2019 (145 POSTS)
Urban J , Wikoff D , Suh M , Britt J , Harvey S , Chappell G, Haws L . Comparison of NTP OHAT and US EPA TSCA study quality criteria: Trichloroethylene (TCE) and congenital heart defects (CHDs) as a case study. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
McIntyre B, Zorilla L, Borghoff S , Foster P. Assessment of avobenzone, ensulizole, homosalate, and padimate-O in endocrine disruptor screening panel studies. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: safety assessment
Thompson CM , Gentry R. An updated mode-of-action analysis for formaldehyde-induced nasal tumors in rodents: A case study using the IPCS MOA and human relevance frameworks. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: formaldehyde , mode of action
Borghoff SJ , Fitch S , Huggett, Wikoff D . A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine disrupting properties of perfluorohexanoic acid (PFHxA). 2019. Poster at Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: PFAS
Chappell GA, Rager JE, Wolf JC, Babic M, LeBlanc KJ, Ring CL, Harris MA, Thompson C . Similarities in the transcriptomic signatures in the duodenum of mice exposed to hexavalent chromium, captan, or folpet inform the mechanisms of chemical-induced mouse small intestine cancer. Presentation at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: Cancer , chromium , transcriptomics
Ring CL, Urban J , Wikoff D , Thompson C , Budinsky RA, Haws LC . Application of systematic review and quantitative evidence integration methods to support risk assessment: Characterization of the dose-response relationship between exposure to dioxin-like compounds (DLC) and sperm count. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: dioxin , risk assessment , Systematic Review
Henderson RG , Doepker C , Lopez JG. Safety evaluation of L-theanine administered via hard chew to dogs. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
Sterner TR, Covington TR , Merrill EA, Mattie DR. Novel array approach to mixtures model streamlines predictions of cochlea and brain region tissue concentrations from JP-8 inhalation exposure. Poster presented at the Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Pitts E, Gearhart JM, Covington TR , Duran CM, Yamamoto DP, McKenzie-Smith D, Ott DK, Pangburn HA. Thermal stress effects on physiologically based pharmacokinetic model for Department of Defense personnel. Poster presented at the Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Covington TR . Translating an existing physiologically-based pharmacokinetic model for isopropanol from a scalar to an array format. Poster presented at the Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Suh M , Wikoff D , Lipworth L, Goodman M, Fitch S , Mittal L , Ring C, Proctor D . 2019. Hexavalent chromium and stomach cancer: A systematic review and meta-analysis. Crit Rev Toxicol 49(2):140-159; doi: 10.1080/10408444.2019.1578730 . PMID: 30896278.
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Publication: Manuscripts
/ Topics: Cancer , chromium , meta-analysis , Metals , Systematic Review
Vincent MJ , Allen BA, Palacios OM, Haber LT, Maki KC. 2019. Meta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterol. Am J Clin Nutr 109(1):7–16, doi: 10.1093/ajcn/nqy273.
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Publication: Manuscripts
/ Topics: Toxicology
Vincent MJ , Kozal SJ, Thompson WJ, Maier A, Dotson GS, Best EA, Mundt KA. 2019. Ethylene oxide: Cancer evidence integration and dose-response implications. Dose Response 17(4):1559325819888317; doi: 10.1177/1559325819888317 . PMID:3185323510.
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Publication: Manuscripts
/ Topics: Air Quality , Cancer
Prior H, Monticello T , Boulifard V, Brennan FR, Kimber I. 2019. Integration of consortia recommendations for justification of animal use within current and future drug development paradigms. Int J Toxicol 38(4):319-325; doi: 10.1177/1091581819852922 .
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Publication: Manuscripts
/ Topics: drug development , safety assessment
Schaefer H , Fitzpatrick S, Flannery B. Chemical contaminants in children’s food: A review of recent literature. Abstract 2640, Society of Toxicology 58th Annual Meeting, Baltimore, MD, 2019.
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Publication: Abstracts and Presentations
/ Topics: Exposure Assessment , food additives , food safety , NHANES
Anyangwe N, Fitzpatrick S, Flannery B, Mattia A, Schaefer H , Tyler T, Whiteside C. Use of dog studies in US FDA’s safety assessments for food additives and color additives. Abstract 2781, Society of Toxicology 58th Annual Meeting, Baltimore, MD, 2019.
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Publication: Abstracts and Presentations
/ Topics: food additives , safety assessment
Wheeler MW , Piegorsch WW, Bailer AJ. 2019. Quantal risk assessment database: A database for exploring patterns in quantal dose‐response data in risk assessment and its application to develop priors for Bayesian dose‐response analysis. Risk Anal 39(3):616-29; doi: 10.1111/risa.13218 . PMCID: PMC6408269
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Publication: Manuscripts
/ Topics: Bayesian modeling , benchmark dose estimation (BMD) , dose-response , risk analysis , risk assessment
Wheeler MW . 2019. Bayesian additive adaptive basis tensor product models for modeling high dimensional surfaces: An application to high-throughput toxicity testing. Biometrics 75(1):193-201; doi: 10.1111/biom.12942 . PMCID: PMC6363906.
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Publication: Manuscripts
/ Topics: Bayesian modeling , dose-response , modeling
Choksi N , Clippinger AJ, Gehen S, Corvaro M, Ng S, Kolle SNE, van Cott A, et al. Defined approach for detection of eye irritants and corrosives for pesticide formulations. Poster presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: pesticides
Sedykh A, Choksi N , Allen D, Kleinstreuer N, Casey W, Shah R. Mixture-based modeling of chemical ocular toxicity based on the US EPA hazard categories. Poster presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019
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