2019 (13 POSTS)
Andersen ME, Gentry PR, Swenberg JA, Mundt KA, White KW, Thompson C , Bus J, Sherman JH, et al. 2019. Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop. Regul Toxicol Pharmacol 106(Aug):210–223; doi: 10.1016/j.yrtph.2019.04.015 . PMID: 31059732.
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Topics: formaldehyde , risk assessment
Klaren WD , Ring C, Harris MA, Thompson CM , Borghoff S , Sipes NS, Hsieh JH, Auerbach SS, Rager JE. 2019. Identifying attributes that influence in vitro-to-in vivo concordance by comparing Tox21 bioactivity versus DrugMatrix transcriptomic responses across 130 chemicals. Toxicol Sci 167(1):157–171; doi: 10.1093/toxsci/kfy220 . PMID: 30202884.
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Topics: transcriptomics
Rager JE, Suh M , Chappell G, Thompson CM , Proctor DM . 2019. Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis. Toxicol Lett 305(May 1):40-50; doi: 10.1016/j.toxlet.2019.01.011 . PMID: 30690063.
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Topics: carcinogens , chromium , transcriptomics
Gentry R, Greene T, Granzen A, Thompson CM . Formaldehyde and leukemia: A case study using the IPCS MOA and human relevance frameworks. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Topics: Cancer , formaldehyde
Thompson CM , Gentry R. An updated mode-of-action analysis for formaldehyde-induced nasal tumors in rodents: A case study using the IPCS MOA and human relevance frameworks. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Topics: formaldehyde , mode of action
Chappell GA, Rager JE, Wolf JC, Babic M, LeBlanc KJ, Ring CL, Harris MA, Thompson C . Similarities in the transcriptomic signatures in the duodenum of mice exposed to hexavalent chromium, captan, or folpet inform the mechanisms of chemical-induced mouse small intestine cancer. Presentation at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Topics: Cancer , chromium , transcriptomics
Ring CL, Urban J , Wikoff D , Thompson C , Budinsky RA, Haws LC . Application of systematic review and quantitative evidence integration methods to support risk assessment: Characterization of the dose-response relationship between exposure to dioxin-like compounds (DLC) and sperm count. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Topics: dioxin , risk assessment , Systematic Review
Clewell RA, Thompson CM , Clewell HJ. 2019. Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment. Chem Biol Interact 301(March 1):112–127; doi: 10.1016/j.cbi.2019.01.025 . PMID: 30763550.
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Topics: carcinogens , risk assessment
2018 (9 POSTS)
Urban J , Wikoff D , Haws L , Fitch S , Ring C, Thompson C , Suh M . 2018. Systematic review protocol: Systematic review and meta-regression to characterize the dose-response relationship between exposure to dioxin-like compounds during sensitive windows of development and reduced sperm count. Zenodo. http://doi.org/10.5281/zenodo.1636357 .
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Topics: dioxin , Systematic Review
Wikoff DS, Thompson C , Rager J, Chappell G, Fitch S, Doepker C . 2018. Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates. Food Chem Toxicol 120(Oct):709-723; doi: 10.1016/j.fct.2018.08.031 . PMID: 30134152.
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Topics: Exposure Assessment , food safety , Food science , nutrition , risk analysis
Thompson CT , Suh M , Chappell G, Borghoff S , Ellis-Hutchings, R, Wiench, K, Finch, L, Proctor DM . 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96(Jul):178–189; doi: 10.1016/j.yrtph.2018.05.006 . PMID: 29738809.
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Topics: carcinogens , mode of action , risk assessment
Proctor DM , Suh M , Chappell G, Borghoff SJ , Thompson CM , Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol 96(July):30-40; doi: 10.1016/j.yrtph.2018.04.016 . PMID: 29684431.
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Topics: Adverse outcome pathways (AOPs) , Cancer , genotoxicity
Moffat I, Martinova N, Seidel C, Thompson CM . 2018. Hexavalent chromium in drinking water. J AWWA 110(5):E22-E35; doi: 10.1002/awwa.1044 .
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Topics: chromium , water
Suh M , Proctor DM , Chappell G, Rager JE, Thompson CM , Borghoff S , Finch L, Ellis-Hutchings R, Wiench K. 2018. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicol 402-403(June 1):50-67; doi: 10.1016/j.tox.2018.04.006 . PMID: 29689363.
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Topics: carcinogens , chemical safety assessment , consumer products , genotoxicity , microplastics
Thompson CM , Wolf JC, Suh M , Proctor DM , Haws LC , Harris MA. Toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens; captan, folpet, and hexavalent chromium: Evidence for an adverse outcome pathway. Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.
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Topics: carcinogens , chromium
Thompson CM , Suh M , Proctor DM , Harris MA. Ten factors for considering the mode of action of Cr(VI)-induced intestinal tumors in rodents. Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.
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Topics: chromium , mode of action
Thompson CM , Kirman CR, Hays SM, Suh M , Harvey SE , Proctor DM , Rager JE, Haws LC , Harris MA. 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545 . PMID: 29064106.
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Topics: chromium , pharmacokinetics
2017 (10 POSTS)
Thompson CM , Wolf, JC, McCoy A, Suh M , Proctor DM , Kirman CR, Haws LC , Harris MA. 2017. Comparison of toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens captan, folpet, and hexavalent chromium. Toxicol Pathol 45(8):1091–1101; doi: 10.1177/019262331yy4324 . PMID: 29161989.
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Topics: carcinogens , chromium
Thompson CM, Suh M, Proctor DM, Haws LC , Harris MA. 2017. Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents. Mutat Res 823(Nov):45-57; doi: 10.1016/j.mrgentox.2017.08.004 . PMID: 28985946.
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Topics: chromium , mode of action
Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C , Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; doi: 10.1021/acs.chemrestox.7b00221 . PMID: 28927277.
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