Publication Topic

Patlewicz G, Richard AM, Williams AJ, Judson RS, Thomas RS. 2022. Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing. Comput Toxicol 24(Nov):100250; doi: 10.1016/j.comtox.2022.100250. PMID: 36969381.

Foster MJ, Patlewicz G, Shah I, Haggard DE, Judson RS, Paul Friedman K. 2022. Evaluating structure-based activity in a high throughput assay for steroid biosynthesis. Comput Toxicol 24(Nov):100245; doi: 10.1016/j.comtox.2022.100245. PMID: 37841081.

Ponder J, Rajagopal R, Singal M, Baker N, Patlewicz G, Roggen E, Cochrane S, Sullivan K. 2022. “In Litero” screening. Retrospective evaluation of clinical evidence to establish a reference list of human chemical respiratory sensitizers. Front Toxicol 4(Jul 15):916370; doi: 10.3389/ftox.2022.916370. PMID: 35910543.

Karmaus A, Mansouri K, To K, Blake B, Fitzpatrick J, Strickland J, Patlewicz G, Allen D, et al. 2022. Evaluation of variability across rat acute oral systemic toxicity studies. Toxicol Sci 188(1):34-47; doi: 10.1093/toxsci/kfac042. PMID: 35426934.

Patlewicz G. 2022. Editorial: Reflections of the QSAR2021 meeting. Comput Toxicol 22(May):100221; doi: 10.1016/j.comtox.2022.100221. PMID: 35252631.

Rooney J, Abedini J, Bell S, Chang X, Cook B, Ceger P, Choksi N, et al. Building confidence in alternative methods through ICE. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.

Allen DG, Rooney J, To K, Choksi N, Ceger P, Daniel A, et al. Variability in reference test method data and the impact on NAM evaluations. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.

Boyce M, Meyer B, Grulke C, Lizarraga L, Patlewicz G. 2022. Comparing the performance and coverage of selected in silico (liver) metabolism tools related to reported studies in the literature to inform analogue selection in read-across: A case study. Comput Toxicol 21(Feb):100208; doi: 10.1016/j.comtox.2021.100208. PMID: 35386221.

Beal MA, Gagne M, Kulkarni SA, Patlewicz G, Thomas RS, Barton-Maclaren TS. 2022. Implementing in vitro bioactivity to modernize priority setting of chemical inventories. ALTEX 39(1):123-139; doi: 10.14573/altex.2106171. PMID: 34818430.

Shah I, Tate T, Patlewicz G. 2021. Generalized Read-Across prediction using genra-py. Bioinformatics 37(19):3380-3381; doi: 10.1093/bioinformatics/btab210. PMID: 33772575.

Rooney JP, Choksi NY, Ceger P, Daniel AB, Truax J, Allen D, Kleinstreuer N 2021. Analysis of variability in in vivo rabbit skin irritation assay results. Regul Toxicol Pharmacol 122(June):104920; doi: 10.1016/j.yrtph.2021.104920. PMID: 33757807.

Pangburn HA, Linakis MW, Chushak YG, Covington TR, McCarthy MJ, Gearhart JM. New approach methodologies informing operational Air Force mission. Presentation at the Society of Toxicology Annual Meeting, virtual event, March 2021.

Rovida C, Escher SE, Herzler M, Bennekou SH, Kamp H, Kroese DE, Maslankiewicz L, Moné MJ, Patlewicz G, et al. 2021. NAM-supported read-across: From case studies to regulatory guidance in safety assessment. ALTEX 38(1):140-150; doi: 10.14573/altex.2010062. PMID: 33452529.

House JS, Grimm FA, Klaren WD, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, Ketelsegers HB, Gant TW, Wright FA, Rusyn I. 2020. Grouping of UVCB substances with new approach methodologies (NAMs) data. ALTEX 38(1):123–137; doi: 10.14573/altex.2006262.

Rovida C, Barton-Maclaren T, Benfenati E, Caloni F, Chandrasekera PC, Chesne C, Cronin MTD,.., Patlewicz G, et al. 2020. Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology. ALTEX 37(4):579-606; doi: 10.14573/altex.1912181. PMID: 32369604.

Nelms MD, Pradeep P, Patlewicz G. 2019. Evaluating potential refinements to existing Threshold of Toxicological Concern (TTC) values for environmentally-relevant compounds. Regul Toxicol Pharmacol 109(Dec):104505; doi: 10.1016/j.yrtph.2019.104505. PMID: 31639428.

Helman G, Shah I, Patlewicz G. 2019. Transitioning the Generalized Read-Across approach (GenRA) to quantitative predictions: A case study using acute oral toxicity data. Comput Toxicol 12(Nov):1000097; doi: 10.1016/j.comtox.2019.100097. PMID: 33623834.

Webster F, Gagne M, Patlewicz G, Pradeep P, Trefiak N, Judson R, Barton-Maclaren TS. 2019. Predicting estrogen receptor activation by a group of substituted phenols: An integrated approach to testing and assessment case study. Regul Toxicol Pharmacol 106(Aug):278-291; doi: 10.1016/j.yrtph.2019.05.017. PMID: 31121201.

Patlewicz G, Lizarraga L, Rua D, Allen DG, Daniel A, Fitzpatrick SC, Garcia-Reyero N, Gordon J, et al. 2019. Exploring current read-across applications and needs among selected US federal agencies. Regul Toxicol Pharmacol 106(Aug):197-209; doi: 10.1016/j.yrtph.2019.05.011. PMID: 31078681.

Choksi NY, Truax J, Layton A, Matheson J, Mattie D, Varney T, et al. 2019. United States regulatory requirements for skin and eye irritation testing. Cutan Ocul Toxicol 38(2):141–155; doi: 10.1080/15569527.2018.1540494. PMID: 30418044.