2017 (63 POSTS)
Wirbisky-Hershberger SE , Sanchez OF, Horzmann KA, Thanki D, Yuan C, Freeman JL. 2017. Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression. Food Chem Toxicol 109(Pt 1):727–734; doi: 10.1016/j.fct.2017.08.041 .
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Topics: atrazine
Monticello TM , Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, et al. 2017. Current nonclinical testing paradigm enables safe entry to First-in-Human clinical trials: The IQ consortium nonclinical translational database. Toxicol Appl Pharmacol 334(Nov 1):100-109; doi: 10.1016/j.taap.2017.09.006 .
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Topics: nonclinical safety assessment
Pradeep P, Mansouri K, Patlewicz G , Judson RS. 2017. A systematic evaluation of analogs and automated read-across prediction of estrogenicity: A case study using hindered phenols. Comput Toxicol 4(Nov):22-30; doi: 10.1016/j.comtox.2017.09.001 . PMID: 30057968.
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Topics: read-across
Franzen A , Greene T, Van Landingham C, Gentry R. 2017. Toxicology of octamethylcyclotetrasiloxane (D4). Toxicol Lett 279(Suppl 1):2–22. doi: 10.1016/j.toxlet.2017.06.007 . PMID: 28645863.
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Topics: inhalation toxicology , mode of action , pharmacokinetics
Huddle MG, Goman AM, Kernizan FC, Foley DM, Price C , Frick KD, Lin FR. 2017. The economic impact of adult hearing loss: A systematic review. JAMA Otolaryngol: Head Neck Surg 143(10):1040–1048; doi: 10.1001/jamaoto.2017.1243 .
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Topics: hearing loss , Systematic Review
Shao K, Allen BC, Wheeler MW . 2017. Bayesian hierarchical structure for quantifying population variability to inform probabilistic health risk assessments. Risk Anal 37(10):1865-78; doi: 10.1111/risa.12751 .PMCID: PMC6151353.
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Topics: Bayesian modeling , risk assessment
Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C , Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; doi: 10.1021/acs.chemrestox.7b00221 . PMID: 28927277.
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Topics: arsenic , benchmark dose estimation (BMD)
Thompson CM , Young RR, Dinesdurage H, Suh M , Harris MA, Rohr AC, Proctor DM . 2017. Assessment of the mutagenic potential of hexavalent chromium in the duodenum of Big Blue® rats. Toxicol Appl Pharmacol 330(1):48-52; 10.1016/j.taap.2017.07.002 . PMID: 28687238.
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Topics: chromium
Young LY, Sacks NC , Cyr PL , Sharma A, Dahdal DN. 2017. Comparison of claims data on hospitalization rates and repeat procedures in patients receiving a bowel preparation prior to colonoscopy. Sage Open Med 5(Aug 31):2050312117727999; doi: 10.1177/205031211772799 . PMID: 28894587.
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Topics: Epidemiology , Health Economics and Outcomes Research (HEOR)
Jackson MA, Yang L, Lea I , Rashid A, Kuo B, Williams A, Lyn Yauk C, Fostel J. 2017. The TGx-28 65 biomarker online application for analysis of transcriptomics data to identify DNA damage-inducing chemicals in human cell cultures. Environ Mol Mutagen 58(7):529–535; doi: 10.1002/em.22114 . PMID: 28766826.
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Topics: biomarkers , transcriptomics
Iwata Y, Klaren WD , Lebakken CS, Grimm FA, Rusyn I. 2017. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. Assay Drug Dev Technol 15(6):267–279; doi: 10.1089/adt.2017.786 . PMID: 28771372.
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Topics: test methods
Patlewicz G , Helman G, Pradeep P, Shah I. 2017. Navigating through the minefield of read-across tools: A review of in silico tools for grouping. Comput Toxicol 3(Aug):1-18; doi: 10.1016/j.comtox.2017.05.003 . PMID: 30221211.
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Topics: read-across
Wallace TC, Frankenfeld CL . 2017. Dietary protein intake above the current RDA and bone health: A systematic review and meta-analysis. J Am Coll Nutr 36(6):481–496; doi: 10.1080/07315724.2017.1322924 . PMID: 28686536.
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Topics: nutrition , Systematic Review
Bichteler A, Wikoff DS , Loko F, Harris MA. 2017. Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005-2006 and 2007-2008: A multiple imputation and trending approach incorporating NHANES pooled sample data. Environ Int 105(Aug):112-125; doi: 10.1016/j.envint.2017.05.003 . PMID: 28527750.
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Topics: dioxin , NHANES
Butler LD, Guzzie-Peck P, Hartke J, Bogdanffy MS, Will Y, Diaz D, Mortimer-Cassen E,…, Greene N , et al. 2017. Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective. Regul Toxicol Pharmacol 87(Sup 3):S1-S15; doi: 10.1016/j.yrtph.2017.05.009 . PMID: 28483710.
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Topics: drug development , nonclinical safety assessment
Hoffmann S, de Vries RB, Stephens ML, Beck NB, Dirven HAAM, Fowle III JR, Goodman JE,…, Wikoff D , et al. 2017. A primer on systematic reviews in toxicology. Arch Toxicol 91(7):2551-2575; doi: 10.1007/s00204-017-1980-3 . PMID: 28501917.
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Topics: Systematic Review
Schaefer HR , Myers, JL. 2017. Development of an inhalation unit risk factor for ethylene dibromide. Inhal Toxicol 29(7):304-309; doi: 10.1080/08958378.2017.1369603 . PMID: 28891353.
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Topics: inhalation toxicology
Rager JE, Ring CL, Fry RC, Suh M , Proctor DM , Haws L , Harris MA, Thompson CM . 2017. High-throughput screening data interpretation in the context of in vivo transcriptomic responses to oral Cr(VI) exposure. Toxicol Sci 158(1):199–212; doi: 10.1093/toxsci/kfx085 . PMID: 28472532.
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Topics: chromium , transcriptomics
Klaren WD , Vine D, Vogt S, Robertson LW. 2017. Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25(17):16427–16433; doi: 10.1007/s11356-017-0202-0 .
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Topics: Metals
Burns A , Shin J, Unice KM, Gaffney SH, Kreider ML, Gelatt RN, Panko JM . 2017. Combined analysis of job and task benzene air exposures among workers at four US refinery operations. Toxicol Ind Health 33(3):193–210; doi: 10.1177/0748233715619072 . PMID: 26862134.
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