East A, Rish W, Klaren WD . Using NHANES data to characterize the magnitude of allostatic load in vulnerable communities: Impact to existing risk assessment uncertainty/variability factors. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Thompson CM , Heintz MM , Wolf JC, Cheru R, Haws LC , Cullen JM. 2023. Assessment of mouse liver histopathology following exposure to HFPO-DA with emphasis on understanding mechanisms of hepatocellular death. Toxicol Pathol 51(1–2):4–14; doi: 10.1177/01926233231159078 . PMID: 36987989.
View Abstract
Publication: Manuscripts
/ Topics: ammonium , Exposure Assessment , PFAS
Heintz MM , Haws LC , Klaunig JE, Cullen JM, Thompson CM . 2023. Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans. Toxicol Sci 192(1):15–29; doi: 10.1093/toxic/kfad004 . PMID: 36629480.
View Abstract
Publication: Manuscripts
/ Topics: Cancer , mode of action , PFAS
Sterner TR, Covington TR . Complex mixtures: Array modeling of jet fuel components. Poster presented at the Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Covington TR , Sterner TR. Physiologically-based pharmacokinetic model to predict HFC-134a in exhaled breath following albuterol inhaler use. Poster presented at the Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Choksi NY, Fitch S, Harris MA, Thompson CM , Wikoff DS . Reliability assessment of guideline-based studies using systematic review critical appraisal tools. Poster presented at Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023.
Publication: Abstracts and Presentations
/ Topics: Systematic Review
Lynch H, O’Neill H, Buerger AN , Rogers K. Mode-of-action analysis of thyroid hormone effects of perfluorobutane sulfonic acid. Presented at Society of Toxicology Meeting, 2023.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Pastula S , Suh M , Jiang X , Reichert H , Movva N , Fryzek J, Simões EAF. Respiratory syncytial virus (RSV) and bronchiolitis epidemiology among the United States infant Medicaid populations in seven states. Poster 191, International Society for Pharmacoepidemiology (ICPE) annual meeting, Halifax, Nova Scotia, August 2023.
View Abstract
Publication: Abstracts and Presentations
/ Topics: Epidemiology
Thompson CM, Wikoff DS , Proctor DM, Harris MA. An evaluation of risk assessments on hexavalent chromium [Cr(VI)]: The past, present, and future of mode of action research. Poster presented at Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023.
Publication: Abstracts and Presentations
/ Topics: chromium , mode of action , risk assessment
Franzen AC, Thompson CM, Brorby GP , Wikoff DS , Ilkbahar Z, Doepker C . Risk assessment of three smoke flavoring primary products currently under re-evaluation by EFSA. Poster presented at Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023.
Publication: Abstracts and Presentations
/ Topics: food additives , food safety , Food science , risk assessment
Fitch S, Rogers J, Marty S, Ellis-Hutchings R, Becker R, Wikoff D . Development of a study quality tool for use in a systematic review of literature reporting microplastic exposure and reproductive and developmental toxicity. Poster presented at Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023.
Publication: Abstracts and Presentations
/ Topics: microplastics , Systematic Review
Sakolish C, Moyer H , Fergusson SS, Chiu WA, Rusyn I. Analysis of reproducibility and robustness of PhysioMimix T12, a proximal renal tubule microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs and chemicals. Abstract 3635, Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023.
View Abstract
Publication: Abstracts and Presentations
/ Topics: pharmacokinetics
Moyer HL , Kim S, Lam BP, Valdiviezo A, Richardson L, Menon R, Rusyn I, Han A. Evaluating mechanistic underpinnings of environmental chemical effects on feto-maternal interface using a human organ-on-chip model. Abstract 3007, Society of Toxicology 62nd Annual Meeting, Nashville, TN, March 2023. Winner, Perry J. Gehring Best Graduate Student Abstract Award, Risk Assessment Specialty Section.
View Abstract
Publication: Abstracts and Presentations
/ Topics: Exposure Assessment , modeling
Schaefer H . Evidence-based methods in toxicology: Progress in the past decade and collaborative projections for the future. Abstract 1218, Society of Toxicology 62nd Annual Meeting, Nashville, TN, 2023.
View Abstract
Publication: Abstracts and Presentations
/ Topics: Systematic Review
Thompson CM , Proctor DM , Harris MA. 2023. Letter to “Chepelev et al. Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data.” Environ Mol Mutagen 64(4):259–260; doi: 10.1002/em.22537 . PMID: 36916184.
Publication: Manuscripts
/ Topics: carcinogens , dose-response , regulatory toxicology
Sterner TR, Covington TR , Mattie DR. 2023. Complex mixtures: Array PBPK modeling of jet fuel components. Toxics 11(2):187; doi: 10.3390/toxics11020187 . PMID: 36851061.
View Abstract
Publication: Manuscripts
/ Topics: PBPK/PBDE
Pang F, Dean R, Jensen I , Bean K, Fields C, Miller B. 2023. The cost-effectiveness of OTL-200 for the treatment of metachromatic leukodystrophy (MLD) in the US. Mol Gene Metab 138(2):107258; doi: 10.1016/j.ymgme.2022.107258 .
Publication: Abstracts and Presentations
/ Topics: Health Economics and Outcomes Research (HEOR) , Metachromatic leukodystrophy (MLD)
Wheeler MW , Lim S, House JS, Shockley KR, Bailer AJ, Fostel J, Yang L, Talley D, Raghuraman A, Gift JS. 2023. ToxicR: A computational platform in R for computational toxicology and dose–response analyses. Comp Toxicol 25(Feb):100259; doi: 10.1016/j.comtox.2022.100259 . PMCID: PMC9997717.
View Abstract
Publication: Manuscripts
/ Topics: benchmark dose estimation (BMD)
East A , Dawson DE, Brady S, Vallero DA, Tornero-Velez R. 2023. A scoping assessment of implemented toxicokinetic models of per- and polyfluoro-alkyl substances, with a focus on one-compartment models. Toxics 11(2):163; doi: 10.3390/toxics11020163 . PMID: 36851038.
View Abstract
Publication: Manuscripts
/ Topics: modeling , PFAS , scoping review , toxicokinetics
Grover A, Sankaranarayanan S, Mathur V, Suri P, Qiu H, Andrews-Zwilling Y, Mease K , Taylor LK, Cahir-McFarland E, Keswani S, Yednock T. 2023. Pharmacokinetic and target engagement measures of ANX007, an anti-C1q antibody fragment, following intravitreal administration in nonhuman primates. Invest Opthalmol Visual Sci 64(2)3; 10.1167/iovs.64.2.3 . PMID: 36729444.
View Abstract