Publications

Patlewicz G, Dean J, Gibbons C, Judson R, Keshava N, Vegosen L, Martin T, Pradeep P, et al. 2021. Integrating publicly available information to screen potential candidates for chemical prioritization under the Toxic Substances Control Act: A proof of concept case study using genotoxicity and carcinogenicity. Comput Toxicol 20(Nov):100185; doi: 10.1016/j.comtox.2021.100185. PMID: 35128218.

Shah I, Tate T, Patlewicz G. 2021. Generalized Read-Across prediction using genra-py. Bioinformatics 37(19):3380-3381; doi: 10.1093/bioinformatics/btab210. PMID: 33772575.

Lizarraga LE, Patlewicz G, Dean JL II, et al. 2021. Provisional Peer-Reviewed Toxicity Values for 3,4-Toluenediamine (CASRN 496-72-0). Cincinnati (OH): U.S. Environmental Protection Agency; Aug. Available from: https://www.ncbi.nlm.nih.gov/books/NBK584583/

Lizarraga LE, Patlewicz G, Dean JL II, Zhao QJ, Kaiser JP. 2021. Provisional Peer-Reviewed Toxicity Values for 3,4-Toluenediamine (CASRN 496-72-0). Cincinnati (OH): U.S. Environmental Protection Agency; 2021 Aug. PMID: 36191119.

Tate T, Wambaugh J, Patlewicz G, Shah I. 2021. Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data: A proof-of-concept case study. Comput Toxicol 19(Aug):100171; doi: 10.1016/j.comtox.2021.100171. PMID: 37309449.

Houck KA, Patlewicz G, Richard A, Williams AJ, Smeltz M, Clifton, MS, Wetmore B, Medvedev A, Makarov SS. 2021. Bioactivity profiling of per- and polyfluoroalkyl substances identifies potential toxicity pathways related to molecular structure. Toxicology 457(June 15):152789; doi: 10.1016/j.tox.2021.152789. PMID: 33887376.

Pradeep P, Judson RS, DeMarini DM, Keshava N, Martin TM, Dean J, Gibbons CF,…, Patlewicz G. 2021. An evaluation of existing QSAR models and structural alerts and development of new ensemble models for genotoxicity using a newly compiled experimental dataset. Comput Toxicol 18(May):100167; doi.org/10.1016/j.comtox.2021.100167. PMID: 34504984.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Alberga D et al. 2021. CATMoS: Collaborative acute toxicity modeling suite. Environ Health Perspect 129(4):47013; doi: 10.1289/EHP8495. PMID: 33929906.

Brozek JL, Canelo-Aybar C, Akl EA, Bowen JM, Bucher J, Chiu WA, Cronin M, Djulbegovic B,…, Patlewicz G, et al. 2021. GRADE Guidelines 30: The GRADE approach to assessing the certainty of modeled evidence—An overview in the context of health decision-making. J Clin Epidemiol 129(Jan):138-150; doi: 101016/j.jclinepi.2020.09.018. PMID: 32980429.

Rovida C, Escher SE, Herzler M, Bennekou SH, Kamp H, Kroese DE, Maslankiewicz L, Moné MJ, Patlewicz G, et al. 2021. NAM-supported read-across: From case studies to regulatory guidance in safety assessment. ALTEX 38(1):140-150; doi: 10.14573/altex.2010062. PMID: 33452529.

Nelms MD, Karmaus AL, Patlewicz G. 2020. An evaluation of the performance of selected (Q)SARs/expert systems for predicting acute oral toxicity. Comput Toxicol 16(Nov):100135; doi: 10.1016/j.comtox.2020.100135. PMID: 33163737.

Pradeep P, Patlewicz G, Pearce R, Wambaugh J, Wetmore B, Judson R. 2020. Using chemical structure information to develop predictive models for in vitro toxicokinetic parameters to inform high-throughput risk-assessment. Comput Toxicol 16(Nov):100136; doi: 10.1016/j.comtox.2020.100136. PMID: 34124416.

Nelms MD, Patlewicz G. 2020. Derivation of new threshold of toxicological concern values for exposure via inhalation for environmentally-relevant chemicals. Front Toxicol 2:580347; doi: 10.3389/ftox.2020.580347. PMID: 35296122.

Jackson AC, Liu J, Vallanat B, Jones C, Nelms MD, Patlewicz G, Corton JC. 2020. Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics 12(9):1400-1415; doi: 10.1039/d0mt00071j. PMID: 32661532.

Patlewicz G. 2020. Navigating the minefield of computational toxicology and informatics: Looking back and charting a new horizon. Front Toxicol 2:2; doi: 10.3389/ftox.2020.00002. PMID: 35296116.

Rovida C, Barton-Maclaren T, Benfenati E, Caloni F, Chandrasekera PC, Chesne C, Cronin MTD,.., Patlewicz G, et al. 2020. Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology. ALTEX 37(4):579-606; doi: 10.14573/altex.1912181. PMID: 32369604.

Nelms MD, Pradeep P, Patlewicz G. 2019. Evaluating potential refinements to existing Threshold of Toxicological Concern (TTC) values for environmentally-relevant compounds. Regul Toxicol Pharmacol 109(Dec):104505; doi: 10.1016/j.yrtph.2019.104505. PMID: 31639428.

Helman G, Patlewicz G, Shah I. 2019. Quantitative prediction of repeat dose toxicity values using GenRA. Regul Toxicol Pharmacol 109(Dec):104480; doi: 10.1016/j.yrtph.2019.104480. PMID: 31550520.

Nelms MD, Lougee R, Roberts DW, Richard A, Patlewicz G. 2019. Comparing and contrasting the coverage of publicly available structural alerts for protein binding. Comput Toxicol 12(Nov):100100; doi: 10.1016/j.comtox.2019.100100. PMID: 37701288.

Helman G, Shah I, Patlewicz G. 2019. Transitioning the Generalized Read-Across approach (GenRA) to quantitative predictions: A case study using acute oral toxicity data. Comput Toxicol 12(Nov):1000097; doi: 10.1016/j.comtox.2019.100097. PMID: 33623834.