Publication Topic

Rose WC, Marathe PH, Jang G, Monticello TM, Balasubramanian BN, Long B, Fairchild C, Wall ME, Wani MC. 2006. Novel fluoro-substituted campthothecins: In vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization. Cancer Chemother Pharmacol 58(1):73-85; doi: 10.1007/s00280-005-0128-y.

Teeguarden JG, Waechter JM Jr, Clewell HJ 3rd, Covington TR, Barton HA. 2005. Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding and uterine tissue dose metrics of bisphenol A: A physiologically based pharmacokinetic approach. Toxicol Sci 85(2):429–446; doi: 10.1093/toxsci/kfi135.

Gentry PR, Haber LT, McDonald TB, Zhao Q, Covington T, Nance P, Clewell HJ III, Lipscomb JC, Barton HA. 2005. Data for physiologically based pharmacokinetic modeling in neonatal animals: Physiological parameters in mice and Sprague-Dawley rats. J Children’s Health 2(3–4):363–411; doi: 10.3109/15417060490970430.

Teeguarden JG, Waechter JM, Clewell HJ, Covington TR, Barton HA. Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding and uterine tissue dose metrics of bisphenol A: A physiologically based pharmacokinetic approach. Poster presented at Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.

Kester JE, Gentry P, Covington TR, Clewell HJ. Issues in the use of PBPK modeling in the development of cancer slope factors for perchloroethylene. Poster presented at the Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.

Clewell HJ, Gentry PR, Covington TR, Sarangapani R, Teeguarden JG. 2004. Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Toxicol Sci 79(2):381–93; doi: 10.1093/toxsci/kfh109.

Gentry RP, Covington TR, Clewell HJ III. 2003. Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation. Regul Toxicol Pharmacol 38(1):1–16; doi: 10.1016/S0273-2300(03)00047-3.

Gentry R, Teeguarden J, Sarangapani R, Covington T, Lawrence G, McDonald T, Shipp A, Clewell H. Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences in tissue dosimetry. Poster presented at Society of Toxicology 41st Annual Meeting, Nashville, TN, March 2002.

Covington TR, Teeguarden J, Sarangapani R, Gentry PR, Clewell HJ. Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Presentation at the Annual Society for Risk Analysis Conference, Seattle, WA, December 2001.

Clewell HJ, Gentry PR, Gearhart JM, Covington TR, Banton MI, Andersen ME. 2001. Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone. Toxicol Sci 63(2):160–172; doi: 10.1093/toxsci/63.2.160.

Thompson CM, Capdevila JH, Strobel HW. 2000. Recombinant P450 2D18 metabolism of dopamine and arachidonic acid. J Pharmacol Exper Ther 294(3):1120–1130; doi: 10.1016/S0022-3565(24)39180-3.

Clewell HJ III, Gentry PR, Allen BC, Covington TR, Gearhart JM. 2000. Development of a physiologically-based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment. Environ Health Perspect 108(Suppl 2):283–305; doi: 10.1289/ehp.00108s2283.

Clewell HJ, Gentry PR, Gearhart JM, Born SL, Lehman-McKeeman LD, Covington TR. Development of a physiologically-based pharmacokinetic (PB-PK) model and human health risk assessment for coumarin. Poster presented at Society of Toxicology 39th Annual Meeting, Philadelphia, PA, March 2000.

Clewell HJ, Gearhart JM, Gentry PR, Covington TR, Van Landingham CB, Crump KS, and Shipp AM. 1999. Evaluation of the uncertainty in an oral reference dose for methylmercury due to interindividual variability in pharmacokinetics. Risk Anal 19(4):541–552; doi: 10.1111/j.1539-6924.1999.tb00427.x.

Rish W, Kirman CR, Hays SM, Gargas ML, Andersen ME, Reitz RH, Guengerich FP, Green T, McConnell EE, Buckpit A, Voytek P, Dugard PH. 1999. Developing a physiologically based pharmacokinetic model to describe methylene chloride kinetics at the subcellular level. Toxicologist 48, Paper No. 671. Presented at Society of Toxicology 38th Annual Meeting, New Orleans, LA, March 1999.

Gentry R, Clewell H, Gearhart J, Covington T, Andersen M. Development of a physiologically-based pharmacokinetic (PB-PK) model for isopropanol and acetone. Poster presented at  Society of Toxicology 38th Annual Meeting, New Orleans, LA, March 1999.

Van Landingham CB, Covington TR, Gearhart JM, Clewell HJ. Evaluation of the uncertainty in the RfD for methylmercury due to interindividual variability in pharmacokinetics. Poster presented at Society of Toxicology 37th Annual Meeting, Seattle, WA, March 1998.

Covington TR, Barton HA, Clewell HJ III. Evaluating pharmacokinetics and pharmacodynamics for noncancer effects from trichloroethylene (TCE). Poster presented at  Society of Toxicology 36th Annual Meeting, Cincinnati, OH, March 1997.

Allen BC, Covington TR, Clewell HJ III. 1996. Investigation of the impact of pharmacokinetic variability and uncertainty on risks predicted with a pharmacokinetic model for chloroform. Toxicology 111(1-3):289–303; doi: 10.1016/0300-483X(96)03383-5.

Covington TR, Clewell HJ III, Gearhart JM, Andersen ME. Developing physiologically-based pharmacokinetic (PB-PK) models for manganese and iron. Poster presented at the Society of Toxicology Annual Meeting, Anaheim, CA, March 1996.