2016 (74 POSTS)
Wang A, Richhariya A, Gandra SR, Calimlim B, Quek RGW, Nordyke RJ , Toth P. 2016. Systematic review of LDL-C apheresis for the treatment of familial hypercholesterolemia. J Am Heart Assoc 5(7):e003294; doi: 10.1161/JAHA.116.003294 . PMID: 27385428.
View Abstract
Topics: Epidemiology
Maskrey JR, Insley A, Hynds ES, Panko JM . 2016. Air monitoring of volatile organic compounds at relevant receptors during hydraulic fracturing operations in Washington County, Pennsylvania. Environ Monit Assess 188(7):410; doi: 10.1007/s10661-016-5410-4 . PMID: 27312253.
View Abstract
Topics: Air Quality , community health , fracking , VOCs
Jensen IS , Wu C, Fan W, Lodise T, Nicolau, DP, DuFour S, Cyr PL , et al. 2016. Use of oritivancin in moderate-severe ABSSSI patients requiring IV antibiotics: US hospital budget impact analysis. J Manag Care Spec Pharm 22(6):752-64; doi: 10.18553/jmcp.2016.22.6.752 . PMID: 27231802.
View Abstract
Topics: Epidemiology , Health Economics and Outcomes Research (HEOR)
Wikoff DS , Rager JE, Haws LC , Borghoff SJ . 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77(June):143-159. doi: 10.1016/j.yrtph.2016.01.018 . PMID: 26828025.
View Abstract
Topics: flame retardants
Edmondson SD, Zhu C, Kar NF, Di Salvo J, Nagabukuro H, Sacre-Salem B, Dingley K , et al. 2016. Discovery of vibegron: A potent and selective beta 3 adrenergic receptor agonist for the treatment of overactive bladder. J Med Chem 59(2):609–623; doi: 10.1021/acs.jmedchem.5b01372 . PMID: 26709102.
View Abstract
Topics: drug development
Zhu C, Kar NF, Li B, Costa M, Dingley KH , Di Salvo J, et al. 2016. Discovery of benzamides as potent human β3 adrenergic receptor agonists. Bioorg Med Chem Lett 26(1):55–59; doi: 10.1016/j.bmcl.2015.11.030 . PMID: 26590100.
View Abstract
Topics: chemical safety assessment
Wilson JE, Kurukulasuriya R, Sinz C, Matthew Lombardo, Kate Bender, Dann Parker, … Dingley K , et al. 2016. Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes. Bioorg Med Chem Lett 26(12):2947–2951; doi: 10.1016/j.bmcl.2016.04.018 . PMID: 27240550.
View Abstract
Topics: diabetes , pharmacokinetics
Guo L, Parker DL, Zang Y, Sweis RF, Liu W, Sherer EC, … Dingley KH , et al. 2016. Discovery and optimization of a novel triazole series of GPR142 agonists for the treatment of type 2 diabetes. ACS Med Chem Lett 7 (12):1107–1111; doi: 10.1021/acsmedchemlett.6b00314 . PMID: 27994747.
View Abstract
Topics: diabetes
Cowan DM, Maskrey JR, Fung ES, Woods TA, Stabryla LM, Scott PK, Finley BL . 2016. Best-practices approach to determination of blood alcohol concentration (BAC) at specific time points: Combination of ante-mortem alcohol pharmacokinetic modeling and post-mortem alcohol generation and transport considerations. Regul Toxicol Pharmacol 78(July):24–36; doi: 10.1016/j.yrtph.2016.03.020 . PMID: 27041394.
View Abstract
Topics: modeling , pharmacokinetics
Sacks NC , Sharma A, Cyr PL , Liu Y , Miller DJ, Chiarella MT, Louie AC. 2016. Outcomes for older patients with acute myeloid leukemia (AML): Multiple hospitalizations and high mortality rates. Value in Health 19(7):A611; doi: 10.1016/j.jval.2016.09.1523 .
View Abstract
Topics: Cancer , Health Economics and Outcomes Research (HEOR)
Alexander DD, Bylsma LC , Elkayam L, Nguyen DL. 2016. Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature. World J Gastrointest Pharmacol Ther 7(2):306-319; doi: 10.4292/wjgpt.v7.i2.306 . PMID: 27158547.
View Abstract
Topics: nutrition
Hanlon P, Brorby GP , Krishan M. 2016. A risk-based strategy for evaluating mitigation options for processed-formed compounds in food: Workshop proceedings. Int J Toxicol 35(3):358–370; doi: 10.1177/1091581816640 . PMID: 27102178.
View Abstract
Topics: Food science , risk assessment
Paustenbach DJ, Insley AL, Maskrey JR, Bare JL , Unice KM, Conrad VB, Iordanidis L, Reynolds DW, DiNatale KD, Monnot AD. 2016. Analysis of total arsenic content in California wines and comparison to various health risk criteria. Am J Enol Viticult 67(2):179–187; doi: 10.5344/ajev.2015.15041 .
Topics: arsenic , Exposure Assessment , Food science
Sacks NC , Cabral HJ, Pizer SD, Burgess JF. 2016. Myopic and forward looking behavior in branded oral anti-diabetic consumption: An example from Medicare Part D. Health Econ 26(6):753-764; doi: 10.1002/hec.3355 . PMID: 27150938.
View Abstract
Topics: diabetes , Health Economics and Outcomes Research (HEOR)
Patlewicz GY , Fitzpatrick J. 2016. Current and future perspectives on the development, evaluation and application of in silico approaches for predicting toxicity. Chem Res Toxicol 29(4):438-451; doi: 10.1021/acs.chemrestox.5b00388 . PMID: 26686752.
View Abstract
Topics: computational toxicology
Sisler JD, Pirela SV, Shaffer J, Mihalchik AL , Chisholm WP, Andrew ME, Schwegler-Berry D, Castranova V, et al. 2016. Toxicological assessment of CoO and La2 O3 metal oxide nanoparticles in human small airway epithelial cells. Toxicol Sci 150(2):418-428; doi: 10.1093/toxsci/kfw005 . PMID: 26769336.
View Abstract
Topics: nanomaterials
Thompson CM , Bichteler A, Rager JE, Suh M , Proctor DM , Haws LC , Harris MA. 2016. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium. Mut Res/Genet Toxicol Environ Mutagen 800-801(April):28-34; doi: 10.1016/j.mrgentox.2016.01.008 . PMID: 27085472.
View Abstract
Topics: carcinogens , chromium , mode of action
Williams RV, Amberg A, Brigo A, Coquin L, Giddings A, Glowienke S, Greene N , et al. 2016. It’s difficult, but important, to make negative predictions. Regul Toxicol Pharmacol 76(Apr):79-86; doi: 10.1016/j.yrtph.2016.01.008 . PMID: 26785392.
View Abstract
Topics: NAMs
Barber C, Cayley A, Hanser T, Harding A, Heghes C, Vessey JD, Werner S,…, Greene N . 2016. Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained. Regul Toxicol Pharmacol 76(Apr):7-20; doi: 10.1016/j.yrtph.2015.12.006 . PMID: 26708083.
View Abstract
Topics: modeling , NAMs
Doucette A, Jiang X, Fryzek J, Coalson J, McLaurin K, Ambrose CS. 2016. Trends in respiratory syncytial virus and bronchiolitis hospitalization rates in high-risk infants in a United States nationally representative database, 1997-2012. PLoS One 11(4):e0152208; doi: 10.1371/journal.pone.0152208 . PMID: 27050095.
View Abstract