Mihalchik-Burhans A . And you want this by when? Making the successful transition from the bench to consulting. Oral presentation at the American College of Toxicology 39th Annual Meeting, West Palm Beach, FL, November 2018.
Publication: Abstracts and Presentations
/ Topics: collaboration
Thompson CM , Wolf JC, Suh M , Proctor DM , Haws LC , Harris MA. Toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens; captan, folpet, and hexavalent chromium: Evidence for an adverse outcome pathway. Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.
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Publication: Abstracts and Presentations
/ Topics: carcinogens , chromium
Thompson CM , Suh M , Proctor DM , Harris MA. Ten factors for considering the mode of action of Cr(VI)-induced intestinal tumors in rodents. Society of Toxicology 57th Annual Meeting, San Antonio, TX, March 2018.
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Publication: Abstracts and Presentations
/ Topics: chromium , mode of action
Proctor DM . Updating the regulatory risk assessment for hexavalent chromium in California: Implications for regulatory standards. Association of Environmental Health Sciences San Diego, CA, March 2018.
Publication: Abstracts and Presentations
/ Topics: chromium , regulatory toxicology , risk assessment
Thompson CT , Suh M , Chappell G, Borghoff S , Ellis-Hutchings, R, Wiench, K, Finch, L, Proctor DM . 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96:178–189; doi: 10.1016/j.yrtph.2018.05.006 .
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Publication: Manuscripts
/ Topics: carcinogens , mode of action , risk assessment
Suh M , Proctor DM , Chappell G, Rager JE, Thompson CM , Borghoff S , Finch L, Ellis-Hutchings R, Wiench K. 2018. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicol 402-403(June 1):50-67; doi: 10.1016/j.tox.2018.04.006 .
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Publication: Manuscripts
/ Topics: carcinogens , chemical safety assessment , consumer products
Proctor DM , Suh M , Chappell G, Borghoff SJ , Thompson CM , Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol, 96(July):30-40; doi: 10.1016/j.yrtph.2018.04.016 .
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Publication: Manuscripts
/ Topics: Adverse outcome pathways (AOPs) , Cancer , genotoxicity
Proctor DM . Hexavalent chromium in drinking water: When is the science sufficient to deviate from defaults? Invited Speaker, Genetic and Environmental Toxicology Association (GETA). Thresholds in Toxicology and Risk Assessment Fall Symposium, Oakland, CA, November 2018.
Publication: Abstracts and Presentations
/ Topics: chromium , water
Movva N , Jani A. 2018. The value of pay-for-performance in England: An evaluation of NHS England’s Quality Outcomes Framework. Value in Healthcare Review Working Paper No. 2; University of Oxford Research Archive .
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Publication: Manuscripts
/ Topics: Health Economics and Outcomes Research (HEOR)
DeGeorge J, Robertson S, Butler L, Derzi M, Stoch SA, Diaz D, Hartke J,…, Greene N . 2018. An industry perspective on the 2017 EMA guideline on first‐in‐human and early clinical trials. Clin Pharm Ther 103(4):566-569; doi: 10.1002/cpt.984 . PMID: 29285748.
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Publication: Manuscripts
/ Topics: drug development
Clippinger A, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G , et al. 2018. Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. Toxicol In Vitro 48(April):53-70; doi: 10.1016/j.tiv.2017.12.011 . PMID: 29277654.
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Publication: Manuscripts
/ Topics: inhalation toxicology , NAMs , regulatory toxicology
Fryzek J, Reichert H , Summers N, Townes L, Deuson R, Alexander DD, Vanderpuye-Orgle J. 2018. Indirect treatment comparison of cabazitaxel for patients with metastatic castration-resistant prostate cancer who have been previously treated with a docetaxel-containing regimen. PLoS One 13(4):e0195790; doi: 10.1371/journal.pone.0195790 . PMID: 29641566.
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Publication: Manuscripts
/ Topics: Cancer , drug development
Lea IA , Borghoff S , Travlos GS. 2018. Electrolytes, blood gases and acid-base balance. In: Kurtz DM, Travlos GS (eds): The Clinical Chemistry of Laboratory Animals (3rd edition). CRC Press, Boca Raton, FL; doi: 10.1201/9781315155807 .
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Publication: Book Chapters
/ Topics: mode of action
Shay Hynds EC, Ierardi AM, Burns AM , Finley BL . Derivation of a chronic oral RfD for antimony. Abstract 3448, Society of Toxicology 57th Annual Meeting, San Antonio, TX, 2018.
Publication: Abstracts and Presentations
/ Topics: Metals
Kovochich M, Fung D, Unice KM, Mahoney SL, Paustenbach DJ, Finley BL . Understanding divergent outcomes in MoM-THA patient populations with well-fixed components: A critical appraisal of patient management protocols and revision trends (2000-2017). Poster presentation at Society of Toxicology 57th Annual Meeting, San Antonio, TX, 2018.
Publication: Abstracts and Presentations
/ Topics: Metals
Kovochich M, Fung ES, Mahoney SL, Unice KM, Fung D, Paustenbach DJ, Finley BL . Characterizing cytotoxic and inflammatory responses to metal-on-metal wear debris from normal versus edge-loading conditions. Poster presentation at Society of Toxicology 57th Annual Meeting, San Antonio, TX, 2018.
Publication: Abstracts and Presentations
/ Topics: Metals
Burns AM , Benson SM, Best E, Hollins DM, Finley BL . An ecological epidemiology investigation of talc consumption in the US and trends in female cancer rates. Poster presentation at Society of Toxicology 57th Annual Meeting, San Antonio, TX, 2018.
Publication: Abstracts and Presentations
/ Topics: Cancer , Epidemiology , talc
Brorby GP . The ongoing controversy surrounding the effects of short-term exposure to trichloroethylene. Presented at the Association for Environmental Health and Sciences Foundation Annual International Conference, San Diego, CA, March 2018.
Publication: Abstracts and Presentations
/ Topics: trichloroethylene
Thompson CM , Kirman CR, Hays SM, Suh M , Harvey SE , Proctor DM , Rager JE, Haws LC , Harris MA. 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545 .
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