Publications

Wheeler MW, Bailer AJ, Cole T, Park RM, Shao K. 2017. Bayesian quantile impairment threshold benchmark dose estimation for continuous endpoints. Risk Anal 37(11):2107-18; doi: 10.1111/risa.12762. PMCID: PMC5740488.

Wirbisky-Hershberger SE, Sanchez OF, Horzmann KA, Thanki D, Yuan C, Freeman JL. 2017. Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression. Food Chem Toxicol 109:727–734.

Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, et al. 2017. Current nonclinical testing paradigm enables safe entry to First-in-Human clinical trials: The IQ consortium nonclinical translational database. Toxicol Appl Pharmacol 334(Nov 1):100-109; doi: 10.1016/j.taap.2017.09.006.

Huddle MG, Goman AM, Kernizan FC, Foley DM, Price C, Frick KD, Lin FR. 2017. The economic impact of adult hearing loss: A systematic review. JAMA Otolaryngol: Head Neck Surg 143(10):1040–1048; doi: 10.1001/jamaoto.2017.1243.

Shao K, Allen BC, Wheeler MW. 2017. Bayesian hierarchical structure for quantifying population variability to inform probabilistic health risk assessments. Risk Anal 37(10):1865-78; doi: 10.1111/risa.12751.PMCID: PMC6151353.

Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C, Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; doi: 10.1021/acs.chemrestox.7b00221.

Thompson CM, Suh M, Proctor DM, Haws LC, Harris MA. 2017. Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents. Mutation Res 823:45-57.

Sheppard A, Baker E, Bermudez D, Blattner J, Boyd K, O’Neal S, Rahim T, Whittle E. Implementing an alternate testing strategy for assessing skin irritation. Abstract #2734, Society of Toxicology 56th Annual Meeting, Baltimore, MD, 2017.

Sheppard A, Baker E, Bermudez D, Blattner J, Boyd K, O’Neal S, Rahim T, Whittle E. Use of alternative methods to assess skin irritation of chemical mixtures. World Congress for Alternatives to Animal Testing, Seattle, WA, 2017.

Thompson CM, Young RR, Dinesdurage H, Suh M, Harris MA, Rohr AC, Proctor DM. 2017. Assessment of the mutagenic potential of hexavalent chromium in the duodenum of Big Blue® rats. Toxicol Appl Pharmacol 330(1):48-52; 10.1016/j.taap.2017.07.002.

Schaefer HR, Myers, JL. 2017. Development of an inhalation unit risk factor for ethylene dibromide. Inhal Toxicol 29(7):304-309; doi: 10.1080/08958378.2017.1369603. PMID: 28891353.

Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. Diminished phosphorylation of CREB Is a key event in the dysregulation of gluconeogenesis, glycogenolysis and fatty acid oxidation in PCB126 hepatotoxicity. Society of Toxicology 56th Annual Meeting, Baltimore, MD, and NIEHS Environmental Health Science FEST, Durham, NC, 2017.

Iwata Y, Klaren W, Grimm F, Rusyn I. A multidimensional high-throughput approach for toxicity evaluation of environmental chemicals in induced pluripotent stem cell-derived endothelial cells. Society of Toxicology 56th Annual Meeting, Baltimore, Md, 2017.

Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I. 2017. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. Assay Drug Dev Technol 15(6):267–279; doi; 10.1089/adt.2017.786. PMID: 28771372.

Ruzin A, Levin-Sparenberg E, Pastula S, Jiang X, Fryzek J, Tovchigrechko A, Lu B, Yu L, Hackett J, Villafana T, Esser MT. Characterization of RSV strains among U.S. patients in the OUTSMART RSV program during 2015-16. Abstract and poster presentation, ID Week 2017, San Diego, CA, October 2017.

Garabrant D, Pastula S. Asbestos and EMP fiber potency analysis. Abstract and oral presentation, Monticello Conference, Charlottesville, VA, October 2017.

Robison TW. Dealing with extractables & leachables from a regulatory perspective: 1. Design of extractables & leachables studies; and 2. Safety assessment of leachables. Smithers Rapra Extractables and Leachables USA Annual Meeting, 2017.

Wikoff DS, Rager JE, Harvey S, Haws L, Chappell G, Borghoff S. Development and refinement of a framework for quantitative consideration of study quality and relevance in the evaluation of mechanistic data based on key characteristics of carcinogens. Society of Risk Analysis Annual Meeting, Arlington, VA, December 2017.

Wikoff DS, Welsh BT, Henderson R, Brorby G, Britt J, Myers E, Goldberger J, Lieberman HR, O’Brien C, Doepker C. Application of systematic reviews in the evaluation of caffeine safety: Potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.

Klaren WD, Vine D, Vogt S, Robertson LW. 2017. Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25(17):16427–16433; doi:10.1007/s11356-017-0202-0.