Publication Topic

Pangburn HA, Linakis MW, Chushak YG, Covington TR, McCarthy MJ, Gearhart JM. New approach methodologies informing operational Air Force mission. Presentation, Society of Toxicology 60th Annual Meeting, Virtual, March 2021.

Rovida C, Escher SE, Herzler M, Bennekou SH, Kamp H, Kroese DE, Maslankiewicz L, Moné MJ, Patlewicz G, et al. 2021. NAM-supported read-across: From case studies to regulatory guidance in safety assessment. ALTEX 38(1):140-150; doi: 10.14573/altex.2010062. PMID: 33452529.

Gao R, Guan N, Huang M, Foreman J, Kung M, Rong Z, Su Y, Sweet L, et al. 2020. Read-across: Principle, case study and its potential regulatory application in China. Regul Toxicol Pharmacol 116(Oct):104728; doi: 10.1016/j.yrtph.2020.104728. PMID: 32649957.

House JS, Grimm FA, Klaren WD, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, et al. 2020. Grouping of UVCB substances with new approach methodologies (NAMs) data. ALTEX 38(1):123–137; doi: 10.14573/altex.2006262. PMID: 33086383.

Rovida C, Barton-Maclaren T, Benfenati E, Caloni F, Chandrasekera PC, Chesne C, Cronin MTD,.., Patlewicz G, et al. 2020. Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology. ALTEX 37(4):579-606; doi: 10.14573/altex.1912181. PMID: 32369604.

Nelms MD, Pradeep P, Patlewicz G. 2019. Evaluating potential refinements to existing Threshold of Toxicological Concern (TTC) values for environmentally-relevant compounds. Regul Toxicol Pharmacol 109(Dec):104505; doi: 10.1016/j.yrtph.2019.104505. PMID: 31639428.

Helman G, Shah I, Patlewicz G. 2019. Transitioning the Generalized Read-Across approach (GenRA) to quantitative predictions: A case study using acute oral toxicity data. Comput Toxicol 12(Nov):1000097; doi: 10.1016/j.comtox.2019.100097. PMID: 33623834.

Webster F, Gagne M, Patlewicz G, Pradeep P, Trefiak N, Judson R, Barton-Maclaren TS. 2019. Predicting estrogen receptor activation by a group of substituted phenols: An integrated approach to testing and assessment case study. Regul Toxicol Pharmacol 106(Aug):278-291; doi: 10.1016/j.yrtph.2019.05.017. PMID: 31121201.

Patlewicz G, Lizarraga L, Rua D, Allen DG, Daniel A, Fitzpatrick SC, Garcia-Reyero N, Gordon J, et al. 2019. Exploring current read-across applications and needs among selected US federal agencies. Regul Toxicol Pharmacol 106(Aug):197-209; doi: 10.1016/j.yrtph.2019.05.011. PMID: 31078681.

Choksi NY, Truax J, Layton A, Matheson J, Mattie D, Varney T, et al. 2019. United States regulatory requirements for skin and eye irritation testing. Cutan Ocul Toxicol 38(2):141–155; doi: 10.1080/15569527.2018.1540494. PMID: 30418044.

Helman G, Shah I, Williams AJ, Edwards J, Dunne J, Patlewicz G. 2019. Generalized Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard. ALTEX 36(3):462-465; doi: 10.14573/altex.1811292. PMID: 30741315.

Swartz C, Howard AS, Choksi N, Rauer A, Allen DG, Recio L, Karmaus AL. An integrated approach for animal-free genotoxicity testing: In vitro and in silico evaluation and mode-of-action classification. Poster presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.

Helman G, Shah I, Patlewicz G. 2018. Extending the Generalized Read-Across approach (GenRA): A systematic analysis of the impact of physicochemical property information on read-across performance. Comput Toxicol 8(Nov):34-50; doi: 10.1016/j.comtox.2018.07.001. PMID: 31667446.

Patlewicz G, Wambaugh JF, Felter S, Simon TW, Becker RA. 2018. Utilizing Threshold of Toxicological Concern (TTC) with High Throughput Exposure Predictions (HTE) as a risk-based prioritization approach for thousands of chemicals. Comput Toxicol 7(Aug):58-67; doi: 10.1016/j.comtox.2018.07.002. PMID: 31338483.

Patlewicz G, Cronin MTD, Helman G, Lambert JC, Lizarraga LE, Shah I. 2018. Navigating through the minefield of read-across frameworks: A commentary perspective. Comput Toxicol 6(May):39-54; doi: 10.1016/j.comtox.2018.04.002.

Clippinger A, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G, et al. 2018. Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. Toxicol In Vitro 48(April):53-70; doi: 10.1016/j.tiv.2017.12.011. PMID: 29277654.

Choksi N, Daniel A, Lebrun S, Nguyen M, DeGeorge G, Willoughby JA, et al. Performance of the OptiSafe ocular irritation assay in a three-laboratory validation study. Poster presented at Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.

Rusyn I, Greene N. 2018. The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. Toxicol Sci 161(2):276-284; doi: 10.1093/toxsci/kfx196. PMID: 29378069.

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Williams RV, Amberg A, Brigo A, Coquin L, Giddings A, Glowienke S, Greene N, et al. 2016. It’s difficult, but important, to make negative predictions. Regul Toxicol Pharmacol 76(Apr):79-86; doi: 10.1016/j.yrtph.2016.01.008. PMID: 26785392.

Barber C, Cayley A, Hanser T, Harding A, Heghes C, Vessey JD, Werner S,…, Greene N. 2016. Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained. Regul Toxicol Pharmacol 76(Apr):7-20; doi: 10.1016/j.yrtph.2015.12.006. PMID: 26708083.