2016 (74 POSTS)
Wang BW, Klaren WD , Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status and MnSOD in the rat. Toxicol Sci 150(1):15–26; doi: 10.1093/toxsci/kfv312 . PMID: 26660635.
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Topics: Manganese , PCBs
Klaren WD , Flor SS, Gibson-Corley KN, Ludewig G, Robertson LW. 2016. Metallothionein’s role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption. Toxicol Rep 3:21–28; doi: 10.1016/j.toxrep.2015.12.001 . PMID: 26770886.
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Topics: PCBs
Klaren WD , Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851–859; 10.1021/acs.chemrestox.6b00022 . PMID: 26967026.
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Topics: food safety , Food science
Wang A, Richhariya A, Gandra SR, Calimlim B, Quek RGW, Nordyke RJ , Toth P. 2016. Systematic review of LDL-C apheresis for the treatment of familial hypercholesterolemia. J Am Heart Assoc 5(7):e003294; doi: 10.1161/JAHA.116.003294 . PMID: 27385428.
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Topics: Epidemiology
Maskrey JR, Insley A, Hynds ES, Panko JM . 2016. Air monitoring of volatile organic compounds at relevant receptors during hydraulic fracturing operations in Washington County, Pennsylvania. Environ Monit Assess 188(7):410; doi: 10.1007/s10661-016-5410-4 . PMID: 27312253.
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Topics: Air Quality , community health , fracking , VOCs
Jensen IS , Wu C, Fan W, Lodise T, Nicolau, DP, DuFour S, Cyr PL , et al. 2016. Use of oritivancin in moderate-severe ABSSSI patients requiring IV antibiotics: US hospital budget impact analysis. J Manag Care Spec Pharm 22(6):752-64; doi: 10.18553/jmcp.2016.22.6.752 . PMID: 27231802.
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Topics: Epidemiology , Health Economics and Outcomes Research (HEOR)
Wikoff DS , Rager JE, Haws LC , Borghoff SJ . 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77(June):143-159. doi: 10.1016/j.yrtph.2016.01.018 . PMID: 26828025.
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Topics: flame retardants
Edmondson SD, Zhu C, Kar NF, Di Salvo J, Nagabukuro H, Sacre-Salem B, Dingley K , et al. 2016. Discovery of vibegron: A potent and selective beta 3 adrenergic receptor agonist for the treatment of overactive bladder. J Med Chem 59(2):609–623; doi: 10.1021/acs.jmedchem.5b01372 . PMID: 26709102.
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Topics: drug development
Zhu C, Kar NF, Li B, Costa M, Dingley KH , Di Salvo J, et al. 2016. Discovery of benzamides as potent human β3 adrenergic receptor agonists. Bioorg Med Chem Lett 26(1):55–59; doi: 10.1016/j.bmcl.2015.11.030 . PMID: 26590100.
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Topics: chemical safety assessment
Wilson JE, Kurukulasuriya R, Sinz C, Matthew Lombardo, Kate Bender, Dann Parker, … Dingley K , et al. 2016. Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes. Bioorg Med Chem Lett 26(12):2947–2951; doi: 10.1016/j.bmcl.2016.04.018 . PMID: 27240550.
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Topics: diabetes , pharmacokinetics
Guo L, Parker DL, Zang Y, Sweis RF, Liu W, Sherer EC, … Dingley KH , et al. 2016. Discovery and optimization of a novel triazole series of GPR142 agonists for the treatment of type 2 diabetes. ACS Med Chem Lett 7 (12):1107–1111; doi: 10.1021/acsmedchemlett.6b00314 . PMID: 27994747.
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Topics: diabetes
Cowan DM, Maskrey JR, Fung ES, Woods TA, Stabryla LM, Scott PK, Finley BL . 2016. Best-practices approach to determination of blood alcohol concentration (BAC) at specific time points: Combination of ante-mortem alcohol pharmacokinetic modeling and post-mortem alcohol generation and transport considerations. Regul Toxicol Pharmacol 78(July):24–36; doi: 10.1016/j.yrtph.2016.03.020 . PMID: 27041394.
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Topics: modeling , pharmacokinetics
Sacks NC , Sharma A, Cyr PL , Liu Y , Miller DJ, Chiarella MT, Louie AC. 2016. Outcomes for older patients with acute myeloid leukemia (AML): Multiple hospitalizations and high mortality rates. Value in Health 19(7):A611; doi: 10.1016/j.jval.2016.09.1523 .
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Topics: Cancer , Health Economics and Outcomes Research (HEOR)
Alexander DD, Bylsma LC , Elkayam L, Nguyen DL. 2016. Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature. World J Gastrointest Pharmacol Ther 7(2):306-319; doi: 10.4292/wjgpt.v7.i2.306 . PMID: 27158547.
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Topics: nutrition
Hanlon P, Brorby GP , Krishan M. 2016. A risk-based strategy for evaluating mitigation options for processed-formed compounds in food: Workshop proceedings. Int J Toxicol 35(3):358–370; doi: 10.1177/1091581816640 . PMID: 27102178.
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Topics: Food science , risk assessment
Paustenbach DJ, Insley AL, Maskrey JR, Bare JL , Unice KM, Conrad VB, Iordanidis L, Reynolds DW, DiNatale KD, Monnot AD. 2016. Analysis of total arsenic content in California wines and comparison to various health risk criteria. Am J Enol Viticult 67(2):179–187; doi: 10.5344/ajev.2015.15041 .
Topics: arsenic , Exposure Assessment , Food science
Sacks NC , Cabral HJ, Pizer SD, Burgess JF. 2016. Myopic and forward looking behavior in branded oral anti-diabetic consumption: An example from Medicare Part D. Health Econ 26(6):753-764; doi: 10.1002/hec.3355 . PMID: 27150938.
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Topics: diabetes , Health Economics and Outcomes Research (HEOR)
Patlewicz GY , Fitzpatrick J. 2016. Current and future perspectives on the development, evaluation and application of in silico approaches for predicting toxicity. Chem Res Toxicol 29(4):438-451; doi: 10.1021/acs.chemrestox.5b00388 . PMID: 26686752.
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Topics: computational toxicology
Sisler JD, Pirela SV, Shaffer J, Mihalchik AL , Chisholm WP, Andrew ME, Schwegler-Berry D, Castranova V, et al. 2016. Toxicological assessment of CoO and La2 O3 metal oxide nanoparticles in human small airway epithelial cells. Toxicol Sci 150(2):418-428; doi: 10.1093/toxsci/kfw005 . PMID: 26769336.
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Topics: nanomaterials
Thompson CM , Bichteler A, Rager JE, Suh M , Proctor DM , Haws LC , Harris MA. 2016. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium. Mut Res/Genet Toxicol Environ Mutagen 800-801(April):28-34; doi: 10.1016/j.mrgentox.2016.01.008 . PMID: 27085472.
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