2019

Fung ES, Novick RM, Drechsel DA, Towle KM, Novick RM, Paustenbach DJ, Monnot AD. 2019. Tier-based skin irritation testing of hair cleansing conditioners and their constituents. Cutan Ocul Toxicol 38(1):44-47, DOI: 10.1080/15569527.2018.1512610.

View Abstract

Adams R, Brickel J, Bhat VS. 2019. Chemical-specific maximum allowable levels for pesticide residues in dietary supplements. Food Chem Toxicol 123:511-519.

View Abstract

Gollapudi P, Bhat VS, Eastmond D. 2019. Concentration-response studies of the chromosome-damaging effects of topoisomerase II inhibitors determined in vitro using human TK6 cells. Mut Res Gen Toxicol Environ Mutagen 841:49-56.

View Abstract

Czerkies LM, Finn KL, Kineman BD, Reichert HA, Cohen SS, Carvalho RS. 2019. Use of a partially hydrolyzed 100% whey-based infant formula with Lacrobacillus reuteri in infants with caregiver-perceived intolerance. J Pedat Health Nutr, Open Access.

View Abstract

Monnot AD, Towle KM, Fung ES, Novick RM, Paustenbach DJ, Drechsel DA. 2019. A skin sensitization induction risk assessment of common ingredients present in commercially available cleansing conditioners. Dermatitis 30(2):116–128.

View Abstract

Marschke S, Rish W, Mauro J. 2019. Radiation exposures from the beneficial use of alumina production residue. J AWWA online.

View Abstract

Benson SM, Maskrey JR, Nembhard MD, Unice KM, Shirley MA, Panko JM. 2019. Evaluation of personal exposure to surgical smoke generated from electrocautery instruments: A pilot study. Ann Work Expos Health wxz070; open access.

View Abstract

Krelder ML, Unice KM, Panko JM. 2019. Human health risk assessment of tire and road wear particles (TRWP) in air. Hum Ecol Risk Assess, open access.

View Abstract

Chappell GA, Borghoff SJ, Pham L, Doepker CL, Wikoff DS. 2019. Lack of potential carcinogenicity for sucralose — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol (in press).

View Abstract

Wikoff DS, Chappell GA, Fitch S, Doepker CL, Borghoff SJ. 2019. Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol (in press).

View Abstract

Bylsma LC, Ording AG, Rosenthal A, Öztürk B, Fryzek JP, Arias JM, Röth A, Berentsen S. 2019. Occurrence, thromboembolic risk, and mortality in Danish patients with cold agglutinin disease. Blood Advances 3(20):2980–2985.

View Abstract

Thompson C, Chappell G, Cullen J, Wolf JC, Haws L. Development of an oral reference dose for GenX using the latest toxicological and risk assessment methodologies: Environmental risk assessment of per- and polyfluoroalkyl substances (PFAS). SETAC North America Focused Topic Meeting, Durham, NC, August 2019.

Chappell GA, Thompson CM, Wolf J, Cullen J, Haws LC. Transcriptomic responses in livers of GenX-treated mice demonstrate up-regulation of PPAR signaling and related pathways. Environmental Mutagenesis and Genomics Society, Washington, DC, September 2019.

Thompson CM. The useful chemistry of perfluorinated compounds: Managing safety. The sticky subject of non-stick: Regulatory science challenges of per- and poly-fluorinated compounds (PFAS). Texas A&M University Interdisciplinary Faculty of Toxicology Training Program, 2019 Annual Regulatory Science Symposium. August 20, 2019.

Andersen ME, Gentry PR, Swenberg JA, Mundt KA, White KW, Thompson C, Bus J, Sherman JH, Greim H, Bolt H, Marsh GM, Checkoway H, Coggon D, Clewell HJ. 2019. Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop. Regul Toxicol Pharmacol 106:210–223.

View Abstract

Clewell RA, Thompson CM, Clewell HJ. 2019. Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment. Chem Biol Interact 301:112–127.

View Abstract

Chappell G, Rager J, Wolf J, Babic M, Leblanc, Ring C, Harris MA, Thompson CM. 2019. Comparison of gene expression responses in the small intestine of mice following exposure to three carcinogens using the S1500+ gene set informs a potential common adverse outcome pathway. Toxicol Pathol 47(7):851-864.

View Abstract

van de Ligt J, Borghoff SJ, Yoon M, Ferguson LJ, DeMaio W, McClanahan RH. 2019. Nondetectable or minimal detectable residue levels of N-(n-butyl) thiophosphoric triamide in bovine tissues and milk from a 28-d NBPT dosing study. Translat An Sci 3(4).

View Abstract

Cekola P, Henrikson A, Reichert H, Cohen S, Huhmann M, Torres KA. Clinical use and safety of an amino acid-based infant formula in a real world setting. Poster at NASPGHAN, Chicago, IL, October 2019.

Cohen SS, Roger VL, Weston SA, Jiang R, Movva N, Yusuf A, Chamberlain AM. Development of computable phenotypes to identify heart failure patients with preserved ejection fraction. Poster at International Society for Pharmacoepidemiology, Philadelphia, PA, August 2019.

Boice JD Jr, Cohen SS, Mumma MT, Ellis ED. 2019. The Million Person Study, whence it came and why. Int J Radiat Biol 4:1–14, doi: 1080/09553002.2019.1589015.

View Abstract

Chamberlain AM, Cohen SS, Killian JM, Monda KL, Weston SA, Okerson T. 2019. Lipid-lowering prescription patterns in patients with diabetes mellitus or cardiovascular disease. Am J Cardio 124(7):995–1001.

View Abstract

Bylsma LC, Dean R, Lowe K, Sangaré L, Alexander DD, Fryzek JP. 2019. The incidence of infusion reactions associated with monoclonal antibody drugs targeting the epidermal growth factor receptor in metastatic colorectal cancer patients: A systematic literature review and meta‐analysis of patient and study characteristics. Cancer Med 8(12):5800–5809.

View Abstract

Mease K. Managing immunogenicity in the absence of an ADA assay is no monkey business (case study). Presentation at 25th annual Charles River Biotech Symposium, Carlsbad, CA, September 8–11, 2019.

View Abstract

Lansita J, Weis S. A peek into the black box—Insight from former FDA reviewers on the BLA review process. Presentation at 25th annual Charles River Biotech Symposium, Carlsbad, CA, September 8–11, 2019.

View Abstract

Nordyke RJ, Reichert H, Bylsma LC, Jackson JJ, Gage SM, Fryzek J, Roy-Chaudhury P, Lithgow T. 2019. Costs attributable to arteriovenous fistula and arteriovenous graft placements in hemodialysis patients with Medicare coverage. Am J Nephrol [Online first, abstract only]: doi: 10.1159/000502507.

View Abstract

Thompson CM, Fitch SE, Ring C, Rish W, Cullen JM, Haws LC. 2019. Development of an oral reference dose for the perfluorinated compound GenX. J Appl Toxicol 39:1267–1282.

View Abstract

Yoon M, Ring C, Van Landingham CB, Suh M, Song G, Antonijevic T, Gentry PR, Taylor MD, Keen AM, Andersen ME, Clewell JH. 2019. Assessing children’s exposure to manganese in drinking water using a PBPK model. Toxicol Appl Pharmacol 380:114695

View Abstract

Fitch S, Goyak K, Green Maia, Grimm F, Wikoff D. 2019. Estrogen-mediated outcomes for alkylphenols via an adverse outcome pathway (AOP) construct. Open Science Framework, August.

View Abstract

Pham LL, Watford S, Friedman KP, Fostel J, Wignall J, Shapiro A. 2019 (in press). Python BMDS: A Python interface library and web application for the canonical EPA dose-response modeling software. Reprod Toxicol (journal pre-proof).

View Abstract

Watford S, Pham LL, Brown J, Wignall J, Shin R, Martin M, Friedman KP. 2019. ToxRefDB 2.0: Improved utility for predictive and retrospective toxicology analyses. Reprod Toxicol 89:145–158. doi: 10.1016/j.reprotox.2019.07.012.

View Abstract

Pham LL, Truong L, Ouedraogo G, Loisel-Joubert S, Martin MT, Friedman KP. 2019. Profiling 58 compounds including cosmetic-relevant chemicals using ToxRefDB and ToxCast. Food Chem Toxicol 132:110718. doi: 10.1016/j.fct.2019.110718.

View Abstract

Fergie J, Gonzales T, Jiang X, Fryzek J, Rizzo CP. Respiratory syncitial virus hospitalizations (RSVH) and all-cause bronchiolitis hospitalizations (BH) among 29-34 weeks gestational age (wGA) preterm infants before and after the 2014 American Academy of Pediatrics (AAP) immunoprophylaxis policy change using the Children’s Hospital Association’s Pediatric Health Information System (PHIS). Poster presentation at IDWeek, Washington, DC, October 2–6, 2019.

View Abstract

Röth A,  Fryzek J, Jiang X, Reichert H, Morales J, Broome CM. Seasonal patterns of thromboembolic events in cold agglutinin disease (CAD) in the United States. Presentation at 81st Annual Meeting of the Japanese Society of Hematology, Tokyo, Japan, October 11–13, 2019.

View Abstract

Röth A, Fryzek J, Jiang X, Reichert H, Morales J, Broome CM. Seasonal patterns of anemia, hemolytic markers, healthcare resource utilization, and thromboembolic events in cold agglutinin disease. Presentation at German Society for Hematology and Medical Oncology, Berlin, Germany, October 11–14, 2019.

View Abstract

Proctor D. Use of the latest science in cancer risk assessment for hexavalent chromium: Is it time to step away from the default regulatory approaches? Invited presentation to the International Union of Toxicology (IUTOX) / International Congress of Toxicology (ICT) meeting, Honolulu, HI, June 17, 2019.

Ring CL, Arnot JA, Bennett DH, Egeghy PP, Fantke P, Huang L, Isaacs KK, Jolliet O, Phillips KA, Price PS, Shin H-M, Westgate JN, Setzer RW, Wambaugh JF. 2019. Consensus modeling of median chemical intake for the U.S. population based on predictions of exposure pathways. Environ Sci Technol 53:719–732.

View Abstract

Insley AL,.Maskrey JR, Hallett LA, Reid RCD, Hynds ES, Winter C, Panko JM. Occupational survey of airborne metal exposures to welders, metalworkers, and bystanders in small fabrication shops. Poster at American Industrial Hygiene Conference and Exhibition, Minneapolis, MN, May 20–24, 2019.

Hopkins B, Cohen SS, Irvin SR, Alberda C. 2019. Achieving protein targets in the ICU using a specialized high-protein enteral formula: A quality improvement project. Nutr Clin Practice, DOI: 10.1002/ncp.10364 – Hopkins_Cohen_NCP_2019.

View Abstract

Unice KM, Weeber MP, Abramson MM, Reid RCD, van Gils JAG, Markus AA, Vethaak AD, Panko JM. 2019. Characterizing export of land-based microplastics to the estuary – Part II: Sensitivity analysis of an integrated geospatial microplastic transport modeling assessment of tire and road wear particles. Sci Tot Environ 646:1650–1659.

View Abstract

Unice KM, Weeber MP, Abramson MM, Reid RCD, van Gils JAG, Markus AA, Vethaak AD, Panko JM. 2019. Characterizing export of land-based microplastics to the estuary — Part I: Application of integrated geospatial microplastic transport models to assess tire and road wear particles in the Seine watershed. Sci Tot Environ 646:1639–1649.

View Abstract

Panko JM, Hitchcock KM, Fuller GW, Green D. 2019. Evaluation of tire wear contribution to PM2.5 in urban environments. Atmosphere 10(2):99, https://doi.org/10.3390/atmos10020099.

View Abstract

Insley AL, Maskrey JR, Hallett LA, Reid RCD, Hynds ES, Winter C, Panko JM. 2019. Occupational survey of airborne metal exposures to welders, metalworkers, and bystanders in small fabrication shops. J Occup Environ Hyg 16:6:410–421, DOI: 10.1080/15459624.2019.1603389.

View Abstract

Wikoff D, Haws L, Ring C, Budinsky R. 2019. Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. J Appl Toxicol, doi: 10.1002/jat.3814, open access.

View Abstract

Wikoff D, Erranguntla N, Lewis J, Foreman J. A fit-for-purpose framework for use of systematic methods in risk assessment. Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.

Urban J, Wikoff D, Haws L. Three-tiered approach to integrating evidence streams assessing gestational trichloroethylene exposure and congenital heart defects (TCE-CHD). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine. Washington, DC, June 2019.

Borghoff S, Fitch S, Britt J, Franke K, Wikoff D. Application of the EFSA/ECHA endocrine disruption guidance as a framework for evidence integration in a weight-of-evidence (WoE) analysis for oxybenzone (BP-3). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions. National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.

Kreider ML, Hynds ES, Panko JM. Evaluation of tire and road wear particles (TRWP) in air in Delhi, India. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 10–14, 2019.

View Abstract

Honda GS, Pearce RG, Pham LL, Setzer RW, Wetmore BA, Sipes NS, Gilbert J, Franz B, Thomas RS, Wambaugh JF. 2019. Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions. PLoS ONE 14(5):e0217564.

View Abstract

Pham LL, Sheffield T, Pradeep P, Brown J, Haggard D, Wambaugh J, Judson R, Friedman KP. 2019. Estimating uncertainty in the context of new approach methodologies for potential use in chemical safety evaluation. Curr Opin Toxicol 15:40-47.

View Abstract

Chamberlain AM, Cohen SS, Weston SA, Fox KM, Xiang P Killian JM Qian Y. 2019. Relation of cardiovascular events and deaths to low-density lipoprotein cholesterol level among statin-treated patients with atherosclerotic cardiovascular disease. Am J Cardiol 123(11):1739-1744.

View Abstract

Storm HM, Shepard J, Czerkies LM, Kineman B, Cohen SS, Reichert H, Carvalho R. 2019. 2’-Fucosyllactose is well tolerated in a 100% whey, partially hydrolyzed infant formula with Bifidobacterium lactis: A randomized controlled trial. Global Pediat Health 6:1–10. DOI: 10.1177/2333794X19833995.

View Abstract

Klosterbuer A, Neutel JM, Cohen SS, Periman S. Plasma glucose and insulin response to high protein oral nutritional supplements in adults with type 2 diabetes mellitus. Poster at ASPEN 2019 Nutrition Science & Practice Conference, March 2019, Phoenix, AZ.

View Abstract

Wikoff D. Rigor and resources for systematic reviews in toxicology: Case study applications in food safety, consumer product safety, and environmental health risk assessment. Presented at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Gentry R, Greene T, Granzen A, Thompson CM. Formaldehyde and leukemia: A case study using the IPCS MOA and human relevance frameworks. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Urban J, Wikoff D, Suh M, Britt J, Harvey S, Chappell G, Haws L. Comparison of NTP OHAT and US EPA TSCA study quality criteria: Trichloroethylene (TCE) and congenital heart defects (CHDs) as a case study. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

McIntyre B, Zorilla L, Borghoff, S, Foster P. Assessment of avobenzone, ensulizole, homosalate, and padimate-O in endocrine disruptor screening panel studies. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Thompson CM, Gentry R. An updated mode-of-action analysis for formaldehyde-induced nasal tumors in rodents: A case study using the IPCS MOA and human relevance frameworks. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Borghoff SJ, Fitch S, Huggett, Wikoff D. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine disrupting properties of perfluorohexanoic acid (PFHxA). 2019. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Saili KS, Zurlinden TH, Antonijevic T, Shah I, Deisenroth C, Knudsen TB. Endodermal differentiation trajectories diverge with increasing all-trans retinoic acid (ATRA) exposure. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Yoon M, Ring C, Van Landingham CV, Gentry PR, Taylor MD, Keene AM, Clewell HJ. Assessing early life drinking water exposures to manganese (Mn). Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Chappell GA, Rager JE, Wolf JC, Babic M, LeBlanc KJ, Ring CL, Harris MA, Thompson C. Similarities in the transcriptomic signatures in the duodenum of mice exposed to hexavalent chromium, captan, or folpet inform the mechanisms of chemical-induced mouse small intestine cancer. Presentation at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Ring CL, Urban J, Wikoff D, Thompson C, Budinsky RA, Haws LC. Application of systematic review and quantitative evidence integration methods to support risk assessment: Characterization of the dose-response relationship between exposure to dioxin-like compounds (DLC) and sperm count. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Henderson RG, Doepker C, Lopez JG. Safety evaluation of L-theanine administered via hard chew to dogs. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.

View Abstract

Suh M, Wikoff D, Lipworth L, Goodman M, Fitch S, Mittal L, Ring C, Proctor D. 2019. Hexavalent chromium and stomach cancer: A systematic review and meta-analysis. Crit Rev Toxicol [ePub ahead of print]: doi: 10.1080/10408444.2019.1578730.

View Abstract

Fitch S, van de Ligt J, Payne L, Doepker C, Kleinman R, Handu D, Cohen SM, Anyangwe N, Wikoff D. 2019. Systematic map protocol: A systematic map of the use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS). Open Science Framework.

View Abstract

Rager JE, Suh M, Chappell G, Thompson CM, Proctor DM. 2019. Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis. Toxicol Lett 305:40-50.

View Abstract

Wikoff DS, Rager JE, Chappell GA, Fitch S, Haws L, Borghoff SJ. 2019. A framework for systematic evaluation and quantitative integration of mechanistic data in assessments of potential human carcinogens. Toxicol Sci 167(2):322-335.

View Abstract

Suh M, Casteel S, Dunsmore M, Ring C, Verwiel A, Proctor DM. 2019. Bioaccessibility and relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations. Sci Tot Environ 660:677–689.

View Abstract

2018

Wikoff D. Problem formulation: Lessons and tools from practical applications involving systematic review of mechanistic data. Presented at Strategies and Tools for Conducting Systematic Reviews of Mechanistic Data to Support Chemical Assessments, National Academies of Sciences, Engineering, and Medicine. Washington, D.C., December 2018.

Urban J, Wikoff D, Haws L, Fitch S, Ring C, Thompson C, Suh M. 2018. Systematic review protocol: Systematic review and meta-regression to characterize the dose-response relationship between exposure to dioxin-like compounds during sensitive windows of development and reduced sperm count. Zenodo. http://doi.org/10.5281/zenodo.1636357.

View Abstract

Kimzey AL, Piche M-S, Wood M, Weir AB, Lansita J. 2018. 11.19 – Immunophenotyping in drug development. In: Comprehensive Toxicology, 3rd Ed. Vol 11:399–427.

View Abstract

Brorby G, Ring C, Loko F, Harris MA. Characterization of hexavalent chromium and total chromium in drinking water monitoring data. Poster MP 117. Society of Environmental Toxicology and Chemistry (SETAC) North America 39th Annual Meeting, Sacramento, CA, November 4–8, 2018.

View Abstract

Tsaioun K, Dirven H, Beck Færden K, Wikoff D, Ram R, Kleinstreuer N, McCormack A, Wright R, Vist GE, Fitch S. 2018. Systematic reviews of the hepatotoxic effects of specified compounds/drugs as observed in humans and experimental animals (rats, mice, dogs and non-human primates). PROSPERO CRD42018112353.

View Abstract

Hughes B, Cox K, Bhat VS. 2018. Derivation of an oral reference dose (RfD) for di-2-ethylhexyl cyclohexan-1,4-dicarboxylate (DEHCH), an alternative to phthalate plasticizers. Regul Toxicol Pharmacol 92:128-137.

View Abstract

Drechsel DA, Barlow CA, Bare JL, Jacobs NF, Henshaw JL. 2018. Historical evolution of regulatory standards for occupational and consumer exposures to industrial talc. Regul Toxicol Pharm 91:251–267.

View Abstract

Towle KM, Drechsel DA, Fung E, Novick RM, Paustenbach DJ, Monnot AD. 2018. A quantitative risk assessment of the skin sensitization induction potential of the Kathon CG preservative in rinse-off and leave-on personal care and cosmetic products. Dermatitis 29(3):132–138.

View Abstract

Drechsel DA, Towle KM, Fung E, Novick RM., Paustenbach DJ, Monnot AD. 2018. Chemical stability analysis of hair cleansing conditioners under high-heat conditions experienced during hair styling processes. Cosmetics 5(1):23.

View Abstract

Fung ES, Drechsel DA, Towle KM, Hoang MT, Novick RM, Poteete C, Paustenbach DJ, Monnot AD. 2018. Screening-level safety assessment of personal care product constituents using publicly available data. Cosmetics 5(2):38.

View Abstract

Drechsel DA, Towle KM, Fung E, Novick RM., Paustenbach DJ, Monnot AD. 2018. Evaluation of skin sensitization induction potential from daily exposure to fragrances in personal care products. Dermatitis 29(6):324–331.

View Abstract

Suh M, Wikoff D, Harvey S, Mittal L, Lipworth L, Goodman M, Goodmanson A, Ring C, Rohr A, Proctor D. Hexavalent chromium and stomach cancer: A systematic review and meta-analysis. Presented at Joint Annual Meeting of International Society of Exposure Science and International Society for Environmental Epidemiology (ISES-ISEE 2018), Ottawa, Canada, August 2018.

View Abstract

Borghoff SJ, Fitch S, Rager JE, Huggett D. 2018. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid. Regul Toxicol Pharmacol 99:168–181.

View Abstract

Ring CL, Suh M, Casteel S, Dunsmore M, Verwiel A, Proctor D. Relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations. Presented at Joint Annual Meeting of International Society of Exposure Science and International Society for Environmental Epidemiology (ISES-ISEE 2018), Ottawa, Canada, August 2018.

View Abstract

Harrill AH, Borghoff S, Zorrilla L, Blystone C, Kissling GE, Malarkey D, Shockley K, Travlos G, DeVito MJ. 2018. NTP Research Report on baseline characteristics of Diversity Outbred (J:DO) mice relevant to toxicology studies. National Toxicology Program Research Report 6, Research Triangle Park, NC.

View Abstract

Klaren WD, Ring C, Harris MA, Thompson CM, Borghoff S, Sipes NS, Hsieh J-H, Auerbach SS, Rager JE. 2018. Identifying attributes that influence in vitro-to-in vivo concordance by comparing in vitro Tox21 bioactivity versus in vivo DrugMatrix transcriptomic responses across 130 chemicals. Toxicol Sci kfy220, available at https://doi.org/10.1093/toxsci/kfy220.

View Abstract

Wikoff DS, Thompson C, Rager J, Chappell G, Fitch S, Doepker C. 2018. Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates. Food Chem Toxicol 120:709-723.

View Abstract

Moffat I, Martinova N, Seidel C, Thompson CM. 2018. Hexavalent chromium in drinking water. Journal AWWA 110:5.

View Abstract

Benson SM, Maskrey JR, Nembhard M, Panko JM. Characterization of surgical smoke generated from electrocautery instruments: A pilot study. Poster at the 2018 American Occupational Health Conference (AOHC) 103rd Annual Meeting, New Orleans, LA, April 29 – May 2, 2018.

Panko J, Kreider M, Unice K. 2018. Review of tire wear emissions. Chapter 7 in: Amato (ed)., Non-Exhaust Emissions — An Urban Air Quality Problem for Public Health; Impact and Mitigation Measures. Elsevier, Amsterdam, Netherlands, pp.147–160.

