2014 (9 POSTS)
Johnson GE, Soeteman-Hernandez, Gollapudi BB, Bodger OG, Dearfield KL, RH Heflich, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM , Abraham L , Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. 2014. Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Molec Mutagen 55(8):609-623; doi: 10.1002/em.21870/em.21870 .
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Topics: risk assessment
Hixon JG, Thompson C, Bichteler A, Abraham L . Smoothing regression splines as the basis for dose-response modeling. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.
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Topics: dose-response , modeling
Thompson CM, Proctor DM, Suh M, Wolf JC, Haws LC, Seiter JM, Chappell MA, Harris MA. X-ray fluorescence microspectroscopic analysis of duodenal mucosae following Cr(VI) exposure in drinking water. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.
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Topics: chromium
Wikoff D, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Haws LC . Development of an oral cancer slope factor and lifetime average daily dose estimates for TBBPA. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.
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Topics: Cancer , flame retardants
Thompson CM , Kirman CR, Proctor DM , Haws LC , Suh M , Hays S, Hixon JG, Harris MA. 2014. A chronic oral reference dose for hexavalent chromium-induced intestinal cancer. J Appl Toxicol 34:525-536. doi: 10.1002/jat.2907 .
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Topics: Cancer , chromium
Suh M, Thompson C, Kirman C, Carakostas M, Haws LC, Harris M, Proctor D . 2014. High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice. Food Chem Toxicol 65:381-388; doi: 10.1016/j.fct.2014.01.009 .
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Topics: chromium , water
2013 (10 POSTS)
Kirman CR, Aylward LL, Suh M , Harris MA, Thompson CM , Haws LC , Proctor DM , Lin SS, Parker W, Hays SM. 2013. Physiologically based pharmacokinetic model for humans orally exposed to chromium. Chem Biol Interact 204(1):13-27; doi: 10.1016/j.cbi.2013.04.003 .
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Topics: chromium , modeling , PBPK/PBDE , pharmacokinetics
O’Brien T, Ding H, Suh M , Thompson C , Parsons BL, Harris MA, Winkelman WA, Wolf JC, Hixon JG, Schwartz AM, Myers MB, Haws LC , Proctor DM. 2013. Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water. Mutat Res 754:15-21. doi: 10.1016/j.mrgentox.2013.03.008 .
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Topics: chromium , water
Rowlands JC, Budinsky R, Gollapudi B, Black MB, Wolfinger RD, Cukovic D, Bombkowski A, Thompson CM , Urban JD , Thomas RS. 2013. A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes. Toxicol Sci 136(2):595-604; doi: 10.1093/toxsci/kft203 .
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Topics: dioxin
Suh M, Thompson CM, Hixon JG, Harris MA, Kirman CR, Hays S, Haws LC, Proctor DM . 2013. Potential involvement of oxidative stress and iron disturbance in the development of oral cavity tumors in rats exposed to hexavalent chromium. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.
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Topics: chromium
Thompson CM , Proctor DM , Suh M , Haws LC , Kirman CR, Harris MA. 2013. Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans. Crit Rev Toxicol 43(3):244-274; doi: 10.3109/10408444.2013.768596 .
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Topics: chromium , Exposure Assessment , mode of action
Urban JD, Thompson CM, Deskin R, Waite M, Haws LC . 2013. Development of an oral cancer slope factor for acrylamide based on tumors relevant to humans. Presented at Society of Toxicology 52nd Annual Meeting, San Antonio, TX, March 2013.
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Topics: Cancer , Exposure Assessment
Thompson CM, Kirman CR, Proctor DM, Suh M, Hays SM, Haws LC , Harris MA. A chronic oral reference dose for hexavalent chromium. Presented at Society of Toxicology 52nd Annual Meeting, San Antonio, TX, March 2013.
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Topics: chromium
Proctor DM, Suh M, Thompson CM , Harris MA. 2013. Mode of action evaluation for hexavalent chromium-induced lung cancer. Presented at Society of Toxicology 52nd Annual Meeting, March 10-14, San Antonio, TX.
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Topics: Cancer , chromium , mode of action
Thompson CM , Gaylor DW, Tachovsky JA, Perry C, Carakostas MC, Haws LC . 2013. Development of a chronic noncancer oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling. J Appl Toxicol 33(12):1395-1406; doi: 10.1002/jat.2799 .
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Topics: benchmark dose estimation (BMD) , modeling , water
Kirman CR, Thompson CM, Proctor DM, Suh M, Haws LC , Harris MA, Hays SM. Using PBPK modeling to address diurnal variation and age differences in hexavalent chromium toxicokinetics in humans. Presented at Society of Toxicology 52nd Annual Meeting,San Antonio, TX, March 2013.
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Topics: chromium , modeling , PBPK/PBDE , pharmacokinetics , toxicokinetics
2012 (15 POSTS)
Kirman CR, Hays SM, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM . 2012. Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium. Chem Biol Interact 200(1):45-64; doi: 10.1016/j.cbi.2012.08.016 .
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Topics: chromium , modeling , pharmacokinetics
Kopec AK, Thompson CM , Kim S, Forgacs AL, Zacharewski TR. 2012. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelium. Toxicol Appl Pharmacol 262(2):124-138; doi: 10.1016/j.taap.2012.04.026 .
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Topics: chromium
Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DM , Harris MA, Haws LC , Thompson CM. 2012. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water. Toxicol Appl Pharmacol 259(1):13-26; doi: 10.1016/j.taap.2011.11.012.
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Topics: chromium , water
Harris MA, Thompson CM , Wolf JC, Fedorov Y, Hixon JG, Proctor DM, Suh M, Haws LC . Assessment of genotoxic potential of Cr(VI) in the intestine via in vivo intestinal micronucleus assay and in vitro high content analysis in differentiated and undifferentiated caco-2. Presented at Society of Toxicology 51st Annual Meeting, San Francisco, CA, March 2012.
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