Publications

Patlewicz G, Helman G, Pradeep P, Shah I. 2017. Navigating through the minefield of read-across tools: A review of in silico tools for grouping. Comput Toxicol 3(Aug):1-18; doi: 10.1016/j.comtox.2017.05.003. PMID: 30221211.

Judson RS, Martin M, Patlewicz G, Wood CE. 2017. Retrospective mining of toxicology data to discover multispecies and chemical class effects: Anemia as a case study. Regul Toxicol Pharmacol 86(June):74-92; doi: 10.1016/j.yrtph.2017.02.015. PMID: 28242142.

Fitzpatrick J, Patlewicz G. 2017. Application of IATA – A case study in evaluating the global and local performance of a Bayesian network model for skin sensitization. SAR QSAR Environ Res 28(4):297-310; doi: 10.1080/1062936X.2017.1311941. PMID: 28423913.

Fitzpatrick JM, Roberts DW, Patlewicz G. 2017. What determines skin sensitization potency–Myths, maybes and realities. The 500 molecular weight cut-off – An updated analysis. J Appl Toxicol 37(1):105-116; doi: 10.1002/jat.3348. PMID: 27283458.

Fitzpatrick JM, Roberts DW, Patlewicz G. 2017. Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization. J Appl Toxicol 37(1):117-127; doi: 10.1002/jat.3354. PMID: 27357739.

Patlewicz G, Casati S, Basketter D, Asturiol D, Roberts DW, Lepoittevin J-P, Aschberger K. 2016. Can currently available non-animal methods detect pre and pro haptens relevant for skin sensitization? Regul Toxicol Pharmacol 82(10):147-155;p doi: 10.1016/j.yrtph.2016.08.007. PMID: 27569201.

Roberts DW, Api AM, Patlewicz G, Schultz TW. 2016. Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitization potency. Part 1. Underlying physical organic chemistry principles and the extent to which they are represented in the LLNA validation dataset. Regul Toxicol Pharmacol 80(Oct):247-254; doi: 10.1016/j.yrtph.2016.07.007. PMID: 27424000.

Worth A, Patlewicz G. 2016. Integrated approaches to testing and assessment. Adv Exp Med Biol 856:317-342; doi: 10.1007/978-3-319-33826-2_13. PMID: 27671729.

Patlewicz G, Worth AP, Ball N. 2016. Validation of computational methods. Adv Exp Med Biol 856:165-187; doi: 10.1007/978-3-319-33826-2_6. PMID: 27671722.

Richard A, Judson R, Houck K, Grulke C, Volarath P, Thillainadarajah I, Yang C,…, Patlewicz G, et al. 2016. The ToxCast chemical landscape: Paving the road to 21st century toxicology. Chem Res Toxicol 29(8):1225-1251; doi: 10.1021/acs.chemrestox.6b00135. PMID: 27367298.

Shah I, Liu J, Judson RS, Thomas R, Patlewicz G. 2016. Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information. Reg Toxicol Pharmacol 79(Aug):12-24; doi: 10.1016/j.yrtph.2016.05.008. PMID: 27174420.

Samuel GO, Hoffmann S, Wright R, Lalu MM, Patlewicz G, Becker RA, DeGeorge GL, Fergusson D, et al. 2016. Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review. Environ Int 92-93(July-Aug):630-646; doi: 10.1016/j.envint.2016.03.010. PMID: 27039952.

Patlewicz GY, Fitzpatrick J. 2016. Current and future perspectives on the development, evaluation and application of in silico approaches for predicting toxicity. Chem Res Toxicol 29(4):438-451; doi: 10.1021/acs.chemrestox.5b00388. PMID: 26686752.

Ball N, Cronin MTD, Shen J, Blackburn K, Booth ED, Bouhifd M, Donley E,…, Patlewicz G, et al. 2016. Toward good read-across practice (GRAP) guidance. ALTEX 33(2):149-166; doi: 10.14573/altex.1601251. PMID: 26863606.

Becker RA, Patlewicz G, Simon T, Rowlands JC, Budinsky RA. 2015. The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor. Regul Toxicol Pharmacol 73(1):172-190; doi: 10.1016/j.yrtph.2015.06.015. PMID: 26145830.

Petkov P, Patlewicz G, Schultz TW, Honma M, Todorov M, Kotov S, Dimitrov SD, Donner EM, Mekenyan OM. 2015. A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity? Regul Toxicol Pharmacol 72(1):17-25; doi: 10.1016/j.yrtph.2015.03.003. PMID: 25792138.

Patlewicz G, Ball N, Boogaard P, Becker RA, Hubesch B. 2015. Building scientific confidence in the development and evaluation of read-across. Regul Toxicol Pharmacol 72(1):117-133; doi: 10.1016/j.yrtph.2015.03.015. PMID: 25857293.

Patlewicz G, Simon T, Rowlands JC, Budinsky R, Becker RA. 2015. Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes. Regul Toxicol Pharmacol 71(3):463-477; doi: 10.1016/j.yrtph.2015.02.011. PMID: 25707856. (Top 10 Paper for RASS Award at SOT 2016)

Becker RA, Paul KB, Simon TW, Marty S, Patlewicz G, Rowland JC. 2015. An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept. Regul Toxicol Pharmacol 71(3):398-408; doi: 10.1016/j.yrtph.2015.01.008. PMID: 25656492.

Patlewicz G, Worth A. 2008. Review of Data Sources, QSARs and Integrated Testing Strategies for Skin Sensitization. EUR 23225 EN.