370801903750.

Gearhart JM, Covington TR, Robinson PJ, Whalley CE, McGuire JM, Evans RA, et al. Simulation of VX exposure in multiple species by means of a physiologically based pharmacokinetic/pharmacodynamic model. Poster presented at the Bioscience Review Conference, Baltimore, MD, May 2008.

Teeguarden JG, Gearhart J, Clewell HJ III, Covington TR, Nong A, Andersen ME. 2007. Pharmacokinetic modeling of manganese. III. Physiological approaches accounting for background and tracer kinetics. J Toxicol Environ Health A 70:1515–1526.