Wikoff D, Goodrum P, Haws L, Budinsky R. Application of quantitative approaches to assess uncertainties in the development of toxicity values: A case study involving the reference dose (RfD) for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

View Abstract

Urban JD, Harvey S, Haws LC, Wikoff D. Assessment of study quality (risk of bias) in understanding the relationship between congenital heart defects (CHDs) and exposures to trichloroethylene (TCE). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

View Abstract

Wikoff D. Moving beyond theory to the use of systematic review to support regulatory decision making for evidence-based risk assessment. Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

View Abstract

Borghoff S, Wikoff D, Urban JD, Rager JE. A systematic approach to identify plausible mode-of-actions (MOA) for an increased incidence of lung tumors in mice with chronic exposure to 4-methylimidazole (4-MEI). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

View Abstract

Wikoff DS, Miller GW. 2018. Systematic reviews in toxicology (Editorial). Toxicol Sci 163(2):335–337.

View Abstract

Thompson CM, Wolf JC, Suh M, Proctor DM, HJaws LC, Harris MA. Toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens; captan, folpet, and hexavalent chromium: Evidence for an adverse outcome pathway. Society of Toxicology Annual Meeting, San Antonio, TX, March 11-15, 2018.

View Abstract

Thompson CM, Suh M, Proctor DM, Harris MA. Ten factors for considering the mode of action of Cr(VI)-induced intestinal tumors in rodents. Society of Toxicology Annual Meeting, San Antonio, TX, March 11-15, 2018.

View Abstract

Proctor, DM. Updating the regulatory risk assessment for hexavalent chromium in California: Implications for regulatory standards. Association of Environmental Health Sciences San Diego, CA, March 20, 2018.

Thompson CT, Suh M, Chappell G, Borghoff S, Ellis-Hutchings, R, Wiench, K, Finch, L, Proctor, DM. 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96:178–189 doi: 10.1016/j.yrtph.2018.05.006.

Suh M, Proctor DM, Chappell G, Rager JE, Thompson CM, Borghoff S, Finch L, Ellis-Hutchings R, Wiench K. 2018. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicology 402-403:50-67, doi: 10.1016/j.tox.2018.04.006.

View Abstract

Proctor DM, Suh M, Chappell G, Borghoff SJ, Thompson CM, Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol, 96:30-40, doi: 10.1016/j.yrtph.2018.04.016.

View Abstract

Proctor DM. Hexavalent chromium in drinking water: When is the science sufficient to deviate from defaults? Invited Speaker, Genetic and Environmental Toxicology Association (GETA).  Thresholds in Toxicology and Risk Assessment Fall Symposium.  Oakland, CA, November 14, 2018.

Brorby GP. 2018. The ongoing controversy surrounding the effects of short-term exposure to trichloroethene. Presented at the Association for Environmental Health and Sciences Foundation Annual International Conference, March 19–22, San Diego, CA.

Thompson CM, Kirman CR, Hays SM, Suh M, Harvey SE, Proctor DM, Rager JE, Haws LC, Harris MA. 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545.

View Abstract

Verougstraete V, Henderson R, Mackie C, Newson T, Oller A. 2018. Human health (toxicity) assessment of complex inorganic materials. In: Verougstraete V (ed), Risk Management of Complex Inorganic Materials. Elsevier Inc. ISBN 978-0-12-811063-8.

View Abstract

Wikoff D, Urban JD, Harvey S, Haws LC. 2018. Role of risk of bias in systematic review for chemical risk assessment: A case study in understanding the relationship between congenital heart defects and exposures to trichloroethylene. Int J Toxicol, DOI: 0.1177/1091581818754330.

View Abstract

Doepker C, Franke K, Myers E, Goldberger JJ, Lieberman HR, O’Brien C, Peck J, Tenenbein M, Weaver C, Wikoff D. 2018. Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Nutrients 10:1536, doi: 10.3390/nu10101536.

View Abstract

Rish W, Pfau EJ. 2018. Bounding analysis of drinking water health risks from a spill of hydraulic fracturing flowback water. Risk Analysis 38(4):724-754, DOI: 10.1111/risa.12884.

View Abstract

2017

Lansita JMease KM, Qiu H, Yednock T, Sankaranarayanan S, Kramer S. 2017. Nonclinical development of ANX005: A humanized anti-Clq antibody for treatment of autoimmune and neurodegenerative diseases. Int J Toxicol 1-14. DOI: 10.1177/1091581817740873.

View Abstract

Bhat VS, Meek B (M.E.), Valcke M, EnglishJC, Boobis AR, Brown RJ. 2017. Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance. Crit Rev Toxicol 47:733-753.

View Abstract

Gaffney SH, Grespin M, Garnick L, Drechsel DA, Hazan R, Paustenbach DJ, Simmons BD. 2017. Anthophyllite asbestos: State of the science review. J Appl Toxicol 37(1):38–49.

View Abstract

Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C, Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; DOI: 10.1021/acs.chemrestox.7b00221.

View Abstract

Petrisor IG. 2017. Application of classic and emerging techniques to solve environmental forensics puzzles. In: Practical Environmental Forensics (Ed. by Farid Achour), in press.

Thompson CM, Suh M, Proctor DM, Haws LC, Harris MA. 2017. Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents. Mutation Res 823:45-57.

View Abstract

Thompson CM, Young RR, Dinesdurage H, Suh M, Harris MA, Rohr AC, Proctor DM. 2017. Assessment of the mutagenic potential of hexavalent chromium in the duodenum of Big Blue® rats. Toxicol Appl Pharmacol 330(1):48-52.

View Abstract

Wikoff DS, Rager JE, Harvey S, Haws LChappell G, Borghoff S. Development and refinement of a framework for quantitative consideration of study quality and relevance in the evaluation of mechanistic data based on Key Characteristics of Carcinogens. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.

View Abstract

Wikoff DS, Welsh BT, Henderson R, Brorby G, Britt J, Myers E, Goldberger J, Lieberman HR, O’Brien C, Doepker C. Application of systematic reviews in the evaluation of caffeine safety: Potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.

View Abstract

Panko J, Hitchcock K, Fung M, Spencer PJ, Kingsbury T, Mason AM. 2017. A comparative evaluation of five hazard screening tools. Integr Environ Assess Manag 13(1):139–154.

See also: Panko J, Hitchcock K, Fung M, Spencer PJ, Kingsbury T, Mason AM. 2017. Letter to the Editor: Authors’ response to Turner et al. Integr Environ Assess Manag 13(1):15–16.

View Abstract

Perez AL, Gauthier AM, Ferracini T, Cowan DM, Kingsbury T, Panko J. 2017. The challenge of predicting problematic chemicals using a decision analysis tool: Triclosan as a case study. Integr Environ Assess Manag 13(1):198–207.

View Abstract

Burns A, Shin J, Unice KM, Gaffney SH, Kreider ML, Gelatt RN, Panko JM. 2017. Combined analysis of job and task benzene air exposures among workers at four US refinery operations. Toxicol Indust Health 33(3):193–210.

View Abstract

Ring CL, Pearce RG, Setzer RW, Wetmore BA, Wambaugh JF. 2017. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability. Environ Int 106:105–118.

View Abstract

Chappell GA, Rager JE. 2017. Epigenetics in chemical-induced genotoxic carcinogenesis. Current Opinion Toxicol 6:10-17.

View Abstract

Bichteler A, Wikoff DS, Loko F, Harris MA. 2017. Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005-2006 and 2007-2008: A multiple imputation and trending approach incorporating NHANES pooled sample data. Environ Int 105(2017):112-125.

View Abstract

Hoffmann S, de Vries RB, Stephens ML, Beck NB, Dirven HAAM, Fowle III JR, Goodman JE, Hartung T, Kimber I, Lalu MM, Thayer K, Whaley P, Wikoff D, Tsaioun K. 2017. A primer on systematic reviews in toxicology. Arch Toxicol DOI: 10.1007/s00204-017-1980-3.

View Abstract

Rager JE, Ring CL, Fry RC, Suh M, Proctor DM, Haws L, Harris MA, Thompson CM. 2017. High-throughput screening data interpretation in the context of in vivo transcriptomic responses to oral Cr(VI) exposure. Toxicol Sci 158(1):199–212. https://doi.org/10.1093/toxsci/kfx085

View Abstract

Wikoff D, Welsh BT, Henderson R, Brorby GP, Britt J, Myers E, Goldberger J, Lieberman HR, O’Brian C, Peck J, Tenebein M, Weaver C, Harvey S, Urban J, Doepker C. 2017. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 109(Pt1):585-648. https://doi.org/10.1016/j.fct.2017.04.002.

View Abstract

Kirman CR, Suh M, Proctor DM, Hays SM. 2017. Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations. Toxicol Appl Pharmacol 325:9-17.

View Abstract

Wikoff DS, Rager J, Harvey S, Haws L, Chappell G, Borghoff S. 2017. Framework for quantitative consideration of study quality and relevance in the systematic evaluation of mechanistic data per the Ten Key Characteristics of Carcinogens. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

View Abstract

Welsh BT, Todorovic J, Kirson D, Allen HM, Bayly MD, Mihic SJ. 2017. Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor. Brain Res 1657:148-155. 

View Abstract

Mease K, Kimzey A, Lansita J. 2017. Biomarkers for nonclinical infusion reactions in marketed biotherapeutics and considerations for study design. Curr Opin Toxicol (4:1–15).

View Abstract

Doepker D, Tyndall K, Lane R, Wikoff D, Thompson C, Harvey S, Schmitt D. 2017. A proposed ADI for nitrate. Poster presented at Society of Toxicology Annual Meeting, March 16, Baltimore, MD.

View Abstract

Borghoff SJ, Ring C, Banton MI, Leavens TL. 2017. Ethyl tertiary butyl ether (ETBE) and tertiary butyl alcohol (TBA) physiologically based pharmacokinetic (PBPK) model in rats: Contribution of binding to ?2u-globulin and non-linear kinetics to kidney and liver responses in rats. Poster presented at Society of Toxicology Annual Meeting, March 16, Baltimore, MD.

View Abstract

Thompson C, Rager J, Suh M, Proctor D, Haws L, Harris M. 2017. Mechanistic support for nonlinear risk assessment of rat oral cavity tumors induced by exposure to Cr(VI) in drinking water. Poster presented at Society of Toxicology Annual Meeting. March 15, Baltimore, MD.

View Abstract

Chappell G, Welsh B, Harvey S, Harris M, Wikoff D. 2017. Validation and application of a text mining tool in the identification and categorization of mechanistic data: A case study in improving problem formulation of carcinogenicity assessments. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

View Abstract

Proctor DM, Suh M, Dunsmore D, Verwiel A, Casteel S. 2017. Bioaccessibility and relative oral bioavailability of cobalt and nickel from metal alloys in soil and dust. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

View Abstract

Kirman CR, Proctor D, Suh M, Haws L, Harris M, Thompson C, Hays S. 2017. Using physiologically based pharmacokinetic modeling to address potentially sensitive subpopulations exposed to hexavalent chromium. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

View Abstract

Rager JE, Thompson CM, Ring C, Fry RC, Harris MA. 2017. Integration of transcriptomics and high-throughput screening predictions with robust in vivo data to inform hexavalent chromium mode of action. Poster presented at Society of Toxicology Annual Meeting, March 14, Baltimore, MD.

View Abstract

Thompson C, Kirman C, Suh M, Proctor D, Haws L, Harris M, Hays S. 2017. Risk assessment of oral exposure to Cr(VI): Integration of mode of action, pharmacokinetics, and dose-response modeling. Poster presented at Society of Toxicology Annual Meeting, March 14, Baltimore, MD.

View Abstract

Mease K, Kimzey A, Lansita J. 2017. Failed dose formulation analysis during a GLP study — Now what? Poster presented at Society of Toxicology Annual Meeting, March 14, Baltimore, MD.

View Abstract

Suh M, Harvey S, Wikoff D, Mittal L, Ring C, Goodmanson A, Proctor D. 2017. Meta-analysis of hexavalent chromium and stomach cancer. Poster presented at Society of Toxicology Annual Meeting, March 13, Baltimore, MD.

View Abstract

Thompson CM, Wolf, JC, McCoy A, Suh M, Proctor DM, Kirman CR, Haws LC, Harris MA. 2017. Comparison of toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens captan, folpet, and hexavalent chromium. Toxicol Pathol 45(8):1091–1101. DOI: 10.1177/019262331yy4324.

View Abstract

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Chjoksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS. 2017. In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicol in Vitro 47:213–227.

View Abstract

2016

Thompson CM, Bichteler A, Rager JE, Suh M, Proctor DM, Haws LC, Harris MA. 2016. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium. Mut Res/Genetic Toxicol Environ Mutagen 800-801:28-34.

View Abstract

Wikoff D, Suh M, Harvey S, Proctor D, Beretvas T, Goodman M, Lipworth L. 2016. Systematic review and meta-analysis of occupational exposure to Cr(VI) and stomach cancer. PROSPERO 2016:CRD42016051625 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016051625

Lake AD, Wood CD, Bhat VS, Chorley BN, Carswell GK, Sey Y, Kenyon EM, Padnos B, Moore TM, Tennant AH, Schmid JE, George BJ, Ross DG, Hughes MG, Corton JC, Simmons JE, McQueen CA, Hester SD. 2016. Dose and effect thresholds for early key events in a PPARα-mediated mode of action. Toxicol Sci 149:312-325.

View Abstract

Hester SD, Bhat VS, Chorley BN, Carswell G, Jones W, Ward W, Wehmas L, Wood CE. 2016. Editor’s Highlight: Dose-response analysis of RNA-seq profiles in archival formalin-fixed paraffin-embedded (FFPE) samples. Toxicol Sci 154:202-213.

View Abstract

Thompson CM, Rager JE, Suh M, Ring CL, Proctor DM, Haws LC, Fry RC, Harris MA. 2016. Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment. Environ Molec Mutagen 57:706-716.

View Abstract

De Flora S, Camoirano A, Micale RT, La Maestra S, Savarino V, Zentilin P, Marabotto E, Suh M, Proctor DM. 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid.  I. Chemical reduction and mitigation of mutagenicity. Toxicol Appl Pharmacol   306:113-119.

View Abstract

Rager J, Thompson C, Auerbach S, Fry R. 2016. Integrating genomic and epigenomic data into risk assessment applications through dose response modeling: Case study with prenatal arsenic exposure. Environmental Mutagenesis and Genomics Society, September 25, Kansas City, KS. 

View Abstract

Borghoff SJ, Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes.  J Appl Toxicol, DOI 10.1002/jat.3412

View Abstract

Wikoff D, Borghoff S, Rager J, Harvey S, Haws L. 2016. A systematic review of the mechanistic evidence of tetrabromobisphenol TBBPA as a human carcinogen according to the ten key characteristics of carcinogens (TKCC) identified by Smith et al. (2016). PROSPERO 2016:CRD42016046429 Available from:  http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016046429

Haws L. 2016. Vapor intrusion – Solid ground or quick sand? Invited Speaker. Presented at the 28th Annual Texas Environmental Superconference, August 5, Austin, TX.

Haws L. 2016. Vapor intrusion – Technical issues. Invited Speaker. Presented at the Semi-Annual South Central Regional Meeting of the Auditing Roundtable, August 3, Austin, TX.

Thompson CM, Suh M, Mittal L, Wikoff D, Welsh B, Proctor DM. 2016. Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations. Regul Toxicol Pharmacol 80:60-70.

View Abstract

Borghoff SJ. 2016. Organization and review of mechanistic data according to “Ten Key Characteristics of Carcinogens” (TKCC) {Smith et al., 2016}. Presented at the 42nd Annual Summer Meeting of the Toxicology Forum, July, Salt Lake City, UT.

Panko JM, Benson SM, Kreider ML. Meta-analysis of lung cancer risk related to diesel exposure by occupation and evaluation of exposure response. Abstract #2976. Poster at Society of Toxicology Annual Meeting, New Orleans,LA, March 13–17, 2016.

View Abstract

Gloekler L, Shay EC, Schmidt N, Haghighat B, Panko JM, Cowan DM, Paustenbach DJ. Flame-retardants in upholstered furnishings: An assessment of health risk and fire-related deaths in the era of California Technical Bulletin (TB-117). Abstract #2669. Poster at Society of Toxicology Annual Meeting, New Orleans, LA, March 13–17, 2016.

View Abstract

Maskrey JR, Insley A, Hynds ES, Panko JM. 2016. Air monitoring of volatile organic compounds at relevant receptors during hydraulic fracturing operations in Washington County, Pennsylvania. Environ Monit Assess 188(7):1–12, Article 410.

View Abstract

Suh M, Thompson CM, Brorby GP, Mittal L, Proctor DM. 2016. Inhalation cancer risk assessment of cobalt metal. Regul Toxicol Pharm 79(2016):74-82.

View Abstract

Kirman CR, Suh M, Hays SM, Gürleyük H, Gerads R, De Flora S, Parker W, Lin S, Haws LC, Harris MA, Proctor DM. 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid.  II. Ex vivo gastric reduction modeling. Toxicol Appl Pharmacol 306:120-133.

View Abstract

Haws L. 2016. Trichlorethylene exposure and development of fetal cardiac malformations: What do the data tell us about inhalation exposures resulting from vapor intrusion and potential health risks to pregnant women? – Introduction. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Proctor DM. 2016. Cancer risk assessment for ingested hexavalent chromium:  Challenges and controversies – Introduction. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA [session introduction; no abstract].

Wikoff D, Borghoff SJ, Rager JE, Haws LC. 2016. Human relevance assessment of tetrabromobisphenol-A (TBBPA) induced uterine adenocarcinomas: Mode of action dependent on high dose molecular initiating event (MIE). Presented in the “Flame Retardants” session at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Suh M. 2016. Cumulative risk assessment of urban air toxics: A pilot study in San Antonio, Texas. Presented in the “Quantitative Cumulative Risk Assessment: Is it Feasible Today?” Session of the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Thompson CM. 2016. Non-mutagenic MOA for Cr(VI) involving intestinal cytotoxicity and regenerative hyperplasia. Platform presentation in the “The Cancer Risk Assessment for Ingested Hexavalent Chromium: Challenges and Controversies” Session. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Borghoff SJ,  Wikoff D, Rager JE, Haws LC. 2016. Tetrabromobisphenol A (TBBPA); Dose- and time-dependent changes in plasma TBBPA and its conjugates over 28 days of administration. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.

View Abstract

DeVito MJ, Borghoff SJ, Zorilla LM, Shockley K, Kissling G,  Travlos G. 2016. The effects of a high fat (HF) diet on male diversity outbred (DO) mice. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Cullen JM, Ward JM, Thompson CM. 2016. Re-evaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from four studies of hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Thompson CM, Suh M, Proctor DM, Rager JE, Haws LC, and Harris MA. 2016. Assessment of the in vivo genotoxicity of CrVI in target organs identified in a two-year cancer bioassay. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Suh M, Crump K, Mittal L, Hirsch S, Valdes Salgado R, BartlettC, Van Landingham C, Rohr A, Proctor DM. 2016. Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Brorby GP, Suh M, Thompson CM, Mittal L, Proctor DM. 2016. Inhalation cancer risk assessment of cobalt metal. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

View Abstract

Verwiel A, Proctor D, Tachovsky A. 2016. Principal component analysis of metals in soil and dust to distinguish background and anthropogenic sources in an urban area. Association for Environmental Health and Sciences Foundation Annual Meeting, March 14, San Diego, CA.

View Abstract

Cullen JM, Ward JM, Thompson CM. 2016. Reevaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from 4 studies of hexavalent chromium in drinking water. Toxicologic Pathol 44(2):279-89.

View Abstract

Wikoff DS, Britt JK.  2016. The role of systematic review in the practice of toxicology and risk assessment – An appreciation for the primary tool in evidence-based approaches.  Toxicology: Open Access 2(110):1-4. 

View Abstract

Wikoff DS, Rager JE, Haws LC, Borghoff SJ. 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77:143-159. doi: 10.1016/j.yrtph.2016.01.018

View Abstract

Hanlon P, Brorby GP, Krishan M. 2016. A risk-based strategy for evaluating mitigation options for processed-formed compounds in food: Workshop proceedings. Int J Toxicol 35(3):358–370.

View Abstract

Schmitt D, Levy R, Carroll B. 2016. Toxicological evaluation of ß-caryophyllene oil: Subchronic toxicity in rats. Int J Toxicol 35(5):558–567.

View Abstract

Borghoff SJ, Wikoff D, Harvey S, Haws L. 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi:10.1016/j.toxrep.2016.01.007

View Abstract

Doepker C, Lieberman HR, Smith AP, Peck JD, El-Sohemy A, Welsh BT. 2016. Caffeine: Friend or Foe? Annu Rev Food Sci Technol. DOI: 10.1146/annurev-food-041715-033243

View Abstract

2015

Proctor DM, Suh M, Mittal L, Hirsch S, Salgado RV, Bartlett C, Van Landingham C, Rohr A, Crump K. 2015. Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers. J Expo Sci Environ Epidemiol 26(2):224-231. doi: 10.1038/jes.2015.77.

View Abstract

James RC, Britt JK, Halmes NC, Guzelian PS. 2015. Evidence-based causation in toxicology: A 10-year retrospective. Hum Exp Toxicol 34(12):1245–1252.

View Abstract

Hester S, Eastmond DA, Bhat VS. 2015. Developing toxicogenomics as a research tool by applying benchmark dose-response modeling to inform chemical mode of action and tumorigenic potency. Invited Contribution, Special Issue on Toxicogenomics: The emergence of a new research and regulatory paradigm. Inter J Biotechnol 14:28-46.

View Abstract

Wikoff D, Doepker C, Welsh B, Urban J, Henderson R, Britt J, Harvey S, Goldberger J, Myers E, O’Brien C, Peck J, Lieberman H, Weaver C, Tenebein M. 2015. Systematic review of the adverse bone and calcium balance effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026609 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015026609 (Systematic Review Protocol Registration)

Wikoff D, Doepker C, Welsh B, Urban J, Henderson R, Brorby G, Britt J, Harvey S, Goldberger J, Myers E, O’Brien C, Peck J, Lieberman H, Weaver C, Tenebein M. 2015. Systematic review of the adverse cardiovascular effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026673 Available from http://www.crd.york.ac.uk/PROSPERO/display_record. asp?ID=CRD42015026673 (Systematic Review Protocol Registration)

Lansita JA, Burke JM, Apgar JF, Mounho-Zamora B. 2015. An introduction to the regulatory and nonclinical aspects of the nonclinical development of antibody drug conjugates. Pharmceut Res 32(11):3584-3592. DOI 10.1007/s11095-015-1742-y

View Abstract

Hughes BJ, LeBaron MJ, Thomas J, Kan HL, Lynch AM, Borghoff SJ, Green S, Mensing T, Sarang SS, Smulders CJGM. 2015. Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, 2015. San Diego, CA.

