Publication Topic

Hanser T, Ahlberg E, Amberg A, Anger LT, Barber C, Brennan RJ, Brigo A,…, Greene N, et al. 2025. Data-driven federated learning in drug discovery with knowledge distillation. Nat Mach Intell 7(Mar):423–436; doi: 10.1038/s42256-025-00991-2.

Schaefer H. An introduction to evidence integration. Abstract 1333, Society of Toxicology 64th Annual Meeting, Orlando, FL, 2025

Bartlett C, Rigutto G. Use of NAMs to fill data gaps in support of populating a centralized repository of chemical hazard assessments for alternative assessments. Abstract 1161, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025.

Patlewicz G, Williams AJ, Adams M, Shah I, Paul-Friedman K. 2025. A cheminformatics workflow to select representative TSCA chemicals for New Approach Methodology (NAM) screening. Chem Res Toxicol 38(1):129-144; doi: 10.1021/acs.chemrestox.4c00367. PMID: 39655894.

Haber LT, Bradley MA, Buerger AN, Behrsing H, Burla S, Clapp PW, et al. 2024. New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: Workshop report. Front Toxicol 6:1431790; doi: 10.3389/ftox.2024.1431790. PMID: 39439531.

Wang Y, Le Y, Harris KL, Chen Y, Li X, Faske J, Wynne RA,…, Robison TW, et al. 2024. Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations. Mutat Res Genet Toxicol Environ Mutagen 897(Jul):503786; doi: 10.1016/j.mrgentox.2024.503786. PMID: 39054009.

Kenyon MO, Martin M, Martin EA, Brandstetter S, Wegesser T, Greene N, Harvey J. 2024. Deriving acceptable limits for non-mutagenic impurities in medicinal products–Durational adjustments. Regul Toxicol Pharmacol 150(June):105644; doi: 10.1016/j.yrtph.2024.105644. PMID: 38761968.

Madl AK, Donnell MT, Covell L. Synthetic vitreous fibers (SVFs): Adverse outcome pathways (AOPs) and considerations for new generation new approach methods (NAMs). Poster presentation P863/Abstract 4288, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.

Bartlett C, Heine L. Broadening the use of read-across to guide the selection of safer chemical ingredients. Toxicology and Risk Assessment Conference, Dayton, OH, April 2023.

Patlewicz G, Shah I. 2023. Towards systematic read-across using Generalized Read-Across (GenRA). Comput Toxicol 25(Feb):100258; doi: 10.1016/j.comtox.2022.100258. PMID: 37693774.

Adams M, Hilde H, Chang D, Richard A, Williams AJ, Shah I, Patlewicz G. 2023. Development of a CSRML version of the Analog Identification Methodology (AIM) fragments and their evaluation within the Generalized Read-Across (GenRA) approach. Comput Toxicol 25(Feb):100256; doi: 10.1016/j.comtox.2022.100256. PMID: 36733411.

Lizarraga L, Suter GW, Lambert JC, Patlewicz G, Zhao JQ, Dean JL, Kaiser P. 2023. Advancing the science of a read-across framework for evaluation of data poor chemicals incorporating systematic and new approach methods. Regul Toxicol Pharm 137(Jan):105293; doi: 10.1016/j.yrtph.2022.105293. PMID: 36414101.

Cronin MTD, Bauer FJ, Bonnell M, Campos B, Ebbrell DJ, Firman JW, Gutsell S, Hodges G, Patlewicz G, et al. 2022. A scheme to evaluate structural alerts to predict toxicity–Assessing confidence by characterizing uncertainties. Regul Toxicol Pharmacol 135(Nov):105249; doi: 10.1016/j.yrtph.2022.105249. PMID: 36041585.

Patlewicz G, Richard AM, Williams AJ, Judson RS, Thomas RS. 2022. Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing. Comput Toxicol 24(Nov):100250; doi: 10.1016/j.comtox.2022.100250. PMID: 36969381.

Foster MJ, Patlewicz G, Shah I, Haggard DE, Judson RS, Paul Friedman K. 2022. Evaluating structure-based activity in a high throughput assay for steroid biosynthesis. Comput Toxicol 24(Nov):100245; doi: 10.1016/j.comtox.2022.100245. PMID: 37841081.

Ponder J, Rajagopal R, Singal M, Baker N, Patlewicz G, Roggen E, Cochrane S, Sullivan K. 2022. “In Litero” screening. Retrospective evaluation of clinical evidence to establish a reference list of human chemical respiratory sensitizers. Front Toxicol 4(Jul 15):916370; doi: 10.3389/ftox.2022.916370. PMID: 35910543.

Karmaus A, Mansouri K, To K, Blake B, Fitzpatrick J, Strickland J, Patlewicz G, Allen D, et al. 2022. Evaluation of variability across rat acute oral systemic toxicity studies. Toxicol Sci 188(1):34-47; doi: 10.1093/toxsci/kfac042. PMID: 35426934.

Patlewicz G. 2022. Editorial: Reflections of the QSAR2021 meeting. Comput Toxicol 22(May):100221; doi: 10.1016/j.comtox.2022.100221. PMID: 35252631.

Rooney J, Abedini J, Bell S, Chang X, Cook B, Ceger P, Choksi N, et al. Building confidence in alternative methods through ICE. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.

Allen DG, Rooney J, To K, Choksi N, Ceger P, Daniel A, et al. Variability in reference test method data and the impact on NAM evaluations. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.