2017 (62 POSTS)
Thompson CM , Wolf, JC, McCoy A, Suh M , Proctor DM , Kirman CR, Haws LC , Harris MA. 2017. Comparison of toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens captan, folpet, and hexavalent chromium. Toxicol Pathol 45(8):1091–1101; doi: 10.1177/019262331yy4324 . PMID: 29161989.
View Abstract
Topics: carcinogens , chromium
Sanz F, Pognan F, Steger-Hartmann T, Díaz C, Cases M, Pastor M, Marc P,…, Greene N , et al. 2017. Legacy data sharing to improve drug safety assessment: The eTOX project. Nat Rev Drug Discov 6(12):811-812; doi: 10.1038/nrd.2017.177 . PMID: 29026211.
View Abstract
Topics: drug development , safety assessment
Schaefer HR , Myers, JL. 2017. Guidelines for performing systematic reviews in the development of toxicity factors. Regul Toxicol Pharmacol 91(Dec):124-141; doi: 10.1016/j.yrtph.2017.10.008 . PMID: 29080853.
View Abstract
Topics: risk assessment , Systematic Review
Wheeler MW , Dunson DB, Herring AH. 2017. Bayesian local extremum splines. Biometrika 104(4):939-52; doi: 10.1093/biomet/asx039 . PMID: 29422695.
View Abstract
Topics: Bayesian modeling
Stephenson CJ, Rossheim ME, Frankenfeld CL , Boncy J, Okech BO, von Fricken ME. 2017. Cross-sectional analysis of the association between bedtime and malaria exposure in the Ouest and Sud-Est Departments of Haiti. Acta Tropica 176(Dec):188–19; doi: 10.1016/j.actatropica.2017.08.011 . PMID: 28818627.
View Abstract
Topics: malaria
Lansita J, Mease KM , Qiu H, Yednock T, Sankaranarayanan S, Kramer S. 2017. Nonclinical development of ANX005: A humanized anti-Clq antibody for treatment of autoimmune and neurodegenerative diseases. Int J Toxicol 36(6)449-462; doi: 10.1177/1091581817740873 . PMID: 29202623.
View Abstract
Topics: drug development , nonclinical safety assessment
Williams A, Grulke C, Edwards J, McEachran A, Mansouri K, Baker N, Patlewicz G , Shah I, et al. 2017. The CompTox Chemistry Dashboard–A community data resource for environmental chemistry. J Cheminform 9(1):61; doi: 10.1186/s13321-017-0247-6 . PMID: 29185060.
View Abstract
Topics: computational toxicology
Liu J, Patlewicz G , Williams A, Thomas RS, Shah I. 2017. Predicting organ toxicity using in vitro bioactivity data and chemical structure. Chem Res Toxicol 30(11):2046-2059; doi: 10.1021/acs.chemrestox.7b00084 . PMID: 28768096.
View Abstract
Topics: computational toxicology , modeling
Thompson CM, Suh M, Proctor DM, Haws LC , Harris MA. 2017. Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents. Mutat Res 823(Nov):45-57; doi: 10.1016/j.mrgentox.2017.08.004 . PMID: 28985946.
View Abstract
Topics: chromium , mode of action
Wheeler MW , Bailer AJ, Cole T, Park RM, Shao K. 2017. Bayesian quantile impairment threshold benchmark dose estimation for continuous endpoints. Risk Anal 37(11):2107-18; doi: 10.1111/risa.12762 . PMID: 28555874.
View Abstract
Topics: Bayesian modeling , benchmark dose estimation (BMD) , modeling
Vincent MJ , Parker A, Maier A. 2017. Cleaning and asthma: A systematic review and approach for effective safety assessment. Regul Toxicol Pharmacol 90(Nov):231–243; doi: 10.1016/j.yrtph.2017.09.013 . PMID: 28918194.
View Abstract
Topics: chemical safety assessment , consumer products , Systematic Review
Wikoff D , Welsh BT, Henderson R , Brorby GP , Britt J ,…, Harvey S, Urban J, Doepker C . 2017. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 109(Pt1):585-648; doi: 10.1016/j.fct.2017.04.002 . PMID: 28438661.
View Abstract
Topics: food safety , Food science , Systematic Review
Vincent MJ , Bernstein JA, Basketter D, LaKind JS, Dotson GS, Maier A. 2017. Chemical-induced asthma and the role of clinical, toxicological, exposure and epidemiological research in regulatory and hazard characterization approaches. Regul Toxicol Pharmacol 90(Nov):126–132; doi: 10.1016/j.yrtph.2017.08.018 . PMID: 28866265.
View Abstract
Topics: Epidemiology , Exposure Assessment , regulatory toxicology
Wirbisky-Hershberger SE , Sanchez OF, Horzmann KA, Thanki D, Yuan C, Freeman JL. 2017. Atrazine exposure decreases the activity of DNMTs, global DNA methylation levels, and dnmt expression. Food Chem Toxicol 109(Pt 1):727–734; doi: 10.1016/j.fct.2017.08.041 . PMID: 28859886.
View Abstract
Topics: atrazine
Monticello TM , Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, et al. 2017. Current nonclinical testing paradigm enables safe entry to First-in-Human clinical trials: The IQ consortium nonclinical translational database. Toxicol Appl Pharmacol 334(Nov 1):100-109; doi: 10.1016/j.taap.2017.09.006 . PMID: 28893587.
View Abstract
Topics: nonclinical safety assessment
Pradeep P, Mansouri K, Patlewicz G , Judson RS. 2017. A systematic evaluation of analogs and automated read-across prediction of estrogenicity: A case study using hindered phenols. Comput Toxicol 4(Nov):22-30; doi: 10.1016/j.comtox.2017.09.001 . PMID: 30057968.
View Abstract
Topics: read-across
Franzen A , Greene T, Van Landingham C, Gentry R. 2017. Toxicology of octamethylcyclotetrasiloxane (D4). Toxicol Lett 279(Suppl 1):2–22. doi: 10.1016/j.toxlet.2017.06.007 . PMID: 28645863.
View Abstract
Topics: inhalation toxicology , mode of action , pharmacokinetics
Gentry R, Franzen A , Van Landingham C, Greene T, Plotzke K. 2017. A global human health risk assessment for octamethylcyclotetrasiloxane (D4). Regul Toxicol Pharmacol 279(Sup 1):23-41; doi: 10.1016/j.toxlet.2017.05.019 . PMID: 28522410.
View Abstract
Topics: chemical safety assessment , consumer products , risk assessment
Shao K, Allen BC, Wheeler MW . 2017. Bayesian hierarchical structure for quantifying population variability to inform probabilistic health risk assessments. Risk Anal 37(10):1865-78; doi: 10.1111/risa.12751 . PMID: 28032899.
View Abstract
Topics: Bayesian modeling , risk assessment
Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C , Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; doi: 10.1021/acs.chemrestox.7b00221 . PMID: 28927277.
View Abstract