View Abstract

Kirman CR, Proctor DM, Suh M, Hays S. 2015. Reduction of hexavalent chromium by gastric fluids from fed and fasted individuals with applications to toxicokinetic modeling. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Suh M, Mittal L, Hirsch S, Valdes R, Bartlett C, Rohr A, Proctor D. 2015. Lung cancer risk in chromate production workers exposed to hexavalent chromium. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Britt J, James R. 2015. Welding and occupational exposure to manganese fumes and Parkinson’s disease:  An evidence-based causation analysis. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Mounho-Zamora B, Weissman I, Volkmer J, Willingham S, Prohaska S, Howard M, Jie L, Majeti R.2015.  Nonclinical safety assessment of a monoclonal antibody against CD47. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Doepker C, Brorby G. 2015. The role of the toxicologist in required food safety plans:  A case study of ochratoxin A (OTA) in coffee. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Proctor D, Suh M, Thompson C, Hixon, G. 2015. Inhalation cancer risk assessment of titanium dioxide. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Urban JD, Thompson CM, Plunkett LM, Perry CS, Haws LC. 2015. A state of the science copper reference dose for soil remediation. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Harris MA, Thompson CM, Proctor DM, Suh M, Wolf JC, Seiter JM, Chappell MA, Haws LC. 2015. Analysis of duodenal crypt health following exposure to Cr(VI) in drinking water. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Thompson CM, Young RR, Suh M, Dinesdurage H, Elbekai R, Harris MA, Rohr AC, Proctor DM. 2015. Hexavalent chromium does not induce mutations in the oral mucosa of transgenic Big Blue® rats following drinking water exposures at a carcinogenic dose. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Thompson CM, Suh M, Hixon G, Bichteler A. 2015. Comparison of smoothing spline regression and conventional modeling approaches for quantitative risk sssessments of human dioxin exposure. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Borghoff SJ, Wikoff D, White MC, Thompson C, Haws LC. 2015. Identification of the molecular initiating event (MIE) for TBBPA induced uterine tumors in the framework of an adverse outcome pathway (AOP). Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Wikoff D, White MC, Borghoff SJ, Haws LC. 2015. Evaluation of tetrabromobisphenol A (TBBPA)-induced endocrine-related target gene activity using high-throughput screening data from ToxCast. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

View Abstract

Brorby G, Suh M, Bichteler A, Proctor D. Use of cluster analysis and homogeneity testing to characterize distributions of exposures among beryllium workers: Tools for developing occupational exposure limits from quantitative risk assessment.  Presented at International Society of Exposure Science 25th Annual Meeting, Henderson, NV, October 18-22, 2015.

Thompson CM, Wolf JC, Elbekai RH, Paranjpe MG, Seiter JM, Chappell MA, Tappero RV, Suh M, Proctor DM, Bichteler A, Haws LC, Harris MA. 2015. Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron x-ray fluorescence microscopy. Mut Res 789–790:61–66.

View Abstract

Mason AM, Spencer PJ, Panko JM. A pilot project reveals prominent hazard screening tools fall short on performance expectations. Poster at the 54th Annual Meeting and Society of Toxicology (SOT) Meeting, San Diego, CA, March 22–26, 2015.

View Abstract

Panko JM, Hitchcock KM, Fung M, Spencer PJ, Kingsbury T, Mason AM. A comparative evaluation of seven hazard screening tools. Poster at 25th Annual Meeting of NorCal SETAC, Sacramento, CA, April 29–30, 2015.

Panko JM, Hitchcock KM. From critical reviews of hazard assessment tools to building a product evaluation framework: Can we bridge the gaps with a super tool? Presentation at the American Industrial Hygiene Conference & Expo (AIHce), Salt Lake City, UT, May 30 – June 4, 2015.

Unice KM, Bare JL, Kreider ML, Panko JM. Evaluation of leachate from tire and road wear particles (TRWP) upflow percolation column tests. Poster at Society of Environmental Toxicology and Chemistry, 36th Annual Meeting, Salt Lake City, UT, November 1–5, 2015.

Gauthier AM, Fung M, Panko J, Kingsbury T, Perez AL, Hitchcock K, Ferracini T, Sahmel J, Banducci A, Jacobsen M, Abelmann A, Shay E. 2015. Chemical assessment state of the science: Evaluation of 32 decision-support tools used to screen and prioritize chemicals. Integr Environ Assess Manag 11(2):242–255.

View Abstract

Kreider ML, Cyrs WD, Tosiano MA, Panko JM. 2015. Evaluation of quantitative exposure assessment method for nanomaterials in mixed dust environments: Application in tire manufacturing facilities. Ann Occup Hyg
59(9):1122–1134.

View Abstract

Thompson CM, Young RR, Suh M, Dinesdurage HR, Elbekai RH, Harris MA, Rohr AC, Proctor DM. 2015. Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats. Environ Mol Mutagen 56:621-628.

View Abstract

James RC, Roberts SM, Williams PL. 2015. General principles of toxicology. In: Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition. John Wiley and Sons, New York.

Young RR, Thompson CM, Dinesdurage HR, Elbekai RH, Suh M, Rohr AC, Proctor DM. 2015. A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats. Environ Mol Mutagen 56:629-636.

View Abstract

James RC, Roberts SM. 2015. Hepatoxicity: Toxic effects on the liver. In: Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition. John Wiley and Sons, New York, NY.

Stuchal LD, James RC, Roberts SM. 2015. Human health risk assessment. In: Principles Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition. John Wiley and Sons, New York, NY.

Borghoff SJ, Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC.  2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicology 333(2015):1-13.

View Abstract

Lansita JA, Mounho-Zamora B. 2015. The development of therapeutic monoclonal antibodies:  Overview of the nonclinical safety assessment. Curr Pain Headache Rep 19(3):472.

View Abstract

Britt JK. 2015. Properties and effects of pesticides. In: Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition. John Wiley and Sons, New York.

Urban JD, Carakostas MC, Taylor SL. 2015. Steviol glycoside safety: Are highly purified steviol glycoside sweeteners food allergens? Food Chem Toxicol 75: 71-78.

View Abstract

Thompson CM, Seiter J, Chappell MA, Tappero RV, Proctor DMSuh M, Wolf JC, Haws LC, Vitale R, Mittal L, Kirman CR, Hays SM, Harris MA. 2015. Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water. Toxicol Sci 143(1): 16-25.

View Abstract

Ramani T, Auletta CS, Weinstock D, Mounho-Zamora B, Ryan PC, Salcedo TW, Bannish G. 2015. Cytokines: The good, the bad, and the deadly. Int J Toxicol 34(4):355–365, DOI 10.1177/1091581815584918.

View Abstract

Wikoff D, Doepker C, Welsh B, Goldberger J, Lieberman H, Myers E, O’Brien C, Peck J, Tenebein M, Weaver C. Systematic review of the adverse behavioral effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015027413 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015027413 (Systematic Review Protocol Registration)

Wikoff D, Doepker C, Welsh B, Harvey S, Goldberger J, Lieberman H, Myers E, O’Brien C, Peck J, Tenebein M, Urban J, Weaver C. Systematic review of the adverse reproductive and developmental effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026736 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015026736 (Systematic Review Protocol Registration)

Wikoff D, Doepker C, Welsh B, Harvey S, Goldberger J, Lieberman H, Myers E, O’Brien C, Peck J, Tenebein M, Urban J, Weaver C. Systematic review of acute adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026704 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015026704 (Systematic Review Protocol Registration)

2014

Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308. doi: 10.1002/jat.3132.

View Abstract

Fitzgerald L, Wikoff DS. 2014. Persistent organic pollutants. In: Wexler P (Ed.), Encyclopedia of Toxicology, 3rd edition, vol 3. Elsevier, Inc., Academic Press, pp. 820-825.

Borghoff SJ, Hard GC, Poet TS, Davis J, Green S, Hughes B, Mensing T, Sarang SS. 2014. Methyl isobutyl ketone (MIBK) induces an exposure-related increase in measures of a2u-globulin (a2u) nephropath in male but not female F344 rats. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Geter DR, Bhat VS, Gollapudi BB, Sura R, Hester SD. 2014. Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway. Toxicol Sci 138:425-445.

View Abstract

Wood CE, Jokinen MP, Johnson CL, Olson GR, Hester S, George M, Chorley B, Carswell G, Carter JH, Wood CR, Bhat VS, Corton JC, DeAngelo AB. 2014. Comparative time course profiles of phthalate stereoisomers in mice. Toxicol Sci 139:21-34.

View Abstract

Bhat VS, Durham JL, Ball GL, English JC. 2014. Derivation of an oral reference dose (RfD) for the non-phthalate alternative plasticizer, 1,2-cyclohexane dicarboxylic acid, di-isononyl ester (DINCH®). J Toxicol Environ Health B Crit Rev 17:63-94.

View Abstract

Bhat VS, Durham JL, English JC. 2014. Derivation of an oral reference dose (RfD) for the plasticizer, di-(2-propylheptyl)phthalate (Palatinol® 10-P). Regul Toxicol Pharmacol 70:65-74.

View Abstract

Chang CH, Drechsel DA, Kitson RA, Siegel D, You Q, Backos DS, Ju C, Moody CJ, Ross DR. 2014. 19-Substituted benzoquinone ansamycin heat shock protein-90 inhibitors: Biological activity and decreased off-target toxicity. Molec Pharmacol 85(6):849–857.

View Abstract

Kerger BD, James RC, Galbraith DA. 2014. Tumors that mimic asbestos-related mesothelioma: Time to consider a genetics-based tumor registry? Frontiers in Genetics 5(151):1-14.

View Abstract

Haws LC, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Wikoff D. 2014. Development of non-cancer based toxicity factors and daily dose estimates for TBBPA. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Kirman CR, Proctor D, Suh M, Thompson CM, Harris MA, Haws LC, Hays SM. 2014. Variation analysis of PBPK model parameters for describing the delivery of Cr(VI) to the small intestines of humans. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Petrisor IG. 2014. Environmental Forensics Fundamentals: A Practical Guide. CRC Press, Taylor & Francis Group, Boca Raton, London, New York, 395 pages.

Proctor DM, Suh M. Campleman SL, Thompson CM. 2014. Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures. Toxicology 325:160-179.

View Abstract

Hays SM, Kirman CR, Suh M, Proctor DM.  2014. Gastric reduction of hexavalent chromium [Cr(VI)] in fed and fasted human stomach samples. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Johnson GE, Soeteman-Hernandez, Gollapudi BB, Bodger OG, Dearfield KL, RH Heflich, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CMAbraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. 2014. Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Molec Mutagen 55(8):609-623. doi: 10.1002/em.21870/em.21870.

View Abstract

Henderson R, Verougstraete V, Anderson K, Arbildua JJ, Brock TO, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon GOdnevall Wallinder I, Rodriguez PH, Van Assche F, Wilrich P, Oller AR. 2014. Inter-laboratory validation of bioaccessibility testing for metals. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Lancaster JL, Antonijevic T, Starobin JM. 2014. Ordering and stability in lipid droplets with applications to low-density lipoproteins. Physical Review E89(6):062708.

View Abstract

Henderson R, Verougstraete V, Anderson K, Arbildua JJ, Brock TO, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon G, Wallinder IO, Rodriguez PH, Assche FV, Wilrich P, Oller AR. 2014. Interlaboratory validation of bioaccessibility testing for metals. Regul Toxicol Pharmacol 70(1):170-181. doi: 10.1016/j.yrtph.2014.06.02.

View Abstract

Hixon JG, Thompson C, Bichteler A, Abraham L. 2014. Smoothing regression splines as the basis for dose-response modeling. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Panko JM. Green chemistry: A critical element of sustainable development and product stewardship. Presentation at The American Industrial Hygiene Conference & Exposition (AIHce), San Antonio, TX, May 31 – June 5, 2014.

Kreider ML, Cyrs WD, Tosiano MA, Panko JM. Method development for nanomaterials exposure assessment in mixed dust environments. Presentation at The American Industrial Hygiene Conference & Exposition (AIHce), San Antonio, TX, May 31 – June 5, 2014.

Cyrs WD, Tosiano MA, Panko JM, Kreider ML. Use of a novel method to assess exposure to nanoscale carbon black and amorphous silica at two tire manufacturing facilities. Presentation at The American Industrial Hygiene Conference & Exposition (AIHce), San Antonio, TX, May 31 – June 5, 2014.

Panko JM. Chemical selection tools analysis project & results. Presented at GlobalChem. Global Chemical Regulations Conference, Baltimore, MD, March 3–5, 2014.

Faber W, Kirkpatrick D, Coder P, Li P, Borghoff S, Banton M. 2014. Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC). Regul Toxicol Pharmacol 68:332-342.

View Abstract

Proctor DM, Suh M, Tachovsky JA, Abraham L, Hixon JG, Brorby GP, Campleman SL. 2014. Cumulative risk assessment of urban air toxics: A pilot study in San Antonio, Texas. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

James RC, Britt J, Halmes N, Guzelian P. 2014. Comments on recent discussions providing differing causation methodologies. Hum Experim Toxicol 33(1):109-112.

View Abstract

Suh M, Yzenas JJ, Proctor DM. 2014. Evaluation of electric arc furnace-processed steel slag for dermal corrosion, irritation, and sensitization. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG and others. 2014. t4 Workshop report — Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. Altex 31(1):63-78.

View Abstract

Thompson CM, Proctor DM, Suh M, Wolf JC, Haws LC, Seiter JM, Chappell MA, Harris MA. 2014. X-ray fluorescence microspectroscopic analysis of duodenal mucosae following Cr(VI) exposure in drinking water. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Song G, Darr DB, Santos CM, Ross M, Valdivia A, Jordan JL, Midkiff BR, Cohen S, Feinberg NN, Miller CR, Tarrant TK, Rogers AB, Dudley AC, Perou CM, Zamboni WC. 2014. Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models. Clin Cancer Res 20(23):6083–6095.

View Abstract

Suh M, Troese MJ, Hall DA, Yasso B, Yzenas JJ, Proctor DM. 2014. Evaluation of electric arc furnace-processed steel slag for dermal corrosion, irritation, and sensitization from dermal contact. J Appl Toxicol 34(12):1418-1425. DOI: 10.1002/jat.2974.

View Abstract

Urban JD, Doepker CL, Cuellar-Kingston N, van de Ligt J, Carakostas M. 2014. Do highly purified steviol glycoside sweeteners cause food allergies? Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

View Abstract

Wikoff, D., Thompson, C., Perry, C., White, M., Fitzgerald, L., Borghoff, S., Haws, L.C. Development of an oral cancer slope factor and lifetime average daily dose estimates for TBBPA. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, 2014. Phoenix, AZ.

View Abstract

Bunch AG, Perry CS, Abraham L, Wikoff DS, Tachovsky JA, Hixon JG, Urban JD, Harris MA, Haws LC. 2014. Evaluation of impact of shale gas operations in the Barnett Shale region on volatile organic compounds in air and potential human health risks. Sci Tot Environ 468-469(2014):832-842.

View Abstract

Suh M, Abraham L, Hixon JG, Proctor D. 2014. The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001–2002 and 2007–2008 National Health and Nutrition Examination Surveys. J Expos Sci Epidemiol 24:579-587.

View Abstract

Urban JD, Wikoff DS, Bunch ATG, Harris MA, Haws LC. 2014. A review of background dioxin concentrations in urban/suburban and rural soils across the United States: Implications for site assessments and the establishment of soil cleanup levels. Sci Tot Environ 466-467:586-597.

View Abstract

Thompson CM, Kirman CR, Proctor DMHaws LCSuh M, Hays S, Hixon JG, Harris MA. 2014. A chronic oral reference dose for hexavalent chromium-induced intestinal cancer. J Appl Toxicol 34:525-536. doi: 10.1002/jat.2907.

View Abstract

Mahadevan B, Thorsrud BA, Brorby GP, Ferguson HE. 2014. A 3-week dietary safety study of octenyl succinic anhydride (OSA)-modified starch in neonatal farm piglets. Food Chem Toxicol 72:83-89.

View Abstract

Suh M, Thompson C, Kirman C, Carakostas M, Haws LC, Harris M, Proctor D. 2014. High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice. Food  Chem Toxicol 65:381-388.

View Abstract

2013

Henderson R, Verougstraete V, Anderson K, Arbildua JJ, Brock TO, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon GOdnevall Wallinder I, Rodriguez PH, Van Assche F, Wilrich P, Oller AR. 2013. Interlaboratory comparison of bioaccessibility tests for metals. Annual meeting of the Belgian Society for Toxicology and Ecotoxicology (BelTox).

Mounho-Zamora B. 2013. Regulatory standards for the approval of biosimilar products: A global review. In Weinbauer GF,  Vogel F, eds. Challenges in Nonhuman Primate Research in the 21st Century. Waxmann, pg 9-34.

MacDonell MM, Haroun LA, Teuschler LK, Rice ER, Hertzberg RC, Butler JP, Chang Y, Clark S, Johns AP, Perry CS, Garcia SS, Jacobi JH, Scofield MA. 2013. Cumulative risk assessment toolbox: Methods and approaches for the practitioner. J Toxicol 2013:310904.

View Abstract

Willhite CC, Ball GL, Bhat VS. 2013. Emergency do not consume/do not use concentrations for blended phosphates in drinking water. Human Exper Toxicol 32:241-259.

View Abstract

Willhite CC, Bhat VS, Ball GL, McLellan CJ. 2013. Emergency do not consume/do not use concentrations for potassium permanganate in drinking water. Human Exper Toxicol 32:275-298.

View Abstract

Willhite C, Ball GL, Bhat VS. 2013. Emergency do not consume/do not use concentrations for ferric chloride in drinking water. Human Exper Toxicol 32:260-274.

View Abstract

Bhat VS, Hester SD, Nesnow S, Eastmond DA. 2013. Concordance of transcriptional and apical benchmark dose levels for conazole-induced liver effects in CD-1 mice. Toxicol Sci 136:205-215.

View Abstract

Kirman CR, Aylward LL, Suh MHarris MAThompson CMHaws LCProctor DM, Lin SS, Parker W, Hays SM. 2013. Physiologically based pharmacokinetic model for humans orally exposed to chromium. Chem Biol Interact 204(1):13-27. doi:pii: S0009-2797(13)00082-3. 10.1016/j.cbi.2013.04.003.

View Abstract

Dourson ML, Gadagbui B, Griffin S, Garabrant DH, Haws LC, Kirman C, Tohyama C. 2013. The importance of problem formulations in risk assessment: A case study involving dioxin-contaminated soil. Regul Toxicol Pharmacol 66(2):208-216.

View Abstract

Lamm SH, Britt JK, James RC. 2013. Multiple myeloma risk and benzene exposure among pliofilm workers – A re-analysis using an internal reference group. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

View Abstract

Hadley P, Petrisor IG. 2013. Incremental sampling: Challenges and opportunities for environmental forensics. Environ Foren 14(2):109–120.

View Abstract

O’Brien T, Ding H, Suh MThompson C, Parsons BL, Harris MA, Winkelman WA, Wolf JC, Hixon JG, Schwartz AM, Myers MB, Haws LC, Proctor DM. 2013. Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water. Mutat Res 754:15-21. doi: 10.1016/j.mrgentox.2013.03.008

View Abstract

Wikoff D, Fitzgerald L, Haws L, Harris M. 2013. Health-based framework for evaluating the safety of hydraulic fracturing products. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

View Abstract

Rowlands JC, Budinsky R, Gollapudi B, Black MB, Wolfinger RD, Cukovic D, Bombkowski A, Thompson CM, Urban JD, Thomas RS. 2013. A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes. Toxicol Sci 136(2):595-604.

View Abstract

Thompson CMProctor DMSuh MHaws LC, Kirman CR, Harris MA. 2013. Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans. Crit Rev Toxicol 43(3): 244-274.

View Abstract

Suh M, Thompson CM, Hixon JG, Harris MA, Kirman CR, Hays S Haws LC, Proctor DM. 2013. Potential involvement of oxidative stress and iron disturbance in the development of oral cavity tumors in rats exposed to hexavalent chromium. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

View Abstract

Haws L, Hixon GDeVito M, Walker N, Kuriakose L, Harris M, Birnba0um L, Wikoff D. 2013. Development of weighted distributions of relative potency estimates for dioxin-like compounds. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

View Abstract

Kreider ML, Unice KM, Panko JM. Framework for quantitative exposure assessment of nanostructured materials in occupational settings. Presented at the TechConnect World 2013 — Nanotech, Microtech, Biotech, Cleantech Joint 2013 Conferences, Washington, DC, May 12–15, 2013.

Panko JM, Kreider NK, Unice KM. Tire industry project — An industry-wide product sustainability initiative. Session: Stewardship & Sustainability, Presentation at The American Industrial Hygiene Conference & Exposition (AIHce) in Montreal, Quebec, May 20, 2013.

Avens HJ, Gross S, Banducci AM, Sahmel J, Tvermoes BE, Panko JM. Characterization of surface spills associated with hydraulic fracturing operations. Session: Oil and Gas, Presentation at The American Industrial Hygiene Conference & Exposition (AIHce) in Montreal, Quebec, May 21, 2013.

Kingsbury T, Gauthier AM, Ferracini TV, Panko JM, Perez AL. Predicting chemistries targeted for deselection: A case study with triclosan. Session: Stewardship & Sustainability. Poster at The American Industrial Hygiene Conference & Exposition (AIHce) in Montreal, Quebec, May 21, 2013.

Gauthier AM, Kingsbury T, Ferracini TV, Panko JM. Beyond the standards: Comparing sustainability reports of consumer products companies. Session: Stewardship & Sustainability. Poster at The American Industrial Hygiene Conference & Exposition (AIHce) in Montreal, Quebec, May 21, 2013.

Tosiano MA, Panko JM, Scott PK. Risk based evaluation of the chemical constituents in hydraulic fracturing fluid using the chemical disclosure registry FracFocus. Poster at Society of Environmental Toxicology and Chemistry, 34th Annual Meeting, Nashville, TN, November 11–14, 2013.

Hitchcock KM, Shay ED, Panko JM. Making product and chemical safety decisions from varying stakeholder viewpoints. Poster platform presentation at Society of Environmental Toxicology and Chemistry, 34th Annual Meeting, Nashville, TN, November 11–14, 2013.

Shay EC, Panko JM. Community-focused remediation and risk assessment at a former manufactured gas plant site. Poster at Society of Environmental Toxicology and Chemistry, 34th Annual Meeting, Nashville, TN, November 11–14, 2013.

Brorby GP, Sheehan PJ, Berman DW, Bogen KT, Holm SE. 2013. Exposures from chrysotile-containing joint compound: Evaluation of new model relating respirable dust to fiber concentrations. Risk Analysis 33(1): 161-176.

View Abstract

Urban JD, Thompson CM, Deskin R, Waite M, Haws LC. 2013. Development of an oral cancer slope factor for acrylamide based on tumors relevant to humans. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

View Abstract

Panko JM, Chu J, Kreider ML, Unice KM. 2013. Measurement of airborne concentrations of tire and road wear particles in urban and rural areas of France, Japan, and the United States. Atmos Environ 72:192–199.

View Abstract

Gross SA, Avens HJ, Banducci AM, Sahmel J, Panko JM, Tvermoes BE. 2013. Analysis of BTEX groundwater concentrations from surface spills associated with hydraulic fracturing operations. J Air Waste Manage Assoc 63(4):424–432.

View Abstract

Kreider ML, Burns AM, DeRose GH, Panko JM. 2013. Protecting workers from risks associated with nanomaterials: Part II — Best practices in risk management. Occup Safety Health 82(9):20–24.

View Abstract

Kreider ML, Burns AM, DeRose GH, Panko JM. 2013. Protecting workers from risks associated with nanomaterials: Part I — Exposure assessment. Occup Safety Health 82:7.

View Abstract

Unice KM, Kreider ML, Panko JM. 2013. Comparison of tire and road wear particle concentrations in sediment for watersheds in France, Japan, and the United States by quantitative pyrolysis GC/MC analysis. Environ Sci Technol 47(15):8138–8147.

View Abstract

Urban JD, Carakostas MC, Brusick, DJ. 2013. Steviol glycoside safety: Is the genotoxicity database sufficient? Food Chem Toxicol 51:386-390.

