2012 (12 POSTS)
Thompson CM , Fedorov Y, Brown DD, Suh M , Proctor DM, Kuriakose L, Haws L, Harris MA. 2012. Assessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysis. PLoS ONE 7(8):e42720; doi: 10.1371/journal.pone.0042720 .
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Topics: Cr(VI) MOA Study , Hexavalent Chromium
Thompson CM, Hixon JG, Proctor DM, Haws LC, Suh M, Urban JD, Harris MA. 2012. Assessment of genotoxic potential of Cr(VI) in the mouse duodenum: An in silico comparison with mutagenic and nonmutagenic carcinogens across tissues. Regul Toxicol Pharmacol 64(1):68-76; doi: 10.1016/j.yrtph.2012.05.019
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Topics: chromium , Cr(VI) MOA Study
Thompson CM , Proctor DM , Suh M , Haws LC , Hebert CD, Mann JF, Shertzer HG, Hixon JG, Harris MA. 2012. Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: Implications for carcinogenic modes of action. Toxicol Sci 125(1):79-90; doi: 10.1093/toxsci/kfr280 .
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Topics: carcinogens , Cr(VI) MOA Study , Hexavalent Chromium
Perry C , Tachovsky JA, Ke M, Urban J , Haws L . Natural gas exploration and production in the Barnett Shale: Assessment of exposures to volatile organic compounds (VOCs). Presented at Society of Toxicology 51st Annual Meeting, San Francisco, CA, March 2012.
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Topics: VOCs
Proctor DM, Thompson CM, Suh M, Haws LC , Harris MA. 2012. Mode of action for intestinal carcinogenesis of ingested hexavalent chromium in mice. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.
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Topics: Hexavalent Chromium
Thompson CM, Hixon JG, Kopec AK, Harris MA, Proctor DM, Haws LC . Assessment of genotoxic potential of Cr(VI) in the mouse duodenum via toxicogenomic profiling. Presented at Society of Toxicology 51st Annual Meeting, San Francisco, CA, March 2012.
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Topics: chromium , Cr(VI) MOA Study
Wikoff D , DeVito M, Walker N, Hixon G, Harris M, Tachovsky A, Birnbaum L, Haws L . Application of machine learning in the development of a weighting framework for evaluating estimates of relative potency for dioxin-like compounds. Presented at Society of Toxicology 51st Annual Meeting, San Francisco, CA, March 2012.
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Topics: dioxin
2011 (10 POSTS)
Thompson C , Perry C , Gaylor D, Tachovsky A, Burkhalter B, Haws L . Derivation of an oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling. Presented at Society of Toxicology 50th Annual Meeting, Washington DC, March 2011.
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Topics: modeling , Toxicology
Thompson CM, Proctor DM, Haws LC, Hebert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG, Zacharewski TR, Harris MA. 2011. Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium. Toxicol Sci 123(1):58-70; doi: 10.1093/toxsci/kfr164
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Topics: Cr(VI) MOA Study , Hexavalent Chromium
Urban J , Fitzgerald L, Burkhalter B, Staskal D, Harris M, Haws L . BTEX serum levels in the general U.S. population: An analysis of 2003-2004 NHANES dataset. Presented at Society of Toxicology 50th Annual Meeting, Washington, D.C., March 2011.
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Topics: benzene , NHANES , VOCs
Thompson CM, Haws LC, Harris MA, Gatto NM, Proctor DM . 2011. Application of the U.S. EPA mode of action framework for purposes of guiding future research: A case study involving the oral carcinogenicity of hexavalent chromium. Toxicol Sci 119(1):20-40; doi: 10.1093/toxsci/kfq320 .
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Topics: Cr(VI) MOA Study , Hexavalent Chromium
Haws LC , DeVito MJ, Walker NJ,Harris MA, Tachovsky JA, Birnbaum LS, Farland WH, Wikoff DS . Development of a consensus-based weighting framework for evaluating estimates of relative potency for dioxin-like compounds that includes consideration of data from human cells. Presented at Dioxin 2011, Brussels, Belgium, August 2011.
Topics: dioxin
Haws LC, Fitzgerald L, Burkhalter B, Harris M, Wikoff DS. Assessment of the US EPA’s proposed toxicological values for TCDD for regulation of dioxin-like compounds in foods: Bridging the science divide in a global market. Presented at Dioxin 2011, Brussels, Belgium, August 2011.
Topics: dioxin , Food science
Wikoff DS, Thompson C, Walker N, DeVito M, Harris M, Birnbaum L, Haws L. Derivation of relative potency estimates using benchmark dose modeling: A case study with TCDF. Presented at Dioxin 2011, Brussels, Belgium, August 2011.
Topics: dioxin , modeling
Fitzgerald L, Burkhalter B, Urban J, Staskal D, Harris M, Haws L . VOC serum levels in the general U.S. population: An analysis of the 2003-2004 NHANES dataset. Presented at Society of Toxicology 50th Annual Meeting, Washington, D.C., March 2011
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Topics: NHANES , VOCs
Haws L, Proctor D, Thompson C , Harris M. 2011. Research plan to fill data gaps in the mode of action for cancer risk assessment of hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.
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Topics: Hexavalent Chromium
Proctor D, Haws L , Thompson C , Harris M. 2011. Use of mode of action and pharmacokinetics to inform the cancer risk assessment of ingested Cr(VI): A case study. Presented at the Society of Toxicology 50th Annual Meeting, March 6-10, 2011, Washington, D.C.
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Topics: Cancer , Hexavalent Chromium , pharmacokinetics , risk assessment
2010 (12 POSTS)
Harris M, Tachovsky JA, Staskal-Wikoff D , Aylward L, Burkhalter B, Simon T, Haws L . Serum concentrations of dioxin-like compounds in a population in Midland, Michigan: An evaluation of the impact of soil exposures. Presented at Dioxin 2010, San Antonio, TX, September 2010.
Topics: dioxin
Harris M, Tachovsky JA, Staskal-Wikoff D , Simon T, Burkhalter B, Urban J , Haws L . 2010. Assessment of the impact of various soil cleanup levels on serum concentrations of dioxin-like compounds in humans. Presented at Society of Toxicology 49th Annual Meeting, Salt Lake City, Utah, March 2010.
Topics: dioxin
Haws L . Biomonitoring – A tool for assessing community exposures to air toxics. Presented at the Air Quality 2010 Conference, University of Texas School of Law, November 2010.