Publications

Fisk L, Greene N, Naven R. 2018. Physicochemical properties and structural alerts. In: Chen M, Will Y (eds), Drug-Induced Liver Toxicity, Humana: New York, pp. 61-76; doi: 10.1007/978-1-4939-7677-5_4.

Rusyn I, Greene N. 2018. The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. Toxicol Sci 161(2):276-284; doi: 10.1093/toxsci/kfx196. PMID: 29378069.

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Butler L, Guzzie-Peck P, Hartke J, Bogdanffy M, Will Y, Diaz D, Mortimer-Cassen E,.., Greene N, et al. Revised draft EMA guidance on early clinical trials: Potential impacts and industry response. Abstract P204, American College of Toxicology 2017 Annual Meeting, Palm Springs, CA, 2017. Int J Toxicol 37(1):75-76; doi: 10.1177/10915818177494, 2018.

Sanz F, Pognan F, Steger-Hartmann T, Díaz C, Cases M, Pastor M, Marc P,…, Greene N, et al. 2017. Legacy data sharing to improve drug safety assessment: The eTOX project. Nat Rev Drug Discov 6(12):811-812; doi: 10.1038/nrd.2017.177. PMID: 29026211.

Butler LD, Guzzie-Peck P, Hartke J, Bogdanffy MS, Will Y, Diaz D, Mortimer-Cassen E,…, Greene N, et al. 2017. Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective. Regul Toxicol Pharmacol 87(Sup 3):S1-S15; doi: 10.1016/j.yrtph.2017.05.009. PMID: 28483710.

Williams RV, Amberg A, Brigo A, Coquin L, Giddings A, Glowienke S, Greene N, et al. 2016. It’s difficult, but important, to make negative predictions. Regul Toxicol Pharmacol 76(Apr):79-86; doi: 10.1016/j.yrtph.2016.01.008. PMID: 26785392.

Barber C, Cayley A, Hanser T, Harding A, Heghes C, Vessey JD, Werner S,…, Greene N. 2016. Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained. Regul Toxicol Pharmacol 76(Apr):7-20; doi: 10.1016/j.yrtph.2015.12.006. PMID: 26708083.

Shah F, Leung L, Barton HA, Will Y, Rodrigues AD, Greene N, Aleo MD. 2015. Setting clinical exposure levels of concern for drug-induced liver injury (DILI) using mechanistic in vitro assays. Toxicol Sci 147(2):500-14; doi: 10.1093/toxsci/kfv152. PMID: 26206150.

Greene N, Pennie W. 2015. Computational toxicology: Friend or foe? Toxicol Res 4(5):1159-1172; doi: 10.1039/c5tx00055f.

Steinbach T, Gad-McDonald S, Kruhlak N, Powley M, Greene N. 2015. (Q)SAR: A tool for the toxicologist. Int J Toxicol 34(4):352-4; doi: 10.1177/1091581815584914. PMID: 25979517.

Greene N, Dobo KL, Kenyon MO, Cheung J, Munzner J, Sobol Z, Sluggett G, Zelesky T, et al. 2015. A practical application of two in silico systems for identification of potentially mutagenic impurities. Regul Toxicol Pharmacol 72(2):335-49; doi: 10.1016/j.yrtph.2015.05.008. PMID: 25980641.

Zhang L, McHale CM, Greene N, Snyder R, Rich IN, Aardema MJ, Roy S, Pfuhler S, et al. 2014. Emerging approaches in predictive toxicology. Environ Mol Mutagen 55(9):679-88; doi: 10.1002/em.21885. PMID: 25044351.

Shah F, Louise-May S, Greene N. 2014. Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines. Bioorg Med Chem Lett 24(12):2753-2757; doi: 10.1016/j.bmcl.2014.04.039. PMID: 24794102.

Shah F, Hashimoto T, Segall MD, Greene N. 2014. Finding the rules for successful drug optimization. Drug Discov Today 18(13-14):659-666; doi: 10.1016/j.drudis.2014.01.005.

Davis PA, Wiegers TC, Roberts PM, King BL, Lay JM, Lennon-Hopkins K, Sciaky D,…, Greene N, et al. 2013. A CTD–Pfizer collaboration: Manual curation of 88 000 scientific articles text mined for drug–disease and drug–phenotype interactions. Database 2013(Nov 28):bat080; doi: 10.1093/database/bat080. PMID: 24288140.

Sutter A, Amberg A, Boyer S, Brigo A, Contrera JF, Custer LL, Dobo KL,…, Greene N, et al. 2013. Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities. Regul Toxicol Pharmacol 67(1):39-52; doi: 10.1016/j.yrtph.2013.05.001. PMID: 23669331.

Greene N, Gosink M. 2013. Computational toxicology experience and applications for risk assessment in the pharmaceutical industry. Chapter 10 in: Fowler BA (ed), Computational Toxicology: Methods and Applications. Elsevier-Academic Press, pp. 171-193; doi: 10.1016/B978-0-12-396461-8.00012-9.

Shah F, Greene N. 2013. Analysis of Pfizer compounds in EPA’s ToxCast chemicals-assay space. Chem Res Toxicol 27(1):86-98; doi: 10.1021/tx400343t. PMID: 24328225.

Naven RT, Swiss R, Klug-McLeod J, Will Y, Greene N. 2013. The development of structure-activity relationships for mitochondrial dysfunction: Uncoupling of oxidative phosphorylation. Toxicol Sci 131(1):271-278; doi: 10.1093/toxsci/kfs279. PMID: 22977170.

Naven RT, Greene N, Williams RV. 2012. Latest advances in computational genotoxicity prediction. Exp Opin Drug Metabol 8(12):1579-87; doi: 10.1517/17425255.2012.724059. PMID: 22998164.