View Abstract

Thompson CM, Kirman CR, Proctor DM, Suh M, Hays SM, Haws LC, Harris MA. 2013. A chronic oral reference dose for hexavalent chromium. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

View Abstract

Thompson CM, Gaylor DW, Tachovsky JA, Perry C, Carakostas MC, Haws LC. 2013. Development of a chronic noncancer oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling. J Appl Toxicol 33(12):1395-1406.

View Abstract

Proctor DM, Suh M, Thompson CM, Harris MA. 2013. Mode of action evaluation for hexavalent chromium-induced lung cancer. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

View Abstract

Kirman CR, Thompson CM, Proctor DM, Suh M, Haws LC, Harris MA, Hays SM. 2013. Using PBPK modeling to address diurnal variation and age differences in hexavalent chromium toxicokinetics in humans. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

View Abstract

2012

Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Mariggio MA, Onofrj M, Thomas A, Li H, Mangold JE, Signore AP, Demarco U, Demady DR, Nabili P, Lazrove E, Smith PJS, Gribkoff VK, Jonas EA. 2012. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res 1446:1–11.

View Abstract

Kirman, CR, Hays, SM, Aylward, LL, Suh, M, Harris, MA, Thompson, CM, Haws, LC, Proctor, DM. 2012. Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium. Chem Biol Interact 200(1):45-64.

View Abstract

Brorby G, Proctor D, Perry C, Fitzgerald L, Tachovsky A. 2012. Probabilistic risk assessment of human exposure to iron and steel slag. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Drechsel DA, Estevez AG, Barbeito L, Beckman JS. 2012. Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS. Neurotoxicol Res 22(4):251–264.

View Abstract

Doepker CL, Maier A, Willis A, Hermansky S. 2012. Toxicology of flavors in the food industry. Chapter 7 In: Bingham E, Cohrssen B., eds. Patty’s Toxicology, Sixth ed. New York: Wiley & Sons.

Kopec AK, Thompson CM, Kim S, Forgacs AL, Zacharewski TR. 2012. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelium. Toxicol Appl Pharmacol 262(2):124-138.

View Abstract

Finch G, Mounho B. 2012. Development of biosimilar products: Overview of standards and regulations. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Katyal A, Petrisor IG. 2012. Innovative sustainable drought management strategy incorporating forensic techniques and policy framework. Environ Foren 13(2):122–139.

View Abstract

Wikoff DW, Fitzgerald LBirnbaum L. 2012. Persistent organic pollutants: An overview. In: Schecter, A. (ed.), Dioxins and Health Including Other Persistent Organic Pollutants and Endocrine Disruptors, 3rd edition. John Wiley & Sons, Inc., pp. 1-35.

Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DMHarris MAHaws LCThompson CM. 2012. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water. Toxicol Appl Pharmacol 259(1):13-26.

View Abstract

Harris MA, Thompson CM, Wolf JC, Fedorov Y, Hixon JG, Proctor DM, Suh M, Haws LC. 2012. Assessment of genotoxic potential of Cr(VI) in the intestine via in vivo intestinal micronucleus assay and in vitro high content analysis in differentiated and undifferentiated caco-2. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Proctor DMSuh M, Aylward LL, Kirman CR, Harris MAThompson CM, Gürleyük H, Gerads R, Haws LC, Hays SM. 2012. Hexavalent chromium reduction kinetics in rodent stomach contents. Chemosphere 89(5): 487-493.

View Abstract

Haws L, Fitzgerald L, Burkhalter K, Wikoff D. 2012. US EPA’s proposed toxicity values for TCDD: Implications for decision-making regarding the safety of foods in the United States. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Thompson CM, Fedorov Y, Brown DD, Suh MProctor DM, Kuriakose L, Haws L, Harris MA. 2012. Assessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysis. PLoS ONE 7(8): e42720.

View Abstract

Hays SM, Kirman C, Aylward L, Suh M, Proctor D. 2012. Gastric reduction of Cr(VI) in mice, rats and humans. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Suh M, Ke JG, Hixon G, Proctor DM. Urinary perchlorate, nitrate, thiocyanate and thyroid hormone levels in participants of National Health and Nutrition Examination Survey (NHANES) 2001-2002. Presented at the International Society of Environmental Epidemiology’s 24th Annual Meeting, Columbia, SC, August 26-30, 2012.

Panko JM. Evaluation of the potential aquatic toxicity of TRWP to algae, daphnids and fish. Tire Technology Expo, Cologne, Germany, February 14–16, 2012.

Panko JM, Zöller M, Tartaglino U, Peters F, Unice KM, Kreider ML, Crawford M. Tire and road wear particles: A comprehensive evaluation of environmental health issue. Tire Technology Expo, Cologne, Germany. February 14, 2012.

Panko JM. Ambient air quality associated with hydraulic fracturing operations. Presented at the 21st Annual Business and Industry’s Sustainability and Environmental Health & Safety Symposium, Cincinnati, OH, March 27, 2012.

Kreider ML, Panko JM, Finley BL. 2012. Effects of subacute inhalation exposure to tire and road wear particles in rats. Presented at the 2012 Health Effects Institute (HEI) Annual Conference, Chicago, IL, April 15–17, 2012.

Hitchcock K, Scott PK, Unice KM, Panko JM. Comparing the chemical footprint of hydraulic fracturing fluids used in natural gas extraction. Presented at the 6th SETAC World Congress and 22nd Annual SETAC Europe Meeting, Berlin, Germany, May 20–24, 2012.

Unice KM, Chu J, McAtee BL, Panko JM. Evaluation of tire and road wear particles in the Seine River watershed: A sustainability initiative of the global tire industry. Presented at the 6th SETAC World Congress and 22nd Annual SETAC Europe Meeting, Berlin, Germany, May 20–24, 2012.

Kreider ML, Panko JM. Effects of subacute inhalation exposure to tire and road wear particles in rats. Presented at Eurotox 2012, Stockholm, Sweden, June 17–20, 2012.

Unice KM, Chu J, Panko JM. Evaluation of tire and road wear particles in the Yodo River watershed: A global tire industry sustainability initiative. Presented at SETAC Asia/Pacific 2012 Meeting, Kumamoto, Japan, September 24–27, 2012.

Unice KM, Panko JM. Analytical method development and validation of a pyrolysis-GC/MS method to quantify tire and road wear particles in environmental samples. Presented at SETAC Asia/Pacific 2012 Meeting, Kumamoto, Japan, September 24–27, 2012.

Kreider ML, Unice KM, Panko JM. A case study in understanding exposure associated with nanostructured materials: Carbon black and amorphous silica. Presented at SETAC Asia/Pacific 2012 Meeting, Kumamoto, Japan, September 24–27, 2012.

Hitchcock KM, Panko JM, Scott PK, Unice KM, Shay EC. Responding to community concerns surrounding hydraulic fracturing activities near a school. SETAC North America 33rd Annual Meeting, Long Beach, CA, November 11–15, 2012.

Sahmel J, Cowan DM, Panko JM, Paustenbach DJ. 2012. Future trends in risk management: Control banding and REACH. Chapter 19 in: Perkins J, Gray C. (eds). Modern Industrial Hygiene, Volume III: Control of Chemical Agents, Part IV: Risk Management. ACGIH, Cincinnati, OH, pp. 727–764.

Hitchcock KM, Panko JM, Scott PK. 2012. Incorporating chemical footprint reporting into social responsibility reporting. Integr Environ Assess Manag 8(3):386–388.

View Abstract

Thompson CM, Hixon JG, Proctor DM, Haws LC, Suh M, Urban JD, Harris MA. 2012. Assessment of genotoxic potential of Cr(VI) in the mouse duodenum: An in silico comparison with mutagenic and nonmutagenic carcinogens across tissues. Regul Toxicol Pharmacol 64(1): 68-76.

View Abstract

Hixon JG, Proctor D. 2012. Use of constrained logistic regression models for the dose-response analysis of beryllium sensitization and chronic beryllium disease with mean exposure. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Panko JM, Kreider ML, McAtee BL, Marwood C. 2012. Chronic toxicity of tire and road wear particles to water- and sediment-dwelling organisms. Ecotoxicology 22(1):13–21, doi: 10.1007/s10646-012-0998-9.

View Abstract

Kreider ML, Doyle-Eisele M, Russell RG, McDonald JD, Panko JM. 2012. Evaluation of potential for toxicity from subacute inhalation of tire and road wear particles in rats. Inhal Toxicol 24(12):907–917.

View Abstract

Unice KM, Kreider ML, Panko JM. 2012. Use of a deuterated internal standard with pyrolysis-GC/MS dimeric marker analysis to quantify tire tread particles in the environment. Int J Environ Res Pub Health 9:4033–4055.

View Abstract

Thompson CMProctor DMSuh MHaws LC, Hebert CD, Mann JF, Shertzer HG, Hixon JG, Harris MA. 2012. Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: Implications for carcinogenic modes of action. Toxicol Sci 125(1):79-90.

View Abstract

Kim S, Kopec A, Forgacs AL, Thompson CM, Zacharewski T. 2012. Genome-wide gene expression analysis of Cr(VI) effects in Fisher rat small intestinal epithelium. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Thompson CMProctor DM, Harris MA. 2012. Duodenal GSH/GSSG ratios in mice following oral exposure to Cr(VI). Toxicol Sci 126(1):287-288.

View Abstract

Kirman CR, Hays SM, Aylward LL, Suh M, Proctor D. 2012. Physiologically-based pharmacokinetic model for mice, rats and humans orally-exposed to chromium. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Berman DW, Brorby GP, Sheehan PJ, Bogen KT, Holm SE. 2012. More on the dynamics of dust generation: The effects of mixing and sanding chrysotile, calcium carbonate, and other compounds on the characteristics of joint-compound dusts. Ann Occup Hyg 56(7):852-867.

View Abstract

Kopec A, Forgacs AL, Kim S, Thompson CM, Zacharewski T. 2012. Comparative toxicogenomic analysis of Cr(VI) effects in rat and mouse small intestine. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Fowler, JC, Bhattacharya S, Urban JD, Vaidehi N, Mailman RB. 2012. Receptor conformations involved in dopamine D2L receptor functional selectivity induced by selected transmembrane 5 serine mutations. Mol Pharmacol 81(6):820-831.

View Abstract

Mounho B. 2012. Overview of the history and development of regional guidelines for the approval of biosimilar products. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Henderson RG, Durando J, Oller A, Merkel DJ, Marone PA,  Bates HK. 2012. Acute oral toxicity of nickel compounds. Regul Toxicol Pharmacol 62(3):425-432.

View Abstract

O’Brien TJ, Hao D, Suh M, Proctor D, Thompson CM, Harris MA, Parsons BL, Meyers MB. 2012. K-ras codon 12 GGT to GAT mutation is not elevated in the duodenum of mice subchronically exposed to hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Henderson RG, Cappellini D, Seilkop SK, Bates HK, Oller AR. 2012. Oral bioaccessibility testing and read-across hazard assessment of nickel compounds. Regul Toxicol Pharmacol 63(1):20-28.

View Abstract

Perry C, Tachovsky JA, Ke M, Urban J, Haws L. 2012. Natural gas exploration and production in the Barnett Shale: Assessment of exposures to volatile organic compounds (VOCs). Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Urban J, Budinsky R, Rowlands J. 2012. An evaluation of single nucleotide polymorphisms in the human heat shock protein 90kDa alpha and beta isoforms. Drug Metab Pharmacokinet 27(2):268-278.

View Abstract

Proctor DM, Thompson CM, Suh M, Haws LC, Harris MA. 2012. Mode of action for intestinal carcinogenesis of ingested hexavalent chromium in mice. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Thompson CM, Hixon JG, Kopec AK, Harris MA, Proctor DM, Haws LC. 2012. Assessment of genotoxic potential of Cr(VI) in the mouse duodenum via toxicogenomic profiling. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Urban J, Rowlands JC, Budinsky R, Dombkowski A, Thompson CM, Thomas RS. 2012. A genomics-based benchmark dose analyses of relative potencies of dioxin-like compounds in primary rat hepatocytes. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Wikoff D, DeVito M, Walker N, Hixon G, Harris M, Tachovsky A, Birnbaum L, Haws L. 2012. Application of machine learning in the development of a weighting framework for evaluating eEstimates of relative potency for dioxin-like compounds. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

View Abstract

Mounho B. 2012. Regulatory standards for the approval of biosimilar products: A global review. Presented in Münster, Germany, May 23.

Mounho B. 2012. History and review of regulatory pathways for the approval of biosimilar products. Presented at Applied Pharmaceutical Toxicology Annual Meeting, May 17, Baltimore, MD.

2011

Thompson CPerry C, Gaylor D, Tachovsky A, Burkhalter B, Haws L. 2011. Derivation of an oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Thompson CM, Proctor DM, Haws LC, Hebert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG,  Zacharewski TR, Harris MA. 2011. Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium. Toxicol Sci 123(1): 58-70.

View Abstract

Bogen KT, Brorby GP, Berman DW, Sheehan PJ, Floyd M.  2011. Measuring mixed cellulose ester (MCE) filter mass under variable humidity conditions.  Ann Occup Hyg 55(5)485-494.

View Abstract

Mounho B. 2011. Definitions and standards for the approval of biosimilar products. Presented at American College of Toxicology Annual Meeting, November, Phoenix, AZ.

Urban J, Fitzgerald LBurkhalter B, Staskal D, Harris M, Haws L. 2011. BTEX serum levels in the general U.S. population: An analysis of 2003-2004 NHANES dataset. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Cantu D, Fulton RE, Drechsel DA, Patel M. 2011. Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and hydrogen peroxide. J Neurochem 118(1):79–92.

View Abstract

Thompson CM, Haws LC, Harris MA, Gatto NM, Proctor DM. 2011. Application of the U.S. EPA mode of action framework for purposes of guiding future research: A case study involving the oral carcinogenicity of hexavalent chromium. Toxicol Sci 119(1):20-40.

View Abstract

Bussiere J, Leach M, Price K, Mounho B, Lightfoot-Dunn R. 2011. Survey results on the use of the tissue cross-reactivity immunohistochemistry assay. Reg Toxicol Pharm 59(3):493-505.

View Abstract

Diliberto JJ, Sirinek L, Burkhalter B, Wikoff DS, Hixon G, Becker J, Patterson DG, Turner W, Tachovsky JA, Birnbaum LS, Haws LC. 2011. Endometriosis in a cohort of women living in the Kanawha River Valley in West Virginia: Blood levels of non-dioxin-like PCBs and relationship with BMI and age. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Oller A, Henderson RG. 2011. Bioaccessibility testing and its application to read-across for hazard assessment and risk characterisation of metals. Annual meeting of the Belgian Society for Toxicology and Ecotoxicology (BelTox).

Brorby GP, Sheehan PJ, Berman DW, Bogen KT, Holm SE. 2011. Potential artifacts associated with historical preparation of joint compound samples and reported airborne asbestos concentrations.  J Occup Environ Hyg 8(5):271–278.

View Abstract

Haws LC, DeVito MJ, Walker NJ, Harris MA, Tachovsky JA, Birnbaum LS, Farland WH, Wikoff DS. 2011. Development of a consensus-based weighting framework for evaluating estimates of relative potency for dioxin-like compounds that includes consideration of data from human cells. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Semeraro A, Patriarca M, Taylor A, Henderson R, Bates H. 2011. Nickel kinetics after oral exposure: Urinary excretion. IUPAC 4th International Symposium for Trace Elements in Food.

Haws LC, Fitzgerald LBurkhalter B, Harris M, Wikoff DS. 2011. Assessment of the US EPA’s proposed toxicological values for TCDD for regulation of dioxin-like compounds in foods: Bridging the science divide in a global market. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Gujral JS, Proctor DM, Su SH, and Fedoruk JM. 2011. Water adherence factors for human skin. Risk Analysis 31(8):1271-1280.

View Abstract

Rowlands JC, Urban J, Wikoff DS, Budinsky R. 2011. The presence and estimated functional effect of single nucleotide polymorphisms at the AIP, ARNT, HSP90AA1, AND HSP90AB1 loci in the human population. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Kreider ML, Panko JM, McDonald JD, McAtee BL, Finley BL, Seagrave J. Effects of intratracheal instillation of tire and road wear particles (TRWP) and tread particles (TP) on inflammation and cytotoxicity in rat lung: A comparative toxicity study. Society of Toxicology Annual Meeting, Baltimore, MD, March 2011.

Grespin ME, Le MH, Panko JM. Safety data sheet alteration during alignment with the Globally Harmonized System of Classification (GHS) and implications for chemical manufacturers, suppliers and distributors. Society for Risk Analysis Annual Meeting, Charleston, SC, December 2011.

Hitchcock KM, Panko JM, Scott PK. The chemical footprint: An emerging indicator of environmental performance. Society for Environmental Toxicology and Chemistry, Boston, MA, November 2011.

Gaffney SH, Panko JM, Unice KM, Burns AM, Kreider ML, Gelatt RH, Booher LE, Paustenbach DJ. 2011. Occupational exposure to benzene at the ExxonMobil refinery in Baytown, TX (1978-2006). J Exp Sci Environ Epidemiol 21:169–185.

View Abstract

Marwood C, McAtee BL, Kreider ML, Ogle RS, Finley BL, Sweet LI, Panko JM. 2011. Acute aquatic toxicity of tire and road wear particles to alga, daphnid and fish. Ecotoxicology 20:2079, doi: 10.1007/s10646-011-0750-x.

View Abstract

Panko JM, Hitchcock KM. 2011. Chemical footprint: Enduring product sustainability. EM: AWMA Magazine for Environ Managers, December:12–15.

View Abstract

Miletich J, Eich G, Grampp G, and Mounho B. 2011. Guiding principles for a global “patients first” standard. mAbs 3(3):318-325.

View Abstract

Thomas RS, Rowlands JC, Budinsky RA, Thompson CM, Urban JD. Dombkowski, A. 2011. Genomic approaches for relative potency assessment. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Rowlands JC, Urban JD, Wikoff DS, Budinsky RA. 2011. An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor-interacting protein (AIP) gene. Drug Metab Pharmacokinet 26(4):431-439.

View Abstract

Wikoff DS, Thompson C, Walker N, DeVito M, Harris M, Birnbaum L, Haws L. 2011. Derivation of relative potency estimates using benchmark dose modeling: A case study with TCDF. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Sheehan PJ, Brorby GP, Berman DW, Bogen KT, Holm SE. 2011. Chamber for testing asbestos-containing products:  Validation and testing of a re-created chrysotile-containing joint compound.  Ann Occup Hyg 55(7):797-809.

View Abstract

Budinsky R, Urban J, Rowlands JC. 2011. An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor nuclear translocator gene. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Ceder R, Merne M, Nilsson J-A, Staab C, Höög J-O, Thompson CM, Grafström RC. 2011.  Toxicogenomic profiling of formaldehyde-exposed normal and transformed human oral keratinocytes. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Fitzgerald LBurkhalter B, Urban J, Staskal D, Harris M, Haws L. 2011. VOC serum levels in the general U.S. population: An analysis of the 2003-2004 NHANES dataset. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Haws L, Proctor D, Thompson C, Harris M. 2011. Research plan to fill data gaps in the mode of action for cancer risk assessment of hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Tichomirowa MA, Bariler A, Daly AF, Jaffrain-Rea M-L, Ronchi CL, Yaneva M, Urban JD, Petrossians P, Elenkova AP, Tabarin A, Desailloud R, Maiter D, Schürrmeyer T, Cozzi R, Theodoropoulou M, Sievers C, Bernabeu I, Naves LA, Chabre O, Fajardo Montañana C, Hana V, Halaby G, Delemer B, Labarta JI, Sonnet E, Ferrandez A, Hagelstein MTS, Caron P, Stalla GK, Bours V, Zacharieva S, Spada A, Brue T, Beckers A. 2011. High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas. Eur J Endocrinol 165(4):509-515.

View Abstract

Urban JD, Rowlands JC, Budinsky RA. 2011. Single nucleotide polymorphisms in the human aryl hydrocarbon receptor nuclear translocator (ARNT) gene. Drug Metab Pharmacokinet 26(6):637-645.

View Abstract

Henderson RG, Cappellini D, Seilkop S, Oller A, Bates H. 2011. Bioaccessibility-based read-across assessment of nickel compounds for oral systemic toxicity. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Wilson VS, Keshava N, Hester S, Segal D, Chiu W, Thompson CM, Euling SY. 2013. Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment. Toxicol Appl Pharmacol 271:299–308.

View Abstract

Kim S, Thompson CM, Kopec AK, Harris MA, Zacharewski TR. 2011. Comparison of basal and CrVI-mediated solute carrier gene expression in rodent duodenal epithelium. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Buckley L, Chapman K, Burns Naas LA, Todd M, Martin P, Lansita J. 2011. Considerations regarding nonhuman primate use in safety assessment of biopharmaceuticals. Int J Toxicol 30(5):583-590.

View Abstract

Proctor D, Haws L,Thompson C, Harris M. 2011. Use of mode of action and pharmacokinetics to inform the cancer risk assessment of ingested Cr(VI): A case study. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, 2011. Washington, D.C.

View Abstract

Proctor D, Meek B. 2011. Using mode of action data to guide quantitative cancer risk assessment: A case study of hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Staskal-Wikoff D, Budinsky R, Rowlands JC. 2011. Single nucleotide polymorphisms in the human aryl hydrocarbon receptor interacting protein (AIP) gene from six ethnic populations. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

View Abstract

Franke K, Paustenbach D. 2011. Government and Navy knowledge regarding health hazards of asbestos: A state of the science evaluation (1900 to 1970). Inhal Toxicol 23(S3):1–20.

View Abstract

2010

Harris M, Tachovsky JA, Staskal-Wikoff D, Aylward L, Burkhalter B, Simon T, Haws L. 2010. Serum concentrations of dioxin-like compounds in a population in Midland, Michigan: An evaluation of the impact of soil exposures. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Johns DO, Owens EO, Thompson CM, Sonawane B, Hattis D, Krishnan K. 2010. Physiological parameters and databases for PBPK modeling. Chapter 5 in: Quantitative Modeling in Toxicology. Krishnan K, Andersen M (eds.). Wiley, p. 107.

View Abstract

Drechsel DA, Patel M. 2010. Respiration-dependent hydrogen peroxide removal in brain mitochondria via the thioredoxin/peroxiredoxin system. J Biol Chem 285(36):27850–27858.

View Abstract

Harris M, Tachovsky JA, Staskal-Wikoff D, Simon T, Burkhalter B, Urban J, Haws L. 2010. Assessment of the impact of various soil cleanup levels on serum concentrations of dioxin-like compounds in humans. Presented at the 49th Annual Meeting of Society of Toxicology. March 7-11, Salt Lake City, Utah.

Birnbaum LS, Staskal-Wikoff D. 2010. 5th International PCB Workshop–Summary and implications. Environ Int 36(8):814-818.

View Abstract

Knox AS, Petrisor IG, Turick CE, Roberts J, Paller MH, Reible D, Forrest CR. 2010. Life span of biopolymer sequestering agents for contaminant removal and erosion resistance. In: Biopolymers (Ed. by M. Elnashar), INTECH, ISBN 978-953-307-109-1, DOI: 10.5772/10259.

View Abstract

Haws L. 2010. Biomonitoring – A tool for assessing community exposures to air toxics. Presented at the Air Quality 2010 conference, hosted by the University of Texas School of Law,  November 19.

Gatto NM, Kelsh MA, Mai DH, Suh M, Proctor DM. 2010. Occupational exposure to hexavalent chromium and cancers of the gastrointestinal tract: A meta-analysis. Cancer Epidemiol 34(4):388-99.

