2024 (15 POSTS)
Karamertzanis P, Patlewicz G , Sannicola M, Paul-Friedman K, Shah I. 2024. Systematic approaches for the encoding of chemical groups: A case study. Chem Res Toxicol 37(4):600-619; doi: 10.1021/acs.chemrestox.3c00411 . PMID: 38498310.
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Topics: regulatory toxicology
Judson RS, Smith D, DeVito M, Wambaugh JF, Wetmore BA, Paul Friedman K, Patlewicz G , Thomas RS, et al. 2024. A comparison of in vitro points of departure with human blood levels for per- and polyfluoroalkyl substances (PFAS). Toxics 12(4):271; doi: 10.3390/toxics12040271 . PMID: 38668494.
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Topics: PFAS
Tate T, Patlewicz G , Shah I. 2024. A comparison of machine learning approaches for predicting hepatotoxicity potential using chemical structure and targeted transcriptomic data. Comput Toxicol 29(March):100301; doi: 10.1016/j.comtox.2024.100301 . PMID: 38993502.
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Topics: transcriptomics
Chang D , Cowden J, Davidson-Fritz S, Dean J, Devito M, Everett L, Harrill A,.., Patlewicz G , et al. 2024. Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (ETAPs). EPA/600/X-23/084. U.S. Environmental Protection Agency: Washington, DC; doi: 10.23645/epacomptox.25365550 .
Topics: risk assessment , Toxicology , transcriptomics
Brennan A, Chang D, Cowden J, Davidson-Fritz S, Dean J, Devito M, Ford J, … , Patlewicz G , et al. 2024. EPA Transcriptomic Assessment Product (ETAP) for Perfluoro-3-Methoxypropanoic Acid. EPA/600/X-24/066. U.S. Environmental Protection Agency: Washington, DC; doi: 10.23645/epacomptox.25352962 .
Topics: risk assessment , Toxicology , transcriptomics
Patlewicz G . Comparing expert-driven read-across assessments using the generalized read-across framework. Abstract 1110, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
Topics: read-across
Shirke AV, Radke EG, Lin C, Blain R, Vetter N, Lemeris C, Hartman P,.., Patlewicz G , et al. 2024. Expanded systematic evidence map for hundreds of per- and polyfluoroalkyl substances (PFAS) and comprehensive PFAS human health dashboard. Environ Health Perspect 132(2):026001; doi: 10.1289/EHP134 . PMID: 38319881.
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Topics: PFAS
2023 (11 POSTS)
Bowden A, Escher S, Rose J, Sadekar N, Patlewicz G , O’Keeffe L, Bury D, Hewitt NJ, et al. 2023. Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) – State of the science and next steps. Regul Toxicol Pharmacol 142(Aug):105434; doi: 10.1016/j.yrtph.2023.105434 . PMID: 37302561.
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Topics: risk assessment
Maloney EM, Villeneuve DL, Jensen KM, Blackwell BR, Kahl MD, Poole ST, Vitense K, Feifarek, DJ, Patlewicz G , et al. 2023. Evaluation of complex mixture toxicity: An experimental and database-driven analysis in the Milwaukee estuary (WI, USA) using whole-mixture and component-based evaluation methods. Environ Toxicol Chem 42(6):1229-1256; doi: 10.1002/etc.5571 . PMID: 36715369.
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Topics: ecotoxicology
Nyffeler J, Willis C, Harris FR, Foster MJ, Chambers B, Culbreth M, Brockway RE,…, Patlewicz G , et al. 2023. Application of cell painting for chemical hazard evaluation in support of screening-level chemical assessments. Toxicol Appl Pharmacol 468(June 1):116513; doi: 10.1016/j.taap.2023.116513 . PMID: 37044265.
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Topics: chemical safety assessment
Patlewicz G , Paul Friedman K, Houck K, Zhang L, Huang R, Xia M, Brown J, Simmons SO. 2023. Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library. Comput Toxicol 26(May):100271; doi: 10.1016/j.comtox.2023.100271 . PMID: 37388277.
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Topics: modeling
Richard AM, Lougee R, Adams M, Hidle H, Yang C, Rathman J, Magdziarz T, Bienfait B, Williams AJ, Patlewicz G . 2023. A new CSRML structure-based fingerprint method for profiling and categorizing per- and polyfluoroalkyl substances (PFAS). Chem Res Toxicol 36(3):508–534; doi: 10.1021/acs.chemrestox.2c00403 . PMID: 36862450.
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Topics: PFAS
Carstens KE, Freudenrich T, Wallace K, Choo S, Carpenter A, Smeltz M, Clifton MS,…, Patlewicz G , et al. 2023. Evaluation of per- and polyfluoroalkyl substances (PFAS) in vitro toxicity testing for developmental neurotoxicity. Chem Res Toxicol 36(3):402–419; doi: 10.1021/acs.chemrestox.2c00344 . PMID: 36821828.
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Topics: PFAS
Patlewicz G , Shah I. 2023. Towards systematic read-across using Generalized Read-Across (GenRA). Comput Toxicol 25(Feb):100258; doi: 10.1016/j.comtox.2022.100258 . PMID: 37693774.
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Topics: NAMs
Houck K, Paul Friedman K, Feshuk M, Patlewicz G , Smeltz M, Clifton S, Wetmore BA, Velichko S, et al. 2023. Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells. ALTEX 40(2):248–270; doi: 10.14573/altex.220304 . PMID: 36129398.
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Topics: chemical safety assessment , PFAS
Adams M, Hilde H, Chang D, Richard A, Williams AJ, Shah I, Patlewicz G . 2023. Development of a CSRML version of the Analog Identification Methodology (AIM) fragments and their evaluation within the Generalized Read-Across (GenRA) approach. Comput Toxicol 25(Feb):100256; doi: 10.1016/j.comtox.2022.100256 . PMID: 36733411.
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Topics: NAMs
Boyce M, Favela KA, Bonzo JA, Chao A, Lizarraga L, Moody LR, Owens EO, Patlewicz G , et al. 2023. Identifying xenobiotic metabolites with in silico prediction tools and LCMS suspect screening analysis. Front Toxicol 5(Jan 18):1051483; doi: 10.3389/ftox.2023.1051483 . PMID: 36742129.
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Topics: spectrometry
Lizarraga L, Suter GW, Lambert JC, Patlewicz G , Zhao JQ, Dean JL, Kaiser P. 2023. Advancing the science of a read-across framework for evaluation of data poor chemicals incorporating systematic and new approach methods. Regul Toxicol Pharm 137(Jan):105293; doi: 10.1016/j.yrtph.2022.105293 . PMID: 36414101.
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Topics: NAMs
2022 (21 POSTS)
Shah I, Bundy J, Chambers B, Everett L, Haggard D, Harrill J, Judson R, Nyffeler J, Patlewicz G . 2022. Navigating transcriptomic connectivity mapping workflows to link chemicals with bioactivities. Chem Res Toxicol 35(11):1929-1949; doi: 10.1021/acs.chemrestox.2c00245 . PMID: 36301716.
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Topics: transcriptomics
Zwickl CM, Graham JC, Holly RA, Bassan A, Ahlberg E, Amberg A, Anger LT,.., Patlewicz G , et al. 2022. Principles and procedures for assessment of acute toxicity incorporating in silico methods. Comput Toxicol 24(Nov):100237; doi: 10.1016/j.comtox.2022.100237 . PMID: 36818760.
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