Publication Topic

Richard A, Judson R, Houck K, Grulke C, Volarath P, Thillainadarajah I, Yang C,…, Patlewicz G, et al. 2016. The ToxCast chemical landscape: Paving the road to 21st century toxicology. Chem Res Toxicol 29(8):1225-1251; doi: 10.1021/acs.chemrestox.6b00135. PMID: 27367298.

Patlewicz GY, Fitzpatrick J. 2016. Current and future perspectives on the development, evaluation and application of in silico approaches for predicting toxicity. Chem Res Toxicol 29(4):438-451; doi: 10.1021/acs.chemrestox.5b00388. PMID: 26686752.

Ball N, Cronin MTD, Shen J, Blackburn K, Booth ED, Bouhifd M, Donley E,…, Patlewicz G, et al. 2016. Toward good read-across practice (GRAP) guidance. ALTEX 33(2):149-166; doi: 10.14573/altex.1601251. PMID: 26863606.

Greene N, Pennie W. 2015. Computational toxicology: Friend or foe? Toxicol Res 4(5):1159-1172; doi: 10.1039/c5tx00055f.

Steinbach T, Gad-McDonald S, Kruhlak N, Powley M, Greene N. 2015. (Q)SAR: A tool for the toxicologist. Int J Toxicol 34(4):352-4; doi: 10.1177/1091581815584914. PMID: 25979517.

Greene N, Dobo KL, Kenyon MO, Cheung J, Munzner J, Sobol Z, Sluggett G, Zelesky T, et al. 2015. A practical application of two in silico systems for identification of potentially mutagenic impurities. Regul Toxicol Pharmacol 72(2):335-49; doi: 10.1016/j.yrtph.2015.05.008. PMID: 25980641.

Panko JM. Chemical selection tools analysis project and results. Presented at GlobalChem. Global Chemical Regulations Conference, Baltimore, MD, March 2014.

Sutter A, Amberg A, Boyer S, Brigo A, Contrera JF, Custer LL, Dobo KL,…, Greene N, et al. 2013. Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities. Regul Toxicol Pharmacol 67(1):39-52; doi: 10.1016/j.yrtph.2013.05.001. PMID: 23669331.

Greene N, Gosink M. 2013. Computational toxicology experience and applications for risk assessment in the pharmaceutical industry. Chapter 10 in: Fowler BA (ed), Computational Toxicology: Methods and Applications. Elsevier-Academic Press, pp. 171-193; doi: 10.1016/B978-0-12-396461-8.00012-9.

Shah F, Greene N. 2013. Analysis of Pfizer compounds in EPA’s ToxCast chemicals-assay space. Chem Res Toxicol 27(1):86-98; doi: 10.1021/tx400343t. PMID: 24328225.

Naven RT, Greene N, Williams RV. 2012. Latest advances in computational genotoxicity prediction. Exp Opin Drug Metabol 8(12):1579-87; doi: 10.1517/17425255.2012.724059. PMID: 22998164.

Dobo KL, Greene N, Fred C, Glowienke S, Harvey JS, Hasselgren C, Jolly R, Kenyon MO, et al. 2012. In silico methods combined with expert knowledge rule out mutagenic potential of pharmaceutical impurities: An industry survey. Regul Toxicol Pharmacol 62(3):449-455; doi: 10.1016/j.yrtph.2012.01.007. PMID: 22321701.

Wang X, Greene N. 2012. Comparing measures of promiscuity and exploring their relationship to toxicity. Molec Inform 3(2):145-159; doi: 10.1002/minf.201100148. PMID: 27476959. Awarded Best Paper of 2012 by the editors of Molecular Informatics.

Greene N, Aleo MD, Louise-May S, Price DA, Will Y. 2010. Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies. Bioorg Med Chem Lett 20(17):5308-5312; doi: 10.1016/j.bmcl.2010.06.129. PMID: 20655216.

Naven RT, Louise-May S, Greene N. 2010. The computational prediction of genotoxicity. Exp Opin Drug Metabol Toxicol 6(7):1-11; doi: 10.1517/17425255.2010.495118. PMID: 20528613.

Patlewicz G, Worth A. 2008. Review of Data Sources, QSARs and Integrated Testing Strategies for Skin Sensitization. EUR 23225 EN.

Patlewicz G, Gallegos Saliner A, Pavan M, Worth A, Benigni R, Aptula A, , et al. 2007. Chemical Similarity and Threshold of Toxicological Concern (TTC) Approaches. Report of an ECB Workshop held in Ispra, November 2005. EUR 22657 EN.

Worth A, Bassan A, Fabjan E, Gallegos Saliner A, Netzeva T, Patlewicz G, Pavan M, Tsakovska I. 2007. The Use of Computational Methods in the Grouping and Assessment of Chemicals – Preliminary Investigations. EUR 22941 EN.

Worth AP, Bassan A, Gallegos A, Netzeva TI, Patlewicz G, Pavan M, et al. 2005. The Characterization of (Quantitative) Structure-Activity Relationships: Preliminary Guidance. EUR 21866 EN*.

Gallegos A, Patlewicz G, Worth AP. 2005. A Similarity Based Approach for Chemical Category Classification. EUR 21867 EN.