View Abstract

Haws L, Tachovsky JA, Staskal-Wikoff D, Aylward L, Burkhalter B, Urban J, Simon T, Harris M. 2010. An evaluation of the influence of different soil cleanup levels on the concentration of dioxin-like compounds in human serum. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Mounho B, Phillips A, Holcombe K, Grampp G, Lubiniecki T, Mollup I, Jones C. 2010. Global regulatory standards for the approval of biosimilars. Food Drug Law J 65(4):819-837.

View Abstract

Haws L. 2010. Biomonitoring: The circle of life. Presented in the Oil and Gas special session, at the 22nd Annual Texas Environmental Superconference, August 5-6, Austin, TX.

Rowlands CJ, Staskal DF, GollapudI B, Budinsky R. 2010. The Human AHR: Identification of single nucleotide polymorphisms from six ethnic populations. Pharmacogenet Genomics 20(5):283-290.

View Abstract

Panko JM, Kreider ML, Ferrara J. REACH – A review of the regulation and technical components of registration. AIHA Pittsburgh Section, Pittsburgh, PA, February 28, 2010.

Kreider ML, Panko JM, McAtee BL, Sweet LI, Finley BL. 2010. Physical and chemical characterization of tire-related particles: Comparison of particles generated using different methodologies. Sci Total Environ
408(3):652–659.

View Abstract

Gaffney SH, Burns AM, Kreider ML, Unice KM, Widner TE, Paustenbach DJ, Booher LE, Gelatt RN, Panko JM. 2010. Occupational exposure at the ExxonMobil refinery in Beaumont, TX (1976-2007). Int J Hyg Environ Health 213(4):285–301.

View Abstract

Staskal-Wikoff D, Burkhalter B, Stapleton H, Harris M. 2010. PBDEs in Newark Bay sediments. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Sheehan P, Bogen KT, Hicks J, Goswami E, Brorby G, Lau E, Ott B.  2010. Benzene inhalation of parts washers:  New estimates based on measures of occupational exposure to solvent coaromatics.  Risk Analysis 30(8):1249–1267.

View Abstract

Tachovsky JA, Haws L. 2010. Application of principal components analysis and sequential gaussian simulation to a comprehensive soil sampling dataset to predict PCDD/F concentrations in Midland, MI. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Tachovsky JA, Urban JDWikoff DSHaws LC, Harris MA. 2010. Reduction of a large fish tissue analyte database: identifying and assessing data specific to a remediation site for risk assessment application. Chemosphere 80(5):481-488.

View Abstract

Mounho B. 2010. Safety evaluation of biotechnology derived products. Presented at Toxicology for Industrial and Regulatory Scientists, Sponsored by American College of Toxicology. April, Falls Church, VA.

Thompson CM, Grafström RC. 2010. Considerations for the implausibility of leukemia induction by formaldehyde. Toxicol Sci 120(1):230-232.

View Abstract

Mounho, B. 2010. General review of the types of anti-drug antibody-mediated responses that can occur in toxicology studies. Presented at the 49th Annual Meeting of Society of Toxicology, March 7-11, Salt Lake City, Utah.

Tachovsky A, Staskal DUrban J, Harris MA, Haws L. 2010. Assessment of environmental data collected in a community with numerous petroleum refining and petrochemical facilities. Presented at the 49th Annual Meeting of Society of Toxicology. March 7-11, Salt Lake City, Utah.

Thompson CM, Ceder R, Grafström RC. 2010. Formaldehyde dehydrogenase: Beyond phase I metabolism. Toxicol Lett 193(1):1-3.

View Abstract

Tachovsky JA, Haws L. 2010. Geostatistical estimation of soil PCDD/F TEQ using sequential Gaussian simulation and the aggregation of results in Midland, MI. Presented at the Society for Risk Analysis annual meeting, December 5-8, Salt Lake City, UT.

Urban JD, Tachovsky JA, Haws LC, Wikoff Staskal D, Harris MA. 2010. Response to Mugdan et al.’s comment on Urban et al. “Assessment of Human Health Risks Posed by Consumption of Fish from the Lower Passaic River, New Jersey.” Sci Tot Environ 408(6):1468-1470.

View Abstract

Urban J, Burkhalter B, Tachovsky JA, Haws L, Harris M. 2010. Evaluation of polychlorinated naphthalenes (PCNs) in Newark Bay sediment. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Urban JD, Tachovsky JA, Haws LC, Staskal DF, and Harris MA. 2010. Response to Buchanan et al.’s comment on Urban et al. “Assessment of Human Health Risks Posed by Consumption of Fish from the Lower Passaic River, New Jersey.” Sci Tot Environ 408(8):2004-2007.

View Abstract

Driscoll SK, McArdle ME, Plumlee MH and Proctor D. 2010. Evaluation of hexavalent chromium in sediment pore water of the Hackensack River, New Jersey, USA. Environ Toxicol Chem 29(3):617-20.

View Abstract

2009

Haws LC, DeVito MJ, Walker NJ, Birnbaum LS, Farland WH, Harris MA, Tachovsky JA, Unice KM, Scott PK, Staskal-Wikoff DF. 2009. Development of distributions of relative potency estimates to quantitatively assess uncertainty inherent in the TEFs for dioxin-like compounds: A proposed consensus-based weighting. Presented at Dioxin 2009, Beijing, China.

Guzelian PS, Victoroff MS, Halmes C,  James RC. 2009. Clear path: Towards an evidence-based toxicology (EBT). Human & Exp Toxicol 28:71-79.

View Abstract

Drechsel DA, Patel M. 2009. Differential contribution of the mitochondrial respiratory chain to reactive oxygen species production by redox cycling herbicides implicated in parkinsonism. Toxicol Sci 112(2):427–434.

View Abstract

Staskal-Wikoff DFHarris MAHaws LC, Birnbaum LS, Tachovsky JA. 2009. Probabilistic evaluation of cancer and non-cancer risk associated with exposure to BDE 209 in automobiles. Presented at Dioxin 2009. Beijing, China.

Oller AR, Cappellini D, Henderson RG, Bates HK. 2009. Temperature effect on nickel release in ammonium citrate.  J Environ Monit 11(9):1697-1699.

View Abstract

Urban JD, Tachovsky JA, Staskal DF, Haws LC, Harris MA. 2009. Human health risk assessment of consumption of fish from the Lower Passaic River. Presented at the 48th Annual Meeting of Society for Toxicology, March 15-19, Baltimore, MD.

Oller AR, Cappellini D, Henderson RG, Bates HK. 2009. Comparison of nickel release in solutions used for the identification of water-soluble nickel exposures and in synthetic lung fluids. J Environ Monit 11(4):823–829.

View Abstract

Mounho B. 2009. Small molecule and biological therapeutics: History and inherent differences. Presented at Cambridge Healthtech Institute’s PEGS Summit, April 6-10, Boston, MA.

Menzie CA, Ziccardi LM, Lowney YW, Fairbrother A, Shock SS, Tsuji JS, Hamai D, Proctor D, et al. 2009. Importance of considering the framework principles in risk assessment for metals. Environ Sci Technol 43(22):8478-8482.

View Abstract

Mounho B. 2009. Preclinical toxicology studies to support the development of monoclonal abs: Scientific issues and challenges. Presented at Cambridge Healthtech Institute’s PEGS Summit, April 6-10, Boston, MA.

Scott, LLF, Staskal, DF, Williams ES, Luksemburg WJ, Urban JD, Nguyen LM, Haws LC, Birnbaum LS, Paustenbach DJ, Harris MA. 2009. Levels of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in southern Mississippi catfish and estimation of potential health risks. Chemosphere 74(7):1002-10.

View Abstract

Panko JM. Case studies in sustainable packaging. Session: What’s in Your Package? Sustainable Packaging Coalition Conference, Chicago, IL, March 25, 2009.

Panko JM. Progress on a BEEL Guide for d-limonene. Roundtable #224, American Industrial Hygiene Conference and Exhibition, Toronto, ON, June 1–4, 2009.

Widner TE, Paustenbach DJ, Gaffney SH, Panko JM, Unice KM, Burns AM, Kreider ML, Gelatt R, Booher L. Airborne benzene concentrations associated with dock operations at the ExxonMobil Refinery, Baytown, Texas (1978–2007). Presentation #243, American Industrial Hygiene Conference and Exhibition, Toronto, ON, June 1–4, 2009.

Panko JM, McAtee BL, Kreider ML, Gustafsson M, Blomqvist G, Gudmundsson A, Sweet LI, Finley BL. Physio-chemical analysis of airborne tire wear particles. Eurotox 2009, Dresden, Germany, September 2009.

McAtee BL, Kreider ML, Panko JM, Sweet LI, Finley BL. Biological leaching of metals from respirable tire wear particles. Eurotox 2009, Dresden, Germany, September 2009.

Panko JM, Gaffney SH, Kreider ML, Unice KM, Burns AM, Paustenbach DJ, Booher LE, Gelatt RH. Job and task based analysis of benzene air concentrations associated with refinery operations. Benzene 2009: Health Effects and Mechanisms of Bone Marrow Toxicity; Implications for t-AML and the Mode of Action Framework, Munich, Germany, September 2009.

Unice KM, Kreider ML, McAtee BL, Panko JM. Evaluation of extractable organic zinc as a quantitative marker for tire tread particles in environmental matrices. ACS Rubber Division 176th Technical Meeting, Pittsburgh, PA, October 2009.

Harada M, Shibata T, Panko JM, Unice KM. Analysis methodology of rubber fraction in fine particles. ACS Rubber Division 176th Technical Meeting, Pittsburgh, PA, October 2009.

Williams ES, Panko JM, Paustenbach DJ. 2009. The European Union’s REACH Regulation: A review of its history and requirements. Crit Rev Toxicol 39(7):553–575.

View Abstract

Panko JM, Gaffney SH, Burns AM, Unice KM, Kreider ML, Booher LE, Gelatt RH, Marshall JR, Paustenbach DJ. 2009. Occupational exposure to benzene at the ExxonMobil Refinery at Baton Rouge, Louisiana (1977–2005). J Occup Environ Hyg 6:517–529.

View Abstract

Mounho B. 2009. Scientific challenges in preclinical studies to support the clinical development of biologics. Presented at Cambridge Healthtech Institute’s Molecular Medicine Tri-Conference, February 25-27, San Francisco, CA.

Thompson CM, Grafstrom RC. 2009. Commentary: Mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma. Environ Health 8:53.

View Abstract

Mounho B. 2009. Preclinical development of biologics. Presented at Cambridge Healthtech Institute’s Molecular Medicine Tri-Conference, February 25-27, San Francisco, CA.

Thompson CM, Sonawane B, Grafström RC. 2009. The ontogeny, distribution and regulation of alcohol dehydrogenase 3: Implications for pulmonary physiology. Drug Metab Disposit 37(8):1565-1571.

View Abstract

Mounho B. 2009. Comparability challenges: Regulatory and scientific issues in the assessment of biopharmaceuticals. Presented at Drug Information Association Meeting.

Thompson CM, Johns DO, Sonawane S, Barton HA, Hattis D, Tardif R, Krishnan K. 2009. Database for physiologically based pharmacokinetic (PBPK) modeling: Physiological parameters for healthy and health-impaired elderly. J Toxicol Environ Health, Part B 12:1–24.

View Abstract

Mounho B. 2009. Nonclinical safety assessment studies to support manufacturing process changes for Vectibix®. Presented at Drug Information Association Meeting.

Urban, JD, Tachovsky JA, Staskal DF, Haws LC, Harris MA. 2009. Assessment of human health risks posed by consumption of fish from the Lower Passaic River, New Jersey. Sci Total Environ 408(2):209-224.

View Abstract

2008

Demady DR. 2008. Practical considerations in the design of preclinical safety assessments for biopharmaceuticals. Ch 38 in Cavagnaro JA (ed). Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials,1st ed. Wiley, New York, pp. 913–930.

Harris MA, Shay E, Unice KM, Scott LF, Haws LC. 2008. Preliminary evaluation of health risks posed by PCDD/Fs and PCBs from the ingestion of fish from the Lower Passaic River. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Proctor, D. 2008Hexavalent chromium. In: Encyclopedia of Quantiative Risk Analysis and Assessment, Melnick E, Everitt B. (eds.). Wiley.

Drechsel DA, Patel M. 2008. Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson’s disease. Free Radic Biol Med 44(11):1873–1886.

View Abstract

Harris MATachovsky JA, Williams ES, Paustenbach DP, Haws LC. 2008. Assessment of the health risks posed by benzene in soft drinks. Presented at the Society of Toxicology Annual Meeting, March 16-20, Seattle, WA.

DeWoskin RS, Thompson CM. 2008. Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants. Regul Toxicol Pharmacol 51:66–86.

View Abstract

Petrisor IG, Wells J. 2008. Perchlorate – Is nature the main manufacturer? In: Issues in Environmental Science and Technology, Vol. 26: Environmental Forensics. Ed. by R.E. Hester and R.M. Harrison, RSC Publishing, Royal Society of Chemistry, 105–129.

Petrisor IG, Wells J. 2008. Tracking chlorinated solvents in the environment. In: Issues in Environmental Science and Technology, Vol. 26: Environmental Forensics. Ed. by R.E. Hester and R.M. Harrison, RSC Publishing, Royal Society of Chemistry, 130–152.

Haws LC, Unice KM, Tachovsky AT, Harris MA, DeVito MJ, WalkerNJ, Birnbaum LS, Farland WH, Nguyen L, Staskal DF. 2008. Assessment of the impact of using weighted distributions of REPs to develop exposure estimates for dioxin-like compounds. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Donovan E, Unice K, Roberts JD, Harris M, Finley B. 2008. Risk of gastrointestinal disease associated with exposure to pathogens in the water of the Lower Passaic River. Appl Environ Microbiol 74:994-1003.

View Abstract

Haws LC, DeVito MJ, Walker NJ, Birnbaum LS, Unice KM, Scott PK, Harris MATachovsky A, Farland WH, Finley BF,  Staskal DF. 2008. Development of weighted distributions of REPs for dioxin-like compounds: Implications for risk assessment. Presented at the Society of Toxicology Annual Meeting, March 16-20, Seattle, WA.

Donovan EP, Staskal DF, Unice KM, Roberts JD, Haws LC, Finley BL, and Harris MA. 2008. Risk of gastrointestinal disease associated with exposure to pathogens in the sediments of the Lower Passaic River. Appl Environ Microbiol 74:1004-1018.

View Abstract

Haws LCTachovsky JA, Williams ES, Scott LF, Paustenbach D, Harris MA. 2008. Assessment of potential human health risks posed by benzene in beverages. J Food Sci 73(4):T33-T41.

View Abstract

Scott LLF, Staskal DFHarris MA, Finley BL, Haws LC. 2008. Evaluation of dioxin-like compounds in workers from a primary magnesium production facility relative to levels observed in the general US population. Presented at the Society of Toxicology Annual Meeting, March 16-20, Seattle, WA.

Panko JM, Gaffney SH, Unice KM, Kreider ML, Burns AM, Widner TE, Booher LE, Gelatt GL, Paustenbach DJ. Benzene exposures of refinery workers: Baytown, TX (1978-2006). American Industrial Hygiene Conference and Exhibition, June 2008.

Kreider ML, McAtee BL, Sweet LI, Panko JM, Finley BL. Physical and chemical characterization of tire-related particles: Comparison of particles generated using different methodologies. Paper #41, Fall 174th Technical Meeting of the Rubber Division of the American Chemical Society, Louisville, KY, October 2008.

Panko JM, Kreider ML, Sweet LI, McAtee BL, Finley BL. Methods for collecting tire wear particles. Paper #40, Fall 174th Technical Meeting of the Rubber Division of the American Chemical Society, Louisville, KY, October 2008.

Gaffney SH, Kreider ML, Unice KM, Burns AM, Paustenbach DJ, Booher LE, Gelatt RH, Panko JM. Benzene exposure in refinery workers (1976-2006). Abstract #864, International Society for Environmental Epidemiology & International Society of Exposure Analysis 2008 Joint Annual Conference, Pasadena, CA, October 12–16, 2008.

James HR, Barfield L, Britt JK, James RC. 2008. Worker exposure to secondhand smoke: Evaluating a prediction model. Prof Saf Sep:34-44.

View Abstract

Staskal DF, Donovan EP, Haws LC, Roberts JD, Unice KM, Finley BL, Harris MA. 2008. Human health risks associated with exposure to pathogens in waters and sediments of the Lower Passaic River. Presented at the Society of Toxicology Annual Meeting. March 16-20, Seattle, WA.

Makris SL, Thompson CM, Euling SY, Selevan SG, Sonawane B. 2008. A lifestage-specific spproach to hazard and dose-response characterization for children’s health risk assessment. Birth Defects Res Part B 83:530–546.

View Abstract

Staskal DF. 2008. Roundtable: Case study on the risks and benefits of DecaBDE, a major brominated flame retardant. Presented at the Society of Toxicology Annual Meeting, March 16-20, Seattle, WA.

Richardson VM, Staskal DF, Ross DG, Diliberto JJ, Devito MJ, Birnbaum LS. 2008. Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. Toxicol Appl Pharmacol 226(3):244-250.

View Abstract

Staskal DFTachovsky JAHarris MAHaws LC. 2008. Preliminary evaluation of human health risk associated with exposure to PBDEs in the United States. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Scott LLF, Harris MA, Unice KM, Scott P, Nguyen LM, Haws LC, and Paustenbach D. 2008. Addendum to: Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001-2002 National Health and Nutrition Examination Survey of the United States population. J Exp Sci Env Epidemiol 18(5):524-532.

View Abstract

Tachovsky JAHarris MAStaskal DF, Scott LF, Luksemburg WJ, Paustenbach DP, Haws LC. 2008. Analysis of fish tissue concentrations of dioxins and furans using principal components analysis. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Scott PK, Proctor D. 2008. Soil suspension/dispersion modeling methods for estimating health-based soil cleanup levels of hexavalent chromium at chromite ore processing residue sites. J Air Waste Manag Assoc 58(3): 384-403.

View Abstract

Tachovsky JAStaskal DFHarris MA, Scott LF, Luksemburg WJ, Paustenbach DP, Haws LC. 2008. Principal components analysis of PBDE concentrations in fish tissue from southern Mississippi. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Staskal DF, Scott LLF, Haws LC, Luksemburg WJ, Birnbaum LS, Nguyen LM, Urban JD, Williams ES, Paustenbach DJ, Harris MA. 2008. Assessment of polybrominated diphenyl ether exposures and health risks associated with consumption of southern Mississippi catfish. Environ Sci Technol 42(17):6755-6761.

View Abstract

Urban JDHaws LCStaskal DF, Scott LF, Scott PS, Tachovsky AT, Unice KM, Harris MA. A framework for evaluating serum dioxin data derived from biomonitoring studies. Presented at Dioxin 2008, August 17-22, 2008. Birmingham, England.

Subramaniam RP, Chen C, Crump KS, Devoney D, Fox JF, Portier CJ, Schlosser PM, Thompson CM, White P. 2008. Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: Identification of key issues. Risk Analysis 28(4):907–923.

View Abstract

Thompson CM, Subramaniam RP, Grafström RC. 2008. Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde. Toxicol Appl Pharmacol 233(3):355–359.

View Abstract

Thompson CM, Sonawane B, Barton HA, DeWoskin RS, Schlosser P, Lipscomb JC, Chiu W, Krishnan K. 2008. Approaches for applications of physiologically based pharmacokinetic models in risk assessment. J Toxicol Environ Health, Part B 11(7):519–547.

View Abstract

Williams CW, Perry CS. 2008. Risk assessment for arsenic on indoor surfaces. Presented at the Society for Risk Analysis annual meeting, December 7-10, Boston, MA.

DeSesso JM, Watson RE, Keen CL, Hazelden KP, Haws LC, Li AA. 2008. Analysis and integration of developmental neurotoxicity and ancillary data into risk assessment: A case study of dimethoate. J Toxicol Environ Health A 72(2):94-109.

View Abstract

2007

Balouet J-C, Oudijk G, Smith K, Petrisor IG, Grudd H, Stocklassa B. 2007. Applied dendroecology and environmental forensics. Characterizing and age dating environmental releases: Fundamentals and case studies. Environ Foren 8(1):1–17.

View Abstract

Ferriby LL, Knutsen JS, Harris MA, Unice KM, Scott P, Nony P, Haws LC, and Paustenbach D. 2007. Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001-2002 National Health and Nutrition Examination Survey of the United States Population. J Exp Sci Environ Epidemiol 17:358-371.

View Abstract

Britt, J.K. and R.C. James. Toxicology. In: Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc., Hoboken, NJ. pp. 201-252,  2007.

Sampey BP, Carbone DL, Doorn JA, Drechsel DA, Petersen DR.  2007. 4-Hydroxy-2-nonenal adduction of extracellular signal-regulated kinase (Erk) and the inhibition of hepatocyte Erk-Est-like protein-1-activating protein-1 signal transduction. Molec Pharmacol 71(3):871883.

View Abstract

Drechsel DA, Liang LP, Patel M. 2007. 1-Methyl-4-phenylpyridinium-induced alterations of glutathione status in immortalized rat dopaminergic neurons. Toxicol Appl Pharmacol 220(3):341–348.

View Abstract

Sampey BP, Carbone DL, Doorn JA, Drechsel DA, Petersen DR.  2007. 4-Hydroxy-2-nonenal adduction of extracellular signal-regulated kinase (Erk) and the inhibition of hepatocyte Erk-Est-like protein-1-activating protein-1 signal transduction. Molec Pharmacol 71(3):871883.

View Abstract

Drechsel DA, Liang LP, Patel M. 2007. 1-Methyl-4-phenylpyridinium-induced alterations of glutathione status in immortalized rat dopaminergic neurons. Toxicol Appl Pharmacol 220(3):341–348.

View Abstract

Castello PR, Drechsel DA, Patel M. 2007. Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J Biol Chem 282(19):14186–14193.

View Abstract

Castello PR, Drechsel DA, Day BJ, Patel M. 2007. Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins. J Pharma Exp Ther 324(3):970–976.

View Abstract

Proctor DM, Gatto NM, Hong SJ, Allamneni KP. 2007. Mode-of-action framework for evaluating the relevance of rodent forestomach tumors in cancer risk assessment. Toxicol Sci. 98(2):313–326.

View Abstract

DeSesso, J., R.E. Watson, C.L. Keen, K.P. Hazleden, L.C. Haws, and A.A. Li. 2007. Integration of Developmental Toxicity Data into Risk Assessment: A Case Study of Dimethoate. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Staskal, D.F., and L.S. Birnbaum. 2007. Brominated Flame Retardants, Maxcy-Rosenau Public Health and Preventive Medicine, 15th Edition.

Diliberto, J.J., D.F. Staskal, H. Hakk, and L.S. Birnbaum. 2007. Differential urinary protein binding of PBDEs in mice. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Dwyer, M., Perry, C., and Jenkins, A. Trichloroethylene toxicity and risks: recent developments and potential implications. Presented at February 2007 Texas Association of Environmental Professionals — Environmental Challenges and Innovations Conference.

Simon T, Britt JK and James RC. 2007. Development of a neurotoxic equivalence scheme of relative potency for assessing the risk of PCB mixtures. Regul. Toxicol. Pharmacol. 48:148-170.

Emond, C., J. Raymer, E. Garner, J. Diliberto, D. Staskal, and L.S. Birnbaum. 2007. A physiologically-based pharmacokinetic model for developmental exposure to PBDE-47 in rodents. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Panko JM, Unice KM, Shay EC. Javier AF. Assessment of children’s exposures to toluene. Society of Toxicology Conference, March 2007.

