2016 (68 POSTS)
Gökbuget N, Kelsh M , Chia V, Advani A, Bassan R, Dombret H, et al. 2016. Blinatumomab vs historical standard therapy of adult relapsed/refractory acute lymphoblastic leukemia. Blood Cancer J 6(9):e473.
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Topics: Cancer
Mackay CE, Vivanco SN , Yeboah G, Vercellone J. 2016. Assessment of dermal hazard from acid burns with fire retardant garments in a full-size simulation of an engulfment flash fire. Burns 42(6):1350–1356; doi: 10.1016/j.burns.2016.04.012 .
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Topics: flame retardants
Richard A, Judson R, Houck K, Grulke C, Volarath P, Thillainadarajah I, Yang C,…, Patlewicz G , et al. 2016. The ToxCast chemical landscape: Paving the road to 21st century toxicology. Chem Res Toxicol 29(8):1225-1251; doi: 10.1021/acs.chemrestox.6b00135 . PMID: 27367298.
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Topics: computational toxicology
Shah I, Liu J, Judson RS, Thomas R, Patlewicz G . 2016. Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information. Reg Toxicol Pharmacol 79(Aug):12-24; doi: 10.1016/j.yrtph.2016.05.008 . PMID: 27174420.
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Topics: read-across
Thompson CM , Suh M , Mittal L , Wikoff D , Welsh B, Proctor DM . 2016. Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations. Regul Toxicol Pharmacol 80(Oct):60-70; doi: 10.1016/j.yrtph.2016.05.031 .
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Topics: Air Quality , Systematic Review , titanium dioxide
Samuel GO, Hoffmann S, Wright R, Lalu MM, Patlewicz G , Becker RA, DeGeorge GL, Fergusson D, et al. 2016. Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review. Environ Int 92-93(July-Aug):630-646; doi: 10.1016/j.envint.2016.03.010 . PMID: 27039952.
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Topics: scoping review
Jensen I , Zacherle E, Blanchette C, Zhang J, Yin W. 2016. Evaluating cost benefits of combination therapies for advanced melanoma. Drugs Context 5:212297; doi: 10.7573/dic.212297 .
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Topics: Health Economics and Outcomes Research (HEOR)
Wang BW, Klaren WD , Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status and MnSOD in the rat. Toxicol Sci 150(1):15–26; doi: 10.1093/toxsci/kfv312 . PMID: 26660635.
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Topics: Manganese , PCBs
Klaren WD , Flor SS, Gibson-Corley KN, Ludewig G, Robertson LW. 2016. Metallothionein’s role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption. Toxicol Rep 3:21–28. PMID: 26770886.
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Topics: Toxicology
Klaren WD , Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851–859; 10.1021/acs.chemrestox.6b00022 . PMID: 26967026.
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Topics: food safety , Food science
Wang A, Richhariya A, Gandra SR, Calimlim B, Quek RGW, Nordyke RJ , Toth P. 2016. Systematic review of LDL-C apheresis for the treatment of familial hypercholesterolemia. J Am Heart Assoc 5(7):e003294; doi: 10.1161/JAHA.116.003294 . PMID: 27385428.
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Topics: Epidemiology
Maskrey JR, Insley A, Hynds ES, Panko JM . 2016. Air monitoring of volatile organic compounds at relevant receptors during hydraulic fracturing operations in Washington County, Pennsylvania. Environ Monit Assess 188(7):410; doi: 10.1007/s10661-016-5410-4 . PMID: 27312253.
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Topics: Air Quality , community health , fracking , VOCs
Jensen IS , Wu C, Fan W, Lodise T, Nicolau, DP, DuFour S, Cyr PL , et al. 2016. Use of oritivancin in moderate-severe ABSSSI patients requiring IV antibiotics: US hospital budget impact analysis. J Manag Care Spec Pharm 22(6):752-64; doi: 10.18553/jmcp.2016.22.6.752 .
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Topics: Epidemiology , Health Economics and Outcomes Research (HEOR)
Jensen IS , Lodise TP, Fan W, Wu C, Cyr PL , Nicolau DP, DuFour S, et al. 2016. Use of oritavancin in acute bacterial skin and skin structure infection patients receiving intravenous antibiotics: A US hospital budget impact analysis. Clin Drug Investig. 2016 36(2):157-68; doi: 10.1007/s40261-015-0365-8 .
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Topics: Epidemiology , Health Economics and Outcomes Research (HEOR)
Edmondson SD, Zhu C, Kar NF, Di Salvo J, Nagabukuro H, Sacre-Salem B, Dingley K , et al. 2016. Discovery of vibegron: A potent and selective beta 3 adrenergic receptor agonist for the treatment of overactive bladder. J Med Chem 59(2):609–623; doi: 10.1021/acs.jmedchem.5b01372 . PMID: 26709102.
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Topics: Toxicology
Zhu C, Kar NF, Li B, Costa M, Dingley KH , Di Salvo J, et al. 2016. Discovery of benzamides as potent human β3 adrenergic receptor agonists. Bioorg Med Chem Lett 26(1):55–59; doi: 10.1016/j.bmcl.2015.11.030 . PMID: 26590100.
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Topics: Toxicology
Wilson JE, Kurukulasuriya R, Sinz C, Matthew Lombardo, Kate Bender, Dann Parker, … Dingley K , et al. 2016. Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes. Bioorg Med Chem Lett 26(12):2947–2951; doi: 10.1016/j.bmcl.2016.04.018 . PMID: 27240550.
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Topics: diabetes , pharmacokinetics
Guo L, Parker DL, Zang Y, Sweis RF, Liu W, Sherer EC, … Dingley KH , et al. 2016. Discovery and optimization of a novel triazole series of GPR142 agonists for the treatment of type 2 diabetes. ACS Med Chem Lett 7 (12):1107–1111; doi: 10.1021/acsmedchemlett.6b00314 . PMID: 27994747.
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Topics: diabetes
Pierce JS, Ruestow PS, Finley BL . 2016. An updated evaluation of reported no-observed adverse effect levels for chrysotile asbestos for lung cancer and mesothelioma. Crit Rev Toxicol 46(7):561-586; doi: 10.3109/10408444.2016.1150960 .
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Topics: asbestos , Cancer
Cowan DM, Maskrey JR, Fung ES, Woods TA, Stabryla LM, Scott PK, Finley BL . 2016. Best-practices approach to determination of blood alcohol concentration (BAC) at specific time points: Combination of ante-mortem alcohol pharmacokinetic modeling and post-mortem alcohol generation and transport considerations. Regul Toxicol Pharmacol 78:24–36.
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