2016 (74 POSTS)
Wikoff DS , Rager JE, Haws LC , Borghoff SJ . 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77(June):143-159. doi: 10.1016/j.yrtph.2016.01.018 . PMID: 26828025.
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Topics: flame retardants
Edmondson SD, Zhu C, Kar NF, Di Salvo J, Nagabukuro H, Sacre-Salem B, Dingley K , et al. 2016. Discovery of vibegron: A potent and selective beta 3 adrenergic receptor agonist for the treatment of overactive bladder. J Med Chem 59(2):609–623; doi: 10.1021/acs.jmedchem.5b01372 . PMID: 26709102.
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Topics: drug development
Zhu C, Kar NF, Li B, Costa M, Dingley KH , Di Salvo J, et al. 2016. Discovery of benzamides as potent human β3 adrenergic receptor agonists. Bioorg Med Chem Lett 26(1):55–59; doi: 10.1016/j.bmcl.2015.11.030 . PMID: 26590100.
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Topics: chemical safety assessment
Wilson JE, Kurukulasuriya R, Sinz C, Matthew Lombardo, Kate Bender, Dann Parker, … Dingley K , et al. 2016. Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes. Bioorg Med Chem Lett 26(12):2947–2951; doi: 10.1016/j.bmcl.2016.04.018 . PMID: 27240550.
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Topics: diabetes , pharmacokinetics
Guo L, Parker DL, Zang Y, Sweis RF, Liu W, Sherer EC, … Dingley KH , et al. 2016. Discovery and optimization of a novel triazole series of GPR142 agonists for the treatment of type 2 diabetes. ACS Med Chem Lett 7 (12):1107–1111; doi: 10.1021/acsmedchemlett.6b00314 . PMID: 27994747.
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Topics: diabetes
Pierce JS, Ruestow PS, Finley BL . 2016. An updated evaluation of reported no-observed adverse effect levels for chrysotile asbestos for lung cancer and mesothelioma. Crit Rev Toxicol 46(7):561-586; doi: 10.3109/10408444.2016.1150960 .
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Topics: asbestos , Cancer
Cowan DM, Maskrey JR, Fung ES, Woods TA, Stabryla LM, Scott PK, Finley BL . 2016. Best-practices approach to determination of blood alcohol concentration (BAC) at specific time points: Combination of ante-mortem alcohol pharmacokinetic modeling and post-mortem alcohol generation and transport considerations. Regul Toxicol Pharmacol 78(July):24–36; doi: 10.1016/j.yrtph.2016.03.020 .
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Topics: modeling , pharmacokinetics
Pierce JS, Abelmann A, Finley BL . 2016. Comment on flavoring chemicals in e-cigarettes: Diacetyl, 2,-3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored e-cigarettes. Environ Health Persp 124(6):A100–A101; doi: 10.1289/ehp.1611350 .
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Topics: diacetyl
Sacks NC , Sharma A, Cyr PL , Liu Y , Miller DJ, Chiarella MT, Louie AC. 2016. Outcomes for older patients with acute myeloid leukemia (AML): Multiple hospitalizations and high mortality rates. Value in Health 19(7):A611; doi: 10.1016/j.jval.2016.09.1523 .
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Topics: Cancer , Health Economics and Outcomes Research (HEOR)
Alexander DD, Bylsma LC , Elkayam L, Nguyen DL. 2016. Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature. World J Gastrointest Pharmacol Ther 7(2):306-319; doi: 10.4292/wjgpt.v7.i2.306 . PMID: 27158547.
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Topics: nutrition
Scala E, Price C , Day J. 2016. An integrative review of engaging clinical nurses in nursing research. J Nurs Schol 48(4):423–430; doi: 10.1111/jnu.12223 .
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Topics: Systematic Review
Hanlon P, Brorby GP , Krishan M. 2016. A risk-based strategy for evaluating mitigation options for processed-formed compounds in food: Workshop proceedings. Int J Toxicol 35(3):358–370; doi: 10.1177/1091581816640 . PMID: 27102178.
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Topics: Food science , risk assessment
Paustenbach DJ, Insley AL, Maskrey JR, Bare JL , Unice KM, Conrad VB, Iordanidis L, Reynolds DW, DiNatale KD, Monnot AD. 2016. Analysis of total arsenic content in California wines and comparison to various health risk criteria. Am J Enol Viticult 67(2):179–187; doi: 10.5344/ajev.2015.15041 .
Topics: arsenic , Exposure Assessment , Food science
Sacks NC , Cabral HJ, Pizer SD, Burgess JF. 2016. Myopic and forward looking behavior in branded oral anti-diabetic consumption: An example from Medicare Part D. Health Econ 26(6):753-764; doi: 10.1002/hec.3355 . PMID: 27150938.
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Topics: diabetes , Health Economics and Outcomes Research (HEOR)
Patlewicz GY , Fitzpatrick J. 2016. Current and future perspectives on the development, evaluation and application of in silico approaches for predicting toxicity. Chem Res Toxicol 29(4):438-451; doi: 10.1021/acs.chemrestox.5b00388 . PMID: 26686752.
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Topics: computational toxicology
Franzen A , Van Landingham C, Greene T, Plotzke K, Gentry R. 2016. A global human health risk assessment for decamethylcyclopentasiloxane (D5 ). Regul Toxicol Pharmacol 74(Sup):S25–S43; doi: 10.1016/j.yrtph.2015.10.023 .
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Topics: chemical safety assessment , consumer products , risk assessment
Campbell J, Franzen A , Van Landingham C, Lumpkin M, Crowell S, Meredith C, Loccisano A, Gentry R, Clewell H. 2016. Predicting lung dosimetry of inhaled particle-borne benzo(a)pyrene using physiologically based pharmacokinetic modeling. Inhal Toxicol 28(11):520–535; doi: 10.1080/08958378.2016.1214768 .
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Topics: benzene , PBPK/PBDE , pharmacokinetics
Williams RV, Amberg A, Brigo A, Coquin L, Giddings A, Glowienke S, Greene N , et al. 2016. It’s difficult, but important, to make negative predictions. Regul Toxicol Pharmacol 76(Apr):79-86; doi: 10.1016/j.yrtph.2016.01.008 . PMID: 26785392.
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Topics: NAMs
Barber C, Cayley A, Hanser T, Harding A, Heghes C, Vessey JD, Werner S,…, Greene N . 2016. Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained. Regul Toxicol Pharmacol 76(Apr):7-20; doi: 10.1016/j.yrtph.2015.12.006 . PMID: 26708083.
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Topics: modeling , NAMs
Doucette A, Jiang X, Fryzek J, Coalson J, McLaurin K, Ambrose CS. 2016. Trends in respiratory syncytial virus and bronchiolitis hospitalization rates in high-risk infants in a United States nationally representative database, 1997-2012. PLoS One 11(4):e0152208; doi: 10.1371/journal.pone.0152208 . PMID: 27050095.
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