Gaffney SH, Widner TE, Paustenbach DJ, Panko JM, Brown JL, Unice KM. Historical benzene exposure reconstruction: Refinery workers at ExxonMobil Refinery, Baton Rouge, Louisiana (1978-2005). American Industrial Hygiene Conference and Exhibition, June 2007.

Williams PRD, Panko JM, Unice KM, Brown JL, Paustenbach DJ. 2007. Benzene exposures from petroleum-derived solvents containing trace levels of benzene in occupational settings. American Industrial Hygiene Conference and Exhibition, June 2007.

Panko JM, Unice KM, Shay EC. 2007. Recommendations for developing child-focused exposure assessments based on VCCEP experiences. Society for Risk Analysis, December 2007.

Paustenbach DJ, Panko JM, Scott PK, Unice KM. 2007. A methodology for estimating human exposure to perfluorooctanoic acid (PFOA): A retrospective exposure assessment of a community (1951-2003). J Toxicol Environ Health A 70(1):28–57.

View Abstract

Scott PK, Unice KM, Williams S, Panko JM. 2007. Statistical evaluation of metal concentrations as a method for identifying World Trade Center dust in buildings. Environ Forensics 8(4).

View Abstract

Paustenbach DJ, Gaffney SH, Scott PK, Brown JL, Panko JM. 2007. Commentary: High background levels of urinary benzene metabolites found in a volunteer study. J Occup Environ Hyg 4:D71–D77.

Thompson CM and Grafström RC. 2007. Mechanistic considerations for formaldehyde-induced bronchoconstriction involving S-nitrosoglutathione reductase. J Toxicol Environ Health, Part A 71, 244–248.

Ferriby, L.L., M.A. Harris, K.M. Unice, P.K. Scott, L.C. Haws, D.J. Paustenbach. 2007. Development of PCDD/F and dioxin-like PCB serum concentration reference values for the general U.S. population using the 2006 WHO TEFs and the 2001-2002 NHANES data.Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Urban JD, Clarke WP, von Zastrow M, Kobilka B, Nichols DE, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, and Mailman RB. 2007. Functional selectivity and classical concepts of quantitative pharmacology. J. Pharmacol Exp Therap. 320 (1): 1-13.

Harris, M., L.L.F. Scott, L.M. Nguyen, and L.C. Haws. 2007. Trends in elevated blood lead levels of U.S. children and associated demographic characteristics. Ann Epidemiol 17:748.

Urban JD, Vargas G, von Zastrow M, and Mailman RB. 2007. Aripiprazole has functionally selective actions at D2 receptor-mediated signaling pathways. Neuropsychopharmacology. 32 (1): 67-77.

Harris, M.J.A.Tachovsky, E.S. Williams, L.L.F Scott, L. Nguyen, L.C. Haws. 2007. Risks Posed by Air Pollutants in the Houston Metropolitan Area. Society for Risk Analysis Annual Meeting. December 9-12, 2007. San Antonio, TX.

Harris, M.L.C. Haws, A. Tachosvky, E.S. Williams, L.M. Nguyen, L.F. Scott. Interactive Processes in Toxicity Assessments. Air Toxics Research: Implications of Research on Policies to Protect Public Health. June 12-13, 2007. Houston, TX.

Haws, L.C., L.L.F. Scott, D.F. StaskalM.A. Harris, and B.L. Finley. 2007. Dioxin-like compounds in workers at a primary magnesium production facility. Dioxin 2007, September 2-7, 2007. Tokyo, Japan.

Haws, L.C., L.L.F. Scott, D.F. StaskalM. Harris, and B. Finley. 2007. Evaluation of Biomonitoring Data for Dioxin-like Compounds in Workers at a Primary Magnesium Production Facility. Society for Risk Analysis Annual Meeting. December 9-12, 2007. San Antonio, TX.

Haws LC, Walker NJ, DeVito MJ, Birnbaum LS, Unice KM, Scott PK, Harris MA, Farland WH, Finley BL, Staskal DF. 2007. Development of weighted distributions of REPs for dioxin-like compounds (DLCs). Society of Toxicology Annual Meeting. March 25-29, Charlotte, NC.

Mounho, B. Comparison of nonclinical toxicology programs for epidermal growth factor antagonists for cancer therapy: Monoclonal antibodies Vectibix® and Erbitux® vs. small molecules Iressa® and Tarceva®. Presented at BioSafe General Membership Annual Meeting. 2007.

Mounho, B. Therapeutic Biologics. Presenter and course director: Biologics Drug Development: An Integrated Overview of Manufacturing, Nonclinical, Clinical, and Regulatory Requirements, PERI Course. Bethesda, MD. 2007.

Mounho, B. Nonclinical Safety Assessment of Therapeutic Biologics. Presenter and course director: Biologics Drug Development: An Integrated Overview of Manufacturing, Nonclinical, Clinical, and Regulatory Requirements, PERI Course. Bethesda, MD. 2007.

Nguyen, L.M., L.L.F. Scott, M. Harris, and L.C. Haws. Factors Contributing to Blood Lead Levels in U.S. Children Based on NHANES Data. 2007 Ann Epidemiol. 17:734-735.

Perry, C.S. Vibrios in surface waters and a hypothetical scenario using EPA’s Environmental Consequence Assessment Tool (ECAT). Society for Risk Analysis annual meeting, December 9-12, 2007. San Antonio, TX.

Scott, L.L.F., M. Harris, K.M. Unice, P. Scott, L.M. Nguyen, L.C. Haws, and D. Paustenbach. 2007. Effects of excluding serum PCDD/F and dioxin-like PCB data of individuals with incomplete congener profiles on estimates of total TEQ. Ann Epidemiol. 17:732.

Scott, P., L.C. Haws, L. Scott, and M. Harris. 2007. Evaluation of Background 2,3,7,8-PCDD/F Congener Profiles in Human Serum Collected During NHANES 2001-2002 Using Principal Components Analysis. Dioxin 2007, September 2-7, 2007. Tokyo, Japan.

Scott, P., L.C. Haws, L. Scott, and M. Harris. 2007. Evaluation of Background Dioxin-like PCB Congener Profiles in Human Serum Collected During NHANES 2001-2002 Using Principal Components Analysis. Dioxin 2007, September 2-7, 2007. Tokyo, Japan.

Smith, J.D., Perry C., Garcia, S., Jenkins, A., Dwyer, M., Garrahan, K. Emergency Consequence Assessment Tool (ECAT) for USEPA NHSRC. Society for Risk Analysis annual meeting, December 9-12, 2007. San Antonio, TX.

Staskal, D.F., E.P. Donovan, L.C. Haws, J.D. Roberts, K.M. Unice, B.L. Finley, and M.A. Harris. A Quantitative Microbial Risk Assessment for Exposure to Pathogens in Waters and Sediments of the Lower Passaic River. Society for Risk Analysis annual meeting, December 9-12, 2007. San Antonio, TX.

Staskal, D.F., L.L.F. Scott, E.S. Williams, W.J. Luksemburg, L.C. Haws, L.S. Birnbaum, L.M. Nguyen, D.J. Paustenbach, and M.A. Harris. Daily intake estimates of PBDEs associated with consumption of catfish in the U.S. Presented at the Fourth International Workshop on Brominated Flame Retardants. April 24-27, 2007. Amsterdam, the Netherlands.

Staskal, D.F., E. Donovan, J. Roberts, K. Unice, B. Finley, and M. Harris. 2007. Human Health Risk Associated with Exposure to Pathogen-Contaminated Sediments. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Tachovsky, J.A., L.C. Haws, L.F Scott, E.S. Williams, and M. Harris. Benzene in soft drinks and other beverages: Do measured levels pose a human health risk? Society for Risk Analysis’ Annual Meeting. December 9-12, 2007. San Antonio, TX.

Urban, J.D., K. Thornley, R.W. Wightman, and R.B. Mailman. 2007. Pharmacological characterization of the N27-D2L cell line: assessment as a viable cell model for investigating D2L receptor dopaminergic-coupled functions. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Williams, E.S., L.L. Ferriby, L.C. Haws, D.J. Paustenbach, and M.A. Harris. 2007. Assessment of potential human health risks posed by benzene in a commercial beverage. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

2006

Barone S Jr., Brown RC, Euling S, Cohen Hubal E, Kimmel CA, Makris S, Moya J, Selevan SG, Sonawane B, Thomas T, and Thompson CM. 2006. Visión General De La Evaluación Del Rieso En Salud Infantil Empleando Un Enfoque Por Etapas De Desarrollo. Acta Toxicol Argent 14(Suppl):7–10.

Ferriby, L.L., E.S. Williams, W.J. Lukesemburg, D.J. Paustenbach, L.C. Haws, L.S. Birnbaum, and M. Harris. 2006. Comparing polychlorinated biphenyls in farm-raised and wild-caught catfish from southern Mississippi. Organohalogen Compounds. 68: 2527-2530.  Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Becker DS, Long ER, Proctor DM, Ginn TC. 2006. Toxicity and bioavailability of chromium in sediments associated with chromite ore processing residue.  Environ Toxicol Chem. 25(10):2576–2583.

Ferriby, L.L., E.S. Williams, W.J. Lukesemburg, D.J. Paustenbach, L.C. Haws, L.S. Birnbaum, and M. Harris. 2006. Comparing PCDDs, PCDFs, and Dioxin-Like PCBs in Farm-Raised and Wild-Caught Catfish from Southern Mississippi.  Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Haws LC, Su S, Harris MA, DeVito M, Walker N, Farland W, Finley B, and Birnbaum L. 2006. Development of a refined database of mammalian relative potency estimates for dioxin-like compounds. Toxicol Sci. 89(1):4-30.

Ferriby, L.L., K. Franke, K.M. Unice, P. Scott, L.C. HawsM. Harris, and D.J. Paustenbach. 2006. Serum reference levels of PCDD/Fs and dioxin-like PCBs stratified by race/ethnicity, gender and age for the general U.S. population. American Public Health Association Annual Meeting and Exposition. November 4-8, 2006. Boston, MA.

Paustenbach DJ, Fehling K, Scott P, Harris M, and Kerger B. 2006. Identifying soil clean-up criteria for dioxin in urban residential soils: How have 20 years of research and risk assessment experience affected the analysis? J Toxicol Environ Health, Part B. 9:87-145.

Finster M., MacDonell, M., Bhattacharyya, M., Haroun L., Peterson J., and Perry, C. Environmental fate and cumulative risk context for cleanup programs. Society for Risk Analysis’ Annual Meeting. December 3-6, 2006. Baltimore, MD.

Staskal DF, Diliberto JJ and Birnbaum LS. 2006. Impact of repeated exposure on the toxicokinetics of BDE 47 in mice. Toxicol Sci. 89:380-5.

Gough, M., D. Paustenbach, B. Kerger, H. Leung, P. Scott, and M. Harris. 2006. Dioxin and diabetes does the current weight of evidence demonstrate a relationship. Society of Toxicology. March 5-9, 2006. San Diego, CA.

Paustenbach DJ, Gaffney SA, Scott PK, Brown JL, Panko JM. High background levels of urinary benzene metabolites found in volunteer study. Society of Toxicology Conference 2006.

Paustenbach DJ, Panko JM, Scott PK, Unice KM. Retrospective modeling of potential residential exposure to perfluorooctanoic acid (PFOA) releases from a manufacturing facility. Society of Toxicology Conference 2006.

Panko JM, Shay EC. Potential for airborne dispersion of bromadiolone and exposure in an office setting. International Society for Exposure Assessment Conference 2006.

Panko JM, Unice KM, Shay EC, Price P. Assessment of children’s exposures to xylenes. International Society for Exposure Assessment Conference 2006.

Panko JM, Unice KM, Shay EC, Javier AF. 2006. Assessment of children’s exposures to benzene. Society for Risk Analysis, December 2006.

Staskal DF, Diliberto JJ, and Birnbam LS. 2006. Disposition of BDE 47 in developing mice. Toxicol Sci. 90:309-16.

Harris, M., L. Ferriby, J. Knutsen, P. Nony, K. Unice, and D. Paustenbach. 2006. Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001-2002 National Health and Nutrition Examination Survey in the United States. Society of Toxicology. March 5-9, 2006. San Diego, CA.

Staskal DF, Hakk H, Bauer D, Diliberto JJ, and Birnbam LS. 2006. Toxicokinetics of Polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice. Toxicol Sci. 94:28-37.

Haws, L. The use of toxic equivalency factors to assess potential human health risks posed by dioxin-like compounds: Keeping up with the science. Presented at Michigan State University, Toxicology Program Seminar Series. September 26, 2006.

Van den Berg M, Birnbaum L, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws LC, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walke Nr, and Peterson RE. 2006. The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds. Toxicol Sci 93(2):223-241.

View Abstract

Haws, L.C., P.K. Scott, K.M. Unice, M. Gough, M.A. HarrisD.F. Staskal, D.J. Paustenbach, and M. Pavuk. Are Dioxin Body Burdens Surrogates for Other Risk Factors in Associations Between Dioxin and Diabetes?  Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Yoon MY, Lee SJ, Lee BH, Chung JH, Kim YC. 2006. Effects of dimethylsulfoxide on metabolism and toxicity of acetaminophen in mice. Biol Pharmaceut Bull 29(8):1618–1624.

View Abstract

Haws, L.C., M.J. DeVito, L.S. Birnbaum, N.J. Walker, P.K. Scott, K.M. Unice, M.A. Harris, W.H. Farland, B.L. Finley, and D.F. Staskal. An Alternative Method for Establishing TEFs for Dioxin-like Compounds. Part 2. Development of An Approach To Quantitatively Weight the Underlying Potency Data. Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Paustenbach, D.J., M.. Harris, L.L. Ferriby, E.S. Williams, L.C. Haws, K.M. Unice, and P.K. Scott. 2006. Development of PCDD/F TEQ serum reference values for the U.S. population for use in evaluating biomonitoring results. Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Richardson, V.M., D.F. Staskal, J.J. Diliberto, and L.S.Birnbaum. 2006. Effects of BDE 47 on nuclear receptor regulated genes and implications for thyroid hormone disruption. 45th Annual Meeting of Society for Toxicology. March 5-9, 2006. San Diego, CA.

Staskal, D.F., L.L. Ferriby, E.S. Williams, W.J. Luksemburg, L.C. Haws, L.S. Birnbaum, D.J. Paustenbach, and M. Harris. 2006. Polybrominated diphenyl ethers in southern Mississippi catfish. Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Staskal, D.F., J.J. Diliberto, and L.S. Birnbaum. 2006. Effect of age on the tissue distribution of BDE 47 in mice. 45th Annual Meeting of Society for Toxicology. March 5-9, 2006. San Diego, CA.

Urban, J.D., J. Jin, and R.B. Mailman. 2006. N27 dopaminergic cell line: A useful model for studying the mechanisms of action of functionally selective dopaminergic compounds. 45th Annual Meeting of Society for Toxicology. March 5-9, 2006. San Diego, CA.

Van den Berg, M., L. Birnbaum, M. Denison, M. De Vito, W. Farland, M. Feeley, H. Fiedler, H. Hakansson, A. Hanberg, L.C. Haws, M. Rose, S. Safe, D. Schrenk, C. Tohyama, A. Tritscher, J. Tuomisto, M. Tysklind, N. Walker, and R.E. Peterson. 2006. Human And Mammalian Toxic Equivalency Factors For Dioxins And Dioxin-like Compounds: The WHO 2005 Re-Evaluation.  Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Paustenbach, D.J., L.L.F. Scott, L.M. Nguyen, K.M. Unice, P. Scott, L.C. Haws, and M. Harris. 2007. Referent Concentrations of PCDD/Fs and Dioxin-like PCBs in Sera of Persons in the U.S. Based on the New WHO 2006 TEFs and 2001-2002 NHANES Data. Ann Epidemiol. 17:734.

Mounho, B. Chronic Toxicity Studies for Monoclonal Antibodies: Avastin® and Erbitux®. Presented at BioSafe/FDA meeting. 2006.

Mounho, B. The Use of Toxicokinetics and Toxicodynamics in the Safety Assessment and Development of Small and Large Molecule Therapeutic Products. Presenter and Symposium Chair: American College of Toxicology Annual Meeting. 2006.

Mounho, B. Immunomodulation in Nonhuman Primates. Presented at Pharmaceutical Education Associates Immunotoxicology IV Meeting. 2006.

2005

Bauer, D., D.F. Staskal, J.J. Diliberto, and L.S. Birnbaum. 2005. Disposition of BDE 99 and BDE 153 in female mice. Society of Toxicology. March 6-10, 2005. New Orleans, LA.

Connor, K., M. Harris, M. Edwards, A. Chu, G. Clark, and B. Finley. 2005. Estimating the total TEQ in human blood from naturally-occurring vs. anthropogenic dioxins: A dietary study.  Dioxin 2005. August 21-26, 2005. Toronto, Canada.

Harris, M., and B. Finley. Estimating the total TEQ in human blood from naturally-occurring vs. anthropogenic dioxins: a dietary study. Society of Toxicology. March 6-10, 2005. New Orleans, LA.

Harris, M., B. Finley, P. Scott. Development of a relative estimate of potency distribution for 2,3,7,8-TCDF. Dioxin 2005. August 21-26, 2005. Toronto, Canada.

Haws, L. Evaluating Potential Health Risks Posed By PCDDs, PCDFs, and Dioxin-like PCBs: An Approach for Improving the Toxicity Equivalency Factor (TEF) Methodology. 30th Annual Winter Meeting of the Toxicology Forum. February 2, 2005. Washington, DC.

Scott PK, Unice KM, Panko JM. Statistical evaluation of metals concentrations as a method for identifying World Trade Center dust. International Society for Exposure Assessment 2005.

Unice KM, Panko JM, Scott PK. Considerations for reconstruction of TCE exposure from groundwater vapor intrusion. International Society for Exposure Assessment Conference 2005.

Unice KM, Panko JM, Scott PK. Development of exposure assessment models for indoor air exposure to elemental mercury. International Society for Exposure Assessment Conference, 2005.

Panko JM, Unice KM, Brown JL. Comparison of toluene exposures during spray painting using various consumer product exposure models. International Society for Exposure Assessment Conference 2005.

Mounho, B. Differences Between Small Molecules and Biological Therapeutic Drug Products. Society of Toxicology. March 6-10, 2005. New Orleans, LA.

Paustenbach, D.J., K. Fehling, M. Harris, P. Scott, B.D. Kerger. Identifying soil clean-up criteria for dioxin in residential soils: How has 20 years of research and risk assessment experience impacted the analysis? DIoxin 2005. August 21-26, 2005. Toronto, Canada.

Perry, C.S., Garcia, S., Collie, S., MacDonell, M., Femi Adeshina, and Cynthia Sonich-Mullin: Application of provisional advisory levels for EPA National Homeland Security Research Center’s secure, internet-based rapid risk tool. Society for Risk Analysis’ Annual Meeting. December 4-7, 2005. Orlando, FL.

Garabrant G,  James RC. 2005. Trichloroethylene and cancer in humans: Recognizing the need for an evidence based analysis. Toxicology. 212:80-84.

Grasty RC, Bjork JA, Wallace KB, Wolf DC,  Lau CS, Rogers JM. 2005. Effects of prenatal perfluorooctane sulfonate (PFOS) exposure on lung maturation in the perinatal rat. Birth Defects Res B Dev Reprod ToxicolOct; 74(5):405-16.

Guzelian PS, Victoroff M, Halmes NC, James RC and Guzelian CP. 2005. Evidence-based toxicology: A comprehensive framework for causation. Hum. Exp. Toxicol. 24:161-201.

Staskal DF, Diliberto JJ, DeVito MJ and Birnbaum LS. 2005. Inhibition of Human and Rat CYP1A2 by TCDD and Dioxin-like Chemicals. Toxicol Sci. 84: 225-31.

Staskal DF, Diliberto JJ, DeVito MJ, and Birnbaum LS. 2005. Toxicokinetics of BDE 47 in Female Mice: Effects of Dose, Route of Exposure, and Time. Toxicol Sci. 83: 215-23.

Urban, J.D. and R.B. Mailman. 2005. Characterization of the N27 dopaminergic cell line as a model for elucidating the actions of functionally selective dopaminergic ligands. 35th Annual Neuroscience Meeting. November 12-16, 2005. Washington, DC.

Grasty RC, N Roberts, G Klinefelter, JA Bjork, KB Wallace, CS Lau, and JM Rogers (2005). Effects of prenatal perfluorooctanesulfonate (PFOS) exposure on lung maturation in the perinatal rat. Birth Defects Res A Clin Mol Teratol 73: 314.

2004

Gay EA, Urban JD, Nichols DE, Oxford GS, and Mailman RB. 2004. Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states. Mol Pharmacol. 66 (1): 97 – 105.

Connor, K., M. Harris, M. Edwards, A. Chu, G. Clark, and B. Finley. 2004. Estimating the total TEQ in human blood from naturally-occurring vs. anthropogenic dioxins: A dietary study.  Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Proctor DM, Panko JP, Liebig EW, Paustenbach, DJ. 2004. Estimating historical occupational exposure to airborne hexavalent chromium in a chromate production plant: 1940–1972. Occup Environ Hyg. 1:752–767.

Haws, L. Roundtable: Is it Time to Reevaluate the Toxic Equivalency Factors for PCDDs, PCDFs, and Dioxin-Like PCBs? The Use of Toxicity Equivalence Factors (TEFs) for PCDDs, PCDFs, and Dioxin-Like PCBs in Risk Assessment: Improving the Process. Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Schecter, A, Papke O, Tung KC, Staskal DF, and Birnbaum L. 2004. Polybrominated diphenyl ether contamination of United States food. Environ Sci Technol 38(20):5306-5311.

Haws, L.M. Harris, S. Su, L. Birnbaum, M. DeVito, W. Farland, N. Walker, K. Connor, A.Santamaria, and B. Finley. Development of a refined database of relative potency estimates to facilitate better characterization of variability and uncertainty in the current mammalian TEFs for PCDDs, PDCFs, and dioxin-like PCBs. Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Thompson CM, Wojno H, Greiner E, May EL, Rice KC, and Selley DE. 2004. Activation of G-proteins by morphine and codeine congeners: Insights to the relevance of O- and N-demethylated metabolites at μ- and δ-opioid receptors. J Pharmacol Exper Therapeut 308(2):547–554.

Haws, L.M. Harris, S. Su, N. Walker, L. Birnbaum, M. DeVito, W. Farland, K. Connor, A. Santamaria, and B. Finley. A preliminary approach to characterizing variability and uncertainty in the mammalian PCDD/F and PCB TEFs. Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Warren DA, Kerger BD, Britt JK and James RC. 2004. Development of an oral cancer slope factor for Aroclor 1268. Regul Toxicol Pharmacol 40:42-53.

Perry, C.S. and Morton, E. Lessons learned from creating integrated Excel models to calculate human health screening values. Society for Risk Analysis’ Annual Meeting. December 5-8, 2004. Palm Springs, CA.

Panko JM, Unice KM, Shay EC, Price P. 2004. Childhood exposure assessment of acetone. International Society for Exposure Assessment 2004.

Proctor DM, Panko JM, Liebig EW, Paustenbach DJ. 2004. Estimating historical occupational exposure to airborne hexavalent chromium in a chromate production plant: 1940–1972. J Occup Environ Hyg 1(11):752–767.

