Publications

Covington TR, Borghoff SJ, Brorby GP, Doepker CL, Wikoff DS, Franzen AC. Using IVIVE to address systemic exposure challenges in genotoxicity testing of complex mixtures. Poster Session PO-41, American Society for Cellular and Computational Toxicology (ASCCT) 14th Annual Meeting, Gaithersburg, MD, October 2025.

Borghoff SJ, Heintz MM, Rivera BN, Haws L, Thompson C. 2025. Evaluation of an anti-thyroid mode of action for thyroid follicular cell adenomas in female mice exposed to tertiary butyl alcohol. Regul Toxicol Pharmacol 163(Dec):105936; doi: 10.1016/j.yrtph.2025.105936. PMID: 40914479.

Fitch S, Rogers J, Marty S, Norman J, Schneider S, Rushton E, Wikoff D, Ellis-Hutchings R. 2025. Systematic review of potential developmental and reproductive toxicity of microplastics. Toxicol Sci 207(2):289-305; doi: 10.1093/toxsci/kfaf108. PMID: 40794567.

Hampton LMT, Wyler DB, Almroth BC, Coffin S, Cowger W, Doyle D,… Bare JL,… Kennedy SB, et al. 2025. The toxicity of Microplastics Explorer (ToMEx) 2.0. Microplast Nanoplast 5(1):38; doi: 10.1186/s43591-025-00145-6. PMID: 41019257.

Rish W, Racz L, Hale A. 2025. Public radiation dose from conventional gas-well produced water used as a pavement Deicer. J Waste Manag Assoc;  doi: 10.1080/10962247.2025.2565287. Online ahead of print Sept. 23, 2025. PMID: 40985694.

Wambaugh JF, Sipes NS, Padilla Mercado G, Arnot JA, Bertato L, Brown TN, Chirico N,…, Patlewicz G, et al. 2026. Collaborative evaluation of in silico predictions for high throughput toxicokinetics. Toxicol In Vitro 110(Jan):106150; doi: 10.1016/j.tiv.2025.106150. ePub September 20, 2025. PMID: 40983213.

 Klaren WD, Rivera BN, Sheppard AM, Franke K, Wikoff DS. 2025. Approach for systematically assessing study reliability and relevance in evaluations of monosodium glutamate safety. Curr Res Toxicol 9(Sep):100256; doi: 10.1016/j.crtox.2025.100256. PMID: 41030520.

Patlewicz G, Charest N, Ross A, Bledsoe HC, Vidal J, Faramarzi S, Hagan B, Shah I. 2025. Building a compendium of expert driven read-across cases to facilitate an analysis of the contribution that different similarity contexts play in read-across performance. Comput Toxicol 35(Sept):100366; doi: 10.1016/j.comtox.2025.100366.

Mease K. High safety bar, low safety margin case studies. Presented at 29th Annual Charles River Biotech Symposium, Carlsbad, CA, September 8-10, 2025.

Nyffeler J, Harris FR, Willis C, Byrd G, Blackwell B, Escher BI, Kasparek A, Nichols J,…, Patlewicz G, et al. 2025. A combination of high-throughput in vitro and in silico new approach methods (NAMs) for ecotoxicology hazard assessment for fish. Environ Toxicol Chem 44(9):2599-2621; doi: 10.1093/etojnl/vgae083. PMID: 39937625.

Nordyke RJ, Patterson JA, Motyka J, March B, Kirson NY, Long G. 2025. The impact of the Inflation Reduction Act’s drug price negotiation program on incentives for clinical development of new drugs. Value Health; doi: 10.1016/j.jval.2025.08.011. Online ahead of print Sept. 1, 2025. PMID: 40902797.

Karamertzanis PG, Rasenberg M, Shah I, Patlewicz G. 2025. Modelling in vitro mutagenicity using multi-task deep learning and REACH data. Chem Res Toxicol 38(8):1382-1407; doi: 19.1021/acs.chemrestox.5c00152. PMID: 40680271.

Shaw J, Hsu H, Tu H, Chia V, Aggarwal S, Carrigan G, Kelsh MA. Immortal time bias impacts time-to-time event outcomes in cohort with genomic testing. Abstract 6F-03, International Society for Pharmacoepidemiology (ISPE) 41^st Annual Meeting, Washington, DC, August 2025.

Righter R, Yale K, Stewart C, Marshall L, Fairbanks H. Methods in qualitative data analysis to progress community health equity. Abstract 3993/Poster EP02-18, International Society of Exposure Science and International Society for Environmental Epidemiology (ISES/ISEE) Joint Annual Meeting, Atlanta, GA, August 2025.

Rish W, Verwiel A. Importance of epidemiology and visualization to integrate non-chemical stressors into cumulative impact assessment for vulnerable communities. Abstract 568/Poster P47-17, International Society of Exposure Science and International Society for Environmental Epidemiology (ISES/ISEE) Joint Annual Meeting, Atlanta, GA, August 2025.

Muller K, Unice K, Panko J, Ferrari BJD, Breider F, Wagner S. 2025. Risk assessment of tire wear in the environment—A literature review. Environ Sci Process Impacts 27(8):2212-2232; doi: 10.1039/d5em00088b. PMID: 40569214.

Reynolds JI, Johnson BP. 2025. AOP 460: Antagonism of Smoothened receptor leads to orofacial clefting. ALTEX; doi: 10.14573/altex.2407121. Advance online publication August 11, 2025.

Proctor D, Jiang X, Reichert H, Thompson C. 2025. Why rat oral cavity tumors should not be the basis of quantitative cancer risk assessment for oral exposure to hexavalent chromium. Toxicol Sci kfaf112; doi: 10.1093/toxsci/kfaf112. Online ahead of print August 8, 2025. PMID: 40795394.

Moyer HL, Vergara L, Stephan C, Sakolish C, Lin HC, Chiu WA, Villenave R, Hewitt P, et al. 2025. Human small intestinal tissue models to assess barrier permeability: Comparative analysis of caco-2 cells, jejunal and duodenal enteroid-derived cells, and EpiIntestinal^TM tissues in membrane-based cultures with and without flow. Bioengineering (Basel). 12(8):809; doi: 10.3390/bioengineering12080809. PMID: 40868322; PMCID: PMC12384003.

Clouser MC, Suh M, Movva N, Hildebrand JS, Pastula ST, Schoehl M, Hindoyan A, Balasubramanian A, et al. 2025. A systematic literature review of MTAP deletions in solid and hematologic cancers. Cancer Treat Res Comm 44:100966; doi: 10.1016/j.ctarc.2025.100966. PMID: 40729867.