2021 (92 POSTS)
Borghoff SJ , Fitch SE , Black MVB, McMullen PD, Andersen ME, Chappell GA. 2021. A systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole. Regul Toxicol Pharmacol 124(Aug):104977; doi: 10.1016/j.yrtph.2021.104977 . PMID: 34174380.
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Topics: mode of action
Pittman CA, Roura R, Price C , Lin FR, Marrone N, Nieman CL. 2021. Racial/ethnic and sex representation in US-based clinical trials of hearing loss management in adults: A systematic review. JAMA Otolaryngol: Head Neck Surg 147 (7):656–662; https://doi.org/10.1001/jamaoto.2021.0550 .
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Topics: hearing loss , Systematic Review
Yi JS, Pittman CA, Price CL , Nieman CL, Oh ES. 2021. Telemedicine and dementia care: A systematic review of barriers and facilitators. J Am Med Direct Assoc; 22 (7):P1396-P1402; https://doi.org/10.1016/j.jamda.2021.03.015
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Topics: Systematic Review
Whaley P, Blaauboer BJ, Brozek J, Cohen Hubal EA, Hair K, Kacew S, Knudsen TB, Kwiatkowski CF, Mellor DT, Olshan AF, Page MJ, Rooney AA, Radke E, Shamseer L, Tsaioun K, Tugwell P, Wikoff D , Woodruff TJ. 2021. Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do. ALTEX 38(3):513-522. doi: 10.14573/altex.2106111 .
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Topics: Systematic Review
Yin W, Nie Z, Dingley K , Trzoss M, Krilov G, Marshall N et al. 2021. Characterization of potent paracaspase MALT1 inhibitors for hematological malignancies. Blood 138 (Supplement 1):1187; doi: 10.1182/blood-2021-153159 .
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Topics: Cancer , modeling
Dean R, Jensen IS, Cyr PL , Miller B, Maru B, Sproule DM, Feltner DE, et al. 2021. An updated cost-utility model for onasemnogene abeparvovec (Zolgensma®) in spinal muscular atrophy type 1 patients and comparison with evaluation by the Institute for Clinical and Effectiveness Review (ICER). J Mark Access Health Pol 9(1):1889841; doi: 10.1080/20016689.2021.1889841 .
Topics: Health Economics and Outcomes Research (HEOR)
Jaeschke H, Murray FJ, Monnot AD, Jacobson-Kram D, Cohen SM, Hardisty JF, Atillasoy E… Wikoff D , et al. 2021. Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential. Regul Toxicol Pharmacol 120(March):104859; doi: 10.1016/j.yrtph.2020.104859 . PMID: 33388367.
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Topics: carcinogens , pharmacology
Houck KA, Patlewicz G , Richard A, Williams AJ, Smeltz M, Clifton, MS, Wetmore B, Medvedev A, Makarov SS. 2021. Bioactivity profiling of per- and polyfluoroalkyl substances identifies potential toxicity pathways related to molecular structure. Toxicology 457(June 15):152789; doi: 10.1016/j.tox.2021.152789 . PMID: 33887376.
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Topics: PFAS
Rooney JP, Choksi NY , Ceger P, Daniel AB, Truax J, Allen D, Kleinstreuer N 2021. Analysis of variability in in vivo rabbit skin irritation assay results. Regul Toxicol Pharmacol 122(June):104920; doi: 10.1016/j.yrtph.2021.104920 . PMID: 33757807.
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Topics: NAMs , test methods
Proctor DM , Bhat V, Suh M , Reichert H , Jiang X , Thompson CM . 2021. Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches. Regul Toxicol Pharmacol 124(August):104969; doi: 10.1016/j.yrtph.2021.104969 . PMID: 34089813.
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Topics: Cancer , chromium , Exposure Assessment , risk assessment
Nielson CM, Bylsma LC , Fryzek JP, Saad HA, Crawford J. 2021. Relative dose intensity of chemotherapy and survival in patients with advanced stage solid tumor cancer: A systematic review and meta-analysis. Oncologist 26(9):e1609–e1618; doi: 10.1002/onco.13822 . PMID: 33973301.
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Topics: Epidemiology , Systematic Review
Rehorn M, Sacks NC , Emden MR, Healey B, Preib MT, Cyr PL , Pokorney SD. 2021. Prevalence and incidence of patients with paroxysmal supraventricular tachycardia in the United States. J Cardiovasc Electrophysiol 32(8):2199-2206; doi: 10.1111/jce.15109 .
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Topics: Epidemiology
Chew D, Sacks NC , Emden MR, Preib MT, Cyr PL , Wood D, Pokorney SD. 2021. Trends in health care resource use and expenditures in patients with newly diagnosed paroxysmal supraventricular tachycardia in the United States. Am Heart J 233(March):132–140; doi: 10.1016/j.ahj.2020.12.012 .
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Topics: Health Economics and Outcomes Research (HEOR)
Wang Y, Mittelstaedt RA, Wynne R, Chen Y, Cao X, Muskhelishvili L, Davis K, Robison TW , et al. 2021. Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by duplex sequencing. Environ Mol Mutagen 62(5):306-318; doi: 10.1002/em22444 .
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Topics: genotoxicity , test methods
Belair DG, Sudak K, Connelly K, Collins ND , Kopytek SJ, Kolaja KL. 2021. Investigation into the role of ERK in tyrosine kinase inhibitor-induced neuropathy. Toxicol Sci 181(2):160–174; doi: 10.1093/toxsci/kfab033 . PMID: 33749749.
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Topics: toxicokinetics
Ring C, Sipes NS, Hsieh JH, Carberry C, Koval LE, Klaren WD , Harris MA, Auerbach SS, Rager JE. 2021. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high throughput toxicokinetics. Comput Toxicol 18(May):100166; doi: 10.1016/j.comtox.2021.100166 . PMID: 34013136.
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Topics: modeling , toxicokinetics
Alexander DD, Pastula ST , Riordan AS. 2021. Epidemiology of lung cancer among acrylonitrile-exposed study populations: A meta-analysis. Regul Toxicol Pharmacol 122(June):104896; doi: 10.1016/j.yrtph.2021.104896 . PMID: 33617939.
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Topics: Cancer , Epidemiology , Systematic Review
Hathway J, Miller-Wilson L, Yao W, Jensen I , Weinstein M, Parks P. 2021. The health economic impact of varying levels of adherence to colorectal screening on providers and payers. J Med Econ 24(1):69–78; doi: 10.1080/13696998.2020.1858607 .
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Topics: Cancer , Health Economics and Outcomes Research (HEOR)
Pradeep P, Judson RS, DeMarini DM, Keshava N, Martin TM, Dean J, Gibbons CF,…, Patlewicz G . 2021. An evaluation of existing QSAR models and structural alerts and development of new ensemble models for genotoxicity using a newly compiled experimental dataset. Comput Toxicol 18(May):100167; doi.org/10.1016/j.comtox.2021.100167 . PMID: 34504984.
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Topics: genotoxicity
de Vries RBM, Angrish M, Browne P, Brozek J, Rooney AA, Wikoff DS , Whaley P, Edwards SW, et al. 2021. Applying evidence-based methods to the development and use of adverse outcome pathways. ALTEX 38(2):336–347; doi: 10.14573/altex.2101211 .
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