Publication Topic

Covington TR, Gearhart JM, Jakubowski EM, McGuire JM, Evans RA, Hulet SW. Physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling of VX exposure through various routes to multiple species. Poster presented at the Chemical and Biological Defense Physical Science and Technology Conference, New Orleans, LA, November 2008.

Jolliet O, Jiang X, Wenger Y, Milbrath MO, Chang C-W, Chen Q, Hong B, Hedgeman E, et al. 2008. Model formats and use of pharmacokinetic modeling for the statistical analysis of blood dioxin concentrations. Organohalogen Compounds 70:102–105.

Thompson CM, Sonawane B, Barton HA, DeWoskin RS, Schlosser P, Lipscomb JC, Chiu W, Krishnan K. 2008. Approaches for applications of physiologically based pharmacokinetic models in risk assessment. J Toxicol Environ Health B 11(7):519–547; doi: 10.1080/10937400701724337. PMID: 18584453.

Jolliet O, Wenger Y, Adriaens P, Chang C-W, Chen Q,…, Jiang X, Knutson K,…, Reichert H, et al. Explaining age dependency using pharmacokinetic modeling in the analysis of blood TCDD concentrations. Dioxin 2008 Conference, Birmingham, England, August 1, 2008.

Teeguarden JG, Gearhart J, Clewell HJ III, Covington TR, Nong A, Andersen ME. 2007. Pharmacokinetic modeling of manganese. III. Physiological approaches accounting for background and tracer kinetics. J Toxicol Environ Health A 70(18):1515–1526; doi: 10.1080/15287390701384635.

Teeguarden JG, Dorman DC, Nong A, Covington TR, Clewell HJ III, Andersen ME. 2007. Pharmacokinetic modeling of manganese. II. Hepatic processing after ingestion and inhalation. J Toxicol Environ Health A 70(18):1505–1514; doi: 10.1080/15287390701384619.

Teeguarden JG, Dorman DC, Covington TR, Clewell HJ III, Andersen ME. 2007. Pharmacokinetic modeling of manganese. I. Dose dependencies of uptake and elimination. J Toxicol Environ Health A 70(18):1493–1504; doi: 10.1080/15287390701384601.

Hack CE, Covington TR, Lawrence G, Shipp AM, Gentry R, Yager J, Clewell, HJ, III. 2007. A pharmacokinetic model of the intracellular dosimetry of inhaled nickel. J Toxicol Environ Health A 70(5):445–464; doi: 10.1080/15287390600870726.

Emond C, Raymer J, Garner E, Diliberto J, Staskal D, Birnbaum LS. A physiologically-based pharmacokinetic model for developmental exposure to PBDE-47 in rodents. Society of Toxicology 46th Annual Meeting, Charlotte, NC, March 2007.

Rose WC, Marathe PH, Jang G, Monticello TM, Balasubramanian BN, Long B, Fairchild C, Wall ME, Wani MC. 2006. Novel fluoro-substituted campthothecins: In vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization. Cancer Chemother Pharmacol 58(1):73-85; doi: 10.1007/s00280-005-0128-y.

Teeguarden JG, Waechter JM Jr, Clewell HJ 3rd, Covington TR, Barton HA. 2005. Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding and uterine tissue dose metrics of bisphenol A: A physiologically based pharmacokinetic approach. Toxicol Sci 85(2):429–446; doi: 10.1093/toxsci/kfi135.

Gentry PR, Haber LT, McDonald TB, Zhao Q, Covington T, Nance P, Clewell HJ III, Lipscomb JC, Barton HA. 2005. Data for physiologically based pharmacokinetic modeling in neonatal animals: Physiological parameters in mice and Sprague-Dawley rats. J Children’s Health 2(3–4):363–411; doi: 10.3109/15417060490970430.

Teeguarden JG, Waechter JM, Clewell HJ, Covington TR, Barton HA. Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding and uterine tissue dose metrics of bisphenol A: A physiologically based pharmacokinetic approach. Poster presented at Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.

Kester JE, Gentry P, Covington TR, Clewell HJ. Issues in the use of PBPK modeling in the development of cancer slope factors for perchloroethylene. Poster presented at the Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.

Gentry PR, Covington TR, Mann S, Shipp AM, Yager JW, Clewell HJ III. 2004. Physiologically based pharmacokinetic modeling of arsenic in the mouse. J Toxicol Environ Health A 67(1):43–71; doi: 10.1080/15287390490253660.

Clewell HJ, Gentry PR, Covington TR, Sarangapani R, Teeguarden JG. 2004. Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Toxicol Sci 79(2):381–93; doi: 10.1093/toxsci/kfh109.

Gentry RP, Covington TR, Clewell HJ III. 2003. Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation. Regul Toxicol Pharmacol 38(1):1–16; doi: 10.1016/S0273-2300(03)00047-3.

Gentry PR, Covington TR, Clewell HJ, Andersen ME. 2003. Application of a physiologically based pharmacokinetic model for reference dose and reference concentration estimation for acetone. J Toxicol Environ Health A 66(23):2209–2225; doi: 10.1080/713853996.

Clewell H, Crump K, Covington T, Gentry R, Yeager J. A risk assessment for inhaled arsenic based on urinary arsenic concentration using a pharmacokinetic model. Poster presented at the Society of Toxicology Annual Meeting, Salt Lake City, UT, March 2003.

Clewell HJ, Teeguarden J, McDonald T, Sarangapani R, Lawrence G, Covington T, Gentry R, Shipp A. 2002. Review and evaluation of the potential impact of age and gender-specific pharmacokinetic differences on tissue dosimetry. Crit Rev Toxicol 32(5):329–389; doi: 10.1080/20024091064264.