Publications

Hack CE, Covington TR, Lawrence G, Shipp AM, Gentry R, Yager J, Clewell, HJ, III. 2007. A pharmacokinetic model of the intracellular dosimetry of inhaled nickel. J Toxicol Environ Health A 70(5):445–464; doi: 10.1080/15287390600870726.

Gentry PR, Covington TR, Lawrence G, McDonald T, Snow ET, Germolec D, Moser G, Yager JW, Clewell HJ III. 2005. Comparison of tissue dosimetry in the mouse following chronic exposure to arsenic compounds. J Toxicol Environ Health A 68:329–351.

Covington TR, Gentry PR, Van Landingham CB, Andersen ME, Kester JE, Clewell HJ. 2007. The use of Markov chain MonteCarlo uncertainty analysis to support a Public Health Goal for perchloroethylene. Regul Toxicol Pharmacol 47(1):1–18.

Subramaniam RP, Crump KS, Chen C, White P, Van Landingham C, Fox JF, Schlosser P, Covington TR, et al. The role of mutagenicity in describing formaldehyde-induced carcinogenicity: Possible inferences using the CIIT model. Presentation at the Annual Society for Risk Analysis Conference, Baltimore, MD, December 2006.

Crump KS, Subramaniam R, White P, Chen C, Schlosser P, Van Landingham C, Covington TR, DeVoney D. Consideration of uncertainties in the CIIT model for formaldehyde carcinogenicity in the human respiratory tract. Presentation at the Annual Society for Risk Analysis Conference, Baltimore, MD, December 2006.

Teeguarden JG, Dorman DC, Nong A, Covington TR, Clewell HJ III, Andersen ME. 2007. Pharmacokinetic modeling of manganese. II. Hepatic processing after ingestion and inhalation. J Toxicol Environ Health A 70:1505–1514.

Teeguarden JG, Dorman DC, Covington TR, Clewell HJ III, Andersen ME. 2007. Pharmacokinetic modeling of manganese. I. Dose dependencies of uptake and elimination. J Toxicol Environ Health A 70:1493–1504.

David RM, Clewell HJ, Gentry PR, Covington TR, Morgott DA, Marino DJ. 2006. Revised assessment of cancer risk to dichloromethane II. Application of probabilistic methods to cancer risk determinations. Regul Toxicol Pharmacol 45(1):55–65.

Marino DJ, Clewell HJ, Gentry PR, Covington TR, Hack CE, David RM, Morgott DA. 2006. Revised assessment of cancer risk to dichloromethane: Part I Bayesian PBPK and dose-response modeling in mice. Regul Toxicol Pharmacol 45(1):44–54.

Covington TR, Gentry P, Van Landingham CB, Clewell HJ. Issues in using Markov Chain Monte Carlo analysis to calibrate a PBPK model for use in risk assessment: Case studies with dichloromethane and perchloroethylene. Poster presented at the Society of Toxicology Annual Meeting, San Diego, CA, March 2006.

Gentry PR, Haber LT, McDonald TB, Zhao Q, Covington T, Nance P, Clewell HJ III, Lipscomb JC, Barton HA. 2005. Data for physiologically based pharmacokinetic modeling in neonatal animals: Physiological parameters in mice and Sprague-Dawley rats. J Children’s Health 2(3–4):363–411.

Teeguarden JG, Waechter JM, Clewell HJ, Covington TR, Barton HA. Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding and uterine tissue dose metrics of bisphenol A: A physiologically based pharmacokinetic approach. Poster presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 2005.

Kester JE, Gentry P, Covington TR, Clewell HJ. Issues in the use of PBPK modeling in the development of cancer slope factors for perchloroethylene. Poster presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 2005.

Covington TR, Clewell HJ, Fisher JW, Keys DA, Hack C, Zhao JQ. A harmonized PBPK model for trichloroethylene risk assessment. Poster presented at the Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.

Teeguarden JG, Waechter JM Jr, Clewell HJ 3rd, Covington TR, Barton HA. 2005. Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding and uterine tissue dose metrics of bisphenol A: A physiologically based pharmacokinetic approach. Toxicol Sci 85:429–446.

Gentry PR, Covington TR, Mann S, Shipp AM, Yager JW, Clewell HJ III. 2004. Physiologically based pharmacokinetic modeling of arsenic in the mouse. J Toxicol Environ Health A 67:43–71.

Clewell HJ, Gentry PR, Covington TR, Sarangapani R, Teeguarden JG. 2004. Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Toxicol Sci 79(2):381–93.

Gentry RP, Covington TR, Clewell HJ III. 2003. Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation. Regul Toxicol Pharmacol 38(1):1–16; doi: 10.1016/S0273-2300(03)00047-3.

Sarangapani R, Gentry PR, Covington TR, Teeguarden JG, and Clewell HJ. 2003. Evaluation of the potential impact of age- and gender-specific lung morphology and ventilation rate on the dosimetry of vapors. Inhal Toxicol 15(10):987–1016.

Gentry PR, Covington TR, Clewell HJ, Andersen ME. 2003. Application of a physiologically based pharmacokinetic model for reference dose and reference concentration estimation for acetone. J Toxicol Environ Health A 66(23):2209–2225.