2019 (156 POSTS)
Chappell GA, Rager JE, Wolf JC, Babic M, LeBlanc KJ, Ring CL, Harris MA, Thompson C . Similarities in the transcriptomic signatures in the duodenum of mice exposed to hexavalent chromium, captan, or folpet inform the mechanisms of chemical-induced mouse small intestine cancer. Presentation at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: Cancer , chromium , transcriptomics
Ring CL, Urban J , Wikoff D , Thompson C , Budinsky RA, Haws LC . Application of systematic review and quantitative evidence integration methods to support risk assessment: Characterization of the dose-response relationship between exposure to dioxin-like compounds (DLC) and sperm count. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: dioxin , risk assessment , Systematic Review
Henderson RG , Doepker C , Lopez JG. Safety evaluation of L-theanine administered via hard chew to dogs. Poster at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: safety assessment
Sterner TR, Covington TR , Merrill EA, Mattie DR. Novel array approach to mixtures model streamlines predictions of cochlea and brain region tissue concentrations from JP-8 inhalation exposure. Poster presented at the Society of Toxicology Annual Meeting, Baltimore, MD, March 2019.
Publication: Abstracts and Presentations
/ Topics: Exposure Assessment
Pitts E, Gearhart JM, Covington TR , Duran CM, Yamamoto DP, McKenzie-Smith D, Ott DK, Pangburn HA. Thermal stress effects on physiologically based pharmacokinetic model for Department of Defense personnel. Poster presented at the Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
Publication: Abstracts and Presentations
/ Topics: modeling , pharmacokinetics
Covington TR . Translating an existing physiologically-based pharmacokinetic model for isopropanol from a scalar to an array format. Poster presented at the Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
Publication: Abstracts and Presentations
/ Topics: modeling , pharmacokinetics
Suh M , Wikoff D , Lipworth L, Goodman M, Fitch S , Mittal L , Ring C, Proctor D . 2019. Hexavalent chromium and stomach cancer: A systematic review and meta-analysis. Crit Rev Toxicol 49(2):140-159; doi: 10.1080/10408444.2019.1578730 . PMID: 30896278.
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Publication: Manuscripts
/ Topics: Cancer , chromium , meta-analysis , Metals , Systematic Review
Vincent MJ , Kozal SJ, Thompson WJ, Maier A, Dotson GS, Best EA, Mundt KA. 2019. Ethylene oxide: Cancer evidence integration and dose-response implications. Dose Response 17(4):1559325819888317; doi: 10.1177/1559325819888317 . PMID:3185323510.
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Publication: Manuscripts
/ Topics: Air Quality , Cancer
Prior H, Monticello T , Boulifard V, Brennan FR, Kimber I. 2019. Integration of consortia recommendations for justification of animal use within current and future drug development paradigms. Int J Toxicol 38(4):319-325; doi: 10.1177/1091581819852922 .
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Publication: Manuscripts
/ Topics: drug development , safety assessment
Visconti R, Foy J, Brennan S, Collins N , Kolaja K. An in vitro model of il-2-mediated Type 2 innate lymphoid cell proinflammatory cytokine secretion. Abstract #3377, Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
Publication: Abstracts and Presentations
/ Topics: modeling
Belair DG, Waller L, Gustin J, Collins N , Kolaja K. Thalidomide inhibits human iPSC mesendoderm differentiation by modulating cereblon-dependent degradation of SALL4. Abstract #3296, Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
Publication: Abstracts and Presentations
/ Topics: drug interactions
Helman G, Shah I, Williams AJ, Edwards J, Dunne J, Patlewicz G . 2019. Generalized Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard. ALTEX 36(3):462-465; doi: 10.14573/altex.1811292 . PMID: 30741315.
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Publication: Manuscripts
/ Topics: NAMs
Lea I , Liu Y, Sheridan E, Motti D, Martini C, Fostel J, Auerbach S. Hallmark gene set annotation for NTP toxicogenomic studies. Abstract #1743-P119, Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: genotoxicity
Martini C, Liu Y, Motti D, Johnson J, McCormick K, Lea I , Fostel F. Integrating assay datasets into Chemical Effects in Biological Systems (CEBS). Abstract #1749-P125, Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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Publication: Abstracts and Presentations
/ Topics: computational toxicology
Storm HM, Shepard J, Czerkies LM, Kineman B, Cohen SS, Reichert H , Carvalho R. 2019. 2’-Fucosyllactose is well tolerated in a 100% whey, partially hydrolyzed infant formula with Bifidobacterium lactis : A randomized controlled trial. Global Pediat Health 6:1–10; doi: 10.1177/2333794X19833995 . PMID: 30906817.
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Publication: Manuscripts
/ Topics: Food science
Schaefer H , Fitzpatrick S, Flannery B. Chemical contaminants in children’s food: A review of recent literature. Abstract 2640, Society of Toxicology 58th Annual Meeting, Baltimore, MD, 2019.
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Publication: Abstracts and Presentations
/ Topics: Exposure Assessment , food additives , food safety , NHANES
Anyangwe N, Fitzpatrick S, Flannery B, Mattia A, Schaefer H , Tyler T, Whiteside C. Use of dog studies in US FDA’s safety assessments for food additives and color additives. Abstract 2781, Society of Toxicology 58th Annual Meeting, Baltimore, MD, 2019.
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Publication: Abstracts and Presentations
/ Topics: food additives , safety assessment
Wheeler MW , Piegorsch WW, Bailer AJ. 2019. Quantal risk assessment database: A database for exploring patterns in quantal dose‐response data in risk assessment and its application to develop priors for Bayesian dose‐response analysis. Risk Anal 39(3):616-29; doi: 10.1111/risa.13218 . PMCID: PMC6408269
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Publication: Manuscripts
/ Topics: Bayesian modeling , benchmark dose estimation (BMD) , dose-response , risk analysis , risk assessment
Wheeler MW . 2019. Bayesian additive adaptive basis tensor product models for modeling high dimensional surfaces: An application to high-throughput toxicity testing. Biometrics 75(1):193-201; doi: 10.1111/biom.12942 . PMCID: PMC6363906.
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Publication: Manuscripts
/ Topics: Bayesian modeling , dose-response , modeling
Choksi N , Clippinger AJ, Gehen S, Corvaro M, Ng S, Kolle SNE, van Cott A, et al. Defined approach for detection of eye irritants and corrosives for pesticide formulations. Poster presented at Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 2019.
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