Lansita J, Mease KM , Qiu H, Yednock T, Sankaranarayanan S, Kramer S. 2017. Nonclinical development of ANX005: A humanized anti-Clq antibody for treatment of autoimmune and neurodegenerative diseases. Int J Toxicol 36(6)449-462; doi: 10.1177/1091581817740873 . PMID: 29202623.
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Publication: Manuscripts
/ Topics: Toxicology
Wirbisky-Hershberger SE , Sanchez OF, Horzmann KA, Thanki D, Yuan C, Freeman JL. 2017. Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression. Food Chem Toxico l 109:727–734.
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Publication: Manuscripts
/ Topics: Toxicology
Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C , Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; DOI: 10.1021/acs.chemrestox.7b00221.
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Publication: Manuscripts
/ Topics: Toxicology
Thompson CM, Suh M, Proctor DM, Haws LC , Harris MA. 2017. Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents. Mutation Res 823:45-57.
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Publication: Manuscripts
/ Topics: Hexavalent Chromium
Antonia S, Claffey M, Balan G, Barreiro G, Barricklow J, Bohanon, M, Boscoe B, Cappon G , et al. 2017. Discovery and characterization of PF-06462894 (8), an alkyne-lacking metabotropic glutamate receptor 5 negative allosteric modulator profiled in both rat and non-human primates. J Medicinal Chem 60:7764–7780, DOI: 10.1021/acs.jmedchem.7b00604, online article .
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Publication: Manuscripts
/ Topics: Toxicology
Sheppard A , Baker E, Bermudez D, Blattner J, Boyd K, O’Neal S, Rahim T, Whittle E. Implementing an alternate testing strategy for assessing skin irritation. Society of Toxicology, Abstract #2734, Baltimore, MD, 2017.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
Sheppard A , Baker E, Bermudez D, Blattner J, Boyd K, O’Neal S, Rahim T, Whittle E. Use of alternative methods to assess skin irritation of chemical mixtures. World Congress for Alternatives to Animal Testing, Seattle, WA, 2017.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Thompson CM , Young RR, Dinesdurage H, Suh M , Harris MA, Rohr AC, Proctor DM . 2017. Assessment of the mutagenic potential of hexavalent chromium in the duodenum of Big Blue® rats. Toxicol Appl Pharmacol 330(1):48-52; 10.1016/j.taap.2017.07.002 .
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Publication: Manuscripts
/ Topics: chromium , Cr(VI) MOA Study , Hexavalent Chromium
Gadupudi GS, Klaren WD , Olivier AK, Klingelhutz AJ, Robertson LW. Diminished phosphorylation of CREB Is a key event in the dysregulation of gluconeogenesis, glycogenolysis and fatty acid oxidation in PCB126 hepatotoxicity. Society of Toxicology Annual Meeting, Baltimore, Md, and NIEHS Environmental Health Science FEST, Durham, NC, 2017.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
Iwata Y, Klaren W , Grimm F, Rusyn I. A multidimensional high-throughput approach for toxicity evaluation of environmental chemicals in induced pluripotent stem cell-derived endothelial cells. Society of Toxicology Annual Meeting, Baltimore, Md, 2017.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
Iwata Y, Klaren WD , Lebakken CS, Grimm FA, Rusyn I. 2017. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. Assay Drug Dev Technol 15(6):267–279, PMID: 28771372.
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Publication: Manuscripts
/ Topics: Toxicology
Ruzin A, Levin-Sparenberg E, Pastula S , Jiang X, Fryzek J, Tovchigrechko A, Lu B, Yu L, Hackett J, Villafana T, Esser MT. Characterization of RSV strains among U.S. patients in the OUTSMART RSV program during 2015-16. Abstract, poster presentation, ID Week 2017, San Diego, CA, October 2017.
Publication: Abstracts and Presentations
/ Topics: Epidemiology
Garabrant D, Pastula S . Asbestos and EMP fiber potency analysis. Abstract, Oral Presentation, Monticello Conference, Charlottesville, VA, October 2017.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Klaren WD , Vine D, Vogt S, Robertson LW. 2017. Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25(17):16427–16433, PMID: 28940161.
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Publication: Manuscripts
/ Topics: Toxicology
Panko J , Hitchcock K, Fung M, Spencer PJ, Kingsbury T, Mason AM. 2017. A comparative evaluation of five hazard screening tools. Integr Environ Assess Manag 13(1):139–154.
See also: Panko J , Hitchcock K, Fung M, Spencer PJ, Kingsbury T, Mason AM. 2017. Letter to the Editor: Authors’ response to Turner et al. Integr Environ Assess Manag 13(1):15–16.
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Publication: Manuscripts
/ Topics: Toxicology
Perez AL, Gauthier AM , Ferracini T, Cowan DM, Kingsbury T, Panko J . 2017. The challenge of predicting problematic chemicals using a decision analysis tool: Triclosan as a case study. Integr Environ Assess Manag 13(1):198–207.
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Publication: Manuscripts
/ Topics: Toxicology
Burns A, Shin J, Unice KM, Gaffney SH, Kreider ML, Gelatt RN, Panko JM . 2017. Combined analysis of job and task benzene air exposures among workers at four US refinery operations. Toxicol Indust Health 33(3):193–210.
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Publication: Manuscripts
/ Topics: Toxicology
Rish W . Bounding analysis of drinking water health risks from a spill of hydraulic fracturing flowback water. Presented at the Marcellus Shale Coalition Member Meeting, Pittsburgh, PA, January 2017.
Publication: Abstracts and Presentations
/ Topics: Environmental Science
Wang Y, Villalta PW, Peng L, Dingley KH , Malfatti MA, Turteltaub KW, Turesky RJ. 2017. Mass spectrometric characterization of an acid-labile adduct formed with 2-amino-1-methyl-phenylimidazo[4,5-b]pyridine and albumin in humans. Chem Res Toxicol 30(2):705–714; doi: 10.1021/acs.chemrestox.6b00426 . PMID: 27984695.
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Publication: Manuscripts
/ Topics: carcinogens
Harper BH, Wang L, Zhu C, Kar NF, Li B, Moyes CR, … Dingley K , et al. 2017. Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder. Bioorg Med Chem Lett 27(4):1094–1098; doi: 10.1016/j.bmcl.2016.12.033 . PMID: 28089699.
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