View Abstract

Staskal, D.F., J.J. Diliberto, M.J. DeVito, and L.S. Birnbaum. 2004. Tissue distribution and elimination of BDE 47 in mice following a single oral dose.  Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Staskal, D.F., J.J. Diliberto, M.J. DeVito, and L.S. Birnbaum. 2004. Disposition of 2,2’,4,4’-Tetrabromodiphenylether (BDE 47) in Female Mice. 43rd Annual Meeting of Society for Toxicology. March 21-25, 2004. Baltimore, MD.

Urban, J.D., E.A.Gay, and R.B. Mailman. 2004. Functional selectivity as a mechanism of action of newer atypical antipsychotic drugs. 34th Annual Neuroscience Meeting. October 23-27, 2004. San Diego, CA.

Grasty RC, Roberts N, Grey BE, Lau C, Rogers JM. (2004). Effects of prenatal exposure to perfluorooctane sulfonate on the developing lung in the rat. 43rd Annual Meeting of Society for Toxicology. March 21-25, 2004. Baltimore, MD.

Urban, J.D., E.A. Gay, and R.B. Mailman. 2004. Decreased neurological side-effects with aripiprazole: a result of functional selectivity of the D2 receptor? 43rd Annual Meeting of Society for Toxicology. March 21-25, 2004. Baltimore, MD.

Grasty RC, Roberts N, Grey BE, Lau C, Rogers JM. (2004). Perfluorooctane sulfonate (PFOS) alters lung development in the neonatal rat. Birth Defects Research, Part A, 70(5), 42.

Birnbaum LS, and Staskal DF. 2004. Brominated Flame Retardants: Cause for Concern? Environ Health Perspect. 112: 9-17.

2003

Demady DR, Lowe ER, Everett AC, Billecke SS, Kamada Y, Dunbar AY, Osawa Y. 2003. Metabolism-based inactivation of neuronal NO-synthase by components of cigarette and cigarette smoke. Drug Metab Disposit 31(7):1–6.

View Abstract

Birnbaum LS, Staskal DF, and Diliberto JJ. 2003. Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). Environ Inter. 29: 855-860.

Haws, L. Combustion risk modeling and assessment. Presented at the Texas Commission on Environmental Quality Workshop on Hazardous Waste Combustion. May 7, 2003. Austin, TX.

Perry, C.S. Process for development of protective concentration levels for remediation sites in Texas.Presented at Society for Environmental Toxicology and Chemistry (SETAC) meeting. November 9-13, 2003. Austin, TX.

Grasty RC, Grey BE, Wolf DC,  Lau CS, Rogers JM. 2003. Prenatal window of susceptibility to perfluorooctane sulfonate-induced neonatal mortality in the Sprague-Dawley rat. Birth Defects Res (Part B) Dev Reprod ToxicolDec;68(6):465-71.

Staskal, D.F., M.J. DeVito, D.G. Ross, and L.S. Birnbaum. 2003. A Comparison of the metabolism of methoxyresorufin, acetanilide, and caffeine in rat and human CYP1A2 SUPERSOMES. The Toxicologist.

Luippold RS, Mundt KA, Austin RP, Liebig E, Panko JP, Crump C, Crump K, Proctor DM. 2003. Lung cancer mortality among chromate workers. 2003. Occup Environ Med. 60:451−457.

Staskal, D.F., M.J. DeVito, D.G. Ross, and L.S. Birnbaum. 2003. Caffeine, Acetanilide, and Methoxyresorufin Metabolism by Rat and Human CYP1A2 SUPERSOMES and their Inhibition by 2,3,7,8,-Tetrachlorodibenzo-p-dioxin (TCDD). Organohalogen Compounds.

Proctor D, Panko J, Liebig E, Mundt K, Buczynski M, Barnhart R, Harris MA, Morgan R, Finley B, and Paustenbach D. 2003. Workplace concentrations of airborne hexavalent chromium for the Painesville, Ohio chromate production plant. Appl Occ Environ Hyg J. 18(6):430-449.

Grasty RC, Grey BE, Lau CS, Rogers JM. 2003. Window of susceptibility to perfluorooctane sulfonate (PFOS)-induced neonatal mortality in the rat. Birth Defects Research, Part B, 68(3), 5.

Panko JM. Mold problems in buildings. Solving water intrusion and mold problems in Pennsylvania. Lorman Education Services, Altoona, PA, November 5, 2003.

Panko JM. AWMA/Healthy Indoor Partnerships. International Conference on Indoor Air Quality/Health Indoor Environment, Mold Contamination Case Studies, 2003.

Panko JM, Shay EC, Unice KM. Risk perception: The reoccupancy of Lower Manhattan office space following the national tragedies of September 11, 2001. Poster at the Society for Risk Analysis Annual Conference, December 2003.

Proctor DM, Panko JM, Liebig EW, Mundt KA, Buczynski MA, Barnhart RJ, Harris MA, Morgan RJ, Finley BL, Paustenbach DJ. 2003. Workplace airborne hexavalent chromium concentrations for the Painesville, Ohio chromate production plant (1943–1971). Appl Occup Environ Hyg 18(6):430–449.

View Abstract

Luippold RS, Mundt KA, Austin RP, Liebig EW, Panko JM, Crump C, Crump K, Proctor DM. 2003. Lung cancer mortality among chromate production workers. J Occup Environ Med 60:451–457.

View Abstract

Crump C, Crump K, Hack E, Luippold R, Mundt K, Liebig EW, Panko JM, Paustenbach DJ, Proctor DM. 2003. Dose-response and risk assessment of airborne hexavalent chromium and lung cancer mortality. Risk Anal 23(6):1147–1163.

View Abstract

Scott P, Petura J, and Harris MA. 2003. Derivation of a liquid to solid ratio for ASTM method D3987 85 for soils containing chromite ore processing residue using selected unsaturated zone models. Soil Sed Contam. 12(4):443-480.

Lansita, JA, Merok, JR, and Sherley, JL. 2003. “Physicochemical Demonstration of Immortal DNA Strand Segregation,” in “Mechanisms of Toxicity, Carcinogenesis, Cancer Prevention and Cancer Therapy: Abstracts of the Seventeenth Aspen Cancer Conference,” Tox. Path., 31, 163-164.

Merok, JR, Tunstead, JR, Lansita, JA, and Sherley, JL. 2003. Demonstration of an immortal DNA strand mechanism in cells that cycle with asymmetric stem cell kinetics-Implications for mechanisms of human cancer and aging. In: Mechanisms of Toxicity, Carcinogenesis, Cancer Prevention and Cancer Therapy: Abstracts of the Seventeenth Aspen Cancer Conference. Toxicol Pathol 31:165-166.

2002

Demady DR, Jianmongkol S, Vuletich JL, Bender AT, Osawa Y. 2002. Irreversible inactivation of neuronal nitric oxide synthase by agmatine, an endogenous amine formed by decarboxylation of arginine. Molec Pharmacol 59(1):1–6.

View Abstract

Grant RL, Rodriguez R, Hofelt CS, and Haws LC. 2002. Shortcomings in USEPA’s approach for predicting risk due to consumption of animal food products impacted by air emissions from hazardous waste combustion facilities: a case study involving phthalates. Human Ecol Risk Assess. 8(5):1137-1154.

Haws, L. Permitting of Hazardous Waste Combustion Facilities in the State of Texas: Human Health Risks Associated with Fugitive Emissions Sources. Presented at the Texas Chemical Council Quarterly Meeting. August 1, 2002. Houston, TX.

Proctor, D.M. Harris, and D. Rabbe. 2002. Chapter 9: A risk assessment of chromium contaminated soils: ten years of research to characterize the health hazards, in Human and Ecological Risk Assessment: Theory and Practice. D. Paustenbach (ed.). pp. 485–555.

Roberts SM, Jordan KE, Warren DA, Britt JK and James RC. 2002. Evaluation of the carcinogenicity of 1,1-Dichloroethylene (Vinylidene Chloride). Regul. Toxicol. Pharmacol. 35:44-55.

Haws, L. Texas Risk Reduction Program Rule-The Basics. Question and Answer Forum Panelist. Presented at the Texas Natural Resource Conservation Commission Environmental Trade Fair. Waste Remediation Track. May 7, 2002. Austin, TX.

Sanatamaria, A., L. Ferriby, M. Harris, and D. Paustenbach. Use of biomarkers in health risk assessment. In Toxicologic Biomarkers, Anthony DeCaprio (ed.). Informa Healthcare. pp. 85-109.

Merok, JR, Lansita, JA, Tunstead, JR, Sherley, JL. 2002. “Cosegregation of Chromosomes Containing Immortal DNA Strands in Cells that Cycle with Asymmetric Stem Cell Kinetics,” Cancer Res., 62, 6791-6795.

Haws, L. Toxicology and Risk Assessment Resources and Practices in the State of Texas. Presented at the USEPA Region 6 States Risk Assessment Roundtable. April 5, 2002. Dallas, TX.

Hofelt CS, Honeycutt M, McCoy JT, and Haws LC. 2001. Development of a metabolism factor for polycyclic aromatic hydrocarbons for use in multipathway risk assessments for hazardous waste combustion facilities. Reg Toxicol Pharmacol. 33:60-65.

Perry, C.S. TRRP Rule – The basics part 2: human health PCLs and look-up tables. 2002 TNRCC Environmental Trade Fair presentation and paper.

Strobel HW, Thompson CM, Antonovic L. 2001. Cytochromes P450 in brain: function and significance. Current Drug Metabolism. 2(2), 199–214.

Grasty RC, Grey BE, Thibodeaux J, Lau C, Rogers JM. (2002). Critical period for increased neonatal mortality induced by perfluorooctane sulfonate (PFOS) in the rat. The Toxicologist 66 (1-S), 118.

Staskal, D.F., M.J. DeVito, D.G. Ross, and L.S. Birnbaum. 2002. Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. The Toxicologist.

2001

Haws, L. Risk Assessment Coordination Between EPA and States Panelist. Presented at the USEPA Regional Risk Assessors Annual Conference. May 25, 2001. Bandera, TX.

Haws, L. Texas Risk Reduction Program Rule-Practical Applications. Question and Answer Forum Panelist. Presented at the Texas Natural Resource Conservation Commission Environmental Trade Fair. Waste Remediation Track. April 30, 2001. Austin, TX.

Skaggs, Jr. M.M., and M. Harris. 2001. A management trend: towards special remedial organizations. SPE/EPA/DOE Exploration and Production Environmental Conference. February 26-28, 2001. San Antonio, TX.

Tachovsky, J. A., J. T. McCoy, and L. C Haws. Development and implementation of probabilistic risk assessment protocol in Texas. Presented at the 94th Conference of the AWMA. June 24-28, 2001. Orlando, FL.

2000

Noguchi S, Jianmongkol S Bender AT, Kamada Y, Demady DR, Osawa Y. 2000. Guanabenz-mediated inactivation and enhanced proteolytic degradation of neuronal nitric oxide synthase. J Biol Chem 275(4):2376–2380.

View Abstract

Jianmongkol S, Vuletich JL, Bender AT, Demady DR, Osawa Y. 2000. Aminoguanidine-mediated inactivation and alteration of neuronal nitric oxide synthase. J Biol Chem 275(18):13370–13376.

View Abstract

Bender AT, Demady DR, Osawa Y. 2000. Ubiquitination of neuronal nitric oxide synthase in vitro and in vivo. J Biol Chem 275(23):17407–17411.

View Abstract

Finley BL, Proctor DMHarris MA, and Fowler JF. 2000. Letter to the editor. American J Contact Derm. 123-125.

Grant, R.L., D. Morrill, D. Manis, A. Tachovsky, and L.C. Haws. 2000. The Texas combustion project: review of trial burn/risk burn plans and reports. Proceedings, International Conference on Incineration and Thermal Treatment Technologies. May 8–12, 2000. Portland, OR.

James, R.C., S.M. Roberts and P.L. Williams.  General principles of toxicology.  In:  Principles of Toxicology: Environmental and Industrial Applications, Second Edition. P.L. Williams, R.C. James and S.M. Roberts (Eds.), John Wiley & Sons, Inc., New York, NY. pp. 3-34,  2000.

Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM.  2000. Evolutionary relationships between the amphibian, avian, and mammalian stomachs.  Evol DevNov-Dec;2(6):348-59.

Tachovsky, J.A., L.C. Haws, C.S. Hofelt, and J.T. McCoy. 2000. Risk assessment implementation in Texas. Proceedings, International Conference on Incineration and Thermal Treatment Technologies. May 8–12, 2000. Portland, OR.

Roberts, S.M., R.C. James and M.R. Franklin.  Hepatotoxicity: Toxic effects on the liver.  In: Principles of Toxicology: Environmental and Industrial Applications, Second Edition.  P.L. Williams, R.C. James and S.M. Roberts (Eds.), John Wiley & Sons, Inc., New York, NY. pp. 111-128,  2000.

Thompson CM, Capdevila JH, and Strobel HW. 2000. Recombinant P450 2D18 Metabolism of Dopamine and Arachidonic Acid. Journal of Pharmacology and Experimental Therapeutics. 294(3), 1120–1130.

Urban, J.D. and R.B. Mailman. 2005. Functional selectivity as a mechanism of action for newer atypical antipsychotic drugs. Presented at: Merck, West Point, Pennsylvania, USA.

James, R.C. and C.J. Saranko.  Chemical Carcinogenesis.  In: Principles of Toxicology:  Environmental and Industrial Applications, Second Edition.  P.L. Williams, R.C. James and S.M. Roberts (Eds.), John Wiley & Sons, Inc., New York, NY. pp. 265-324,  2000.

James, R.C., D.A. Warren, N.C. Halmes and S.M. Roberts.  Risk Assessment.  In: Principles of Toxicology:  Environmental and Industrial Applications, Second Edition.  P.L. Williams, R.C. James and S.M. Roberts (Eds.), John Wiley & Sons, Inc., New York, NY. pp. 437-477,  2000.

1999

Haws, L. Permitting of Hazardous Waste Combustion Facilities in the State of Texas: Risk Assessment Procedures and Status Update. Presented at the Texas Chemical Council Quarterly Meeting. September 15, 1999. Houston, TX.

1998

Gerhardt B, Kordas TJ, Thompson CM, Patel P, and Vida TV. 1998. The vesicle transport protein, Vps33p, is an ATP binding protein that localizes to the cytosol in an energy dependent manner. J Biol Chem 273(25):15818–15829.

View Abstract

Harris, M., and M.M. Skaggs. A review of chromium treatment technologies, YPF Environmental Congress. September 1998. Buenos Aires, Argentina.

Thompson CM, Kawashima H, and Strobel HW. 1998. Isolation of partially purified P450 2D18 and characterization of activity towards the tricyclic antidepressants imipramine and desipramine. Archives of Biochemistry and Biophysics. 359(1), 115–121.

Fraiser, L.H., J.A. Tachovsky, M.E. King, J.T. McCoy, and L.C. Haws. 1998. Hazardous waste combustion risk assessment experience in the state of Texas. Proceedings, International Conference on Incineration and Thermal Treatment Technologies Conference. May 11–15, 1998. Salt Lake City, UT.

1997

Costa M, Zhitkovich A, Harris MA, Paustenbach D, and Gargas M. 1997. DNA-Protein crosslinks produced by various chemicals in cultured human lymphocytes. J Toxicol Environ Health.

Skaggs, Jr. M.M., and M.A. Harris. 1997. Risk management strategies for site closure actions. National Association for Environmental Management. October 1997. Dallas, TX.

Kawashima H, Kusunose E, Thompson CM, and Strobel HW. 1997. Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain. Archives of Biochemistry and Biophysics. 347(1), 148–154.

Roberts SM, DeMott R and James RC. 1997. Adrenergic modulation of hepatotoxicity.  Drug Metab. Rev. 29: 329-353.

Calabrese EJ, Stanek EJ, James RC and Roberts SM. 1997. Soil ingestion: A concern for acute toxicity in children.  Environ Health Perspect 105:1354-1358.

Scott P, Finley B, Harris MA, and Rabbe D. 1997. Determination of background airborne hexavalent chromium concentrations in industrial areas. J Air Waste Manage. Assoc. 47:592-600.

Paustenbach DJ, Panko JM, Fredrick MM, Finley BL, Proctor DM. 1997. Urinary chromium as a biological marker of environmental exposure: What are the limitations? Regul Toxicol Pharmacol 26(1 Pt 2):S23–S34.

Finley BL, Burton S, Panko JM, Proctor DM. 1997. A preliminary assessment of PCB risks to human and ecological health in the lower Passaic River. J Soc Environ Tox Chem 52(2):95–118.

View Abstract

Thompson CM, Bernhard AE, and Strobel HW. 1997. Barbiturate-induced expression of neuronal nitric oxide synthase in the rat cerebellum. Brain Research. 754, 142–146.

1996

Ramu K, Perry CS, Ahmed T, Pakenham G, and Kehrer JP. 1996. Studies on the basis for the toxicity of acrolein mercapturates. Toxicol Appl Pharmacol 140(2):487-498.

View Abstract

Fraiser, L.H., L.G. Lund, K.H. Tyndall, M.E King, D.A. Schultz, and L.C. Haws. 1996. Case Studies in risk assessment for hazardous waste burning cement kilns. Air and Waste Management Association Specialty Conference. Waste Combustion in Boilers and Industrial Furnaces. March 25-26, 1996. Kansas City, MO.

Sauers L and Perry C.1996. Regulatory affairs – a growing opportunity for toxicologists. SOT Communiqué, May/June 1996.

Lund, L.G., L.C. Haws, J.T. McCoy, L.C. Carlisle, D. Brymer, D. Thompson, and J.M. Wiersema. 1996. Addressing community concerns about industrial emissions and burning of hazardous waste in cement kilns: a summary of environmental data. Air and Waste Management Association Specialty Conference. Waste Combustion in Boilers and Industrial Furnaces. March 25-26, 1996. Kansas City, MO.

McCoy, J.T., L.C. Haws, L.C. Carlisle, J.M. Wiersema, D. Carmichael, D., and S. Mgebroff. 1996. Soil sampling and analysis for PCDDs/PCDFs Downwind of combustion sources in six Texas communities. Society of Environmental Toxicology and Chemistry Annual Meeting Abstract Book.

1995

Huber KM, Mauk MD, Thompson CM, and Kelly PT. 1995. A critical period of protein kinase activity after tetanic stimulation is required for the induction of long-term potentiation. Learning & Memory. 2, 81–100.

Fraiser, L.H., L.G. Lund, K.L. Hueske, and L.C. Haws. 1995. Indirect risk assessment: case studies of hazardous waste combustors. Society of Toxicology Annual Meeting. March 5-9, 1995. Baltimore, MD. The Toxicologist 30:31

Perry CS, Liu XL, Lund LG, and Kehrer JP. 1995. Differential toxicities of cyclophosphamide and its glutathione metabolites to A549 cells. Toxicol. in Vitro. 9:21-26.

Roberts SM, Harbison RD, Westhouse RA and James RC. 1995. Exacerbation of carbon tetrachloride ¬induced liver injury in the rat by methamphetamine.  Toxicol. Lett. 76:77–83.

Roberts SM, Harbison RD and James RC. 1995. Mechanistic studies on the potentiation of carbon tetrachloride hepatotoxicity by methamphetamine.  Toxicology 97:49–57.

Williams CA, James RC and Freeman RW. 1995. Using the EPC approach to develop health based soil and water concentrations for environmental chemicals. Regul Toxicol Pharmacol 22:64–75.

View Abstract

Borgert CJ, S.M. Roberts SM, Harbison RD and James RC. 1995. Influence of soil half–life on risk assessment of carcinogens. Regul. Toxicol. Pharmacol. 22:143–151.

1994

Gargas M, Norton R, Harris MA, Paustenbach D, and Finley B. 1994. Urinary excretion of chromium following ingestion of chromite ore processing residue in humans: implications for biomonitoring. Risk Anal. 14(6):1019-1024.

Haws, L. How Are We Implementing the Combustion Strategy and Indirect Risk Assessment? Presented at the Texas Natural Resource Conservation Commission Hazardous Waste Seminar. October 26-27, 1994. Houston, TX.

Haws LC, Jackson BA, Turnbull D, and Dressler WE. 1994. Two approaches for assessing human cancer risk from disperse blue 1. Reg Toxicol Pharmacol. 19:80-96.

Haws, L. Indirect Risk Assessment. Presented at the Sixth Annual Texas Environmental Superconference. August 4-5, 1994. Austin, TX.

James RC, Roberts SM and Williams PL. 1994. Evaluation of the adequacy of the Threshold Limit Value for cyclonite.  Appl. Occup. Environ. Hyg. 9:485–492.

Haws, L. Overview of TNRCC/EPA Concerns, Strategies, and Schedules Concerning Indirect Risk Assessment Requirements. Presented at the Workshop on Risk Assessment and Waste Incineration Facilities. June 28, 1994, Houston, TX, and June 29, 1994. Austin, TX.

Roberts SM, Harbison RD and James RC. 1994. Methamphetamine potentiation of carbon tetrachloride hepatotoxicity in mice.  J. Pharmacol. Exp. Ther. 271:1051–1057.

Haws, L. Indirect Risk Workshop. Panel Discussant. Presented at the RCRA Policy Forum. January 31, 1994. Washington, DC.

Roberts SM, Harbison RD, Roth L and James RC. 1994. Methylphenidate–induced hepatotoxicity in mice and its potentiation by alpha-adrenergic agonist drugs.  Life Sci. 55:269-281.

Haws, L. Keynote Address. Presented at the DRE Environmental Services Workshop on EPA’s New Policy of Hazardous Waste Combustion. January 21, 1994. Austin, TX.

Williams CA, Jones HD, Freeman RW, Wernke MJ, Williams PL, Roberts SM and James RC. 1994. The EPC approach to estimating safety from exposure to environmental chemicals.  Regul. Pharmacol. Toxicol. 20:259–280.

1993

Copeland TL, Paustenbach DJ, Harris MA, and Otani J. 1993. Comparing the results of a Monte Carlo analysis with EPA’s reasonable maximum exposed individual (RMEI): a case study of a former wood treatment site. Reg Toxicol Pharmacol. 18:275-312.

Haws, L. Principles of Toxicology and Risk Assessment. Presented at the University of Texas at Austin. LBJ School of Public Affairs. September 10, 1993. Austin, TX.

Borgert, C.J., S.M. Roberts, R.C. James and R.D. Harbison. Perspectives on assessment of risks from dermal exposure to polycyclic aromatic hydrocarbons. In: Health Risk Assessment: Dermal and Inhalation Exposure and Absorption of Toxicants. R.G. Wang, J.B. Kanak and H.I. Maibach (Eds.), CRC Press, Boca Raton, FL. pp. 455-470,  1993.

Harris, MA, Zacharewski T, and Safe S. 1993. Comparative potencies of Aroclors 1232, 1248, 1254, and 1260 in male wistar rats—Assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fund Appl Toxicol. 20:456-463.

James RC, Busch H, Tamburro CH, Harbison RD, Schell JD and Roberts SM. 1993. Polychlorinated biphenyl exposure and human disease.  J. Occup. Med. 35:136–148.

James RC, Harbison RD and Roberts SM. 1993. Phenylpropanolamine potentiation of acetaminophen-induced hepatotoxicity:  Evidence for a glutathione-dependent mechanism.  Toxciol.  Appl. Pharmacol. 118:159–168.

1992

Roberts SM, Munson JW, James RC and Harbison RD. 1992. An assay for cocaethylene and other cocaine metabolites in liver using high-performance liquid chromatography.  Anal. Biochem. 202:256-261.

