2025 (4 POSTS)
Klaren W . Targeted state of the science scoping review for incorporating stress within experimental models of chemical toxicity. Abstract 1260, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
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Topics: scoping review , Toxicology
Klaren W . Incorporating stress as a variable into toxicological testing: Advancing our understanding of cumulative impacts. Abstract 1259, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
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Topics: Exposure Assessment , Toxicology
Wikoff DS, Vincent MJ, Heintz MM, Pastula ST, Reichert H, Klaren WD, Haws LC . 2025. Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response. Toxicol Sci 204(1):96-115; doi: 10.1093/toxsci/kfae152 . PMID: 39792025.
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Topics: PFAS , risk assessment , Systematic Review , Toxicology
Kennedy SB, Heintz MM, Klaren WD, Wikoff DS, Haws LC, Fitch SE . 2025. An integrated ecotoxicological study reliability framework for use in toxicity value development. Environ Tox Chem 44(4):1142-1153; doi: 10.1093/etojnl/vgaf030 . PMID: 39873747.
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Topics: Ecology , risk assessment , Toxicology
2024 (4 POSTS)
East A, Klaren W, Covington T, Rish W. Exploring biomarker-based methods to incorporate non-chemical stressor exposures into cumulative assessments for potentially vulnerable population groups. International Society of Exposure Science, Montreal, Canada, October 2024.
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Topics: Air Quality , Epidemiology
Heintz MM , Klaren WD , East AW , Haws LC , McGreal SR, Campbell RR, Thompson CM . 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes. Toxicol Sci 200(1):165–182; doi: 10.1093/toxsci/kfae044 . PMID: 38574381.
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Topics: Toxicology
Heintz MM , Klaren WD , East AW , Haws LC , McGreal SR, Campbell RR, Thompson CM . 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes. Toxicol Sci 200(1):183–198; doi: 10.1093/toxsci/kfae045 . PMID: 38574385.
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Topics: Toxicology
Heintz M , Klaren W , East A , Haws L , Thompson C . Delayed transcriptomic responses in PPARa knockout mouse hepatocytes compared to wild-type hepatocytes exposed to HFPO-DA or PPARa agonist GW7647: Support for a PPARa-dependent mode of action for HFPO-DA in mouse hepatocytes. Abstract 4100, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
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Topics: Toxicology
2023 (5 POSTS)
Ring C, Blanchette A, Klaren WD , Fitch S , Haws L , Wheeler MW , DeVito MJ, Walker N, Wikoff D . 2023. A multi-tiered hierarchical Bayesian approach to derive toxic equivalency factors for dioxin-like compounds. Regul Toxicol Pharmacol 143(11):105464; doi: 10.1016/j.yrtph.2023.105464 . PMID: 37516304.
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Topics: dioxin , Epidemiology
Cordova AC, Klaren WD , Ford LC, Grimm FA, Baker ES, Zhou YH, et al. 2023. Integrative chemical-biological grouping of complex high production volume substances from lower olefin manufacturing streams. Toxics 11(7):586; doi: 10.3390/toxics11070586 . PMID: 37505552.
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Topics: Toxicology
Rivera BN , Svetlik A, Klaren WD, Wikoff DS, Henderson RG. Scoping review of the immunomodulatory effects of cannabidiol: Effects within T cells. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
Topics: Systematic Review
Klaren WD, Heintz MM, East AW, Thompson CM, Haws LC . In vitro transcriptomic analyses informing the mode of action of HFPO-DA (GenX) in the liver. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
Topics: Toxicology
East A, Rish W, Klaren WD . Using NHANES data to characterize the magnitude of allostatic load in vulnerable communities: Impact to existing risk assessment uncertainty/variability factors. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.
Topics: Toxicology
2022 (3 POSTS)
House JS, Grimm FA, Klaren WD , Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, Ketelsegers HB, Gant TW, Wright FA, Rusyn I. 2022. Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays. ALTEX 39(3):388-404; doi: 10.14573/altex.2107051 . PMID: 35288757.
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Topics: Toxicology
Klaren WD , Hoberman AM, Hauswirth JW. Reproduction and developmental toxicological evaluation of piperonyl butoxide (PBO). Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.
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Topics: Toxicology
Fitch S , Klaren WD , LaPlaca S , Payne L, Wikoff D . Comparison of public and private literature databases for toxicological investigations. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, CA, March 2022.
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Topics: Toxicology
2021 (1 POST)
Ring C, Sipes NS, Hsieh JH, Carberry C, Koval LE, Klaren WD , Harris MA, Auerbach SS, Rager JE. 2021. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high throughput toxicokinetics. Comput Toxicol 18(May):100166; doi: 10.1016/j.comtox.2021.100166 . PMID: 34013136.
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Topics: Toxicology
2020 (7 POSTS)
Zorn KM, Foil DH, Russo DP, Clark AM, Hillwalker W, Feifarek D, Jones F, Klaren W , Brinkman A, Ekins S. Generation of machine-learning models to anticipate endocrine disruption. Society of Toxicology 59th Annual Meeting, virtual, 2020.
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Topics: Toxicology
Brinkman AM, Klaren WD , Feifarek DJ, Hillwalker W, Jones F, Zorn KM, Ekins S. Use of a weighted scheme for the interpretation and contextualization of in vitro and in silico-derived estrogenic endpoints. Society of Toxicology 59th Annual Meeting, virtual, 2020.
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Topics: Toxicology
Grimm FA, Klaren WD , Li X, Lehmler HJ, Karmakar M, Robertson LW, Chiu WA. Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Persp 128(7):77008; doi: 10.1289/EHP7030 . PMID: 32701041.
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