2021 (13 POSTS)
de Vries RBM, Angrish M, Browne P, Brozek J, Rooney AA, Wikoff DS , Whaley P, Edwards SW, Morgan RL, Druwe IL, Hoffmann S, Hartung T, Thayer K, Avey MT, Beverly BEJ, Falavigna M, Gibbons C, Goyak K, Kraft A, Nampo F, Qaseem A, Sears M, Singh JA, Willett C, Yost EY, Schünemann H, Tsaioun K. 2021. Applying evidence-based methods to the development and use of adverse outcome pathways. ALTEX — Alternatives to Animal Experimentation , 38(2):336–347, doi: 10.14573/altex.2101211.
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Topics: Systematic Review
Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS . 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150:112045.
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Topics: Systematic Review , Toxicology
Wikoff DS , Urban JD , Ring C, Britt J , Fitch S , Haws LC . 2021. Development of a range of plausible non-cancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on effects on sperm count: Application of systematic review methods and quantitative integration of dose response using meta-regression. Toxicol Sci 179(2):162-182, https://doi.org/10.1093/toxsci/kfaa171.
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Topics: Toxicology
Chappell GA, Wikoff DS , Thompson CM . 2021. Assessment of mechanistic data for hexavalent chromium-induced rodent intestinal cancer using the key characteristics of carcinogens. Toxicol Sci 180(1):38–50.
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Topics: Metals , Toxicology
2020 (9 POSTS)
Wikoff D , Lewis JR, Erraguntla N, Franzen A , Foreman J. 2020. Facilitation of risk assessment with evidence-based methods — A framework for use of systematic mapping and systematic reviews in determining hazard, developing toxicity values, and characterizing uncertainty. Regul Toxicol Pharmacol 118:104790; doi: 10.1016/j.yrtph.2020.104790 . PMID: 33038430.
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Topics: risk assessment , Systematic Review
Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D , Atillasoy E. 2020. Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen. Regul Toxicol Pharmacol 118:104788.
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Topics: Toxicology
Whaley P, Aiassa E, Beausoleil C, Beronius A, Bilotta, G, Boobis A, de Vries R, Hanberg A, Hoffman S, Hunt N, Kwiatkowski CF, Lam J, Lipworth S, Martin O, Randall, N, Rhomberg L, Rooney AA, Holger J, Schünemann HJ, Wikoff D , Wolffe T, Halsall C. 2020. Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER). Environ Int 143:105926.
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Topics: Systematic Review
Urban JD , Wikoff DS , Chappell GA, Harris C, Haws LC . 2020. Systematic evaluation of mechanistic data in assessing in utero exposures to trichloroethylene and development of congenital heart defects. Toxicology 436:152427, doi: 10.1016/j.tox.2020.152427. PMID: 32145346.
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Topics: Toxicology
Chappell GA, Wikoff DS , Doepker CL , Borghoff SJ . 2020. Lack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 141:111375 [open access ].
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Topics: Systematic Review
Henderson RG , Franzen A , Franke K , Payne L, Schmitt D , Wikoff D . Creating a literature database for cannabidiol (CBD): Systematic evidence mapping. Poster for Society of Toxicology , Virtual Annual Meeting, 2020.
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Topics: Cannabinoid/Industrial Hemp , Epidemiology , Systematic Review
Ring C, Fitch S , Haws L , Harris M , Wikoff D . Quantitative integration of dose-response data for relative potency estimates of dioxin-like chemicals. Poster for Society of Toxicology , Virtual Annual Meeting, 2020.
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Topics: Toxicology
Wikoff D , Franzen A , Chappell G, Harris M , Thompson C . Systematic characterization of hexavalent chromium and potential female reproductive outcomes: Application of US EPA critical appraisal tools and stepwise inclusion of mechanistic data. Poster for Society of Toxicology , Virtual Annual Meeting, 2020.
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Topics: Hexavalent Chromium , Metals , Toxicology
Wikoff DS , Bennett DC, Brorby GP , Franke KS . 2020. Evaluation of potential human health risk associated with consumption of edible products from livestock fed ration supplemented with Red Lake Diatomaceous Earth. Food Addit Contam A 37(5):804-814; doi: 10.1080/19440049.2020.1727963 . PMID: 32134694.
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Topics: Food science , risk assessment , Toxicology
2019 (14 POSTS)
Wikoff DS , Chappell GA, Fitch S , Doepker CL , Borghoff SJ . 2019. Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135:110866.
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Topics: Systematic Review , Toxicology
Chappell GA, Borghoff SJ , Pham L, Doepker CL , Wikoff DS . 2019. Lack of potential carcinogenicity for sucralose — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135:110898.
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Topics: Systematic Review , Toxicology
Fitch S , Goyak K, Green M, Grimm F, Wikoff D . 2019. Estrogen-mediated outcomes for alkylphenols via an adverse outcome pathway (AOP) construct. Open Science Framework , August.
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Topics: Systematic Review
Wikoff D , Haws L , Ring C, Budinsky R. 2019. Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. J Appl Toxicol , doi: 10.1002/jat.3814, open access.
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Topics: Toxicology
Wikoff D , Erranguntla N, Lewis J, Foreman J. A fit-for-purpose framework for use of systematic methods in risk assessment. Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.
Topics: Systematic Review , Toxicology
Urban J , Wikoff D , Haws L . Three-tiered approach to integrating evidence streams assessing gestational trichloroethylene exposure and congenital heart defects (TCE-CHD). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine. Washington, DC, June 2019.
Topics: Toxicology
Borghoff S , Fitch S , Britt J , Franke K , Wikoff D . Application of the EFSA/ECHA endocrine disruption guidance as a framework for evidence integration in a weight-of-evidence (WoE) analysis for oxybenzone (BP-3). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.