2021 (88 POSTS)
Werner JA, Davies R, Wahlstrom J, Dahal UP, Jiang M, Stauber J, David B, Siska W…, Monticello TM . 2021. Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat. Toxicol Appl Pharmacol 423(July 15):11578; doi: 10.1016/taap.2021.115578 .
Mayne TJ, Nordyke RJ , Schold JD, Weir MR, Mohan S. 2021. Defining a minimal clinically meaningful difference in 12-month estimated glomerular filtration rate for clinical trials in deceased donor kidney transplantation. Clin Transplant 35(7):e14326; doi: 10.1111/ctr.14326 . PMID: 33896052.
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Topics: Epidemiology
Fitch SE , Payne LE, van de Ligt JLG, Doepker C , Handu D, Cohen SM, Anyangwe N, Wikoff D . 2021. Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): A systematic map. BMC Pub Health 21(1):956; doi: 10.1186/s12889-021-10934-2 . PMID: 34016063.
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Topics: nutrition , Systematic Review
Borghoff SJ , Fitch SE , Black MVB, McMullen PD, Andersen ME, Chappell GA. 2021. A systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole. Regul Toxicol Pharmacol 124(Aug):104977; doi: 10.1016/j.yrtph.2021.104977 . PMID: 34174380.
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Topics: mode of action
Pittman CA, Roura R, Price C , Lin FR, Marrone N, Nieman CL. 2021. Racial/ethnic and sex representation in US-based clinical trials of hearing loss management in adults: A systematic review. JAMA Otolaryngol: Head Neck Surg 147 (7):656–662; https://doi.org/10.1001/jamaoto.2021.0550 .
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Topics: hearing loss , Systematic Review
Yi JS, Pittman CA, Price CL , Nieman CL, Oh ES. 2021. Telemedicine and dementia care: A systematic review of barriers and facilitators. J Am Med Direct Assoc; 22 (7):P1396-P1402; https://doi.org/10.1016/j.jamda.2021.03.015
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Topics: Systematic Review
Whaley P, Blaauboer BJ, Brozek J, Cohen Hubal EA, Hair K, Kacew S, Knudsen TB, Kwiatkowski CF, Mellor DT, Olshan AF, Page MJ, Rooney AA, Radke E, Shamseer L, Tsaioun K, Tugwell P, Wikoff D , Woodruff TJ. 2021. Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do. ALTEX 38(3):513-522. doi: 10.14573/altex.2106111 .
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Topics: Systematic Review
Yin W, Nie Z, Dingley K , Trzoss M, Krilov G, Marshall N et al. 2021. Characterization of potent paracaspase MALT1 inhibitors for hematological malignancies. Blood 138 (Supplement 1):1187; doi: 10.1182/blood-2021-153159 .
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Topics: Cancer , modeling
Dean R, Jensen IS, Cyr PL , Miller B, Maru B, Sproule DM, Feltner DE, et al. 2021. An updated cost-utility model for onasemnogene abeparvovec (Zolgensma®) in spinal muscular atrophy type 1 patients and comparison with evaluation by the Institute for Clinical and Effectiveness Review (ICER). J Mark Access Health Pol 9(1):1889841; doi: 10.1080/20016689.2021.1889841 .
Topics: Health Economics and Outcomes Research (HEOR)
Jaeschke H, Murray FJ, Monnot AD, Jacobson-Kram D, Cohen SM, Hardisty JF, Atillasoy E… Wikoff D , et al. 2021. Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential. Regul Toxicol Pharmacol 120(March):104859; doi: 10.1016/j.yrtph.2020.104859 . PMID: 33388367.
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Topics: carcinogens , pharmacology
Houck KA, Patlewicz G , Richard A, Williams AJ, Smeltz M, Clifton, MS, Wetmore B, Medvedev A, Makarov SS. 2021. Bioactivity profiling of per- and polyfluoroalkyl substances identifies potential toxicity pathways related to molecular structure. Toxicology 457(June 15):152789; doi: 10.1016/j.tox.2021.152789 . PMID: 33887376.
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Topics: PFAS
Proctor DM , Bhat V, Suh M , Reichert H , Jiang X , Thompson CM . 2021. Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches. Regul Toxicol Pharmacol 124(August):104969; doi: 10.1016/j.yrtph.2021.104969 . PMID: 34089813.
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Topics: Cancer , chromium , Exposure Assessment , risk assessment
Nielson CM, Bylsma LC , Fryzek JP, Saad HA, Crawford J. 2021. Relative dose intensity of chemotherapy and survival in patients with advanced stage solid tumor cancer: A systematic review and meta-analysis. Oncologist 26(9):e1609–e1618; doi: 10.1002/onco.13822 . PMID: 33973301.
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Topics: Epidemiology , Systematic Review
Rehorn M, Sacks NC , Emden MR, Healey B, Preib MT, Cyr PL , Pokorney SD. 2021. Prevalence and incidence of patients with paroxysmal supraventricular tachycardia in the United States. J Cardiovasc Electrophysiol 32(8):2199-2206; doi: 10.1111/jce.15109 .
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Topics: Epidemiology
Chew D, Sacks NC , Emden MR, Preib MT, Cyr PL , Wood D, Pokorney SD. 2021. Trends in health care resource use and expenditures in patients with newly diagnosed paroxysmal supraventricular tachycardia in the United States. Am Heart J 233(March):132–140; doi: 10.1016/j.ahj.2020.12.012 .
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Topics: Health Economics and Outcomes Research (HEOR)
Wang Y, Mittelstaedt RA, Wynne R, Chen Y, Cao X, Muskhelishvili L, Davis K, Robison TW , et al. 2021. Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by duplex sequencing. Environ Mol Mutagen 62(5):306-318; doi: 10.1002/em22444 .
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Topics: modeling
Ring C, Sipes NS, Hsieh JH, Carberry C, Koval LE, Klaren WD , Harris MA, Auerbach SS, Rager JE. 2021. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high throughput toxicokinetics. Comput Toxicol 18(May):100166; doi: 10.1016/j.comtox.2021.100166 . PMID: 34013136.
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