2011 (11 POSTS)
Haws L, Proctor D, Thompson C , Harris M. Research plan to fill data gaps in the mode of action for cancer risk assessment of hexavalent chromium in drinking water. Presented at Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.
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Topics: Cancer , chromium , water
Wilson VS, Keshava N, Hester S, Segal D, Chiu W, Thompson CM , Euling SY. 2013. Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment. Toxicol Appl Pharmacol 271(3):299–308; doi: 10.1016/j.taap.2011.01.017 .
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Topics: risk assessment
Proctor D, Haws L , Thompson C , Harris M. 2011. Use of mode of action and pharmacokinetics to inform the cancer risk assessment of ingested Cr(VI): A case study. Presented at the Society of Toxicology 50th Annual Meeting, Washington, DC, March 2011.
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Topics: Cancer , chromium , mode of action , pharmacokinetics , risk assessment
2010 (2 POSTS)
Johns DO, Owens EO, Thompson CM , Sonawane B, Hattis D, Krishnan K. 2010. Physiological parameters and databases for PBPK modeling. Chapter 5 in: Quantitative Modeling in Toxicology. Krishnan K, Andersen M (eds.). Wiley, p. 107.
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Topics: modeling , PBPK/PBDE
Thompson CM , Ceder R, Grafström RC. 2010. Formaldehyde dehydrogenase: Beyond phase I metabolism. Toxicol Lett 193(1):1-3; doi: 10.1016/j.toxlet.2009.11.023 .
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Topics: formaldehyde
2009 (3 POSTS)
Thompson CM , Grafstrom RC. 2009. Commentary: Mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma. Environ Health 8:53; doi: 10.1186/1476-069X-8-53 . PMID: 19939253.
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Topics: Cancer , formaldehyde , Occupational
Thompson CM , Sonawane B, Grafström RC. 2009. The ontogeny, distribution and regulation of alcohol dehydrogenase 3: Implications for pulmonary physiology. Drug Metab Disposit 37(8):1565-1571; doi: 10.1124/dmd.109.027904 .
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Topics: Exposure Assessment , formaldehyde
Thompson CM , Johns DO, Sonawane S, Barton HA, Hattis D, Tardif R, Krishnan K. 2009. Database for physiologically based pharmacokinetic (PBPK) modeling: Physiological parameters for healthy and health-impaired elderly. J Toxicol Environ Health B 12(1):1–24; doi: 10.1080/10937400802545060 . PMID: 19117207.
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Topics: modeling , PBPK/PBDE , pharmacokinetics
2008 (5 POSTS)
DeWoskin RS, Thompson CM. 2008. Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants. Regul Toxicol Pharmacol 51(June):66–86; doi: 10.1016/j.yrtph.2008.02.005 .
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Topics: modeling , PBPK/PBDE
Makris SL, Thompson CM , Euling SY, Selevan SG, Sonawane B. 2008. A lifestage-specific spproach to hazard and dose-response characterization for children’s health risk assessment. Birth Defects Res B 83(6):530–546; doi: 10.1002/bdrb.20176 .
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Topics: risk assessment
Subramaniam RP, Chen C, Crump KS, Devoney D, Fox JF, Portier CJ, Schlosser PM, Thompson CM , White P. 2008. Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: Identification of key issues. Risk Analysis 28(4):907–923; doi: 10.1111/j.1539-6924.2008.01083.x .
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Topics: Cancer , Exposure Assessment , formaldehyde , risk assessment
Thompson CM , Subramaniam RP, Grafström RC. 2008. Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde. Toxicol Appl Pharmacol 233(3):355–359.
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Topics: formaldehyde
Thompson CM , Sonawane B, Barton HA, DeWoskin RS, Schlosser P, Lipscomb JC, Chiu W, Krishnan K. 2008. Approaches for applications of physiologically based pharmacokinetic models in risk assessment. J Toxicol Environ Health B 11(7):519–547; doi: 10.1080/10937400701724337 .
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Topics: modeling , PBPK/PBDE , pharmacokinetics , risk assessment
2007 (1 POST)
Thompson CM , Grafström RC. 2007. Mechanistic considerations for formaldehyde-induced bronchoconstriction involving S-nitrosoglutathione reductase. J Toxicol Environ Health A 71:244–248; doi: 10.1080/15287390701598259 .
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Topics: formaldehyde
2006 (1 POST)
Barone S Jr., Brown RC, Euling S, Cohen Hubal E, Kimmel CA, Makris S, Moya J, Selevan SG, Sonawane B, Thomas T, Thompson CM . 2006. Visión general de la evaluación del rieso en salud infantil empleando un enfoque por etapas de desarrollo. Acta Toxicol Argent 14(Suppl):7–10.
Topics: Epidemiology
2004 (1 POST)
Thompson CM , Wojno H, Greiner E, May EL, Rice KC, Selley DE. 2004. Activation of G-proteins by morphine and codeine congeners: Insights to the relevance of O- and N-demethylated metabolites at μ- and δ-opioid receptors. J Pharmacol Exper Therapeut 308(2):547–554; doi: 10.1124/jpet.103.058602 . PMID: 14600248.
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Topics: pharmacology
2001 (1 POST)
Strobel HW, Thompson CM , Antonovic L. 2001. Cytochromes P450 in brain: Function and significance. Curr Drug Metabol 2(2):199–214; doi: 10.2174/1389200013338577 . PMID: 11469726.
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Topics: drug development , metabolites
2000 (1 POST)
Thompson CM , Capdevila JH, Strobel HW. 2000. Recombinant P450 2D18 metabolism of dopamine and arachidonic acid. J Pharmacol Exper Ther 294(3):1120–1130; doi: 10.1016/S0022-3565(24)39180-3 .
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Topics: pharmacokinetics
1998 (2 POSTS)
Thompson CM , Kawashima H, and Strobel HW. 1998. Isolation of partially purified P450 2D18 and characterization of activity towards the tricyclic antidepressants imipramine and desipramine. Arch Biochem Biophys 359(1):115–121; doi: 10.1006/abbi.1998.0892 .
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Topics: drug interactions
Gerhardt B, Kordas TJ, Thompson CM , Patel P, Vida TV. 1998. The vesicle transport protein, Vps33p, is an ATP binding protein that localizes to the cytosol in an energy dependent manner. J Biol Chem 273(25):15818–15829; doi: 10.1074/jbc.273.25.15818 . PMID: 9624182.
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