Nyffeler J, Harris FR, Willis C, Byrd G, Blackwell B, Escher BI, Kasparek A, Nichols J,…, Patlewicz G , et al. 2025. A combination of high-throughput in vitro and in silico new approach methods (NAMs) for ecotoxicology hazard assessment for fish. Environ Toxicol Chem 44(9):2599-2621; doi: 10.1093/etojnl/vgae083 . PMID: 39937625.
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Publication: Manuscripts
/ Topics: ecotoxicology , NAMs
Nordyke RJ , Patterson JA, Motyka J, March B, Kirson NY, Long G. 2025. The impact of the Inflation Reduction Act’s drug price negotiation program on incentives for clinical development of new drugs. Value Health; doi: 10.1016/j.jval.2025.08.011 . Online ahead of print Sept. 1, 2025. PMID: 40902797.
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Publication: Manuscripts
/ Topics: drug development
Karamertzanis PG, Rasenberg M, Shah I, Patlewicz G . 2025. Modelling in vitro mutagenicity using multi-task deep learning and REACH data. Chem Res Toxicol 38(8):1382-1407; doi: 19.1021/acs.chemrestox.5c00152 . PMID: 40680271.
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Publication: Manuscripts
/ Topics: modeling
Shaw J, Hsu H, Tu H, Chia V, Aggarwal S, Carrigan G, Kelsh MA . Immortal time bias impacts time-to-time event outcomes in cohort with genomic testing. Abstract 6F-03, International Society for Pharmacoepidemiology (ISPE) 41st Annual Meeting, Washington, DC, August 2025.
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Publication: Abstracts and Presentations
/ Topics: Cancer , Epidemiology
Righter R, Yale K , Stewart C, Marshall L, Fairbanks H. Methods in qualitative data analysis to progress community health equity. Abstract 3993/Poster EP02-18, International Society of Exposure Science and International Society for Environmental Epidemiology (ISES/ISEE) Joint Annual Meeting, Atlanta, GA, August 2025 .
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Publication: Abstracts and Presentations
/ Topics: community health
Rish W , Verwiel A . Importance of epidemiology and visualization to integrate non-chemical stressors into cumulative impact assessment for vulnerable communities. Abstract 568/Poster P47-17, International Society of Exposure Science and International Society for Environmental Epidemiology (ISES/ISEE) Joint Annual Meeting, Atlanta, GA, August 2025 .
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Publication: Abstracts and Presentations
/ Topics: chemical safety assessment , community health , Epidemiology , Exposure Assessment
Muller K, Unice K, Panko J , Ferrari BJD, Breider F, Wagner S. 2025. Risk assessment of tire wear in the environment—A literature review. Environ Sci Process Impacts 27(8):2212-2232; doi: 10.1039/d5em00088b . PMID: 40569214.
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Publication: Manuscripts
/ Topics: ecotoxicology , Environmental Science , leachables , risk assessment , tire particles (TRWP)
Reynolds JI , Johnson BP. 2025. AOP 460: Antagonism of Smoothened receptor leads to orofacial clefting. ALTEX; doi: 10.14573/altex.2407121 . Advance online publication August 11, 2025.
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Publication: Manuscripts
/ Topics: Adverse outcome pathways (AOPs) , NAMs
Proctor D, Jiang X, Reichert H, Thompson C . 2025. Why rat oral cavity tumors should not be the basis of quantitative cancer risk assessment for oral exposure to hexavalent chromium. Toxicol Sci kfaf112; doi: 10.1093/toxsci/kfaf112 . Online ahead of print August 8, 2025. PMID: 40795394.
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Publication: Manuscripts
/ Topics: Cancer , chromium , Exposure Assessment , risk assessment
Moyer HL, Vergara L, Stephan C, Sakolish C, Lin HC, Chiu WA, Villenave R, Hewitt P, et al. 2025. Human small intestinal tissue models to assess barrier permeability: Comparative analysis of caco-2 cells, jejunal and duodenal enteroid-derived cells, and EpiIntestinalTM tissues in membrane-based cultures with and without flow. Bioengineering (Basel). 12(8):809; doi: 10.3390/bioengineering12080809 . PMID: 40868322; PMCID: PMC12384003.
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Publication: Manuscripts
/ Topics: NAMs
Clouser MC, Suh M , Movva N , Hildebrand JS, Pastula ST, Schoehl M, Hindoyan A, Balasubramanian A, et al. 2025. A systematic literature review of MTAP deletions in solid and hematologic cancers. Cancer Treat Res Comm 44:100966; doi: 10.1016/j.ctarc.2025.100966 . PMID: 40729867.
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Publication: Manuscripts
/ Topics: Cancer , Systematic Review
Monticello TM , MacLachlan TK, Funk KA, Rock BM, Bussiere JL, Grieves JL, Schuh JCL, Henry S. 2025. Nonclinical safety assessment: An overview of drug and medical device development. Chapter 1 in: Bouchard PR, Sahota PS, Wallace S, Wojcinski ZW, Schumacher VL (eds), Toxicologic Pathology: Nonclinical Safety Assessment, 3rd edition. Boca Raton: CRC Press-Taylor and Francis Group, pp. 3-51.
Publication: Book Chapters
/ Topics: drug development , nonclinical safety assessment
Patlewicz G , Judson, Paul Friedman K, Wetmore BA, DeVito MJ, Harrill JA, Carstens KE, Houck KA, et al. 2025. Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs). J Toxicol Environ Health B online ahead of print July 6; doi: 10.1080/10937404.2025.2521615 . PMID: 40619890.
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Publication: Manuscripts
/ Topics: NAMs , PFAS
Kenyon EM, DeVito MJ, Patlewicz G , Adams LD, Thomas RS, Ambroso JL, Yang X, Blake JC, et al. 2025. Subchronic toxicity of four per- and polyfluoroalkyl substances by oral exposure in Sprague Dawley rats. Toxics 13(7):524; doi: 10.3390/toxics13070524 . PMID: 40710969.
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Publication: Manuscripts
/ Topics: PFAS
Leary A, Shah I, Patlewicz G . 2025. An exploration of the use of hybrid fingerprints in Generalized Read-Across and their impact on predictive performance for selected in vivo toxicity outcomes. Comput Toxicol 34(June):100349; doi: 10.1016/j.comtox.2025.100349 .
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Publication: Manuscripts
/ Topics: NAMs , read-across
Hagan B, Shah I, Patlewicz G . 2025. Can graph similarity metrics be helpful for analogue identification as part of a read-across approach? Comput Toxicol 34(June):100353; doi: 10.1016/j.comtox.2025.100353 .
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Publication: Manuscripts
Muller K, Unice K, Panko J , Wagner S. 2025. Tire emissions during the use phase of tires – Current and future trends. Environ Sci Adv 4(9):1344-1363; doi: 10.1039/d4va00407h .
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Publication: Manuscripts
/ Topics: tire particles (TRWP)
Hughes MF, DeVito MJ, Patlewicz G , Thomas RS, Adams LD, Ambroso JL, Yang X, Upadhyay BG, et al. 2025. Immunotoxicity of four per- and polyfluoroalkyl substances following 28-day oral repeat dosing in rats assessed by the anti-sheep red blood IgM response. Toxics 13(6):490; doi: 10.3390/toxics13060490 . PMID: 40559963.
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