Haws, L. Developmental Toxicity of TCDD and Related Compounds. Presented at the Texas A&M University Faculty of Toxicology Seminar Series. October 12, 1992. College Station, TX.

Roberts, S.M., R.C. James and R.D. Harbison. Cocaine-induced hepatotoxicity.  In: Cocaine: Pharmacology, Physiology and Clinical Strategies.  J.M. Lakosky, M.P. Galloway and F.P. White (Eds.), Telford Press, Boca Raton, FL. pp. 15-33,  1992.

Roth L, Harbison RD, James RC, Tobin T and Roberts SM. 1992. Cocaine hepatotoxicity: Influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis.  Hepatology 15:934-940.

Wenning, R.I., D.J. Paustenbach, M.A. Harris, H. Bedbury. Chemometric Analysis of Potential Sources of Polychlorinated Dibenzo-p Dioxin and Dibenzofuran Residues in Surficial Sediments from Newark Bay, New Jersey. Dioxin 1992. August 24-28, 1992. Tampere, Finland.

Roberts SM, Roth L, Harbison RD and James RC. 1992. Cocaethylene hepatotoxicity in mice.  Biochem. Pharmacol. 43:1989-1995.

Wenning, R.I., D.J. Paustenbach, M.A. Harris, H. Bedbury. Sources of PCDD/Fs in Newark Bay Sediments. 13th Annual Meeting of the Society of Environmental Toxicology and Chemistry. November 8-12, 1992. Cincinnati, OH.

Milner GC, James RC and Nye AC. 1992. Human health-based soil cleanup guidelines for diesel fuel No. 2.  J. Soil Contam. 1:103-158.

Wenning RJ, Harris MA, Ungs MJ, Paustenbach DJ, and Bedbury H. 1992. Chemometric comparison of polychlorinated dibenzo-p-dioxin and dibenzofuran residues in surficial sediments from Newark Bay, New Jersey and other industrialized waterways. Arch Environ Contam Toxicol. 22:397-413.

Wenning RJ, Harris MA, Paustenbach DJ, and Bedbury H. 1992. Potential sources of 1,2,8,9-tetrachlorodibenzo-p-dioxin in the aquatic environment. Ecotoxicol Environ Safety. 23(2):133-146.

Zacharewski T, Harris MA, Biegel L, Morrison V, Merchant M, and Safe S. 1992. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor. Toxicol Appl Pharmacol. 113:311-318.

1991

Couture-Haws L, Harris MW, Lockhart AC, and Birnbaum LS. 1991. Evaluation of the persistence of hydronephrosis induced in mice following in uteri and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Appl Pharmacol. 107:402-412.

Arrellano, L., M. Harris, and S. Safe. 1991. Induction of Cypiai Gene transcription by TCDD in MDA-MB-231 human breast cancer cells. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Couture-Haws L, Harris MW, McDonald MM, Lockhart AC, and Birnbaum LS. 1991. Hydronephrosis in mice exposed to TCDD-contaminated breast milk: identification of the peak period of sensitivity and assessment of potential recovery. Toxicol Appl Pharmacol. 107:413-428.

Copeland, T., M. Harris, B. Finley, and D. Paustenbach. 1991. Health effects and environmental characterization of Octachlorodibenzo-p-dioxin (OCDD): Impact on risk assessment of former wood treatment sites. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Frankos VH, Schmitt DF, Haws LC, McEvily AJ, Iyengar R, Miller SA, Munro IC, Clydsdale FM, Forbes AL, and Sauer RM. 1991. Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for the prevention of melanosis in shrimp. Reg Toxicol Pharmacol. 14:202-212.

Fernandez, P., M. Harris, and S. Safe. 1991. Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on T47-D human breast cancer cell lines. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Piskorska-Pliszczynska, J, Astroff B, Zacharewski T, Harris MA, Rosengren R, Morrison V, Safe L, and Safe S. 1991. Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes. Arch Biochem Biophys 284(1):193-200.

Harris, M., L. Biegel, T. Zacharewski, S. and Safe, S. 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen: effects on nuclear estrogen receptor levels, cell growth and the 17_-Estradiol-induced secretion of proteins in MCF-7 Cells. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Safe S, Astroff B, Harris MA, Zacharewski T, Dickerson R, Romkes M, and Biegel L. 1991. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Pharmacol Toxicol. 69:400-409.

Harris, M., B. Finley, R. Wenning, and D. Paustenbach. 1991. Evaluation of Potential Sources of 1,2,8,9-TCDD in Aquatic Biota from Newark Bay. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Safe S, Harris MA, Biegel L, and Zacharewski T. 1991. Mechanism of Action of TCDD as an antiestrogen in transformed human breast cancer and rodent cell lines. Banbury Report 35: Biological Basis for Risk Assessment of Dioxins and Related Compounds Cold Spring Harbor Laboratory Press. 367-377.

Jackson, B.A., L.C. Haws, R.J. Wixtrom, and T.B. Starr. 1991. Secondary mechanisms in carcinogenesis: breaking out of the no-threshold paradigm. American College of Toxicology Annual Meeting. Savannah, Georgia.

Simmons HF, James RC, Harbison RD, Patel DG and Roberts SM. 1991. Examination of the role of catechotamines in hepatic glutathione suppression by cold-restraint in mice.  Toxicology 67:29–40.

Piskorska-Pliszczynska, J., B. Astroff, T. Zacharewski, M. Harris, R. Rosengren, V. Morrison, L. Safe, and S. Safe. 1991. Mechanism of action of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Antagonists: characterization of [125I]-6-methyl-8-Iodo-1,3-dichlorodibenzofuran-Ah receptor complexes. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Harbison RD, James RC and Roberts SM. 1991. Hepatic glutathione suppression by alpha-adrenoreceptor agonist compounds.  Toxicology 69:279-290.

Roberts SM, Harbison RD, Seng JE and James RC. 1991. Potentiation of carbon tetrachloride hepatotoxicity by phenylpropanolamine.  Toxicol. Appl. Pharmacol. 111:175-188.

Roberts SM, Harbison RD and James RC. 1991. Human microsomal N-oxidative metabolism of cocaine.  Drug Metab. Dispos. 19:1046-1051.

Zacharewski T, Harris MA, and Safe S. 1991. Evidence for a possible mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant Hepa 1c1c7 cells. Biochem Pharmacol. 41:1931-1939.

1990

Couture-Haws L, Abbott BD, and Birnbaum LS. 1990. A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances in understanding the mechanism. Teratol. 42:619-627.

Couture, L.A., M.W. Harris, A.M. Clark, and L.S. Birnbaum. 1990. Persistence of hydronephrosis in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Society of Toxicology Annual Meeting. February 12-16, 1990. Miami Beach, FL. The Toxicologist. 10:313.

Couture, LA, Harris MW, and Birnbaum LS. 1990. Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 15:142-150.

Harris, M., R. Wenning, B. Finley, and D. Paustenbach. 1990. Evaluation of potential sources of 1,2,8,9-TCDD in aquatic biota from Newark Bay. Society of Environmental Chemistry and Toxicology. November 11-15, 1990. Washington, DC.

Harris MA, Piskorska-Pliszczynska J, Zacharewski T, and Safe S. 1990. Human breast cancer cell lines as models for investigating the effects of TCDD and related compounds. Chemosphere. 20(7-9):1135-1140.

Harris, M., T. Zacharewski, S. and Safe, S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: Effects of nuclear estrogen receptor levels in MCF-7 Cells. Society of Toxicology Meeting. February 12-16, 1990. Miami Beach, FL.

Harris MA, Zacharewski T, Piskorska-Pliszcyznska J, Rosengren R, and Safe S. 1990. Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 Mice by 2,3,7,8-tetrachlordibenzo-p-dioxin and related congeners: mechanistic studies. Toxicol Appl Pharmacol. 105:243-253.

Zacharewski, T., J. Piskorska-Pliszczynska, F. Rosengren, B. Astroff, M. Harris, L. Safe, and S.Safe. 1990. 8-Iodo-1,3-dichlorodibenzofuran (I-MCDF) and 125I-MCDF as a 2,3,7,8-Tetrachlordibenzo-p-dioxin (TCDD) antagonist. Society of Toxicology Meeting. February 12-16, 1990. Miami Beach, FL.

Harris MA, Zacharewski T, and Safe S. 1990. Effects of 2,3,7,8-tetrachorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells. Cancer Res. 50:3579-3584.

Randerath K, Putman KL, Randerath E, Harris MA, Zacharewski T, and Safe S. 1990. Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent I-spot DNA adducts in the liver of female and male Sprague-Dawley rats. Chemosphere 20(7-9):1049-1052.

View Abstract

Randerath K, Putman KL, Randerath E, Zacharewski T, Harris MA, and Safe S. 1990. Effects on 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex specific effects and structure-activity relationships. Toxicol Appl Pharmacol. 103:271-280.

Roberts SM, Pounds JG and James RC. 1990. Cocaine toxicity in cultured rat hepatocytes.  Toxicol. Lett. 50: 283-288.

Simmons HF, James RC, Harbison RD and Roberts SM. 1990. Depression of glutathione by cold-restraint in mice.  Toxicology 61:59-71.

Safe S, Harris MA, Zacharewski T, and Biegel L. 1990. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an antiestrogen in human breast cancer cells: mechanistic studies. Proceedings Dioxin `90, Eco-Informa Press. Bayreuth, Germany, 1:137-140.

1989

Biegel L, Harris MA, Davis D, Rosengren R, Safe L, and Safe S. 1989. 2,2′,4,4′,5,5′-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice. Toxicol Appl Pharmacol. 97:561-571.

Couture, L.A., M.W. Harris, and L.S. Birnbaum. Characterization of TCDD-induced hydronephrosis relative to cleft palate in C57BL/6N Mice. Presented at the Society of Toxicology Annual Meeting. February 27-March 3, 1989. Atlanta, GA.

Birnbaum LS, Couture LA, and Elwell MR. 1989. Subchronic effects of exposure to Octachlorodibenzo-p-dioxin (OCDD). Chemosphere. 18(1-6):389-390.

Harris, M., M. Romkes, and S. Safe. Human breast cancer cells as models for investigating Ah receptor mediated processes. Dioxin ’89. September 17-22, 1989. Toronto, Canada.

Couture LA, Harris MW, and Birnbaum LS. 1989. Developmental toxicity of 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) in the Fischer 344 rat. Fundam Appl Toxicol. 12:358-366.

Harris, M., M. Romkes, and S. Safe. Human breast cancer cells as models for investigating Ah receptor mediated processes. Society of Toxicology 28th Annual Meeting. February 27-March 3, 1989. Atlanta, GA.

Harris, MA, Piskorska-Pliszczynska J, Zacharewski T, Romkes M, and Safe S. 1989. Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Res. 49:4531-4535.

Zacharewski, T., M. Harris, and S. Safe. 1989. Structure dependent induction of aryl hydrocarbon hydroxylase of TCDD and related compounds: mechanistic studies. Society of Toxicology 28th Annual Meeting. February 27-March 3, 1989. Atlanta, GA.

Harris MA, Zacharewski T, Astroff B, Kamps C, and Safe S. 1989. Characterization of 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-TCDD antagonist in male rats: induction of monooxygenases. Chemosphere. 19:769-772.

Randerath, K., K.L. Putman, E. Randerath, M. Harris, T. Zacharewski, and S. Safe. Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent i-spot DNA adducts in the liver of female and male Sprague-Dawley rats. Dioxin ’89. September 17-22, 1989. Toronto, Canada.

Harris MA, Zacharewski T, Astroff B, and Safe S. 1989. Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies. Mol Pharmacol. 35:729-735.

Kerger BD, Roberts SM, Harbison RD and James RC. 1989. Antagonism of bromobenzene-induced hepatotoxicity by the a-adrenoreceptor blocking agents, phentolamine and idazoxan: Role of hypothermia.  Toxicol. Appl. Pharmacol. 97:360-369.

Skoulis NP, James RC, Harbison RD and Roberts SM. 1989. Depression of hepatic glutathione by opioid analgesic drugs in mice.  Toxicol. Appl. Pharmacol. 99:139-147.

Skoulis NP, James RC, Harbison RD and Roberts SM. 1989. Perturbation of glutathione by a central action of morphine.  Toxicology. 57:287-302.

Clevenger MA, Roberts SM, Lattin DL, Harbison RD and James RC. 1989. The pharmacokinetics of 2,2’,5,5’-tetrachlorobiphenyl and 3,3’,4,4’-tetrachlorobiphenyl and its relationship to toxicity.  Toxicol. Appl. Pharmacol. 100:315-327.

Safe S, Mason G, Sawyer T, Zacharewski T, Harris MA, Yao C, Keys B, Farrell K, Holcomb M, Davis D, Safe L, Piskorska-Pliszcyzynska J, Leece B, Denomme M, Hutzinger O, Thoma H, Chittim B, and Madge J. 1989. Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review. Toxicol Ind Health. 5(5):757-775.

Safe S, Zacharewski T, Safe L, Harris MA, Yao C, and Holcomb M. 1989. Validation of the AHH induction bioassay for the determination of 2,3,7,8-TCDD toxic equivalents. Chemosphere. 18(1-6):941-946.

Zacharewski T, Harris MA, and Safe S. 1989. Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners. Arch Biochem Biophys. 272(2):344-355.

Zacharewski T, Harris MA, Safe S, Thoma H, Hauschulz G, Knorr E, and Hutzinger O. 1989. Application of the in vitro AHH induction bioassay for determining 2,3,7,8-TCDD equivalents: pyrolyzed flame retardant mixtures. Chemosphere. 18(1-6):383-387.

1988

Birnbaum LS and Couture LA. 1988. Disposition of Octachlorodibenzo-p-dioxin (OCDD) in male rats. Toxicol Appl Pharmacol. 93:22-30.

Couture, L.A., M.W. Harris, and L.S. Birnbaum. Teratogenicity of 2,3,4,7,8-Pentachlorodibenzofuran (4-PeCDF) in F344 rats. Presented at the Society of Toxicology Annual Meeting. February 15-19, 1988. Dallas, TX.

Couture LA, Elwell MR, and Birnbaum LS. 1988. Dioxin-like effects observed in male rats following exposure to Octachlorodibenzo-p-dioxin (OCDD) during a 13-week study. Toxicol Appl Pharmacol. 93:31-46.

Harris, M., T. Zacharewski, B. Astroff, C. Kamps, and S. Safe. Characterization of 6-Methyl-1,3,8-Trichlorodibenz-furan (MCDF) as a 2,3,7,8-TCDD Antagonist in Male Rats: Induction of Monooxygenases. Dioxin ’88 Symposium. August 21-26, 1988. Umea, Sweden.

Harris MA, Kamps C, and Safe S. 1988. Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat. Carcinogenesis. 9(8):1475-1479.

Harris, M., C. Kamps, and S. Safe. Role of 4s binding protein in the induction of aryl hydrocarbon hydroxylase in the rat. Society of Toxicology 27th Annual Meeting. February 15-19, 1988. Dallas, TX

Smith AC, Roberts SM, Berman LM, Harbison RD and James RC. 1988. Effects of piperonyl butoxide on halothane hepatotoxicity and metabolism in the hyperthyroid rat.  Toxicology. 50: 95-105.

Zacharewski, T., M. Harris, and S. Safe. 1988. Validation of the in vitro bioassay: determination of 2,3,7,8-TCDD equivalents in pyrolyzed flame retardants and great lakes fish extracts. Gulf Coast Society of Toxicology and Southwest Environmental Mutagens Society Meeting. 1988. Houston, TX.

James RC, Wessinger WD, Roberts SM, Millner GC and Paule MG. 1988. Centrally mediated opioid induced depletion of hepatic glutathione: Effects of intracerebroventricular administration of mu, kappa, sigma and delta agonists.  Toxicology 51:267-279.

Smith AC, Roberts SM, James RC, Berman LM and Harbison RD. 1988. Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats.  Xenobiotica. 18: 991-1001.

Kerger BD, James RC and Roberts SM. 1988. An assay for phentolamine using high performance liquid chromatography with electrochemical detection.  Anal. Biochem. 170:145-151.

Kerger BD, Gandy J, Bucci TJ, Roberts SM, Harbison RD and James RC. 1988. Antagonism of bromobenzene-induced hepatotoxicity by the alpha-adrenergic blocking agents, phentolamine and idazoxan.  Toxicol. Appl. Pharmacol. 95: 12-23.

Kerger BD, Roberts SM, Hinson JA, Gandy J, Harbison RD and James RC.  1988. Antagonism of bromobenzene-induced hepatotoxicity by phentolamine:  Evidence for a metabolism independent intervention.  Toxicol.  Appl. Pharmacol. 95: 24-31.

Kerger BD, Robert SM and James RC.  1988. Comparison of human and mouse liver microsomal metabolism of bromobenzene and chlorobenzene to 2- and 4-halophenols.  Drug Metab. Dispos. 16:672-677.

Zacharewski T, Harris MA, Safe S, Thoma H, and Hutzinger O. 1988. Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining “2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents”: pyrolyzed brominated flame retardants. Toxicology. 51:177-189.

1987

Robert SM, Grund VR, James RC and Harbison RD.  1987. Histamine and hepatic glutathione in the mouse.  Life Sci. 40:2103-2110.

Couture, L.A., and L.S. Birnbaum. Evaluation of Subchronic exposure to Octachlorodibenzodioxin (OCDD). Presented at the Society of Toxicology Annual Meeting. February 23-27, 1987. Washington, DC.

Gandy, J., C.M. Teaf, F.A. Adatsi, R.C. James and R.D. Harbison. The dependence of male reproductive toxicity on germ cell stage. In: Functional Teratogenesis: Functional Effects on the Offspring after Parental Drug Exposure. T. Fujii and P.M. Adams (Eds.), Teikyo University Press, Tokyo, Japan. pp. 133-143,  1987.

James RC, Schiefer MA, Roberts SM and Harbison RD. 1987. Antagonism of cocaine-induced hepatotoxicity by the a-adrenergic antagonists phentolamine and yohimbine.  J. Pharmacol. Exp. Ther. 242:726-732.

Kamps, C., M. Harris, and S. Safe. 1987. Polynuclear aromatic hydrocarbon—4s binding protein interactions. Structure activity relationships. Society of Toxicology 26th Annual Meeting. February 1987. Washington DC.

Roberts SM, Skoulis NP and James RC.  1987. A centrally mediated effect of morphine to diminish hepatocellular glutathione.  Biochem. Pharmacol. 36:3001-3005.

Safe, S., T. Zacherewski, M. Harris, C. Yao, and M. Holcomb. 1987. Validation of the AHH induction bioassay for the determination of 2,3,7,8-TCDD toxic equivalents. Dioxin ’87 Symposium. October 4-9, 1987. Las Vegas, NV.

Roberts SM, James RC, Simmons HF and Harbison RD. 1987. Alcohol and cocaine-induced liver injury.  Alcohol Health Res. World. 11:20-25.

Zacharewski, T., M. Harris, S. Safe, H. Thoma, G. Hauschulz, E. Knorr, and O. Hutzinger. 1987. Applications of the In vitro AHH induction bioassay for determining 2,3,7,8-TCDD equivalents: pyrolyzed flame retardant mixtures. Dioxin ’87 Symposium. October 4-9, 1987. Las Vegas, NV.

1986

Birnbaum, L.S., and L.A. Couture. 1986. Disposition of Octachlorodibenzo-p-dioxin (OCDD) in rats. Society of Toxicology Annual Meeting. March 3-7, 1986. New Orleans, LA. The Toxicologist. 6:310.

1985

Goodman, D.R., R.C. James and R.D. Harbison.  Chemical-induced heritable cell changes:  Description of mutagenicity assays and applications of test results.  In:  Reproductive Toxicology.  R.L. Dixon (Ed.), Raven Press, New York, NY. pp. 267-285,  1985.

James, R.C.  General Principles of Toxicology.  In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 7-26,  1985.

James, R.C.  Hematotoxicity:  Toxic Effects in the Blood.   In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 59-77,  1985.

James, R.C.  Hepatotoxicity:  Toxic Effects in the Liver.  In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 78-105,  1985.

James, R.C.  Neurotoxicity:  Toxic Effects in the Nervous System.  In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp.123-137,  1985.

James, R.C.  Effects of Organic Solvents.   In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 230-259,  1985.

James, R.C.  Risk Assessment.   In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 369-398,  1985.

James, R.C. and C.M. Teaf.  Carcinogenesis.  In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 301-342,  1985.

1984

James RC, Freeman RW and Harbison RD. 1984. L-alpha-acetylmethadol- induced tissue alterations in mice.  Drug Chem. Toxicol. 7:91-112.

Smith AC, James RC, Berman LM and Harbison RD. 1984. Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthryoid rats.  Fundam. Appl. Toxicol. 4:221-230.

1983

James RC, Roberts SM and Harbison RD. 1983. The perturbation of hepatic glutathione by alpha-2 adrenergic agonists.  Fundam. Appl. Toxicol. 3:303-308.

Smith A, Berman LM, James RC and Harbison RD. 1983. Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.  Biochem. Pharmacol. 32:3531-3539.

1982

James RC and Harbison RD. 1982. Hepatic glutathione and hepatotoxicity:  Effects of cytochrome P-450 complexing compounds SKF525-A, L-alpha acetamethadol (LAAM), norLAAM, and piperonyl butoxide.  Biochem. Pharmacol. 31:1829-1835.

James RC, Goodman DR and Harbison RD. 1982. Hepatic glutathione and hepatotoxicity:  Changes induced by selected narcotics.  J. Pharmacol. Exp. Ther. 221:708-714.

Goodman DR, James RC and Harbison RD. 1982. Placental Toxicology.  Food. Chem. Toxicol. 20:123-128,  1982.

Kupfer A, James RC, Carr K and Branch R. 1982. Analysis of hydroxylated and demethylated metabolites of mephenytoin in man and laboratory animals using gas-liquid chromatography and high-performance liquid chromatography.  J. Chromatogr. 232:93-100.

1981

Desmond PV, James RC, Schenker S and Branch RA. 1981. Preservation of glucuronidation in carbon tetrachloride-induced acute liver injury in the rat.  Biochem. Pharmacol. 30:993-999.

James RC, Villenevue JP, Kupfer AH and Branck RA. 1981. Induction of drug-metabolizing enzymes by the enantionmers of normephenytoin in the rat.  Drug Metab. Dispos. 9:297-302.

James RC, Desmond PV, Kupfer A, Schenker S and Branch RA. 1981. The differential localization of various drug metabolizing systems within the rat liver lobule as determined by the hepatotoxins allyl alcohol, carbon tetrachloride and bromobenzene.  J Pharmacol Exp Ther. 217:127-132.

1980

Verbeeck R, James RC, Taber DF, Sweetman B and Wilkinson GR. 1980. The determination of meperdine, normeperidine and deuterated analogs in blood and plasma by gas chromatography mass spectrometry selected ion monitoring.  Biomed. Mass Spectrom. 7:58-60.

1978

James RC and Franklin MR.  The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.  Toxicol. Appl. Pharmacol. 44:63-73.

James RC and Franklin MR. 1978. Tissue concentrations and the mortality of d-amphetamine in mice:  Change associated with the use of diethaminoethyl 2,2. diphenylvalerate. HCI.  Toxicol. Appl. Pharmacol. 44:75-80.

1975

James RC and Franklin MR. 1975. Comparisons of the formation of cytochrome P-450 complexes absorbing at 455 n.m. in rabbit and rat microsomes.  Biochem. Pharmacol. 24:835-838.