2025 (62 POSTS)
Klaren WD , Rivera BN, Sheppard AM , Franke K , Wikoff DS . 2025. Approach for systematically assessing study reliability and relevance in evaluations of monosodium glutamate safety. Curr Res Toxicol 9(Sep):100256; doi: 10.1016/j.crtox.2025.100256 . PMID: 41030520.
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Topics: food additives , food safety , Food science
Patlewicz G , Charest N, Ross A, Bledsoe HC, Vidal J, Faramarzi S, Hagan B, Shah I. 2025. Building a compendium of expert driven read-across cases to facilitate an analysis of the contribution that different similarity contexts play in read-across performance. Comput Toxicol 35(Sept):100366; doi: 10.1016/j.comtox.2025.100366 .
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Topics: NAMs
Nyffeler J, Harris FR, Willis C, Byrd G, Blackwell B, Escher BI, Kasparek A, Nichols J,…, Patlewicz G , et al. 2025. A combination of high-throughput in vitro and in silico new approach methods (NAMs) for ecotoxicology hazard assessment for fish. Environ Toxicol Chem 44(9):2599-2621; doi: 10.1093/etojnl/vgae083 . PMID: 39937625.
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Topics: ecotoxicology , NAMs
Baldwin WS, Bloom MS, Chung KW, Dasgupta S, DeLorenzo ME, Hunt KJ, Key PB,…, Jacobellis MA , et al. 2025. Toxicological, chemical, social, and economic challenges associated with PFAS and replacement aqueous film-forming foams (AFFF). Toxics 13(9):732; doi: 10.3390/toxics13090732 . PMID: 41012353.
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Topics: PFAS
Karamertzanis PG, Rasenberg M, Shah I, Patlewicz G . 2025. Modelling in vitro mutagenicity using multi-task deep learning and REACH data. Chem Res Toxicol 38(8):1382-1407; doi: 19.1021/acs.chemrestox.5c00152 . PMID: 40680271.
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Topics: modeling , regulatory toxicology
Muller K, Unice K, Panko J , Ferrari BJD, Breider F, Wagner S. 2025. Risk assessment of tire wear in the environment—A literature review. Environ Sci Process Impacts 27(8):2212-2232; doi: 10.1039/d5em00088b . PMID: 40569214.
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Topics: ecotoxicology , Environmental Science , leachables , risk assessment , tire particles (TRWP)
Moyer HL , Vergara L, Stephan C, Sakolish C, Lin HC, Chiu WA, Villenave R, Hewitt P, et al. 2025. Human small intestinal tissue models to assess barrier permeability: Comparative analysis of caco-2 cells, jejunal and duodenal enteroid-derived cells, and EpiIntestinalTM tissues in membrane-based cultures with and without flow. Bioengineering (Basel) 12(8):809; doi: 10.3390/bioengineering12080809 . PMID: 40868322.
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Topics: NAMs
Clouser MC, Suh M , Movva N , Hildebrand JS, Pastula ST, Schoehl M, Hindoyan A, Balasubramanian A, et al. 2025. A systematic literature review of MTAP deletions in solid and hematologic cancers. Cancer Treat Res Comm 44:100966; doi: 10.1016/j.ctarc.2025.100966 . PMID: 40729867.
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Topics: Cancer , Systematic Review
Patlewicz G , Judson, Paul Friedman K, Wetmore BA, DeVito MJ, Harrill JA, Carstens KE, Houck KA, et al. 2025. Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs). J Toxicol Environ Health B online ahead of print July 6; doi: 10.1080/10937404.2025.2521615 . PMID: 40619890.
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Topics: NAMs , PFAS
Kenyon EM, DeVito MJ, Patlewicz G , Adams LD, Thomas RS, Ambroso JL, Yang X, Blake JC, et al. 2025. Subchronic toxicity of four per- and polyfluoroalkyl substances by oral exposure in Sprague Dawley rats. Toxics 13(7):524; doi: 10.3390/toxics13070524 . PMID: 40710969.
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Topics: PFAS
Leary A, Shah I, Patlewicz G . 2025. An exploration of the use of hybrid fingerprints in Generalized Read-Across and their impact on predictive performance for selected in vivo toxicity outcomes. Comput Toxicol 34(June):100349; doi: 10.1016/j.comtox.2025.100349 .
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Topics: NAMs , read-across
Hagan B, Shah I, Patlewicz G . 2025. Can graph similarity metrics be helpful for analogue identification as part of a read-across approach? Comput Toxicol 34(June):100353; doi: 10.1016/j.comtox.2025.100353 .
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Topics: read-across
Munn Z, Pollock D, Stone J, Hasanoff S, Gordon A, Price C , et al. 2025. The impact of using cannabis during pregnancy on the infant and mother: An overview of systematic reviews, evidence map, targeted updates, and de novo synthesis. Aust NZ J Obstet Gynaecol 65(3):312-328; doi: 10.1111/ajo.13916 . PMID: 39699257.
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Topics: Cannabinoid/Industrial Hemp , Systematic Review
Muller K, Unice K, Panko J , Wagner S. 2025. Tire emissions during the use phase of tires – Current and future trends. Environ Sci Adv 4(9):1344-1363; doi: 10.1039/d4va00407h .
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Topics: tire particles (TRWP)
Hughes MF, DeVito MJ, Patlewicz G , Thomas RS, Adams LD, Ambroso JL, Yang X, Upadhyay BG, et al. 2025. Immunotoxicity of four per- and polyfluoroalkyl substances following 28-day oral repeat dosing in rats assessed by the anti-sheep red blood IgM response. Toxics 13(6):490; doi: 10.3390/toxics13060490 . PMID: 40559963.
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Topics: PFAS
Brorby G, Franzen A, Thompson C, Wikoff D, Doepker C . 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 202(Aug):115490; doi: 10.1016/j.fct.2025.115490 . PMID: 40320068.
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Topics: food safety , Food science , genotoxicity , risk assessment , safety assessment
Hagan B, Groff L, Patlewicz G , Shah. 2025. Toward metabolic similarity in read-across: A case study using graph convolutional networks to predict genotoxicity outcomes. Chem Res Toxicol 38(6):1122-1133; doi: 10.1021/acs.chemrestox.5c00120 . PMID: 40432291.
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Topics: genotoxicity
Diemar MG, Giusti A, Michel-Caillet C, Leme DM, Wikoff D , Bloch D, Sass J, Beekmann K, et al. 2025. How to organize a successful toxicology workshop? A participant perspective on the Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) workshop in Oslo, 18-20 June 2024. Arch Toxicol 99(7):3057-3063 ; doi : 10.1007/s00204-025-04064-6 . PMID: 40372420.
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Topics: chemical safety assessment , NAMs , risk assessment , safety assessment
Duong T, Haselkorn T, Miller B, Coats J, Jensen I , Ward E, Wood M, Graham RJ, Servais L. 2025. A real-world analysis of the impact of X-linked myotubular myopathy on caregivers in the United States. Orphanet J Rare Dis 20(1):224. doi: 10.1186/s13023-025-03583-w . PMID: 40355957.
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